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However, to be clear, rapamycin is not approved by the FDA as a life extension drug. In September 1999 rapamycin received FDA approval as an immunosuppressant drug to prevent organ transplant rejection and also, two rapamycin analogs (rapalogs), temsirolimus (Torisel) and everolimus (Afinitor) have gained FDA approval for the treatment of various forms of cancer. However, rapamycin's approval as an immunosuppressant and as a cancer chemotherapy agent has inhibited its acceptance by physicians as a life extension drug.\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eTreatment with rapamycin has resulted in significant increases in lifespan in animal models including yeast, worms, fruit flies, and mice. Animals get many of the same diseases that humans develop. Results from animal studies reveal that rapamycin slows down the onset of many age-related diseases. In addition to improving animals' health, treatment with rapamycin has produced life extensions ranging from 25-60%.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDiscovery of Rapamycin\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eRapamycin is a compound that is produced by a strain of bacteria named \u003ci\u003eStreptomyces hygroscopicus\u003c\/i\u003e.This bacterium was discovered from a soil sample taken during a scientific expedition to Easter Island in 1964. The purpose of that expedition was to search for new compounds that might express antifungal and\/or antibiotic properties. Rapamycin expressed strong antifungal activity. However, efforts to develop rapamycin as an antifungal drug were discontinued when it was discovered to have potent immunosuppressive activity. \u003c\/p\u003e\u003cp\u003eRapamycin also exhibited anti-proliferative properties, which prompted scientists to send samples of rapamycin to the National Cancer Institute (NCI). Tests conducted there revealed two remarkable findings. The first revelation was that rapamycin suppressed the growth in a variety of solid tumors.\u003c\/p\u003e\u003cp\u003eThe second finding was the discovery that rapamycin appeared to be a totally new type of anticancer drug because it functioned by inhibiting cancer growth (cytostatic) rather than by killing cancer cells (cytotoxic). Cytotoxic chemotherapy drugs cause a wide range of side effects because they damage other rapidly dividing cells in the body. Rapamycin's activity against solid tumors plus its cytostatic mechanism of action motivated the NCI to elevate rapamycin to \u003cb\u003e\u003ci\u003e\u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e\u003ci\u003epriority drug\u003c\/i\u003e\u003c\/b\u003e status in order to accelerate additional research. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eRapamycin's Mechanism of Action\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eOver the past 25 years, research into rapamycin's mechanism of action has resulted in the discovery of a new understanding of cellular biology and the aging process. This research has revealed that two mechanisms named mTOR and autophagy, which are found inside every cell, are critical regulators of cellular metabolism. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003emTOR and autophagy are counterbalancing mechanisms that regulate the health and aging process of all living organisms. In my mind, the mTOR\/Autophagy story is even more important than the story about rapamycin. The discovery and understanding of mTOR and autophagy are revealing how we can delay the onset of age-related diseases and achieve significant increases in life span and health span.\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eWhen rapamycin crosses a cellular membrane and enters a cell, it binds with an enzyme that was named mTOR, which stands for the \u003cb\u003emechanistic target of rapamycin (mTOR). \u003c\/b\u003emTOR is a key regulator of cellular metabolism that has stimulated a great deal of scientific interest. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eNow, 25 years after its discovery, over 12,000 papers have been published on mTOR. When nutrients are available to a cell, mTOR sends cellular signals that activate cellular metabolism, telling the cell to use the available nutrients to build new proteins, new enzymes, and other cellular components. mTOR activates cellular anabolic (building) processes of growth and proliferation. \u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eCounterbalancing mTOR is the cellular process known as autophagy. In 2016, Japanese scientist Yoshinori Ohsumi was awarded the Nobel Prize in physiology and medicine for discovering the mechanism of autophagy. PubMed now contains over 30,000 citations with the term autophagy in the title, which gives an indication of the scientific interest in this topic. \u003c\/p\u003e\u003cp\u003eAutophagy has been referred to as the cellular housekeeping process or cellular trash removal. Over time, various cellular components become damaged, break down, and become dysfunctional. If these waste products continue to accumulate, cellular functions would decline, and the cell(s) would eventually die. When autophagy is activated, damaged and dysfunctional cellular components are broken down for reuse and recycling or for removal. Autophagy can also be thought of as cellular detoxification.