{"title":"Developments In Molecular And Cellular Biochemistry","description":null,"products":[{"product_id":"ecce-romani-i-b-book-gilbert-lawall-9780801312106","title":"Ecce Romani I.B","description":"1. 1 Aims and Objectives The major aim of this research is to identify and weigh the importance of factors that promote and constrain, the adoption of environmental initiatives by small and medium sized enterprises (SMEs). The objective is to inform how policy can overcome obstacles so as to promote the adoption of cleaner technology (includ ing environmentally sensitive products (Oosterhuis et al. 1996)) by industry. Cen tral to the research is the testing of a set of hypotheses, which, inter alia, relate the adoption of cleaner technologies to competitiveness, management culture and the importance of the provision of information. The manufacturing sectors consid ered are those dominated by SMEs where product and process environmental re sponse by the firm is important. Of these sectors, furniture, textile finishing, and fruit and vegetable processing were chosen. More specifically the focus is on European SMEs i. e. those employing less than 250 employees. ' Variations within the EU with respect to environmental regulation are exemplified by a study of firms (and plants) across four member states: Germany, North-east Italy, Republic of Ireland and the United Kingdom. The adoption of clean technologies has been slow and uneven and action has mainly involved good housekeeping. Major changes involving large capital spend ing, or material substitution, process redesign or reformulation have been rela tively rare (OECD 1985, 1995; Ashford 1993). The problem is particularly acute amongst SMEs (and the majority of enterprises are SMEs; e. g.","brand":"WoB","offers":[{"title":"US \/ VERY_GOOD \/ SBYB","offer_id":50270232707345,"sku":"CIN0801312108VG","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"US \/ GOOD \/ SBYB","offer_id":50457683362065,"sku":"CIN0801312108G","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/0801312108.jpg?v=1750945866"},{"product_id":"signal-transduction-mechanisms-book-ja-barnes-9781461358336","title":"Signal Transduction Mechanisms","description":"This volume contains the proceedings of an International  Symposium on `Second Messenger Systems - Molecular, Cellular  and Behavioural Aspects', which was held at Tobago on June  16-17, 1994.    The interaction of an extracellular agonist (First Messenger) with its  plasma membrane receptor leads to the transmission of a signal across  the cell membrane and results in the production and\/or activation of  other signalling molecules (Second Messengers). These Second  Messengers control the action of many protein kinases and protein  phosphatases and so lead to cellular responses. Although the  biochemical basis of the transduction of signals in the main  signalling systems in eukaryotic cells is probably largely known,  intensified research is ongoing in the following areas: the discovery  of specific substrates for many protein kinases, elucidation of the  biological significance of the differential tissue expression and  heterogeneity of many signalling proteins, and the unravelling of  diverse interactions (such as signal potentiation, synergism,  antagonism and neuronal co-transmission) between signalling systems.  As knowledge from such studies accumulates, it is becoming clear that  the `cross talk' interactions between signalling systems are important  features of dynamic cell regulation.    This volume is designed to summarize some aspects of the current work  on various Second Messenger Systems and the integration of signals  with respect to plasma membrane receptors. Second Messenger generation  and degradation, protein kinase and phosphatase, cell cycle control,  and cellular learning and memory.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51227735785745,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51227738177809,"sku":"NIN9781461358336","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52681460580625,"sku":"NLS9781461358336","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1461358337.jpg?v=1753788812"},{"product_id":"muscle-physiology-and-biochemistry-book-shoichi-imai-9781461375340","title":"Muscle Physiology and Biochemistry","description":"The papers in this issue were contributed by close friends, the publication of this issue possible. Owing to some un- coworkers and pupils ofProfessor Setsuro Ebashi. They are expected troubles ofone ofthe editors (M. E. ) the publication dedicated to him to commemorate his great and pioneering ofthis issue has been greatly delayed, for which he sincerely contribution to the advancement of muscle physiology and apologizes to all the contributors and other editors. We biochemistry, which in course of time exerted a great in- believe that this issue reveals the present stateofresearch on fluence on the whole field oflife science. We would like to muscle and\/or calcium that had been opened up by Professor express our cordial thanks to an the contributors who made Ebashi. Shoichi Imai, Niigata, Japan Makoto Endo, Saitama, Japan Iwao Ohtsuki, Fakuoka, Japan Molecular and Cellular Biochemistry 190: 3-4, 1999. Dedication Setsuro Ebashi was born in Tokyo on 31st August, 1922. There is aJapanese saying that 'Sandalwood is fragrant even in seed leaf. ' Genius displays itself even in childhood. Finishing the six-year course ofprimary school in five years and the five-year course ofmiddle school in four years, he entered the First High School, the most prestigious high school in Japan, at the age ofonly 15. In July 1942, when he was an undergraduate student of FacultyofMedicine,Tokyo Imperial University (now called University ofTokyo), he by chance visited the laboratory of Dr.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51227738439953,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51227740766481,"sku":"NIN9781461375340","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52681449373969,"sku":"NLS9781461375340","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1461375347.jpg?v=1751053423"},{"product_id":"bioenergetics-of-the-cell-quantitative-aspects-book-valdur-a-saks-9781461375876","title":"Bioenergetics of the Cell: Quantitative Aspects","description":"This volume continues the discussion of the problems of in vivo and in vitro. The recently solved X-ray structure of the mitochondrial creatine kinase and its molecular biology cellular bioenergetics - the tradition we started in 1994 by publication of the focused issue of Molecular and Cellular are analyzed with respect to its molecular physiology and Biochemistry, volume 133\/134 and a book 'Cellular Bio­ functional coupling to the adenine nucleotide translocase, as energetics: role of coupled creatine kinases' edited by V. Saks well as its participation, together with the adenylate kinase and R. Ventura-Clapier and published by Kluwer Publishers, system, in intracellular energy transfer. The results of the Dordrecht -Boston. In the present volume, use of quantitative studies of creatine kinase deficient transgenic mice are methods of studies of organized metabolic systems, such as summarized and analyzed by using mathematical models of mathematical modeling and Metabolic Control Analysis, for the compartmentalized energy transfer, thus combining two investigation of the problems of bioenergetics of the cell is powerful new methods of the research. All these results, described together with presentation of new experimental together with the physiological and NMR data on the cardiac results. The following central problems of the cellular bio­ metabolic and mitochondrial responses to work-load changes energetics are the focus of the discussions: the mechanisms concord to the concept of metabolic networks of energy of regulation of oxidative phosphorylation in the cells in vivo transfer and feedback regulation.