{"title":"Charles J Epstein","description":null,"products":[{"product_id":"consequences-of-chromosome-imbalance-book-charles-j-epstein-9780521254649","title":"The Consequences of Chromosome Imbalance","description":"This book considers in detail the mechanisms of a major human problem. Chromosome imbalance affects all stages of life in ways ranging from spontaneous abortion and retardation to behavioural problems and malignancy. Charles J. Epstein concerns himself with how and why a particular chromosome imbalance produces a specific phenotype. His fundamental goal is to connect chromosome aberrations with functional abnormalities in terms of gene expression, developmental and cell biology, and metabolism. Through his examination of this relationship, we learn more about normal development and function. The book begins with an exploration of several human autosomal aneuploid phenotypes, with particular emphasis on the relationship between genotype and phenotype. In the next part, broad theoretical considerations of the mechanisms which generate these phenotypes are examined with reference to studies on man and other organisms such as bacteria and mice. Experimental approaches to study the effects of aneuploidy are presented next with special attention paid to the development of model systems for studying human aneuploidy.","brand":"WoB","offers":[{"title":"US \/ NEW \/ INGRAM","offer_id":51283064160529,"sku":"NIN9780521254649","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52331810423057,"sku":"NLS9780521254649","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/0521254647.jpg?v=1751326243"},{"product_id":"inborn-errors-of-development-book-charles-j-epstein-9780195145021","title":"Inborn Errors of Development","description":"Disorders that affect tissue differentiation, organogenesis, and morphogenesis constitute a significant proportion of human hereditary diseases. Until very recently, however, their genetic causes and pathogenesis have been unknown. Now, with the elucidation of the molecular pathways that govern developmental processes and with advances in gene identification, the genetic bases of an increasing number of human disorders of development are being discovered and the links between genotype and phenotype established. This extraordinary volume is the first to present in-depth analyses of the human syndromes of abnormal morphogenesis for which the responsible genes have been identified. Following a series of introductory chapters on the general principles of developmental biology, developmental genetics, and the development of individual tissues or organ systems, more than one hundred clinical genetic disorders are considered. The clinical chapters are organized into sections by defined developmental pathways or gene families, and each section is preceded by a general overview. For each disorder the authors cover the disease-causing genes, the role of these genes in development as elucidated in model organisms, the human mutations that have been identified, and the developmental pathogenesis of the condition. Clinical descriptions, along with discussions of therapy and counseling, are provided. This book will be an invaluable resource for physicians, dentists, and other health professionals and for basic scientists interested in developmental processes and genetic perturbations that affect them. It is authoritative, clearly written, consistently organized, and attractively illustrated in color.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51818221076753,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ GOOD \/ INTERNAL","offer_id":51818221371665,"sku":"GOR014410759","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ VERY_GOOD \/ INTERNAL","offer_id":51833432310033,"sku":"GOR014417740","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780195145021.jpg?v=1752491286"},{"product_id":"consequences-of-chromosome-imbalance-book-charles-j-epstein-9780521038096","title":"The Consequences of Chromosome Imbalance","description":"This book considers in detail the mechanisms of a major human problem. Chromosome imbalance affects all stages of life in ways ranging from spontaneous abortion and retardation to behavioural problems and malignancy. 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Experimental approaches to study the effects of aneuploidy are presented next with special attention paid to the development of model systems for studying human aneuploidy.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52335787868433,"sku":"NLS9780521038096","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780521038096.jpg?v=1786119481"},{"product_id":"inborn-errors-of-development-book-charles-j-epstein-9780195306910","title":"Inborn Errors of Development","description":"Discusses the question of whether 'culture' refers to some superorganic entity that exists in its own right, or is only convenient short-hand for the shared beliefs and behaviour of human individuals.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":54713369690385,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ GOOD \/ SBYB","offer_id":54713370018065,"sku":"CIN0195306910G","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780195306910.jpg?v=1790015435"}],"url":"https:\/\/www.worldofbooks.com\/collections\/author-books-by-charles-j-epstein.oembed","provider":"World of Books ","version":"1.0","type":"link"}