{"title":"Iarc Monographs","description":null,"products":[{"product_id":"tobacco-smoking-book-iarc-9789283212386","title":"Tobacco Smoking","description":"Evaluates the carcinogenic risk to humans posed by Tobacco Smoking.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51180498682129,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51180500418833,"sku":"NIN9789283212386","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52429355909393,"sku":"NLS9789283212386","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/928321238X.jpg?v=1751417452"},{"product_id":"some-food-additives-feed-additives-naturally-occurring-substances-book-iarc-9789283212317","title":"Some Food Additives, Feed Additives Naturally Occurring Substances","description":"Evaluates the carcinogenic risk to humans posed by exposure to some Food Additives, Feed Additives Naturally Occurring Substances.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51180499566865,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51180501467409,"sku":"NIN9789283212317","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52427593285905,"sku":"NLS9789283212317","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9283212312.jpg?v=1751191916"},{"product_id":"some-industrial-chemicals-and-dyestuffs-book-iarc-9789283212294","title":"Some Industrial Chemicals and Dyestuffs","description":"Evaluates the carcinogenic risk to humans posed by exposure to some Industrial Chemicals and Dyestuffs.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51180507889937,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51180509757713,"sku":"NIN9789283212294","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52429612417297,"sku":"NLS9789283212294","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9283212290.jpg?v=1751128729"},{"product_id":"some-flame-retardants-and-textile-chemicals-and-exposures-in-the-textile-manufac-book-international-agency-for-resea-9789283212485","title":"Some Flame Retardants and Textile Chemicals and Exposures in the Textile Manufacturing Industry","description":"Evaluates the carcinogenic risk to humans posed by exposure to selected flame retardants and other chemicals used in the textile manufacturing industry. Agents were selected for evaluation on the basis of the availability of data on carcinogenicity and on human exposure. The book also includes an extensive monograph addressing the question of whether employment in the textile manufacturing industry exposes workers to carcinogenic risks.\u003cbr\u003e \u003cbr\u003e Monographs cover six flame retardants (chlorendic acid, chlorinated paraffins, decabromodiphenyl oxide, dimethyl hydrogen phosphite, tetrakis(hydroxymethyl) phosphonium salts, and tris(2-chloroethyl) phosphate), five textile dyes (\u003ci\u003epara\u003c\/i\u003e-chloro-\u003ci\u003eortho\u003c\/i\u003e-toluidine and its strong acid salts, Disperse Blue 1, Disperse Yellow 3, Vat Yellow 4, and 5-nitro-\u003ci\u003eortho\u003c\/i\u003e-toluidine) and nitrilotriacetic acid and its salts. \u003ci\u003ePara\u003c\/i\u003e-chloro-\u003ci\u003eortho\u003c\/i\u003e-toluidine and its strong acid salts were classified as probably carcinogenic to humans; and chlorendic acid chlorinated paraffins, Disperse Blue 1, and nitrilotriacetic acid and its salts were classified as possibly carcinogenic to humans. The remaining chemicals could not be classified.\u003cbr\u003e \u003cbr\u003e The most extensive monograph evaluates occupational exposures in the textile manufacturing industry. Evaluations of risk concentrate on epidemiological evidence of carcinogenicity at the oral and pharyngeal oesophagus and stomach, nasal cavity, larynx, lung, and bladder sites. In view of the strength of findings of bladder cancer among dyers and among weavers and of cancer of the nasal cavity among weavers and other textile workers, the monograph concludes that working in the textile manufacturing industry entails exposures that are possibly carcinogenic to humans.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51180509692177,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51180511658257,"sku":"NIN9789283212485","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52429556711697,"sku":"NLS9789283212485","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9283212487.jpg?v=1783681634"},{"product_id":"miscellaneous-pesticides-book-the-international-agency-for-r-9789283212300","title":"Miscellaneous Pesticides","description":"Evaluates the carcinogenic risk to humans posed by exposure to selected miscellaneous pesticides.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51180510019857,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51180512084241,"sku":"NIN9789283212300","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52429167788305,"sku":"NLS9789283212300","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9283212304.jpg?v=1751351456"},{"product_id":"some-aromatic-amines-hydrazines-and-related-substances-n-nitroso-compounds-and-m-book-iarc-9789283212041","title":"Some Aromatic Amines, Hydrazines and Related Substances, N-Nitroso Compounds and Miscellaneous Alkylating Agents","description":"Evaluates the carcinogenic risk to humans posed by exposure to some Aromatic Amines, Hydrazines and Related Substances, N-Nitroso Compounds \u0026amp; Miscellaneous Alkylating Agents.