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In connection with this further milestone in the story of the drug, a symposium was held in Stockholm on March 14, 1996, under the chairman- ship of Professor N. Rawal to review the current understanding of the ac- tion, efficacy and safety of dipyrone. The highlights of this Hoechst symposium emphasize particularly the therapeutic basis for the use of dipyrone in the modern treatment of acute post-operative pain. 9 Mode of action of dipyrone Professor K. Brune, M. D. 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