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52089105973521,"sku":"NLS9781461375876","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461375876.jpg?v=1756905774"},{"product_id":"molecular-mechanisms-of-metal-toxicity-and-carcinogenesis-book-xianglin-shi-9781461352426","title":"Molecular Mechanisms of Metal Toxicity and Carcinogenesis","description":"During the last two decades, chemical and cellular studies have  contributed enormously to our understanding of metal-induced  carcinogenesis, and many hypotheses on the role of metals in  pathophysiological processes have been investigated. In addition, new  techniques are available to shed light on the mechanism of  carcinogenesis in molecular terms. This conference on Molecular  Mechanisms of Metal Toxicity and Carcinogenesis in September 2000  focused on the latest research in molecular mechanisms of  metal-induced toxicity and carcinogenesis. The conference promoted a  multidisciplinary investigative approach and included presentations  from international experts on state-of-the-art information in this  field.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52143451898129,"sku":"NLS9781461352426","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461352426.jpg?v=1757584542"},{"product_id":"protein-kinase-ck2-from-structure-to-regulation-book-khalil-ahmed-9781461356967","title":"Protein Kinase CK2 — From Structure to Regulation","description":"CK2 is a protein serine\/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is also the recognition that a large number of putative substrates for this kinase have been identified in various compartments of the cell. New evidence from several laboratories has further reinforced the involvement of CK2 in signal transduction related to many cellular functions, thus underscoring the significance of its functional role in normal and abnormal cell growth and proliferation.    This volume provides an overview of the state of knowledge concerning this intriguing protein kinase. It brings together contributions from leading investigators engaged in research in this field. Key developments during the past three years pertain to the elaboration of the crystal structure and definition of novel functions of the kinase, such as its role as an inhibitor of apoptosis. Additionally, the shuttling of the kinase to various compartments in response to physiological and stress stimuli appears to be a key feature of the functional regulation of its activity in the cell.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52144266314001,"sku":"NLS9781461356967","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52953461457169,"sku":"NIN9781461356967","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461356967.jpg?v=1757588123"},{"product_id":"enzyme-induction-and-modulation-book-va-najjar-9781461338819","title":"Enzyme Induction and Modulation","description":"In addition to performing its prime function as a vehicle for scientific communications of varied colora- tions, Molecular and Cellular Biochemistry is again focusing on two subjects which it treats in depth. One of these is a book issue dealing with the transglutaminase reaction. The other is this issue that deals with induction and modulation of enzymes. This is a very broad subject that calls for broader coverage than could be included in one book issue. However, I have elected to include only certain contributions that serve as general examples of the principles involved. There are six articles on enzyme regulation in hepatocyte culture. These include arginase and argino-succi- nate synthetase, y-glutamyl transferase and plasminogen activitor. Other regulatory enzymes that are discussed are protein kinases, 2,3-bisphosphoglycerate synthetases, carbamoyl phosphate synthetase, heme oxygenase, cytochrome P-450, tyrosine hydroxylase, fatty acid synthetase, acetyl eoA carboxylase, among others. Also included is the regulation of several enzyme messengers RNAs. As in the past, subscribers to the journal will receive this double volume as a continuation of regular issues of the journal Molecular and Cellular Biochemistry. This double volume will also be available separately in the form of a book issue to interested readers through Martinus Nijhoff Publishers. v.A. Najjar Part I Molecular and Cellular Biochemistry 53;54,11-21 (1983). (c) 1983, Martinus 1 ij hoff Publishers. Boston. Printed in The Netherlands.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52144514793745,"sku":"NLS9781461338819","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461338819.jpg?v=1757589292"},{"product_id":"reversible-protein-phosphorylation-in-cell-regulation-book-rl-khandelwal-9781461361138","title":"Reversible Protein Phosphorylation in Cell Regulation","description":"2 During our formative years with Dr. Krebs at Davis, ed until the ER becomes substantially depleted of Ca +. California, we (c. and M. Brostrom) were imbued with For example, acute exposure of GH3 pituitary cells to 2 2 our continuing interest in the roles of Ca+ and cAMP in Ca+ ionophore A23187 or EGTA has been found to re- biological control mechanisms. We remember our time sult in the inhibition of amino acid incorporation. disap- with Dr. Krebs with great affection both for his intense pearance of polysomal content with accumulation of interest and high standards in science and for his great monosomes and ribosomal subunits. sharp reduction of decency in the treatment of postdoctoral fellows. We the cellular content of 43S pre initiation complex. and have subsequently aspired, within the constraints of our the phosphorylation of elF-2ex and inhibition of eIF-2B ability, to pattern our behavior in accord with this expe- [15-17]. Neither translational elongation nor peptide rience. Our current research involving the control of chain termination appeared to be affected in these ex- protein synthesis at mRNA translation embodies much periments, since average ribosomal transit times and the methionylation of tRNA;met were not altered. Amino of the familiar in protein phosphorylation with some new twists that we shall highlight in this article with our acid incorporation was unaffected during the period of 2 associate. Dr. Prostko. Ca+ release prior to suppression of initiation.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52144615194897,"sku":"NLS9781461361138","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461361138.jpg?v=1757589747"},{"product_id":"biological-effects-of-glutamic-acid-and-its-derivatives-book-va-najjar-9789400980297","title":"The Biological Effects of Glutamic Acid and Its Derivatives","description":"the GABA increase takes place and (2) the area of the brain that may mediate the anticonvulsant Investigation of the physiology, biochemistry, activity. Three compounds that increase brain pharmacology and anatomy of GAB A and GABA- GABA by distinct mechanisms were used in these containing neural systems, continues to reveal the studies: di-n-propylacetate (DPA, sodium val- rich complexities associated with this neuroactive proate, Depakene(R)), amino-oxyacetic acid amino acid (see recent symposia 1,2,3). Advances (AOA) and y-vinyl GABA (GVG). in the pharmacology of GABA-mimetic agents In the next sections, the metabolism of GABA have resulted in the development of compounds and a brief historical account of the relationship that can selectively activate GABA receptors (4,5, between GABA and anticonvulsant activity are 6, 7), inhibit the synthetic and degradative enzymes outlined followed by a discussion ofthe biochemical for GABA (8, 9) or affect the neuronal and glial and pharmacological effects of the three drugs. In uptake processes for GABA (10, 11). This has particular, the literature pertaining to the suppres- already had a significant impact on our under- sion of seizures and the correlation between anti- standing of the role of GABA in convulsions and a convulsant action and increases in brain G ABA will range of other CNS functions including feeding be examined. (12), cardiovascular control (13), motor activity (14) and release of pituitary hormones (15). Before 1.