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51180523389201,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51180524798225,"sku":"NIN9789283212041","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52429570900241,"sku":"NLS9789283212041","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9283212045.jpg?v=1751254789"},{"product_id":"polynuclear-aromatic-compounds-book-iarc-9789283212348","title":"Polynuclear Aromatic Compounds","description":"Evaluates the carcinogenic risk to humans posed by exposure to selected Polynuclear Aromatic Compounds, Part 3, Industrial Exposures in Aluminium Production, Coal Gasification, Coke Production, and Iron and Steel Founding.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51180523749649,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51180525158673,"sku":"NIN9789283212348","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52427586928913,"sku":"NLS9789283212348","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9283212347.jpg?v=1751032667"},{"product_id":"some-thyrotropic-agents-book-international-agency-for-resea-9789283212799","title":"Some Thyrotropic Agents","description":"This volume evaluates carcinogenicity to humans of 19 chemicals that are carcinogenic to the thyroid follicular-cell epithelium in rodents. These included some so-called \"anti-thyroid\" drugs (methimazole, methylthiouracil, propylthiou-racil and thiouracil); some sedatives (doxylamine succinate and phenobarbital); and some other drugs including the systemic antifungal antibiotic griseofulvin, the diuretic spironolactone, and the antibacterial sulfa drugs sulfamethazine and sulfamethoxazole. Other chemicals are or have been used in agriculture as pesticides (amitrole, chlordane\/heptachlor, hexachlo-robenzene and toxaphene), in foods and cosmetics (kojic acid), in hair dyes (2 4-diaminoanisole) or as industrial chemicals (N N'-diethylthiourea, ethylenethiourea and thiourea).","brand":"WoB","offers":[{"title":"US \/ NEW \/ INGRAM","offer_id":51180527943953,"sku":"NIN9789283212799","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52131899539729,"sku":"NLS9789283212799","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9283212797.jpg?v=1775728669"},{"product_id":"rubber-industry-book-the-international-agency-for-r-9789283215288","title":"The Rubber Industry","description":"Evaluates the carcinogenic risk to humans posed by exposure to the rubber industry.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51180537970961,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51180539511057,"sku":"NIN9789283215288","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52429385040145,"sku":"NLS9789283215288","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9283215281.jpg?v=1750904110"},{"product_id":"some-miscellaneous-pharmaceutical-substances-book-the-international-agency-for-r-9789283212133","title":"Some Miscellaneous Pharmaceutical Substances","description":"Evaluates the carcinogenic risk to humans posed by exposure to some Miscellaneous Pharmaceutical Substances.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51180538200337,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51180539609361,"sku":"NIN9789283212133","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52429331661073,"sku":"NLS9789283212133","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9283212134.jpg?v=1751319913"},{"product_id":"allyl-compounds-aldehydes-epoxides-and-peroxides-book-iarc-9789283212362","title":"Allyl Compounds, Aldehydes, Epoxides and Peroxides","description":"Evaluates the carcinogenic risk to humans posed by exposure to selected Allyl Compounds, Aldehydes, Epoxides and Peroxides.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51180539576593,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51180541051153,"sku":"NIN9789283212362","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52429430948113,"sku":"NLS9789283212362","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/B0041URPIK.jpg?v=1751097273"},{"product_id":"polynuclear-aromatic-compounds-book-iarc-9789283212324","title":"Polynuclear Aromatic Compounds","description":"Evaluates the carcinogenic risk to humans posed by exposure to Polynuclear Aromatic Compounds, Part 1, Chemical, Environmental and Experimental Data.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51180542918929,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51180544327953,"sku":"NIN9789283212324","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52429349060881,"sku":"NLS9789283212324","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9283212320.jpg?v=1750840106"},{"product_id":"polynuclear-aromatic-compounds-book-iarc-9789283212355","title":"Polynuclear Aromatic Compounds","description":"Evaluates the carcinogenic risk to humans posed by exposure to selected Polynuclear Aromatic Compounds, Part 4, Bitumens, Coal-Tars and Derived Products, Shale-Oils and Soots.