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Atualmente, a doen a da pele grumosa constitui uma grande amea a para  frica e para o M dio Oriente. Na Eti pia, s o frequentes os relatos de surtos da doen a em diferentes zonas de produ  o de gado. Os preju zos econ micos da doen a no gado s o compar veis aos causados pela febre aftosa (FA). As taxas de morbilidade da doen a variam entre 80 e 90 por cento e as taxas de mortalidade atingem 40 por cento ou mais em diferentes situa  es. As les es cut neas provocam danos graves e permanentes nas peles. A epidemiologia da LSD   uma doen a infecciosa aguda que afecta bovinos de todas as idades e ra as.   transmitida por insectos que picam. Caracteriza-se por febre, n dulos na pele, membranas mucosas e  rg os internos, emacia  o, g nglios linf ticos aumentados, edema da pele e, por vezes, morte. Os principais factores de risco associados   ocorr ncia da doen a s o a dimens o do efetivo, os pontos de pastagem e de abeberamento comuns, as esta  es h midas do ano e a introdu  o de novos animais no efetivo. 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