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52144982229265,"sku":"NLS9789400980297","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ GARDNERS","offer_id":52152223662353,"sku":"NGR9789400980297","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789400980297.jpg?v=1757591459"},{"product_id":"immunologically-active-peptides-book-va-najjar-9789400980327","title":"Immunologically Active Peptides","description":null,"brand":"WoB","offers":[{"title":"GB \/ NEW \/ GARDNERS","offer_id":52152211570961,"sku":"NGR9789400980327","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52662002090257,"sku":"NLS9789400980327","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789400980327.jpg?v=1757615918"},{"product_id":"detection-of-mitochondrial-diseases-book-fn-gellerich-9781461378006","title":"Detection of Mitochondrial Diseases","description":"In October 1995, the 1st Colloquium on Mitochondria and  Myopathies in Halle\/Saale was organized in Halle\/Saale by the editors  of this focused issue. The meeting took up what might be called an  East German tradition: from 1976 to 1990 Andreas Schmidt organized  seven clinically orientated Colloquia on Myology in Jena, and from  1974 to 1990 a series of twelve Colloquia on Mitochondria focused on  basic research aspects was arranged by Wolfgang Kunz in Magdeburg. At  those meetings, East Germany was a mediator between East European,  West European and American scientists. In continuation of this  tradition, scientists from more than 17 countries working on  mitochondria as neurologists, biochemists, geneticists, or as  physiologists came to Halle. The title of the colloquium indicated the  combination of both basic and clinical mitochondrial research. The  most important contributions of this meeting are now published in this  focused issue. We thank all authors for their patience and cooperation  that have made it possible to produce this unique collection of papers  representing current knowledge on detection of mitochondrial causes of  diseases. We especially thank Prof. N.S. Dhalla for making it possible  to publish these contributions together in this focused issue and also  as a hard-cover book.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52336649175313,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52336649765137,"sku":"NLS9781461378006","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461378006.jpg?v=1758164031"},{"product_id":"adp-ribosylation-metabolic-effects-and-regulatory-functions-book-joel-moss-9781461361206","title":"ADP-Ribosylation: Metabolic Effects and Regulatory Functions","description":"Considering the current interest in cellular regulation and  intracellular signalling systems, it is surprising that the  contribution of ADP-ribosylation reactions to the modulation of a  variety of specific cell processes, in parallel with other  post-translational modifications such as phosphorylation, has not been  generally recognized. While it is not feasible to cover all aspects of  ADP-ribosylation, the thirty-one articles contained in this volume  provide a valuable overview of recent progress in the field within the  context of cell control mechanisms. For the convenience of the reader,  the various topics have been grouped into several sections: (a)  poly(ADP-ribosyl)ation; (b) mono-ADP-ribosylation; (c) toxin  mono-ADP-ribosylation; (d) inhibitors and activators; (e) protein  modification with ADP-ribose and its analogues; and (f)  non-modification forms of ADP-ribose. The contents of the individual  chapters reflect the ideas of the contributors, many of whom have  spent their careers attempting to resolve the biological functions of  ADP-ribosylation. We hope that this publication will serve as a useful  reference for those investigators that are new to the area as well as  those who are actively studying ADP-ribosylation.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52337509138705,"sku":"NLS9781461361206","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52953460506897,"sku":"NIN9781461361206","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461361206.jpg?v=1758166876"},{"product_id":"cellular-basis-of-cardiovascular-function-in-health-and-disease-book-pawan-k-singal-9781461376422","title":"The Cellular Basis of Cardiovascular Function in Health and Disease","description":"This special issue of Molecular and Cellular Biochemistry our their mentor. The ex-students and trainees came from contains original research articles and review papers which all over Canada, the United States, Japan, Slovakia, Ger- were invitedfrom the participants ofa recent meeting organ- many, the Czech Republic, Estoniaand the Netherlands. The izedto honourthe 60th birthdayofNaranjan S. Dhalla, Ph.D., meeting wasjudged to be an overwhelming success in terms M.D. (Hon.). The meeting, organized by Drs. Morris Karma- ofthe scientific content as well as collaborative interactions zyn (London), Grant Pierce (Winnipeg) and Balwant Tuana initiated. (Ottawa), was held at the Best Western Lakeside Inn in We gratefully acknowledge the financial support from Kenora, Ontario, Canada from August 23-25th, 1996. The Pfizer, MerckFrosst, Astra, Ciba-Geigy, the Heart and Stroke meeting was entitled 'The Cellular Basis of Cardiovascular Foundation of Manitoba, the Medical Research Council of Function in Health and Disease'. There were over40 invited Canada, St. Boniface Research Foundation, the NRC Insti- speakers from 15 different countries present at the meet- tute for Biodiagnostics, the ManitobaHealth Research Coun- ing and it was attended by over 280 people. Keynote lectures cil and various sources within the University of Manitoba.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52337712922897,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52337713512721,"sku":"NLS9781461376422","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461376422.jpg?v=1758167522"},{"product_id":"lipid-metabolism-in-the-healthy-and-disease-heart-book-ger-j-van-der-vusse-9781461365594","title":"Lipid Metabolism in the Healthy and Disease Heart","description":"The discovery of the second-messenger functions of on serine and threonine residues. Although there is inositol 1,4,5-trisphosphate (Ins(1 ,4,5)P 3) and 1,2-dia- general agreement that PKC plays an important role in cylglycerol (DAG), the products of receptor-stimulated the initiation and\/or modulation of receptor-linked re- phosphatidylinositol 4,5-bisphosphate (PtdIns( 4,5)P ) 2 sponses, the precise nature or molecular details of this hydrolysis, marked a turning point in the studies on the involvement remain elusive. There are several sugges- mechanisms of mediation of functional hormone and tions of possible functions of PKC, including involve- neurotransmitter responses. The historical background ment in modulation of ionconductance, regulation of of this discovery and the extensive bibliography of the receptor interaction with components of (other) signal 2 enormously expanding knowledge in this field was re- transduction pathways, modulation of Ca + sensitivity cently presented by Rana and Hokin [1], the latter of contractile proteins and gene expression [6]. author who first observed the 'phosphoinositide' effect The receptors involved in the activation of the adeny- 35 years ago. It