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The human-centered virtual machine and its four components are used  for developing intelligent multimedia multi-agent systems in areas  like medical decision support and health informatics, medical image  retrieval, e-commerce, face detection and annotation, internet games  and sales recruitment. The applications in these areas help to expound  various aspects of the human-centered virtual machine including,  human-centered domain modeling, distributed intelligence and  communication, perceptual and cognitive task modeling, component based  software development, and multimedia based data modeling. 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