{"title":"Moyra Smith","description":null,"products":[{"product_id":"molecular-insights-into-development-in-humans-studies-in-normal-development-and-book-moyra-smith-9789814630580","title":"MOLECULAR INSIGHTS INTO DEVELOPMENT IN HUMANS: STUDIES IN NORMAL DEVELOPMENT AND BIRTH DEFECTS","description":"The aim and scope of this book is to review current information on human development and processes of differentiation that have benefited from breakthrough analyses in stem cell biology, elucidation of genome and gene architecture and aspects of regulation of gene expression, analysis of signaling systems and transcription factor actions.Insights into actions of specific genes and their roles in development have been gathered through studies in patients with specific birth defects, including congenital malformations, metabolic defects and functional impairments.The book is organized into three sections, the first dealing with aspects of genomics, gene structure and regulation, analysis of signaling and function of specific organelles. The second section deals with molecular aspects of development of specific organs and structures such as, bone, face, brain, heart, liver, pancreas, kidney. The last section deals with specific malformations and tumors that provide insight into regulation of growth. Environmental factors that impact growth and development are also covered.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51068023734545,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51068024619281,"sku":"NIN9789814630580","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52408035016977,"sku":"NLS9789814630580","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9814630586.jpg?v=1790228197"},{"product_id":"unravelling-complexities-in-genetics-and-genomics-impact-on-diagnosis-counseling-book-moyra-smith-9789814759465","title":"UNRAVELLING COMPLEXITIES IN GENETICS AND GENOMICS: IMPACT ON DIAGNOSIS COUNSELING AND MANAGEMENT","description":"Unravelling Complexities in Genetics and Genomics: Impact on Diagnosis Counseling and Management reviews recent advances in defining genetic and genomic factors that play important roles in diseases in humans. It includes discussions on new technologies in DNA and RNA sequencing, genome analysis, and bioinformatics applied to the study of patients with specific disorders and to normal populations, and illustrates how modern molecular techniques can improve diagnoses and enable the design of specific targeted therapies and methods of prevention. Additional emphasis is placed on the genetic variants and genomic risk factors related to the development of complex common disorders, including neurobehavioral and neurocognitive disorders in children and adults and late onset disorders in adults, including atherosclerosis, type 2 diabetes, cancer, and neurodegenerative disorders.Physicians, nurses, genetic counselors, graduate students in genetics and genomics will find this book a valuable read.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51243293540625,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51243295670545,"sku":"NIN9789814759465","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52476831531281,"sku":"NLS9789814759465","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9814759465.jpg?v=1787479195"},{"product_id":"mechanisms-and-genetics-of-neurodevelopmental-cognitive-disorders-book-moyra-smith-9780128219133","title":"Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders","description":"Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders connects neurodevelopment with genetics and behavior to better understand the underlying factors leading to cognitive neurodevelopmental disorders. This book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology, and many other factors that influence the development of these diseases.\n\n  This book will promote understanding of recent investigations and developments related to brain development from fetal life onward with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ GARDNERS","offer_id":52085212119313,"sku":"NGR9780128219133","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780128219133.jpg?v=1756815419"},{"product_id":"seeking-cures-book-moyra-smith-md-9780199915866","title":"Seeking Cures","description":"Seeking Cures outlines the progress and implications of science's quest to identify therapeutic targets and initiate novel treatments at the gene, RNA, protein, and physiological levels. Also considered are aspects of treatment at the cellular level (e.g., those with hematopoietic stem cells or induced pluripotent stem cells).","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52403208618257,"sku":"NLS9780199915866","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780199915866.jpg?v=1790201763"},{"product_id":"phenotypic-variation-book-moyra-smith-md-phd-mfa-9780195379631","title":"Phenotypic Variation","description":"During the past two decades international collaborative studies have yielded extensive information on genome sequences, genome architecture and their variations. The challenge we now face is to understand how these variations impact structure and function of organelles, physiological systems and phenotype. The goal of this book is to present steps in the pathways of exploration to connect genotype to phenotype and to consider how alterations in genomes impact disease. In this book the author reviews published research in functional genomics carried out primarily since 2006 that sheds light on aspects of phenotypic variation. The goal of functional genomics is to gain insight into mechanisms through which specific changes in genome transcripts and regulation induce changes in proteins, pathways, organelles, cellular and tissue functions, morphology and ultimately in phenotype. Topics reviewed include investigations in genome architecture, gene structure, gene regulation epigenetic modifications and function of organelles including mitochondria, and the endosome lysosome system. New insights into neurodevelopment and neurobehavioral disorders gained through functional genomic research are presented. Aspects of genomic studies in complex common diseases are reviewed. Molecular genetic variations and aberrations in cellular mechanisms involved in protein quality surveillance play a role in late onset diseases and one chapter deals with this topic. Molecular analyses of genes and proteins continue to shed light on the pathogenesis of malformation syndromes and specific examples of such studies are presented. There is growing evidence that late onset disorders such as Parkinson disease, are frequently the end result of defects in functioning of components in different pathways and examples of these are discussed. There is evidence that genetic variation determines differences in response to environmental insults. Genetic variations in complement factor genes are an example of this and are discussed in the context of macular degeneration and pathogenesis of hemolytic uremic syndrome in response exposure to E coli Shiga toxin. In the final chapter the author briefly summarizes key features of the cascade of events that constitute functional genomics.