was, however, the Ca2+ gating hypothe- late cyclase and PtdIns cascade pathways have one com- sis proposed by Michell [2] on basis of a survey of mon feature. They are present in the plasmamembrane observations on the phosphoinositide turnover in a as complexes with GTP binding proteins (G-proteins).","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52338695799057,"sku":"NLS9781461365594","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52953464045841,"sku":"NIN9781461365594","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461365594.jpg?v=1758168951"},{"product_id":"insulin-action-book-ashok-k-srivastava-9781461375845","title":"Insulin Action","description":"In 1996 the 75th anniversary of the discovery of insulin was  celebrated at the University of Toronto, the scene of that discovery  in 1921. This volume was stimulated by the scientific program which  was staged at that time and brought together much of the world's best  talent to discuss and analyze the most recent developments in our  understanding of pancreatic function, insulin secretion, the  interaction of insulin with its target tissues, the mechanism of  insulin action at the cellular level, and the defects which underlie  both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II  (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease.  We have chosen to focus the present volume on work related to insulin  action.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52344630771985,"sku":"NLS9781461375845","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52953462735121,"sku":"NIN9781461375845","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461375845.jpg?v=1758174798"},{"product_id":"stress-adaptation-prophylaxis-and-treatment-book-dipak-k-das-9781461373193","title":"Stress Adaptation, Prophylaxis and Treatment","description":"Stress reaction is likely to play a crucial role in a variety  of degenerative diseases including cancer and cardiovascular diseases.  The process of stress adaptation may appear to be simple, but in  reality this is a very complex process and we are only beginning to  understand the mechanism of adaptation. In January, 1998, scientists  from around the world assembled to discuss the potential applicability  of the concept of stress adaptation in the clinical arena. This volume  contains original research papers presented on this subject during the  conference Stress Adaptation, Prophylaxis and Treatment held in  Calcutta, India, and serves as an up-to-date source of information for  scientists, as well as clinicians interested in applying the concept  of stress adaptation to the cure of diseases.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52351106416913,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52351110054161,"sku":"NLS9781461373193","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461373193.jpg?v=1758180763"},{"product_id":"vanadium-compounds-biochemical-and-therapeutic-applications-book-ashok-k-srivastava-9780792337621","title":"Vanadium Compounds: Biochemical and Therapeutic Applications","description":"The papers in this volume comprise reviews and research papers presented at the Vanadium Symposium held in 1994. The papers are grouped into three main sections: the chemistry; biochemical and physiological aspects; and potential therapeutic use and toxic effects of vanadium compounds.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52351176507665,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52351177523473,"sku":"NLS9780792337621","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780792337621.jpg?v=1758180820"},{"product_id":"cellular-bioenergetics-role-of-coupled-creatine-kinases-book-valdur-a-saks-9781461361190","title":"Cellular Bioenergetics: Role of Coupled Creatine Kinases","description":"Most of the information on the functional role, structure and  molecular biology of creatine kinase is scattered in several hundreds  of publications. The editors of this volume invited all authors who  are most active at present in experimental research on creatine  kinases to summarize their work and make the information easily  available to a wider scientific audience, especially to young  investigators who are entering this field. Since the functional role  of coupled creatine kinases is directly related to the phenomenon of  compartmentation and structural organization of metabolic networks, we  also invited experts in the related areas to contribute to the volume.  Almost all invited authors responded enthusiastically and the results  of this collective work are presented here.    For biochemists, biophysicists, physiologists, and medical research  workers.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52402148311313,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52402148933905,"sku":"NLS9781461361190","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461361190.jpg?v=1758756839"},{"product_id":"vascular-biochemistry-book-peter-zahradka-9781461350101","title":"Vascular Biochemistry","description":"This volume explores all aspects of vascular biochemistry and includes chapters that provide an understanding of vascular function with descriptions of tissue components present in the vascular wall as well as an exploration of the hemodynamic and metabolic activities associated with this function. In addition, some chapters explore the vasculature under conditions which mimic various disease states.    The information provided in this volume will provide new insights into the mechanisms that control vascular function as well as therapies designed to treat vascular disease.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52404337934609,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52404338622737,"sku":"NLS9781461350101","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461350101.jpg?v=1758763969"},{"product_id":"enzyme-induction-and-modulation-book-va-najjar-9780898385830","title":"Enzyme Induction and Modulation","description":"In addition to performing its prime function as a vehicle for scientific communications of varied colora- tions, Molecular and Cellular Biochemistry is again focusing on two subjects which it treats in depth. One of these is a book issue dealing with the transglutaminase reaction. The other is this issue that deals with induction and modulation of enzymes. This is a very broad subject that calls for broader coverage than could be included in one book issue. However, I have elected to include only certain contributions that serve as general examples of the principles involved. There are six articles on enzyme regulation in hepatocyte culture. These include arginase and argino-succi- nate synthetase, y-glutamyl transferase and plasminogen activitor. Other regulatory enzymes that are discussed are protein kinases, 2,3-bisphosphoglycerate synthetases, carbamoyl phosphate synthetase, heme oxygenase, cytochrome P-450, tyrosine hydroxylase, fatty acid synthetase, acetyl eoA carboxylase, among others. Also included is the regulation of several enzyme messengers RNAs. As in the past, subscribers to the journal will receive this double volume as a continuation of regular issues of the journal Molecular and Cellular Biochemistry. This double volume will also be available separately in the form of a book issue to interested readers through Martinus Nijhoff Publishers. v.A. Najjar Part I Molecular and Cellular Biochemistry 53;54,11-21 (1983). (c) 1983, Martinus 1 ij hoff Publishers. Boston. Printed in The Netherlands.