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The role of \"endogenous benzodiazepines. \" This volume summarizes the results of a symposium held in Val David, Quebec from October 3D-November I, 1988, that was devoted to an evaluation of the evidence for and against the various hypothe- ses of HE. Data from studies in patients, in experimental (animal) models of HE, and in cultured cell preparations were discussed. In addition, a review of available approaches to the treatment and man- agement of HE was included. The therapeutic use of lactulose, anti- biotics, dietary treatment, and branched-chain amino acid treatments were included, as well as the results of preliminary studies of the therapeutic use of the benzodiazepine antagonist, flumazenil. Roger F. Butterworth, PhD Gilles Pomier Layrargues, MD v Acknowledgments The symposium was made possible by the generous financial assistance of: Hoffman-La Roche Ltd.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51320641028369,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ GARDNERS","offer_id":51320642863377,"sku":"NGR9781461288510","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52128652755217,"sku":"NLS9781461288510","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1461288517.jpg?v=1751147033"},{"product_id":"biological-methylation-and-drug-design-book-ronald-t-borchardt-9781461293989","title":"Biological Methylation and Drug Design","description":"This book has been developed from its earlier and far less formal presentment as the proceedings of a symposium entitled The Biochemistry of S-Adenosylmethionine as a Basis for Drug Design that was held at the Solstrand Fjord Hotel in Bergen, Norway on June 30-July 4, 1985. The purpose of the symposium was to bring together scientists from various disciplines (biochemistry, pharmacology, virology, immunology, chemistry, medicine, and so on) to discuss the recent advances that have been made in our understanding of the biological roles of S- adenosylmethionine (AdoMet) and to discuss the feasibility of utilizing AdoMet-dependent enzymes as targets for drug design. Thus the information provided herein will be of value not only to basic scientists involved in elucidating the role of AdoMet in biology, but also to medicinal chemists who are using this basic knowledge in the process of drug design. The volume should also be of interest to pharmacologists and clinicians involved in biological evaluation of potential therapeutic agents arising from the efforts of the biochemists and medicinal chemists. 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Initial infection usu­ ally occurs during childhood or the teenage years. It is clear that, de­ pending on the age of the recipient, clinical manifestations of the primary infection can vary. It has been known for 20 years that EBV is the etiologic agent of acute infectious mononucleosis (IM) and is also closely associated with African Burkitt's lymphoma (BL) and naso­ it is a pharyngeal carcinoma (NPC). There is increasing evidence that factor in the etiology of B-celllymphomas, which arise at a high fre­ quency in immunodeficient populations. EBV may also contribute to the development of autoimmune disease. Thus, this virus continues to attract world-wide attention. The major target cell for EBV infection has now been conclusively identified as the complement receptor-type 2 (CR2), the Cd\/Cdg 3 3 receptor on B lymphocyte. It is apparent, however, that other cells also can become infected by EBV, such as epithelial cells in the parotid gland and other epithelial cells in the upper respiratory tract. This might help account for the EBV-assodated carcinomas of the upper respiratory tract. The first in a series of international symposia on EBV -associated diseases focused primarily on Burkitt's-type lymphomas or on NPC (Kyoto 1977; Dusseldorf 1980; Kuala Lumpur 1982) and emphasized mainly the clinical elements of these diseases. 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In fact, the ability for alcohol to disrupt cellular function is at- tributed to its cellular injury without regard to an apparent specific mechanism of action. Nevertheless, the key to an effective treatment to this problem is through research into understanding the mechan- isms underlying how ethanol interacts with cells and membranes. This book is the result of a cooperative effort among scientists from many nations who met in a symposium in Taipei, Taiwan, ROC, July 1988. The focus of this book is on experimental ap- proaches to better understand the molecular mechanisms of ethanol on the biological system. These recent advances in the examination of the alcohol effects on cellular function are divided into four sec- tions. The first section addresses specific actions of ethanol on the central nervous system. 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This volume was assembled to address current research and developing ideas in biomolecular recognition through the contribu- tions presented at the Conference on Mechanisms of Recognition in Biological Macromolecules held in Siena, Italy, September 4-6,1986. 