{"title":"Patrick M Dansette","description":null,"products":[{"product_id":"cytochromes-p450-book-patrick-m-dansette-9783036502564","title":"Cytochromes P450","description":"\u003cp\u003eThis book, Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity, presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in insects.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eThe first paper reports the in silico modeling of human CYP3A4 access channels. The second uses structural methods to explain the mechanism-based inactivation of CYP3A4 by mibefradil, 6,7-dihydroxy-bergamottin, and azamulin. The third article compares electron transfer in CYP2C9 and CYP2C19 using structural and biochemical methods, and the fourth uses kinetic methods to study electron transfer to CYP2C8 allelic mutants. The fifth article characterizes electron transfer between the reductase and CYP using in silico and in vitro methods, focusing on the conformations of the reductase.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eThen, two reviews describe clinical implications in cardiology and oncology and the role of fatty acid metabolism in cardiology and skin diseases. The second review is on the potential use of circulating extracellular vesicles as biomarkers.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eFive papers analyze the CYPomes of diverse microorganisms: the Bacillus genus, Mycobacteria, the fungi Tremellomycetes, Cyanobacteria, and Streptomyces. The sixth focuses on a specific Mycobacterium CYP, CYP128, and its importance in M. tuberculosis.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eThe subject of the last paper is CYP in \u003cem\u003eSogatella furcifera\u003c\/em\u003e, a plant pest, and its resistance to the insecticide sulfoxaflor\u003c\/p\u003e","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51081746481425,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51081749168401,"sku":"NIN9783036502564","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52598165373201,"sku":"NLS9783036502564","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/3036502564.jpg?v=1751063878"},{"product_id":"biological-reactive-intermediates-vi-book-patrick-m-dansette-9781461351856","title":"Biological Reactive Intermediates Vi","description":"Historically we have separated the disciplines of Chemistry and Biochemistry by recognizing that the distinguishing characteristic of Biochemistry is the catalysis of reactions by enzymes. Enzymes permit metabolic reactions which would otherwise require extremes of temperature, pressure or pH, often associated with Chemistry, to proceed under ambient conditions of the body. Under some conditions chemical reactions occur in vivo in which products of enzymatic reactions proceed to undergo further reactions non- enzymatically with cellular macromolecules. The results can often be seen as toxic or carcinogenic responses. The chemicals that initiate these reactions are termed biological reactive intermediates.  The International Symposia on Biological Reactive Intermediates (BRI) began in 1975 at the University of Turku, Finland and have since convened at the University of Surrey, Guildford, The United Kingdom (1980), the University of Maryland, College Park, Maryland (1985), the University of Arizona, Tucson, Arizona (1990), the GSF Forschungszentrum and Technical University of Munich (1995) and, most recently, at the Universite Rene Descartes, Paris, France (2000). The Symposium was organized by an International Planning Committee co-chaired by P. Dansette (Paris, France) and TJ. Monks (Austin, Texas). The committee included: P. H. Beaune (Paris, France), M. Deaforge (Saclay, France), G. P. Gervasi (Pisa, Italy), G. G. Gibson (Guildford, UK), H. Greim (Munich, Germany), DJ. Jollow (Charleston, South Carolina), P. Moldeus (Sodertalje, Sweden), I. G. Sipes (Tucson, Arizona), R. Snyder PJ. van Bladderen (Zeist, The Netherlands). They were (Piscataway, New Jersey), and assisted by an International Scientific Program Advisory Committee which included: TJ.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52144356655377,"sku":"NLS9781461351856","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461351856.jpg?v=1757588523"},{"product_id":"biological-reactive-intermediates-vi-book-patrick-m-dansette-9780306466595","title":"Biological Reactive Intermediates Vi","description":"Historically we have separated the disciplines of Chemistry and Biochemistry by recognizing that the distinguishing characteristic of Biochemistry is the catalysis of reactions by enzymes. Enzymes permit metabolic reactions which would otherwise require extremes of temperature, pressure or pH, often associated with Chemistry, to proceed under ambient conditions of the body. Under some conditions chemical reactions occur in vivo in which products of enzymatic reactions proceed to undergo further reactions non- enzymatically with cellular macromolecules. The results can often be seen as toxic or carcinogenic responses. The chemicals that initiate these reactions are termed biological reactive intermediates.  The International Symposia on Biological Reactive Intermediates (BRI) began in 1975 at the University of Turku, Finland and have since convened at the University of Surrey, Guildford, The United Kingdom (1980), the University of Maryland, College Park, Maryland (1985), the University of Arizona, Tucson, Arizona (1990), the GSF Forschungszentrum and Technical University of Munich (1995) and, most recently, at the Universite Rene Descartes, Paris, France (2000). The Symposium was organized by an International Planning Committee co-chaired by P. Dansette (Paris, France) and TJ. Monks (Austin, Texas). The committee included: P. H. Beaune (Paris, France), M. Deaforge (Saclay, France), G. P. Gervasi (Pisa, Italy), G. G. Gibson (Guildford, UK), H. Greim (Munich, Germany), DJ. Jollow (Charleston, South Carolina), P. Moldeus (Sodertalje, Sweden), I. G. Sipes (Tucson, Arizona), R. Snyder PJ. van Bladderen (Zeist, The Netherlands). They were (Piscataway, New Jersey), and assisted by an International Scientific Program Advisory Committee which included: TJ.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52350769168657,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52350772838673,"sku":"NLS9780306466595","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780306466595.jpg?v=1758180424"}],"url":"https:\/\/www.worldofbooks.com\/collections\/author-books-by-patrick-m-dansette.oembed","provider":"World of Books ","version":"1.0","type":"link"}