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52480887718161,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52480888865041,"sku":"NLS9780898385830","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780898385830.jpg?v=1759850903"},{"product_id":"cardiac-metabolism-in-health-and-disease-book-salah-abdel-aleem-9780792381044","title":"Cardiac Metabolism in Health and Disease","description":"This special issue of Molecular and Cellular Biochemistry  contains original research papers as well as invited reviews focused  in the field of cardiac metabolism and its regulation under normal and  disease conditions. These papers cover many areas under intensive and  rapid development such as the regulation of fatty acid oxidation in  the heart, the role of cardiac glycogen during ischemia, the role of  CPT I isoenzymes, the pathophysiology of diabetic cardiomyopathy,  cardiac protection through regulation of energy production, the role  of fatty acid binding protein under normal and pathological  conditions, and several other important topics in this area of  research. We hope that this special issue of Molecular and  Cellular Biochemistry provides an up-to-date source of  information for scientists and clinicians interested in the mechanism  by which cardiac metabolism is regulated in health and disease and the  mechanistic relationship between disturbances in cardiac metabolism  and the genesis of cardiovascular diseases.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52481801322769,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52481802404113,"sku":"NLS9780792381044","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780792381044.jpg?v=1759852261"},{"product_id":"biochemistry-of-diabetes-and-atherosclerosis-book-james-sc-gilchrist-9781402074233","title":"Biochemistry of Diabetes and Atherosclerosis","description":"Diabetes is an autoimmune, inflammatory disease affecting many different organ systems and exhibiting both primary and secondary defects. Because diabetes affects a wide range of cellular systems, a multidisciplinary effort has been mounted over the past several decades using a wide range of investigative techniques and methodologies in order to identify molecular mechanisms responsible for cellular dysfunction. Because primary defects at various levels of sub-cellular signaling, intracellular calcium handling, protein expression and energy regulation are often a primary consequence of diabetes. This volume is a compilation of new multidisciplinary research that will broaden our current understanding of diabetes and cardiovascular disease as well as provide the basis for the development of novel therapeutic interventions.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52500868464913,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ GARDNERS","offer_id":52500868923665,"sku":"NGR9781402074233","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781402074233.jpg?v=1760139095"},{"product_id":"cellular-fatty-acid-binding-proteins-book-jan-fc-glatz-9781461367567","title":"Cellular Fatty Acid-binding Proteins","description":"Twenty years have elapsed since cytoplasmic proteins exhibiting high-affinity binding of long-chain fatty acids were first identified (Ockner et al., Science 177:56-58, 1972). These cellular fatty acid-binding proteins (FABPs) are now well established to comprise a ligand-defined group of macromolecules belonging to a family of cytoplasmic lipid binding proteins. Unique features of the FABPs are the existence of distinct types of FABP and that these are found in a variety of tissues in remarkable abundance, with some cells expressing more than one type. The physiological significance of the FABPs has only partly been elucidated. By increasing the cytoplasmic solubilization of fatty acids, the cellular FABPs are considered to function primarily in intracellular fatty acid transport, but may also be assigned important regulatory roles in cellular lipid homeostasis as well as in the modulation of cell growth and differentiation. The broad interests in cellular FABPs has led to the organization of the 1st International Workshop on Fatty Acid-Binding Protein, held in Maastricht, the Netherlands, in 1989. Prompted by the success of the first meeting, the 2nd International Workshop on Fatty-Acid-Binding Proteins, which was held again in Maastricht, on August 31 and September 1, 1992, brought together scientific scpecialists in the field of FABP research for two days of intensive and fruitful discussion. This volume is a collection of selected papers from this conference, and thus provides the state-of-the-art knowledge of cellular FABPs. The contributors to this issue represent pioneering as well as new investigators, and also reflect the multidisciplinary nature of research in this exciting and rapidly progressing field.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52597845033233,"sku":"NLS9781461367567","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52953463750929,"sku":"NIN9781461367567","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461367567.jpg?v=1761075014"},{"product_id":"cardiac-metabolism-in-health-and-disease-book-salah-abdel-aleem-9781461376033","title":"Cardiac Metabolism in Health and Disease","description":"This special issue of Molecular and Cellular Biochemistry  contains original research papers as well as invited reviews focused  in the field of cardiac metabolism and its regulation under normal and  disease conditions. These papers cover many areas under intensive and  rapid development such as the regulation of fatty acid oxidation in  the heart, the role of cardiac glycogen during ischemia, the role of  CPT I isoenzymes, the pathophysiology of diabetic cardiomyopathy,  cardiac protection through regulation of energy production, the role  of fatty acid binding protein under normal and pathological  conditions, and several other important topics in this area of  research. We hope that this special issue of Molecular and  Cellular Biochemistry provides an up-to-date source of  information for scientists and clinicians interested in the mechanism  by which cardiac metabolism is regulated in health and disease and the  mechanistic relationship between disturbances in cardiac metabolism  and the genesis of cardiovascular diseases.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52660107444497,"sku":"NLS9781461376033","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52953463030033,"sku":"NIN9781461376033","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461376033.jpg?v=1762264515"},{"product_id":"cellular-fatty-acid-binding-proteins-book-jan-fc-glatz-9780792308966","title":"Cellular Fatty Acid-binding Proteins","description":"Twenty years have elapsed since cytoplasmic proteins exhibiting high-affinity binding of long-chain fatty acids were first identified (Ockner et al., Science 177:56-58, 1972). These cellular fatty acid-binding proteins (FABPs) are now well established to comprise a ligand-defined group of macromolecules belonging to a family of cytoplasmic lipid binding proteins. Unique features of the FABPs are the existence of distinct types of FABP and that these are found in a variety of tissues in remarkable abundance, with some cells expressing more than one type. The physiological significance of the FABPs has only partly been elucidated. By increasing the cytoplasmic solubilization of fatty acids, the cellular FABPs are considered to function primarily in intracellular fatty acid transport, but may also be assigned important regulatory roles in cellular lipid homeostasis as well as in the modulation of cell growth and differentiation. The broad interests in cellular FABPs has led to the organization of the 1st International Workshop on Fatty Acid-Binding Protein, held in Maastricht, the Netherlands, in 1989. Prompted by the success of the first meeting, the 2nd International Workshop on Fatty-Acid-Binding Proteins, which was held again in Maastricht, on August 31 and September 1, 1992, brought together scientific scpecialists in the field of FABP research for two days of intensive and fruitful discussion. This volume is a collection of selected papers from this conference, and thus provides the state-of-the-art knowledge of cellular FABPs. The contributors to this issue represent pioneering as well as new investigators, and also reflect the multidisciplinary nature of research in this exciting and rapidly progressing field.