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In addition to 3',5'-cAMP and 3',5'-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3',5'-cCMP and 3',5'-cUMP, the purine nucleotide 3',5'-cIMP, the 2',3'-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3',5'-cCMP and 3',5'-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3',5'-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52451183755537,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52451184476433,"sku":"NLS9783319526713","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9783319526713.jpg?v=1759360881"},{"product_id":"medikamente-leicht-erklart-book-roland-seifert-9783662623299","title":"Medikamente leicht erklärt","description":"Fast jeder Bundesbürger nimmt Arzneimittel ein, häufig mehrere. Aber oft haben weder Arzt noch Apotheker ausreichend Zeit, dem Patienten zu erklären, warum er ein Arzneimittel benötigt, wie es wirkt und welche unerwünschten Wirkungen es hat. Schaut der Patient dann in den Beipackzettel, wird er meist nicht aufgeklärt, sondern verunsichert. Das führt dann zu Complianceproblemen in der Arzneitherapie. Häufig gehen Patienten auch zu mehreren Ärzten, ohne dass diese davon wissen (Ärzte-Hopping). Verschreiben diese Ärzte mehrere Arzneimittel, kann es zu gefährlichen Wechselwirkungen kommen. Der Gesetzgeber hat diese Problematik erkannt und deshalb kürzlich das Gesetz für mehr Sicherheit in der Arzneimittelversorgung (GSAV) in Kraft gesetzt. Aber für den Patienten ist es schwierig sich objektiv zu informieren. Zwar findet er im Internet unendlich viele „Informationen“, aber Zusammenhänge und Gewichtungen lassen daraus meist nicht herauslesen. Am Ende ist die Verwirrung größer als vorher. 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