{"title":"Rongling Wu","description":null,"products":[{"product_id":"quantitative-methods-for-precision-medicine-book-rongling-wu-9781482219456","title":"Quantitative Methods for Precision Medicine","description":"Modern medicine is undergoing a paradigm shift from a \"one-size-fits-all\" strategy to a more precise patient-customized therapy and medication plan. While the success of precision medicine relies on the level of pharmacogenomic knowledge, dissecting the genetic mechanisms of drug response in a sufficient detail requires powerful computational tools. Quantitative Methods for Precision Medicine: Pharmacogenomics in Action presents the advanced statistical methods for mapping pharmacogenetic control by integrating pharmacokinetic and pharmacodynamic principles of drug-body interactions. Beyond traditional reductionist-based statistical genetic approaches, statistical formulization in this book synthesizes elements of multiple disciplines to infer, visualize, and track how pharmacogenes interact together as an intricate but well-coordinated system to mediate patient-specific drug response.  Features:    Functional and systems mapping models to characterize the genetic architecture of multiple medication processes  Statistical methods for analyzing informative missing data in pharmacogenetic association studies  Functional graph theory of inferring genetic interaction networks from association data  Leveraging the concept of epistasis to capture its bidirectional, signed and weighted properties  Modeling gene-induced cell-cell crosstalk and its impact on drug response  A graph model of drug-drug interactions in combination therapies  Critical methodological issues to improve pharmacogenomic research as the cornerstone of precision medicine   This book is suitable for graduate students and researchers in the fields of biology, medicine, bioinformatics and drug design and delivery who are interested in statistical and computational modelling of biological processes and systems. It may also serve as a major reference for applied mathematicians, computer scientists, and statisticians who attempt to develop algorithmic tools for genetic mapping, systems pharmacogenomics and systems biology. It can be used as both a textbook and research reference. Professionals in pharmaceutical sectors who design drugs and clinical doctors who deliver drugs will also find it useful.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ GARDNERS","offer_id":50697861267729,"sku":"NGR9781482219456","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/148221945X.jpg?v=1750827107"},{"product_id":"statistical-genetics-of-quantitative-traits-book-rongling-wu-9781441919120","title":"Statistical Genetics of Quantitative Traits","description":"Most traits in nature and of importance to agriculture are quantitatively inherited. These traits are di?cult to study due to the complex nature of their inheritance. However, recent developments of genomic technologies provide a revolutionary means for unraveling the secrets of genetic variation in quantitative traits. Genomic te- nologies allow the molecular characterization of polymorphic markers throughout the entire genome that are then used to identify and map the genes or quantitative trait loci (QTLs) underlying a quantitative trait based on linkage analysis. Statistical analysis is a crucial tool for analyzing genome data, which are now becoming increasingly available for a variety of species, and for giving precise exp- nations regarding genetic variation in quantitative traits occurring among species, populations, families, and individuals. In 1989, Lander and Botstein published a ha- mark methodological paper for interval mapping that enables geneticists to detect and estimate individual QTL that control the phenotype of a trait. Today, interval mappingisanimportantstatisticaltoolforstudyingthegeneticsofquantitativetraits at the molecular level, and has led to the discovery of thousands of QTLs responsible for a variety of traits in plants, animals, and humans. In a recent study published in Science, Li, Zhou, and Sang (2006, 311, 1936-1939) were able to characterize the molecular basis of the reduction of grain shattering - a fundamental selection process for rice domestication - at the detected QTL by interval mapping.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52332096782609,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52332097765649,"sku":"NLS9781441919120","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781441919120.jpg?v=1758150521"},{"product_id":"statistical-genetics-of-quantitative-traits-book-rongling-wu-9780387203348","title":"Statistical Genetics of Quantitative Traits","description":"Most traits in nature and of importance to agriculture are quantitatively inherited. These traits are di?cult to study due to the complex nature of their inheritance. However, recent developments of genomic technologies provide a revolutionary means for unraveling the secrets of genetic variation in quantitative traits. Genomic te- nologies allow the molecular characterization of polymorphic markers throughout the entire genome that are then used to identify and map the genes or quantitative trait loci (QTLs) underlying a quantitative trait based on linkage analysis. Statistical analysis is a crucial tool for analyzing genome data, which are now becoming increasingly available for a variety of species, and for giving precise exp- nations regarding genetic variation in quantitative traits occurring among species, populations, families, and individuals. In 1989, Lander and Botstein published a ha- mark methodological paper for interval mapping that enables geneticists to detect and estimate individual QTL that control the phenotype of a trait. Today, interval mappingisanimportantstatisticaltoolforstudyingthegeneticsofquantitativetraits at the molecular level, and has led to the discovery of thousands of QTLs responsible for a variety of traits in plants, animals, and humans. In a recent study published in Science, Li, Zhou, and Sang (2006, 311, 1936-1939) were able to characterize the molecular basis of the reduction of grain shattering - a fundamental selection process for rice domestication - at the detected QTL by interval mapping.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52584069431569,"sku":"NLS9780387203348","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780387203348.jpg?v=1761048934"}],"url":"https:\/\/www.worldofbooks.com\/collections\/author-books-by-rongling-wu.oembed","provider":"World of Books ","version":"1.0","type":"link"}