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52660628390161,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52660629373201,"sku":"NLS9780792308966","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780792308966.jpg?v=1762265640"},{"product_id":"myocardial-ischemia-and-reperfusion-book-michael-v-cohen-9781461372608","title":"Myocardial Ischemia and Reperfusion","description":"The articles collected in this volume largely arose from two  related meetings held last spring. The first was held in Buenos Aires,  Argentina on April 11-12, 1997 and was titled Nuevos Avances en  el Fenomeno de Isquemia y Reperfusion (New Advances in  the Phenomenon of Ischemia and Reperfusion). The second meeting took place in Stara Lesna located in  the High Tatras Mountains of the Slovak Republic on June 27-30,  1997. Both meetings were sponsored by several organizations including the  International Society and Federation of Cardiology, the International  Society for Heart Research and The American Heart Association.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52665956729105,"sku":"NLS9781461372608","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461372608.jpg?v=1762278675"},{"product_id":"oxygen-nitrogen-radicals-cell-injury-and-disease-book-val-vallyathan-9781461353881","title":"Oxygen\/Nitrogen Radicals: Cell Injury and Disease","description":"A veritable mountain of literature has been published showing the causal relationship of reactive oxygen\/nitrogen species in human disease conditions, and there has been an explosion in the understanding of oxidative stress, the protective role of antioxidants and molecular events involved in the regulation of transcription, editing, and translation of key events leading to disease processes. Strategies need to be developed for prevention of diseases by allowing scientists and clinicians to obtain information on new and emerging advances. The molecular mechanisms involved in several diseases including Alzheimer's disease, atherosclerosis, diabetes, arthritis, and Parkinson's disease, as well as disorders of the eye, skin, cardiac, and pulmonary systems are discussed in this volume, along with scientific evidence supporting the value of dietary supplementation with antioxidants in the prevention of cellular damage leading to chronic disease. Special in vivo techniques are also discussed at length, along with the role of molecular studies in human risk assessment.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52666782810385,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52666784317713,"sku":"NLS9781461353881","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461353881.jpg?v=1762280873"},{"product_id":"guanidino-compounds-in-biology-and-medicine-book-joseph-f-clark-9781461349853","title":"Guanidino Compounds in Biology and Medicine","description":"Guanidino compounds comprise Creatine, Arginine, and the Guanidines. In the past two years there have been over 2000 published articles with the names of these compounds in the title. One can go to any nutrition or health food store and buy these as supplements because it is believed they improve health and athletic performance.   This volume includes an up to date summary of the scientific and clinical aspects of essentially all the biologically active Guanidino Compounds. The articles summarize the current scientific knowledge of these compounds with reference to relevant clinical conditions, and discuss the chemical, biological, and clinical functions of these compounds.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52668644196625,"sku":"NLS9781461349853","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461349853.jpg?v=1762285548"},{"product_id":"molecular-and-cellular-effects-of-nutrition-on-disease-processes-book-grant-n-pierce-9780792381716","title":"Molecular and Cellular Effects of Nutrition on Disease Processes","description":"The papers ofthis Special Issue of Molecular and Cellular Nutraceuticals are also known as 'health foods' but they also Biochemistry are invited, peer-reviewed submissions from include any product derived from animal or plant sources speakers who attended the 2nd World Conference of the which ultimately can provide a medical benefit. F our symposia International Society for MolecuIar Nutrition \u0026amp; Therapy. This on various aspects concerning nutraceutical products and the Conference was held fromAugust 2--4th, 1997 in Winnipeg, marketing ofthese compounds was addressed. It is hoped that Canada. The goal of the Conference was to advance our these interactions represent the start of a new, highly interesting knowledge concerning the molecular events which link scientific venture uniting the nutraceutical industry with the nutrition to various disease processes in the body. Attending main stream academic medical research community. The the meeting were scientists from 18 countries ineluding nutraceutical industry is expected to be a multibillion dollar Canada, the United States, Japan, the United Kingdom, a year business world-wide by the turn of the century. The Franee, the Czeeh Republie, Germany, the Netherlands, identification of the active ingredients in any number of Bahrain, Hong Kong, India, Israel, China, Kuwait,Argentina, health foods reputed to be medieally beneficial would be just Sweden, Australia and Mexieo. There were 56 Distinguished one of the goals of such a scientific interaction.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52676393599249,"sku":"NLS9780792381716","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780792381716.jpg?v=1762304155"},{"product_id":"lipid-binding-proteins-within-molecular-and-cellular-biochemistry-book-da-bernlohr-9780792382232","title":"Lipid Binding Proteins within Molecular and Cellular Biochemistry","description":"The breadth of modern biology is characterized by a  comprehension of phenomena at many levels of organization. Such levels  of understanding range from the organismal to the molecular. It is  when all these levels can be discussed together that a sense of true  achievement begins to be felt. The topical area of fatty acid  transport and metabolism was the focus of the Third International  Conference on Lipid-Binding Proteins held at the University of  Minnesota in May 1997. This volume contains a sampling of the  proceedings of this meeting.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52677061804305,"sku":"NLS9780792382232","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780792382232.jpg?v=1762305328"},{"product_id":"molecular-and-cellular-effects-of-nutrition-on-disease-processes-book-grant-n-pierce-9781461376415","title":"Molecular and Cellular Effects of Nutrition on Disease Processes","description":"The papers ofthis Special Issue of Molecular and Cellular Nutraceuticals are also known as 'health foods' but they also Biochemistry are invited, peer-reviewed submissions from include any product derived from animal or plant sources speakers who attended the 2nd World Conference of the which ultimately can provide a medical benefit. F our symposia International Society for MolecuIar Nutrition \u0026amp; Therapy. This on various aspects concerning nutraceutical products and the Conference was held fromAugust 2--4th, 1997 in Winnipeg, marketing ofthese compounds was addressed. It is hoped that Canada. The goal of the Conference was to advance our these interactions represent the start of a new, highly interesting knowledge concerning the molecular events which link scientific venture uniting the nutraceutical industry with the nutrition to various disease processes in the body. Attending main stream academic medical research community. The the meeting were scientists from 18 countries ineluding nutraceutical industry is expected to be a multibillion dollar Canada, the United States, Japan, the United Kingdom, a year business world-wide by the turn of the century. The Franee, the Czeeh Republie, Germany, the Netherlands, identification of the active ingredients in any number of Bahrain, Hong Kong, India, Israel, China, Kuwait,Argentina, health foods reputed to be medieally beneficial would be just Sweden, Australia and Mexieo. There were 56 Distinguished one of the goals of such a scientific interaction.