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These activities are consistent with the notion that they represent the facilitation of normal copper-dependent metabolic processes in dis- ease states. The presentations and interactive discussions that fol- lowed are contained in these proceedings. John R. J. Sorenson Dedication These proceedings are dedicated to those who made this truly memorable scientific and social Arkansas experience possible.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52135037075729,"sku":"NLS9781461289371","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461289371.jpg?v=1757546724"},{"product_id":"directed-drug-delivery-book-ronald-t-borchardt-9781461296034","title":"Directed Drug Delivery","description":"This book is based on the proceedings of the symposium entitled Di- rected Drug Delivery: A Multidisciplinary Problem, which was held in Lawrence, Kansas on October 17-19, 1984. 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Whether other vita- mins can be changed or altered to produce a better anticancer effect than the native compound has been little explored to date, but should be a fruitful pursuit for future study. In our concluding remarks to the First International Conference in 1982, we speculated that rapid advances in our understanding of vi- tamins would occur in the next few years and that large-scale inter- vention trials of vitamins as preventive agents in defined human pop- ulations would be started. This anticipated generation of data on vitamins and their interactions has proceeded rapidly and the impor- tance of interactions between vitamins and other micronutrients in the prevention setting has become better appreciated. 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The purpose of the symposium was to bring together scientists from various disciplines (biochemistry, pharmacology, virology, immunology, chemistry, medicine, and so on) to discuss the recent advances that have been made in our understanding of the biological roles of S- adenosylmethionine (AdoMet) and to discuss the feasibility of utilizing AdoMet-dependent enzymes as targets for drug design. Thus the information provided herein will be of value not only to basic scientists involved in elucidating the role of AdoMet in biology, but also to medicinal chemists who are using this basic knowledge in the process of drug design. The volume should also be of interest to pharmacologists and clinicians involved in biological evaluation of potential therapeutic agents arising from the efforts of the biochemists and medicinal chemists. 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Topics covered in this volume include protein and phospholipid methylations (Section A), nucleic acid methyl- ations (Section B), the regulation of AdoMet, S-adenosylhomocysteine, and methylthioadenosine metabolism (Section C), clinical aspects of AdoMet (Section D), and the design, synthesis, and biological evaluation of trans- methylation inhibitors (Section E).","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52477855564049,"sku":"NLS9780896031029","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53511094305041,"sku":"NIN9780896031029","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780896031029.jpg?v=1759846289"},{"product_id":"tumor-cell-differentiation-book-jarle-aarbakke-9780896031340","title":"Tumor Cell Differentiation","description":"This volume contains the proceedings of an International Sympo- sium on the Biology and Pharmacology of Tumor Cell Differentiation- held on June 29-July I, 1986 at the University of Tromso, Norway. The objective of this meeting was to bring together scientists from various disciplines to discuss recent advances in the understanding of tumor cell differentiation and to bridge the gap between experimental findings and clinical application of new knowledge. Thus the infor- mation will be of value not only to basic scientists involved in mol- ecular and cell biology, but also to pharmacologists and clinicians trying to develop the concept of tumor cell differentiation as a thera- peutic modality. Each plenary speaker and selected poster presenters were requested to submit a comprehensive, up-to-date review of recent contributions to their disciplines related to differentiation and: hematopoietic factors and leukemic cells in culture vitamin deriva- tives and polyamines; nucleosides and methylation; and cell interac- tions.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52480777322769,"sku":"NLS9780896031340","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52740536172817,"sku":"NIN9780896031340","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780896031340.jpg?v=1759850737"},{"product_id":"biology-of-copper-complexes-book-john-r-j-sorenson-9780896031234","title":"Biology of Copper Complexes","description":"In 1928, it was discovered that copper was essential for normal human metabolism. 