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51180547146001,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51180548718865,"sku":"NIN9789283212355","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52429631389969,"sku":"NLS9789283212355","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9283212355.jpg?v=1750904110"},{"product_id":"man-made-vitreous-fibres-book-international-agency-for-resea-9789283212812","title":"Man-made Vitreous Fibres","description":"Reports the conclusions of a scientific working group of 19 experts from 11 countries convened by the Monographs Programme of the International Agency for Research on Cancer (IARC) on the re-evaluation of the carcinogenic risk of airborne man-made vitreous fibres.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51180552356113,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51180554486033,"sku":"NIN9789283212812","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52337563828497,"sku":"NLS9789283212812","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9283212819.jpg?v=1783680333"},{"product_id":"some-traditional-herbal-medicines-some-mycotoxins-naphthalene-and-styrene-book-the-international-agency-for-r-9789283212829","title":"Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene","description":"Traditional herbal medicines encompass an extremely diverse group of preparations that originate from many different cultures. In recent years, such products have become widely available commercially in developed countries where mixtures prepared from medicinal plants have been marketed or uses that were never contemplated in the traditional healing systems from which they emerged.\u003cbr\u003e \u003cbr\u003e In many countries, herbal medicines are not subject to rigorous standards with respect to manufacturing efficacy, quality and safety. For example, herbal remedies containing plant species of the genus Aristolochia and used in Europe for body weight loss have caused kidney disease and urothelial cancers and are now classified as carcinogenic to humans.\u003cbr\u003e \u003cbr\u003e This monograph evaluates the carcinogenic risks to humans posed by the use of some traditional herbal medicines Fumonisin B1 and the industrial organic chemicals naphthalene and styrene and provides an update of the data on the carcinogenicity of aflatoxins. An Annex to the volume describes fungal sources and formation of aflatoxins in foods and feeds and discusses practical strategies for reduction of aflatoxin levels.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51237784518929,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51237787009297,"sku":"NIN9789283212829","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52337567826193,"sku":"NLS9789283212829","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9283212827.jpg?v=1778752468"},{"product_id":"some-industrial-chemicals-book-international-agency-for-resea-9789283212775","title":"Some Industrial Chemicals","description":"Evaluates or re-evaluates the carcinogenic risks to humans posed by exposure to sixteen organic industrial chemicals. These included some aromatic amines (ortho-toluidine, 4-chloro-ortho-toluidine, and 5-chloro-ortho-toluidine), some ethanolamines (di- and triethanolamine and N-nitrosodiethanolamine), and three esters [di(2-ethylhexyl) phthalate (DEHP), di(2-ethylhexyl) adipate, and cinnamyl anthranilate]. Seven of the sixteen compounds were evaluated in previous IARC Monographs and are reconsidered here in the light of new evidence.\u003cbr\u003e Three chemicals were classified or reclassified as probably carcinogenic to humans: ortho-toluidine, 4-chloro-ortho-toluidine, and glycidol. Four compounds, evaluated here for the first time, namely 2,2-bis(bromomethyl)propane-1,3-diol, 2,3-dibromopropan-1-ol, ethylbenzene, and nitromethane, were classified as possibly carcinogenic to humans. N-Nitrosodiethanolamine, which can readily be formed from either di- or triethanolamine in the presence of inorganic nitrite, remained classified as possibly carcinogenic to humans.\u003cbr\u003e For eight compounds, including 5-chloro-ortho-toluidine, coumarin, pyridine, diethanolamine, triethanolamine, di(2-ethylhexyl) adipate, and cinnamyl anthranilate, evidence was judged inadequate to classify these compounds according to their carcinogenicity in humans.\u003cbr\u003e The most extensive monograph is devoted to an evaluation of di(2-ethylhexyl) phthalate (DEHP), which had previously been classified as possibly carcinogenic to humans. Using assessment criteria recently established for compounds that induce peroxisome proliferation in the liver, the evaluation downgraded DEHP to the group of compounds that cannot be classified. Two other compounds that cause peroxisome proliferation, di(2-ethylhexyl) adipate and cinnamyl anthranilate, were also evaluated as not classifiable as to carcinogenicity to humans.