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In each of the above examples, a rapid and accurate assessment of the OP to which the person was exposed, degree of exposure, and time period of exposure will help direct therapy to the victim and assess the level of threat to others. Traditionally, metabolites for speci?c OPs can be measured in the urine after an exposure, such as 3,5,6-trichloro- 2-pyridinol for chlorpyrifos (CPS). However, there are several problems with this method. Usually, the metabolite is excreted for only a short period of several days after a signi?cant exposure. In addition, due to the widespread use of CPS and en- ronmental persistence of its breakdown products, the metabolites appear at a high background level in the general population (Hill et al. 1995). 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