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In addition new data concerning antimicrobial, antiinflammatory, antiulcer, anticancer, anticarcinogenic, analgesic, and radioprotectant activities of copper complexes were presented. These activities are consistent with the notion that they represent the facilitation of normal copper-dependent metabolic processes in dis- ease states. The presentations and interactive discussions that fol- lowed are contained in these proceedings. John R. J. Sorenson Dedication These proceedings are dedicated to those who made this truly memorable scientific and social Arkansas experience possible.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52483750232337,"sku":"NLS9780896031234","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52740501307665,"sku":"NIN9780896031234","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780896031234.jpg?v=1759855207"},{"product_id":"lactoferrin-book-t-william-hutchens-9780896033665","title":"Lactoferrin","description":"This text examines the structure and function of lactoferrin. 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There is increasing evidence that the same is true for the immune system, with the initial interactions between antigen, antigen-presenting cells, and T cells hav- ing a paramount influence on the ensuing events. Thus, analysis of the early stages of the immune responses has been a preoccupation of many immunologists. This has been considerably aided by the capac- ity to expand these early events, and 'immortalize' them as clones of T cells, for detailed analysis. The discovery by Morgan, Ruscetti, and Gallo (Science 193, 1007, 1976) of T-cell growth factor (now termed interleukin-2 or IL-2) has had a major impact in immunology that is far from over. 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The papers in this volume constitute the proceedings of the Sixth International Conference on Methods in Protein Sequence Analysis, which was held at the University of Washington in Seattle, Washington on August 17-21, 1986. This series of conferences has taken place during a period when new techniques in protein chemistry and molecular biology have enabled not only exploration of the control of protein function, but also deduction of the genetic origin of proteins, and labo- ratory generation of rare protein molecules for therapeu- tic and commercial use. The current reports are focused on the means by which experimental questions can be answered rather than on the biological implications in specific systems. The scope of the meeting was quite broad, empha- sizing microanalytical techniques and the relative merits of DNA sequencing, mass spectrometry and more tradi- tional degradation techniques. A highlight of the meeting was the Qrowing awareness of the role of mass spec- trometry In the analysis of proteins. The complementarity of protein sequencing and DNA sequencing techniques was apparent throughout the discussions and several papers dealt with the strategy of obtaining sequence in- formation from small amounts of protein in order that ap- propriate oligonucleotide probes could be constructed and the encoding nucleic acids se. quenced and manipu- lated.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52488079966481,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52488080425233,"sku":"NLS9780896031180","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780896031180.jpg?v=1759862386"},{"product_id":"inositol-and-phosphoinositides-book-john-e-bleasdale-9780896030749","title":"Inositol and Phosphoinositides","description":"The Chilton Conference on Inositol and Phosphoinositides, held on January 9-11, 1984 at Southwestern Medical School, University of Texas Health Science Center, Dallas, Texas, was the third in a series of conferences on cyclitols and phosphoinositides.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52536650924305,"sku":"NLS9780896030749","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53511094337809,"sku":"NIN9780896030749","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780896030749.jpg?v=1760675172"},{"product_id":"molecular-basis-of-lymphokine-action-book-david-r-webb-9780896031395","title":"Molecular Basis of Lymphokine Action","description":"The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. 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One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. 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These small vessels act as major controllers of blood pressure, blood flow, and its distribution, and are involved in a variety of pathological conditions. Vascular diameter is influenced by a host of factors, some extrinsic to the smooth musc1e cells and some intrinsic. One will find contributions in nearly all of the five themes by which the book is organized; these address intra-and extracellular interactions, and membrane receptor pathways using vascular beds as diverse as the brain, he art, lung, kidney, and skin. Basic physiological studies are inc1uded; these examine: growth fac- tors, vasoactive endothelium-derived nitric oxide, the impacts of flow and stretch, myogenic mechanisms, calcium regulation by protein kinase C, and signal transduction pathways of the vascular smooth musc1e cell membrane receptors. 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