{"title":"Stephen Neidle","description":null,"products":[{"product_id":"dna-structure-and-recognition-book-stephen-neidle-9780199634194","title":"DNA Structure and Recognition","description":"This text is a comprehensive survey of DNA structure, from first principles to the ways in which drugs and proteins interact with DNA. Such an understanding of DNA structure is essential for more detailed study in areas such as gene regulation and DNA-targeted drug action. It begins by summarizing the major methods used to study DNA structural features, and provides readers with a critical assessment of these methods in practice. It goes on to describe the structural features of DNA at the basic level and then in detail, and then examines non-standard DNA structures. Finally, it describes the principles of DNA-ligand recognition, with water, drugs and protein interactions being covered. Stephen Neidle is the author of \"Principles of Nucleic Acid Structure\" and \"Understanding DNA\".","brand":"WoB","offers":[{"title":"GB \/ VERY_GOOD \/ INTERNAL","offer_id":49523437371665,"sku":"GOR008542811","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/019963419X.jpg?v=1751070607"},{"product_id":"cancer-drug-design-and-discovery-book-stephen-neidle-9780123965219","title":"Cancer Drug Design and Discovery","description":"Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several sections on the basic and applied science of cancer drug discovery and features those drugs that are now approved for human use and are in the marketplace, as well as those that are still under development. By highlighting some of the general principles involved in taking molecules through basic science to clinical development, this book offers a complete and authoritative reference on the design and discovery of anticancer drugs for translational scientists and clinicians involved in cancer research.","brand":"WoB","offers":[{"title":"US \/ GOOD \/ SBYB","offer_id":50344645165329,"sku":"CIN0123965217G","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"US \/ VERY_GOOD \/ SBYB","offer_id":50761466904849,"sku":"CIN0123965217VG","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/0123965217.jpg?v=1751356059"},{"product_id":"therapeutic-applications-of-quadruplex-nucleic-acids-book-stephen-neidle-9780128103722","title":"Therapeutic Applications of Quadruplex Nucleic Acids","description":"The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligands and the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic acids that will be a major resource in future drug-discovery strategies.    Therapeutic Applications of Quadruplex Nucleic Acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics.    Written by a world leader in this field, this book is a vital resource for researchers in medicinal chemistry, chemical biology, structural biology, drug discovery, and pharmacology in cancer and other therapeutic areas, as well as for chemists and biologists working on nucleic acids, and will be useful for both active researchers and students in these areas.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52150632644881,"sku":"NLS9780128103722","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ GOOD \/ SBYB","offer_id":53615666462993,"sku":"CIN0128103728G","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780128103722.jpg?v=1757610732"},{"product_id":"quadruplex-nucleic-acids-book-stephen-neidle-9780854043743","title":"Quadruplex Nucleic Acids","description":"Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered. Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and stability. The biology of quadruplexes and G-rich genomic regions and G-quartets in supramolecular chemistry and nanoscience are also considered. Surveying the current state of knowledge, and with contributions from leading experts, this is the first comprehensive review of this rapidly growing area. Quadruplex Nucleic Acids is ideal for researchers interested in areas related to chemistry, chemical biology, medicinal chemistry, molecular pharmacology, and structural and molecular biology.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52344558584081,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52344562221329,"sku":"NLS9780854043743","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780854043743.jpg?v=1758174725"},{"product_id":"topics-in-nucleic-acid-structure-book-stephen-neidle-9781349063802","title":"Topics in Nucleic Acid Structure","description":null,"brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52584897118481,"sku":"NLS9781349063802","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781349063802.jpg?v=1761051497"},{"product_id":"topics-in-nucleic-acid-structure-book-stephen-neidle-9781349046935","title":"Topics in Nucleic Acid Structure","description":null,"brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52585680503057,"sku":"NLS9781349046935","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781349046935.jpg?v=1761053298"},{"product_id":"rna-polymerases-as-molecular-motors-book-stephen-neidle-9780854041343","title":"RNA Polymerases as Molecular Motors","description":"The cell can be viewed as a 'collection of protein machines' and understanding these molecular machines requires sophisticated cooperation between cell biologists, geneticists, enzymologists, crystallographers, chemists and physicists. To observe these machines in action, researchers have developed entirely new methodologies for the detection and the nanomanipulation of single molecules. This book, written by expert scientists in the field, analyses how these diverse fields of research interact on a specific example - RNA polymerase. The book concentrates on RNA polymerases because they play a central role among all the other machines operating in the cell and are the target of a wide range of regulatory mechanisms. They have also been the subject of spectacular advances in their structural understanding in recent years, as testified by the attribution of the Nobel prize in chemistry in 2006 to Roger Kornberg. The book focuses on two aspects of the transcription cycle that have been more intensively studied thanks to this increased scientific cooperation - the recognition of the promoter by the enzyme, and the achievement of consecutive translocation steps during elongation of the RNA product. Each of these two topics is introduced by an overview, and is then presented by worldwide experts in the field, taking the viewpoint of their speciality. The overview chapters focus on the mechanism-structure interface and the structure-machine interface while the individual chapters within each section concentrate more specifically on particular processes-kinetic analysis, single-molecule spectroscopy, and termination of transcription, amongst others. Specific attention has been paid to the newcomers in the field, with careful descriptions of new emerging techniques and the constitution of an atlas of three-dimensional pictures of the enzymes involved. For more than thirty years, the study of RNA polymerases has benefited from intense cooperation between the scientific partners involved in the various fields listed above. It is hoped that a collection of essays from outstanding scientists on this subject will catalyse the convergence of scientific efforts in this field, as well as contribute to better teaching at advanced levels in Universities.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52676910776593,"sku":"NLS9780854041343","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780854041343.jpg?v=1762305050"},{"product_id":"quadruplex-nucleic-acids-as-targets-for-medicinal-chemistry-book-stephen-neidle-9780128210178","title":"Quadruplex Nucleic Acids As Targets For Medicinal Chemistry","description":"The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. 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