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52677364449553,"sku":"NLS9781461376415","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461376415.jpg?v=1762305885"},{"product_id":"molecular-mechanisms-of-cellular-growth-book-howard-e-morgan-9780792311836","title":"Molecular Mechanisms of Cellular Growth","description":null,"brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52678851887377,"sku":"NLS9780792311836","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780792311836.jpg?v=1762309145"},{"product_id":"lipid-binding-proteins-within-molecular-and-cellular-biochemistry-book-da-bernlohr-9781461372363","title":"Lipid Binding Proteins within Molecular and Cellular Biochemistry","description":"The breadth of modern biology is characterized by a  comprehension of phenomena at many levels of organization. Such levels  of understanding range from the organismal to the molecular. It is  when all these levels can be discussed together that a sense of true  achievement begins to be felt. The topical area of fatty acid  transport and metabolism was the focus of the Third International  Conference on Lipid-Binding Proteins held at the University of  Minnesota in May 1997. This volume contains a sampling of the  proceedings of this meeting.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52679560167697,"sku":"NLS9781461372363","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461372363.jpg?v=1762310869"},{"product_id":"molecular-and-cellular-view-of-protein-kinase-ck2-book-khalil-ahmed-9781461346487","title":"A Molecular and Cellular View of Protein Kinase CK2","description":"It is now generally recognized that protein kinase signaling is  involved in virtually every aspect of cell function, including growth  and proliferation. The field of protein phosphorylation, including the  enzymes involved in this post-translational modification, continues to  advance at a fascinating pace.    Since the first international meeting on this topic, held in  Heidelberg in 1994, several new avenues of CK2 research have emerged  despite persistent deficiencies in our understanding of the regulation  of its activity. Among the significant new directions are studies  related to the structure of the enzyme, especially its crystal  structure, as well as an interesting aspect of CK2 function that  involves its subunits as binding partners of several other proteins.  In addition, new data have been gathered on the role of CK2 in  transcription as well as in certain other cellular functions. To  address these various aspects of the progress of CK2, a number of key  scientists from different parts of the world came together at the  second international meeting on `A Molecular and Cellular View of  Protein Kinase CK2', held at Villard de Lans near Grenoble on  September 24-26, 1997. The meeting was attended by nearly 50  participants and included 28 presentations, which provide a view of  the latest progress on protein kinase CK2.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52680267366673,"sku":"NLS9781461346487","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461346487.jpg?v=1762312698"},{"product_id":"control-of-gene-expression-by-catecholamines-and-the-renin-angiotensin-system-book-heinz-rupp-9781461369554","title":"Control of Gene Expression by Catecholamines and the Renin-Angiotensin System","description":"The special issue of Molecular and Cellular Biochemistry  focuses on `Control of Gene Expression by Catecholamines and the  Renin-Angiotensin System' in health and disease. In recent years,  great progress has been made in the understanding of catecholamine and  angiotensin II modulated gene expression. There is also increasing  evidence that catecholamine and angiotensin II induced cellular injury  not solely arises from classical pathways but also from a perturbed  gene expression.    Taking into account that catecholamines and angiotensin II are vital  for a balanced gene expression of many cells, the intriguing  possibility arises that various disease are initiated or aggravated by  such an imbalance. Catecholamine and angiotensin II influences can be  in excess arising from, for example, hypercaloric food intake or  psychosocial stress. During early progression of heart failure,  sympathetic activity and angiotensin II influences also become  increased. Due to beta-adrenergic receptor downregulation, depressed  catecholamine influences are expected in the final stage of heart  failure. An imbalanced influence of catecholamines and angiotensin II  on gene expression leads to disordered molecular structures of the  cell and an impaired cell function.    This focused issue is organized into chapters concentrating on  catecholamines, angiotensin II, and the interaction between  catecholamines and angiotensin II. Basic biochemical processes are  covered in detail and the potential of these pathways for explaining  chronic diseases associated with excess catecholamine and angiotensin  II influences should become apparent. It is hoped that this focussed  issue triggers novel research into the development of drugs that are  targeted at diseases characterized by an imbalanced gene expression  involving catecholamines and angiotensin II.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52680483995921,"sku":"NLS9781461369554","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461369554.jpg?v=1762313230"},{"product_id":"novel-methods-in-molecular-and-cellular-biochemistry-of-muscle-book-grant-n-pierce-9781461379188","title":"Novel Methods in Molecular and Cellular Biochemistry of Muscle","description":"Instead, the purpose of the articles found  within this focused volume of Molecular and Cellular  Biochemistry was to describe how the technique is performed on the  laboratory bench so that others less familiar with the technique may  be able to use it in their own labs.