\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eAnimals get many of the same age-related diseases that humans get. Rapamycin gained prominence as a life extension drug based on its ability to treat a variety of age-related diseases and increase the lifespan in numerous species of animals. However, human trials were lacking because ethical issues, costs, and time constraints, make it virtually impossible to conduct life extension trials in humans. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eBreakthrough: Rapamycin's Use in Humans\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eTwas the night before Christmas....on Dec. 24, 2014, a groundbreaking study titled \u003cb\u003e\u003ci\u003emTOR inhibition improves immune function in the elderly \u003c\/i\u003e\u003c\/b\u003ewas published that ushered in the era of rapamycin use in humans. The study was conducted by Joan Mannick, MD, who was a senior scientist at Novartis. In addition to being a human clinical trial, Mannick's study is important because it sheds light on \u003cb\u003eWHY\u003c\/b\u003e and \u003cb\u003eHOW\u003c\/b\u003e rapamycin can be used safely and effectively in humans to slow down the onset of age-related diseases and increase lifespan and healthspan.\u003c\/p\u003e\u003cp\u003eIn this trial, elderly adults were treated with RAD001, which is a synthetic version of rapamycin (a rapalog) whose effects are virtually the same as rapamycin. Dr. Mannick's wanted to evaluate the effects of mTOR inhibition on human aging-related conditions and she chose the immune system, which normally declines with age, as the target for her study. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eIn this 6-week placebo-controlled trial, 218 volunteers who were 65 years of age or older were divided into four groups. The doses administered were 0.5 mg daily, 5.0 mg once weekly, 20 mg once weekly, or placebo. Following 6-weeks of therapy, there was a 2-week drug-free interval followed by administration of the seasonal flu vaccine. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThe immune system of the elderly adults who received a 5 mg dose of RAD001 once weekly exhibited a 20% enhanced response to the influenza vaccine with virtually no side effects. The results of this clinical trial suggested that the ability of rapamycin or similar rapalogs to enhance immune function in elderly adults might be able to delay the onset of age-related diseases in humans.\u003c\/p\u003e\u003cp\u003eJoan Mannick's study helps us understand that rapamycin's initial classification as an immunosuppressant drug was incorrect. Rapamycin is not an immunosuppressant, it is an immunomodulator. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eThe mTOR\/Autophagy Ratio\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eLife....it's all about balance. This is especially true regarding the mTOR\/autophagy ratio. Extreme suppression of mTOR (hypo-functioning) results in suppression of the immune system. This is what happens when rapamycin is administered daily to prevent organ rejection following organ transplant surgeries. \u003c\/p\u003e\u003cp\u003eWhen mTOR is hyper-functioning, the immune system gets exhausted, which also results in immunosuppression. I believe most people alive today suffer from an under-functioning immune system, which is due to the continual over-activation of mTOR. I call this condition \u003cb\u003e\u003ci\u003emTOR Syndrome.\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDysregulated mTOR\/Autophagy Ratio\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eThe majority of Americans are not well. We are literally experiencing an epidemic of epidemics. We have an epidemic of cancer, heart disease, diabetes, obesity, osteoporosis, Alzheimer's disease, ADD\/ADHD, autism, opioid addiction, to name a few. The over-expression of mTOR (mTOR Syndrome) is increasingly being recognized as a fundamental mechanism that is present in many of our common diseases such as cancer, diabetes, cardiovascular disease, and Alzheimer's disease. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eI believe most people living today are suffering to some degree from mTOR Syndrome. Understanding why the mTOR\/autophagy ratio has become so universally unbalanced will help explain our epidemic of chronic degenerative diseases, and also explain why rapamycin appears to be effective (in animal studies) in the treatment of such a wide range of diseases.\u003c\/p\u003e\u003cp\u003eWithin the past 300 years, humans have managed to get the mTOR\/autophagy ratio severely out of balance. Two categories of technological advancement have played a large role in the development of mTOR Syndrome.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThe first technological advancement was the invention and development of refrigeration, which greatly improved the ability to store and preserve foods and make them easily available. Artificial refrigeration began in the mid-1750s. The first home refrigerators were invented in 1913. Fast forward to today and the refrigerator has become the most popular home appliance. According to government data, nearly 100% of American households have a refrigerator and approximately 25% of homes have two (or more) fridges and\/or freezers.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThe second technological advancement that played a major role in dysregulating the mTOR\/autophagy balance was the rapid development of the industries of food processing and packaging. 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