{"title":"David Brownstein Sheryl Shenefelt","description":null,"products":[{"product_id":"the-guide-to-healthy-eating-book-david-brownstein-sheryl-shenef-9780966088250","title":"The Guide to Healthy Eating","description":"\u003cp\u003eHypo- or hypersecretion, alteration in storage, release, catabolism, and post-translational processing of neuropeptides are associated with the etiology of many diseases affecting the central nervous system (CNS). Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics developed as their agonists or antagonists could be useful in the treatment of these CNS maladies. However, peptides face a formidable obstacle in reaching the intended site of action due to the existence of the blood-brain barrier (B), a vital element in the regulation of the internal environment of the brain and the spinal cord. After reviews on the role and neuropharmaceutical potential of peptides, properties of the B in the context of peptide transport in the CNS and potential transport mechanisms to cross the B, this volume discusses the development, present state-of-the-art and future trends of various strategies to overcome this major obstacle to peptide pharmacotherapy involving the CNS. Chapters are devoted to cover invasive approaches that circumvent the B by direct administration into the brain or the spinal cord and by transiently opening the tight junctions of or permeabilizing the endothelial cells separating the systemic circulation from the interstitial fluid of the CNS. Subsequently, physiologically based strategies that utilize biological carriers to gain access to the CNS are discussed in detail, followed by methods encompassing prodrug and chemical delivery\/targeting strategies, which aim at altering the properties of the peptide to enhance B transport, and drug delivery strategies based on peptide vectors. Finally, a comparative evaluation on the present status and perspectives of the techniques is presented.\u003c\/p\u003e","brand":"WoB","offers":[{"title":"GB \/ VERY_GOOD \/ INTERNAL","offer_id":49509432852753,"sku":"GOR004030424","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ GOOD \/ SBYB","offer_id":49530856898833,"sku":"CIN0966088255G","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ VERY_GOOD \/ SBYB","offer_id":49947601633553,"sku":"CIN0966088255VG","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"US \/ WELL_READ \/ SBYB","offer_id":50060026904849,"sku":"CIN0966088255A","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ GOOD \/ INTERNAL","offer_id":51509697872145,"sku":"GOR011745110","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ LIKE_NEW \/ INTERNAL","offer_id":51613266805009,"sku":"GOR014346438","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/0966088255.jpg?v=1751331736"},{"product_id":"the-guide-to-a-dairy-free-diet-book-david-brownstein-sheryl-shenef-9780984086900","title":"The Guide to a Dairy-Free Diet","description":null,"brand":"WoB","offers":[{"title":"US \/ GOOD \/ SBYB","offer_id":49655705075985,"sku":"CIN0984086900G","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ VERY_GOOD \/ SBYB","offer_id":50283313070353,"sku":"CIN0984086900VG","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"US \/ WELL_READ \/ SBYB","offer_id":51828502102289,"sku":"CIN0984086900A","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/0984086900.jpg?v=1750916510"},{"product_id":"the-skinny-on-fats-book-david-brownstein-sheryl-shenef-9780984086924","title":"The Skinny on Fats","description":"\u003cp\u003e\u003cstrong\u003e1:1 In the beginning God created the heaven and the earth.\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e1:1起初，上帝创造了天地。\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003e1:2 And the earth was without form, and void; and darkness was upon the face of the deep. And the Spirit of God moved upon the face of the waters.\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e1:2大地没有形，虚空;黑暗笼罩着深渊。神的灵在水面上移动。\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003e1:3 And God said, Let there be light: and there was light.\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e1:3神说，要有光，就有光。\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003e1:4 And God saw the light, that it was good: and God divided the light from the darkness.\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e1:4神看见光，说是好的，就把光明和黑暗分开。\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003e1:5 And God called the light Day, and the darkness he called Night. And the evening and the morning were the first day.\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e1:5上帝称光明为白昼，称黑暗为黑夜。傍晚和早晨是第一天。\u003c\/p\u003e","brand":"WoB","offers":[{"title":"US \/ VERY_GOOD \/ SBYB","offer_id":52325322326289,"sku":"CIN0984086927VG","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"US \/ GOOD \/ SBYB","offer_id":53675300225297,"sku":"CIN0984086927G","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780984086924.jpg?v=1758026788"}],"url":"https:\/\/www.worldofbooks.com\/collections\/author-books-by-david-brownstein-sheryl-shenefelt.oembed","provider":"World of Books ","version":"1.0","type":"link"}