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52337424826641,"sku":"NLS9789283212775","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52763169980689,"sku":"NIN9789283212775","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789283212775.jpg?v=1758166609"},{"product_id":"surgical-implants-and-other-foreign-bodies-book-international-agency-for-resea-9789283212744","title":"Surgical Implants and Other Foreign Bodies","description":"Evaluates the carcinogenic risks to humans of surgical implants and other foreign bodies. Foreign bodies are defined as any exogenous object that has been introduced into the tissues or cavities of the body and is not rapidly absorbed. The evaluation focuses on exposures caused by the presence in the body of a solid metallic or non-metallic object as a result either of surgery or of involuntary penetration, as through a war wound. Medical and dental devises are grouped together as metallic, non-metallic, and mixed materials, which have different profiles of biological activity.\u003cbr\u003e \u003cbr\u003e The volume opens with a review of key concepts in the understanding of host-material interactions. Subsequent chapters evaluate human exposure data, evidence from case reports, and analytical studies for carcinogenicity in humans and in companion animals, evidence of carcinogenicity of implanted materials from animal experiments, and further background material on mechanisms of degradation and carcinogenicity.\u003cbr\u003e \u003cbr\u003e On the basis of this review, three implants were classified as possibly carcinogenic to humans: polymeric implants prepared as thin smooth films, with the exception of poly(glycolic acid) implants; metallic implants prepared as thin smooth films; and implanted foreign bodies of metallic cobalt metallic nickel and an alloy powder containing 66-67% nickel 13-16% chromium and 7% iron. The remaining materials and implants could not be classified on the basis of available data. The evaluation cites evidence-suggesting lack of carcinogenicity in humans of breast implants made of silicone for female breast carcinoma.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52337436623121,"sku":"NLS9789283212744","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52763202486545,"sku":"NIN9789283212744","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789283212744.jpg?v=1783680635"},{"product_id":"some-chemicals-that-cause-tumours-of-the-kidney-or-urinary-bladder-in-rodents-an-book-international-agency-for-resea-9789283212737","title":"Some Chemicals That Cause Tumours of the Kidney or Urinary Bladder in Rodents and Some Other Substances","description":"Evaluates the carcinogenic risk to humans posed by 20 individual compounds and three groups of compounds (cyclamates, saccharin and its salts, and nitrilotriacetic acid and its salts) that are known to induce tumours of the kidney or urinary bladder in rodents. As data on cancer in humans were judged inadequate for all compounds and groups of compounds the evaluations draw on recent guidelines for determining whether the mechanisms by which a chemical exerts its carcinogenic effects in rodents are relevant to humans. Evaluations also draw on findings from studies of metabolic fate toxic effects reproductive and developmental effects and genetic and related effects. \u003cbr\u003e\u003cbr\u003eSome of the compounds covered in the volume are widely used as chemical intermediates, pesticides, artificial sweeteners and food additives. The volume also includes evaluations of the analgesic and antipyretic paracetamol and several naturally occurring substances in food. All but two of the compounds (meta-dichlorobenzene and methyl tert-butyl ether) were evaluated in previous IARC Monographs. Re-evaluations were made in the light of both new studies of the compounds and a growing body of evidence concerning certain pathological processes that lead to tumour development in the kidney and urinary bladder of rats exposed to some chemicals. \u003cbr\u003e\u003cbr\u003eEight compounds were classified as possibly carcinogenic to humans: ortho-anisidine, chloroform, chlorothalonil, para-dichlorobenzene, hexachloroethane, nitrilotriacetic acid and its salts, sodium ortho-phenylphenate and potassium bromate. The remaining substances could not be classified on the basis of available data.\u003cbr\u003e\u003cbr\u003e\u003ci\u003eSome Chemicals that Cause Tumors of the Kidney or Urinary Bladder in Rodents and Some Other Substances\u003c\/i\u003e","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52337556488465,"sku":"NLS9789283212737","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52763182203153,"sku":"NIN9789283212737","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789283212737.jpg?v=1781171909"},{"product_id":"some-drinking-water-disinfectants-and-contaminants-including-arsenic-book-the-international-agency-for-r-9789283212843","title":"Some Drinking-Water Disinfectants and Contaminants, Including Arsenic","description":"A well-researched report from a working group of 23 experts from 13 countries, convened to evaluate the evidence of carcinogenicity of drinking-water disinfectants and of arsenic (mostly naturally occurring) as a contaminant of drinking-water, and of the water-disinfectant chloramine. The