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Firstly, that our conception of the syndrome is in a state of flux. Gone, for instance, in the past decade or two, is the requirement of a chronic, progressive, irreversible disorder for the diag- nosis. I remember the surgeon who, when I was a student, returned a referral saying he would operate on the man when his dementia got better. Feeling superior, and encouraged by the consultant psychiatrist, we students laughed a good deal at this. Before we finished clerking on that Unit a visiting Professor of Psychiatry had demonstrated the reversibility of the symptoms of dementia in a patient with a rare metabolic disorder. Perhaps ignorance is sometimes an advance on received wisdom. The lesson is the concept of dementia must always reflect the state of knowledge and is therefore in a sense ad hoc. Secondly, what the criteria for, and also who the arbiters of, the diagnosis might be is not always clear. 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A book devoted to depression has the advantage that it has the space at its disposal to explain and clarify concepts and promising ideas that a chapter in even a comprehensive textbook does not have. A single author writing about all the relevant aspects of a subject brings with him the merit of uniformity, continuity and lack of repetition. He is also more fallible in some areas than others, which finds an exact parallel in the experience of clinicians in their practice. A multi-author, multi-specialist work portrays an air of omniscience and omnicompetence which many clinicians find dispiriting. It is likely a considerable number of practising clinicians will have a greater knowledge and experience in some areas of the subject of this book. than I have and will feel emboldened to approach others. The entire work is informed by historical considerations. 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