{"title":"Richard J Ablin","description":null,"products":[{"product_id":"great-prostate-hoax-the-book-richard-j-ablin-9781137278746","title":"The Great Prostate Hoax, the","description":"\u003cp\u003eEvery year, more than a million men undergo painful needle biopsies for prostate cancer, and upward of 100,000 have radical prostatectomies, resulting in incontinence and impotence. But the shocking fact is that most of these men would never have died from this common form of cancer, which frequently grows so slowly that it never even leaves the prostate. How did we get to a point where so many unnecessary tests and surgeries are being done? In \u003ci\u003eThe Great Prostate Hoax\u003c\/i\u003e, Richard J. Ablin exposes how a discovery he made in 1970, the prostate-specific antigen (PSA), was co-opted by the pharmaceutical industry into a multibillion-dollar business. He shows how his discovery of PSA was never meant to be used for screening prostate cancer, and yet nonetheless the test was patented and eventurally approved by the FDA in 1994. Now, doctors and victims are beginning to speak out about the harm of the test, and beginning to search for a true prostate cancer-specific marker.\u003c\/p\u003e","brand":"WoB","offers":[{"title":"US \/ VERY_GOOD \/ SBYB","offer_id":49876288471313,"sku":"CIN1137278749VG","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"US \/ GOOD \/ SBYB","offer_id":49983730974993,"sku":"CIN1137278749G","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ VERY_GOOD \/ INTERNAL","offer_id":50132218970385,"sku":"GOR006087224","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ LIKE_NEW \/ INTERNAL","offer_id":50893206159633,"sku":"GOR009955593","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1137278749.jpg?v=1751334973"},{"product_id":"metastasis-of-prostate-cancer-book-richard-j-ablin-9789401781527","title":"Metastasis of Prostate Cancer","description":"Without metastasis, prostate cancer would be both tolerable and treatable. The high incidence of indolent and organ confined disease is testament to this sweeping generalisation. Equally, if molecular markers of metastatic spread can be identified, then the choice of treatment for many patients would be easier and more radical, even curative. However, should prevention and treatment of the primary tumors prove difficult or impossible, then a knowledge of the phenotype of advanced metastatic tumors should allow us to target these lesions for destruction by conventional (drug based) or more innovative means such as gene and\/or immunotherapy (1). The process of metastasis has been reviewed many times (e. g. , 2) and has been subdivided for ease of analysis into a number of discrete stages (see Figure 1). It has been suggested that at least 10 separate genetic 2. ECM degradation: migration MMP ; Integrin ; TIMP 3. Intravasation MMP TIMP 1. Cellular independence 4. Transport Adhesion loss and evasion (E Cadherin ) of host immune system MHCClass1 ICAM-1 to block T cell receptor 5. Arrest of movement: endothelial adhesion CD44 or switch 6. Extravasation to colonise new site 7. Proliferation at Laminin R distant site to form Integrin switch METASTASIS Figure 1. Stages in prostate cancer metastasis. Basic processes in tumor metastases are indicated in the boxes with some key changes in gene expression indicated at each stage by the solid arrows.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52334718255377,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52334719041809,"sku":"NLS9789401781527","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789401781527.jpg?v=1758157771"},{"product_id":"metastasis-of-prostate-cancer-book-richard-j-ablin-9781402058462","title":"Metastasis of Prostate Cancer","description":"This volume brings together the key research issues in clinical and laboratory science relating to metastasis in prostate cancer. Prostate cancer is an area of intense research effort, and this book provides a window on contemporary research in this important area.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52673021542673,"sku":"NLS9781402058462","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53558139584785,"sku":"NIN9781402058462","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781402058462.jpg?v=1762296011"}],"url":"https:\/\/www.worldofbooks.com\/collections\/author-books-by-richard-j-ablin.oembed","provider":"World of Books ","version":"1.0","type":"link"}