working group also evaluated or re-evaluated four chlorination by-products found in drinking-water, namely chloral hydrate, di- and trichloroacetic acids, and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (also known as MX).","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52337571627281,"sku":"NLS9789283212843","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52763200258321,"sku":"NIN9789283212843","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789283212843.jpg?v=1781171289"},{"product_id":"ionizing-radiation-book-international-agency-for-resea-9789283212782","title":"Ionizing Radiation","description":"Evaluates the carcinogenic risks to humans posed by exposure to X- and g-radiation and to neutrons from external sources. The book opens with a general introduction to nomenclature dissymmetric methods and models in the occupational and environmental settings the behavior of radiation in biological tissues and sources of human exposure. Natural background radiation is identified as by far the largest source of exposure for the world's population. The medical use of X-rays and radiopharmaceuticals constitutes the next most significant source followed by exposure from atmospheric testing of nuclear weapons. The collective doses from other sources of radiation are considered much less important. The first and most monograph on X- and g-radiation reviews the large body of evidence arising from the extensive investigation of carcinogenic effects in humans mainly in survivors of the atomic bombings in Japan and patients exposed to radiation for medical reasons. In both groups, an excess number of cases of leukemia and other cancers have been observed. Irradiation during childhood increases the risk of thyroid cancer while an increase in breast cancer risk has been observed after irradiation of pre-menopausal women. X-rays and g-rays have also been tested for carcinogenicity at various doses and under various conditions in a range of animal species. In adult animals, the incidences of leukemia and of mammary lung and thyroid tumors were increased in a dose-dependent manner with both types of radiation. Prenatal exposure also gave rise to increased incidences of various types of tumors. Based on this evidence the monograph concludes that X-radiation and g-radiation are carcinogenic to humans. The carcinogenic risk to humans posed by exposure to neutrons is evaluated in the second monograph, which concentrates on risks associated with the exposure of patients to neutron radiotherapy beams and exposures of aircraft passengers and crew. In high-altitude cities neutrons can constitute as much as 25% of background radiation. Neutrons from various sources with wide ranges of mean energy have been tested for carcinogenicity in different animal species and at various doses and dose rates. In adult animals, the incidences of leukemia and ovarian mammary lung and liver cancer were increased in a dose-related manner. Prenatal and parental exposure resulted in increased incidences of liver tumors in the offspring. In virtually all studies, neutrons were more effective in inducing tumors than were X-rays and g-rays when compared on the basis of absorbed dose. Although no adequate human carcinogenicity data were available for assessment, the monograph used other relevant data including evidence of DNA damage to reach the conclusion that neutrons are carcinogenic to humans.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52337648402705,"sku":"NLS9789283212782","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52763186331921,"sku":"NIN9789283212782","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789283212782.jpg?v=1773314913"},{"product_id":"some-antiviral-and-antineoplastic-drugs-and-other-pharmaceutical-agents-book-international-agency-for-resea-9789283212768","title":"Some Antiviral and Antineoplastic Drugs and Other Pharmaceutical Agents","description":"Evaluates the carcinogenic risks to humans posed by the use of four antiretroviral agents four DNA topoisomerase II inhibitors used in the treatment of cancer and an additional three pharmaceutical agents (hydroxyures phenolphthalein and vitamin K substances). The volume marks the first IARC evaluation of nucleoside analogs that act as antiviral agents. \u003cbr\u003e\u003cbr\u003eThe evaluation responds in part to recent findings that zidovudine (AZT) an effective antiretroviral agent now being given to pregnant HIV-infected women to prevent maternal-to-fetal transmission of the virus is a transplacental carcinogen in mice. The opening monograph evaluates the carcinogenicity to humans of the antiretroviral nucleoside analogs zidovudine (AZT) zalcitabine (ddC) and didanosine (ddI) and the antiherpesvirus drug aciclovir. Of these aciclovir and didanosine could not be classified on the basis of available data. For zidovudine transplacental administration to mice resulted in an increased incidence and multiplicity of lung and liver tumours and in an increased incidence of female reproductive tract tumours in one study but not in another involving treatment at a lower dose. \u003cbr\u003e\u003cbr\u003eDespite