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52680722481425,"sku":"NLS9781461379188","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461379188.jpg?v=1762313825"},{"product_id":"cellular-fatty-acid-binding-proteins-ii-book-jan-fc-glatz-9781461363538","title":"Cellular Fatty Acid-Binding Proteins II","description":"The cellular functions of lipid-transport proteins cannot can be obtained, as well as structural information re- garding the local environment of the spectroscopic be fully realized without a comprehensive knowledge of probe. However, changes in protein fluorescence upon their binding properties. In particular, it is important to identify physiologically important ligands and establish ligand binding are sometimes too small to quantitate. their binding affinities, stoichiometries and specificities. This is particularly true for L-FABP, which has no tryp- Since many lipid-binding proteins exhibit no enzymatic tophan residues. Also, some lipids lack intrinsic fluores- cence or paramagnetic properties, including many lipids activity, binding parameters provide an important quan- titative measure for comparing the 'activity' of various of physiological interest. In such cases, lipid analogues wild-type and mutant forms. For this purpose, binding containing structure-perturbing anthroylxoxy or doxyl assays that are quantitative, accurate and robust are de- probes are required. Lipids that do have intrinsic fluor- sirable. escence, such as parinaric acid, are labile and prone to For the intracellular fatty acid- and lipid-binding pro- oxidation. The binding of native ligands can be moni- teins, a variety of biochemical and biophysical binding tored by isotope-directed NMR techniques, provided assays have been used. The biochemical assays include that enrichment with 13C or another suitable isotope is those based on gel-filtration [1-3], equilibrium dialysis feasible. Although such NMR methods are useful for de- [4], Lipidex [5,6] and liposomes [7].","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52680781725969,"sku":"NLS9781461363538","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52953462145297,"sku":"NIN9781461363538","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461363538.jpg?v=1762313971"},{"product_id":"cellular-interactions-in-cardiac-pathophysiology-book-jn-slezk-9781461358282","title":"Cellular Interactions in Cardiac Pathophysiology","description":"Despite the considerable success in treating diseases of the  heart and blood vessels, they still remain the major cause of  mortality throughout the world. One of the reasons underlying this  problem is our lack of understanding of the molecular and cellular  aspects of the processes involved.    These problems are fully discussed in Cellular Interactions in  Cardiac Pathophysiology, which draws together 25  contributions from leading investigators from all parts of the world.  The contributions are grouped under three headings: Extracellular  matrix and cardiocyte interaction; Myocytic adaptations and myocardial  injury; and Signal transduction.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52680885076241,"sku":"NLS9781461358282","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461358282.jpg?v=1762314214"},{"product_id":"biochemistry-of-hypertrophy-and-heart-failure-book-lorrie-a-kirshenbaum-9781461348535","title":"Biochemistry of Hypertrophy and Heart Failure","description":"The focus of this special issue of Molecular and Cellular Biochemistry is underlying mechanisms that regulate cardiac growth. The new information provided in this special issue can be utilized to design new treatment modalities that will reduce the incidence of cardiac failure which will improve quality of life in patients with chronic heart disease.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52680917811473,"sku":"NLS9781461348535","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461348535.jpg?v=1762314293"},{"product_id":"molecular-mechanisms-of-cellular-growth-book-howard-e-morgan-9781461367338","title":"Molecular Mechanisms of Cellular Growth","description":null,"brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52681027911953,"sku":"NLS9781461367338","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461367338.jpg?v=1762314565"},{"product_id":"cellular-function-and-metabolism-book-yoshio-yazaki-9781461363446","title":"Cellular Function and Metabolism","description":"A  variety  of metabolic processes are known to be intimately  involved in  the  maintenance  of  cellular structure and function. Special  emphasis  has been laid on understanding heart function and metabolism  in  health  and  disease  in  general,  and cardiac hypertrophy, heart  failure,  and  ischemic  heart disease in particular.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52681214329105,"sku":"NLS9781461363446","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52953461883153,"sku":"NIN9781461363446","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461363446.jpg?v=1762315020"},{"product_id":"adp-ribosylation-reactions-book-r-alvarez-gonzalez-9781461346784","title":"ADP-Ribosylation Reactions","description":"This special issue of Molecular and Cellular Biochemistry  contains twenty-two selected research papers and reviews from a total  of one hundred and ten presentations given at the 12th International  Symposium on ADP-ribosylation Reactions: From Bacterial Pathogenesis  to Cancer, held in Cancun, Mexico, May 10-14, 1997. The  Symposium was hosted by the Sociedad Mexicana de Bioquimica and was  sponsored by the University of North Texas Health Science Center, Fort  Worth, TX, USA.    This volume provides a state-of-the-art source of information for  basic scientists and clinicians who are interested in the molecular,  biochemical, and cellular aspects of protein-(ADP-ribose) transfer  reactions in human health and disease.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52681256075537,"sku":"NLS9781461346784","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461346784.jpg?v=1762315121"},{"product_id":"biochemistry-of-diabetes-and-atherosclerosis-book-james-sc-gilchrist-9781461348528","title":"Biochemistry of Diabetes and Atherosclerosis","description":"Diabetes is an autoimmune, inflammatory disease affecting many different organ systems and exhibiting both primary and secondary defects. Because diabetes affects a wide range of cellular systems, a multidisciplinary effort has been mounted over the past several decades using a wide range of investigative techniques and methodologies in order to identify molecular mechanisms responsible for cellular dysfunction. Because primary defects at various levels of sub-cellular signaling, intracellular calcium handling, protein expression and energy regulation are often a primary consequence of diabetes.    This volume is a compilation of new multidisciplinary research that will broaden our current understanding of diabetes and cardiovascular disease as well as provide the basis for the development of novel therapeutic interventions.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52681467298065,"sku":"NLS9781461348528","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461348528.jpg?v=1762315679"},{"product_id":"cellular-lipid-binding-proteins-book-jan-jansen-9781461348689","title":"Cellular Lipid Binding Proteins","description":"It is well established that cellular lipid binding proteins serve central roles in cellular lipid uptake and metabolism. Evidence has been presented that various metabolic diseases, such as hyperlipidemia, atherosclerosis, insulin resistance, and diabetes, are characterized by malfunctioning or deficiencies in cellular lipid binding proteins. For better understanding of the action of lipids as signaling compounds and the role of lipids in intermediary metabolism, it is essential to have detailed knowledge of the interactions between lipids and their cognant binding proteins. In view of this growing interest in lipid-protein interaction, the 4th International Conference on Lipid Binding Proteins was held in Maastricht, The Netherlands, in June 2001. The proceedings of the previous three meetings have been published in Molecular and Cellular Biochemistry. The present focused issue of Molecular and Cellular Biochemistry comprises selected papers based on the lectures and posters presented during the 4th conference, and provides insight into the significance of these proteins for the functioning of the cell.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52681494135057,"sku":"NLS9781461348689","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461348689.jpg?v=1762315765"}],"url":"https:\/\/www.worldofbooks.com\/collections\/developments-in-molecular-and-cellular-biochemistry-book-series.oembed","provider":"World of Books ","version":"1.0","type":"link"}