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It is a brain disorder that damages some specific types of neurons, leading to degeneration in several parts of the brain causing them to lose their function. This results in uncontrolled movements, loss of intellectual abilities and behavioral disturbances. Since the mutation causes have been discovered, there have been several important advancements in understanding the cellular and molecular agitations. This book consists of current knowledge on a wide variety of issues involving this disease. It will help clinicians, health care providers, researchers and graduate students to enhance their understanding and knowledge about the clinical correlates, genetic issues, neuropathological findings, cellular and molecular events and potential therapeutic interventions involved in Huntington's disease. 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Over 6 million Europeans, out of which more than a quarter of people who are over the age of 85 and 10% who are over the age of 65, have been affected by Alzheimer's Dementia (AD). Given the steady aging of European societies, cognitive decline and dementia have grown into a crucial health problem with a great socioeconomic effect on patients, their caregivers and families, society, and national health care policy. The amount of people with dementia is estimated to double by 2030 and further increase by 2050. There is a critical requirement for creative methods to boost understanding of pathological events that would transform into the establishment of successful prevention or new treatment techniques. Advancements in comprehending pathological events in AD have been achievable by employing cell cultures, genetically modified organisms and animal models that do not have the complexity of events happening in humans. 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