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52453471191313,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52453471846673,"sku":"NLS9780195379631","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780195379631.jpg?v=1791381013"},{"product_id":"journeys-in-medicine-and-research-on-three-continents-over-50-years-book-moyra-smith-9789813209541","title":"JOURNEYS IN MEDICINE AND RESEARCH ON THREE CONTINENTS OVER 50 YEARS","description":"This book presents clinical and research aspects of medicine and social dimensions of healthcare. It is designed for an audience with interest in health and societal factors. It is in part autobiographical, based on different phases of the author's life in medicine over 50 years, who revisited cases and problems encountered as she worked in different countries, including South Africa, Scotland, England and North America. Essays encompass aspects of clinical medicine and aspects of research, particularly in Genetics and Genomic Medicine. New information on the topic or disorder and current opinions and approaches to finding solutions are reviewed.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52453783306513,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52453784027409,"sku":"NLS9789813209541","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789813209541.jpg?v=1788604540"},{"product_id":"gene-environment-interactions-book-moyra-smith-9780128196137","title":"Gene Environment Interactions","description":"Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome’s intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders. \n\n  Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52478585831697,"sku":"NLS9780128196137","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780128196137.jpg?v=1759847401"},{"product_id":"journeys-in-medicine-and-research-on-three-continents-over-50-years-book-moyra-smith-9789813209534","title":"JOURNEYS IN MEDICINE AND RESEARCH ON THREE CONTINENTS OVER 50 YEARS","description":"This book presents clinical and research aspects of medicine and social dimensions of healthcare. It is designed for an audience with interest in health and societal factors. It is in part autobiographical, based on different phases of the author's life in medicine over 50 years, who revisited cases and problems encountered as she worked in different countries, including South Africa, Scotland, England and North America. Essays encompass aspects of clinical medicine and aspects of research, particularly in Genetics and Genomic Medicine. New information on the topic or disorder and current opinions and approaches to finding solutions are reviewed.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52531680608529,"sku":"NLS9789813209534","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789813209534.jpg?v=1788606118"},{"product_id":"progress-pioneers-and-process-studies-in-physiology-and-genetic-medicine-book-moyra-smith-9789813270572","title":"PROGRESS, PIONEERS AND PROCESS: STUDIES IN PHYSIOLOGY AND GENETIC MEDICINE","description":"This book describes the growth of information on specific aspects of physiology and pathology of particular disorders and provides an analysis of the processes and contributions of pioneers to discovery. It begins primarily in the second half of the 19th century and explores specific contributions of researchers through to the 20th and 21st centuries. The book revisits specific aspects of physiology, biochemistry and molecular biology relevant to genetic medicine. In addition, it provides a review of specific human disorders that the author has encountered during her career, as well as an analysis of the progress in determining disease mechanisms and improving therapies.The chapters in this book provide insights into the processes of research and discovery, as well as how elucidation of disease mechanisms translates into research in diagnostics and treatments.The book provides historical information and current information obtained from recent journals and presentations, on each of the topics discussed.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52659177718033,"sku":"NLS9789813270572","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52764000780561,"sku":"NIN9789813270572","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789813270572.jpg?v=1790159818"},{"product_id":"progress-in-genomic-medicine-book-moyra-smith-9780323915472","title":"Progress in Genomic Medicine","description":"Progress in Genomic Medicine: From Research to Clinical Application provides a careful synthesis of the foundations, current trends and translational challenges in genomic medicine, clarifying pathways forward and enabling genomic medicine research and implementation across clinical settings and treatment development. Sections address the history and growth of genetic medicine, with a discussion of key studies in syndrome delineations, inherited diseases, biochemical genetics, and chromosome abnormalities, overview clinical applications made possible through genomic advances, with chapters on DNA sequencing for clinical genetic diagnosis, genotype-phenotype correlations in individuals and across populations, new-born screening for treatable genetic disorders, and more.\n\n  In addition, social, ethical and public health aspects of applying genomic technologies are included throughout. Here, Dr. Smith applies her experience and participation in the field, across its major milestones, to put current research, clinical advances, and ongoing questions in context.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52680448672017,"sku":"NLS9780323915472","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780323915472.jpg?v=1762313141"},{"product_id":"advances-in-genomics-and-neurosciences-for-neurologic-and-behavioral-disorders-book-moyra-smith-9780443451836","title":"Advances in Genomics and Neurosciences for Neurologic and Behavioral Disorders","description":"Advances in Genomics and Neurosciences for Neurologic and Behavioral Disorders explores the latest breakthroughs in genomics and neurosciences, providing essential insights for understanding, diagnosing, and managing neurodevelopmental, psychiatric, and neurodegenerative disorders. The book highlights the intersection of genetic and genomic diagnostic techniques with brain function and structure analysis to enhance therapeutic strategies. Sections cover a wide range of topics, including the analysis of brain circuits, synapses, and neural activity, as well as the role of ion channels and neurotrophins in brain function. It examines advanced genetic and genomic diagnostic methods such as chromosome studies, gene sequencing, RNA analysis, and metabolite profiling.\n\nThe book also addresses neurodevelopmental disorders like cerebral palsy, epilepsy, and autism, psychiatric disorders such as schizophrenia and thought disorders, and the molecular biology of memory and age-related cognitive decline. Organized into five sections, the book includes chapters on the latest techniques for brain analysis, genetic diagnostics, neurodevelopmental and psychiatric disorders, aging-related impairments, and new therapeutic approaches. 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One chapter reviews gene involvement in non-syndromic mental retardation, autism, and language deficits, as well as multifactorial and genetically complex inheritance. 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