observation of toxic effects in some studies of humans human carcinogenicity data were judged to provide inadequate evidence of carcinogenicity in humans. Zidovudine was classified as possibly carcinogenic to humans. Similar weaknesses in human carcinogenicity data for zalcitabine which consistently induces thymic lymphomas in mice resulted in its classification as possibly carcinogenic to humans. \u003cbr\u003e\u003cbr\u003eThe second monograph evaluates four DNA topoisomerase II inhibitors: etoposide teniposide mitoxantrone and amsacrine. Of these etoposide - one of the most widely used and effective cytotoxic drugs in combination therapy - was classified as probably carcinogenic to humans and etoposide in combination with cisplatin and bleomycin was judged to be carcinogenic to humans. Teniposide was classified as probably carcinogenic to humans and mitoxantrone and amsacrine were classified as possibly carcinogenic to humans. \u003cbr\u003e\u003cbr\u003eOf the three pharmaceutical agents evaluated in the final monograph hydroxyurea which is widely used in cancer treatment and increasingly in combination with didanosine in HIV infection could not be classified. Phenolphthalein a widely used laxative now being withdrawn from the market in many countries because of toxicological concerns was classified as possibly carcinogenic. Vitamin K substances could not be classified on the basis of available evidence.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52337650663697,"sku":"NLS9789283212768","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52763170078993,"sku":"NIN9789283212768","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789283212768.jpg?v=1773314633"},{"product_id":"formaldehyde-2-butoxyethanol-and-1-tert-butoxy-2-propanol-book-the-international-agency-for-r-9789283212881","title":"Formaldehyde, 2-Butoxyethanol and 1-Tert-Butoxy-2-Propanol","description":"This eighty-eighth volume of \u003ci\u003eIARC Monographs\u003c\/i\u003eevaluates the available evidence on the carcinogenic potential in humans of formaldehyde, 2-butoxyethanol and 1-tert-butoxypropan-2-ol. Formaldehyde, a potential carcinogen that is found in the workplace and in the environment, has been studied the most widely and has been evaluated three times previously. It is being re-evaluated this time following a recommendation from an Advisory group that identified formaldehyde as a high priority for future re-evaluation, based on the availability of complex mechanistic data and the anticipated publication of new epidemiological studies that became available soon afterwards. The same Advisory Group also identified 2-butoxyethanol and other glycol ethers as high priorities, based on the availability of new carcinogenesis bioassays conducted by the US National Toxicology Program. This is the first evaluation that IARC has made to the two-glycol ethers.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52337654989073,"sku":"NLS9789283212881","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52763182530833,"sku":"NIN9789283212881","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789283212881.jpg?v=1758167333"},{"product_id":"betel-quid-and-areca-nut-chewing-and-some-areca-nut-derived-nitrosamines-book-the-international-agency-for-r-9789283212850","title":"Betel-Quid and Areca-Nut Chewing and Some Areca-Nut-Derived Nitrosamines","description":"This monograph evaluates the evidence of carcinogenicity of Betel-quid and Areca-nut chewing as well as some areca-nut-derived nitrosamines.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52337788125457,"sku":"NLS9789283212850","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52763173683473,"sku":"NIN9789283212850","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789283212850.jpg?v=1778753193"},{"product_id":"non-ionizing-radiation-book-international-agency-for-resea-9789283212805","title":"Non-Ionizing Radiation","description":"This volume evaluates possible carcinogenic hazards from exposures to static and extremely low frequency (ELF) electric and magnetic fields. It is the first of two IARC Monographs volumes on various kinds of non-ionizing radiation. Extremely low frequency (ELF) magnetic field exposures result from proximity to electric power transmission lines, household wiring, and electric appliances and are in addition to the exposure that results from the earth's magnetic field.\u003cbr\u003e \u003cbr\u003e Overall, extremely low frequency magnetic fields were evaluated as possibly carcinogenic to humans (Group 2B). Static magnetic fields and static and extremely low frequency electric fields could not be classified as to carcinogenicity to humans (Group 3).","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52337802641681,"sku":"NLS9789283212805","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52763182432529,"sku":"NIN9789283212805","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789283212805.jpg?v=1783680670"}],"url":"https:\/\/www.worldofbooks.com\/collections\/iarc-monographs-book-series.oembed","provider":"World of Books ","version":"1.0","type":"link"}