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Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.  With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:          Electron transport and energy production Mitochondrial biogenesis and dynamics Mitochondrial signaling Apoptosis and autophagy Pharmacology signaling Epigenetic signaling: mitochondrial methylation and acetylation reactions  An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52692263567633,"sku":"NLS9781439880029","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53252122509585,"sku":"NIN9781439880029","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781439880029.jpg?v=1762341533"},{"product_id":"lipid-oxidation-in-health-and-disease-book-corinne-m-spickett-9781032919867","title":"Lipid Oxidation in Health and Disease","description":"Oxidative modification of lipids and phospholipids—including radical damage, halogenation, and nitration—result in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. Lipid Oxidation in Health and Disease provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes.  Covering the diverse topics that contribute to research in this important field, this book explores:    The mechanisms of lipid oxidation, both enzymatic and non-enzymatic Antioxidant defenses and lipid oxidation Lipid oxidation products and cell signaling The roles of oxidized lipids in specific diseases—including cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer Drug targeting and the therapeutic potential of oxidized lipids  Accurate measurement of the formation of lipid oxidation products and investigation of their biological effects and roles in disease are critical to biomedical science and new targeted therapeutics. Written by acknowledged experts in the field, this book provides a broad survey of both established knowledge and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":53651858456849,"sku":"NLS9781032919867","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781032919867.jpg?v=1781350360"},{"product_id":"hormesis-in-health-and-disease-book-suresh-i-s-rattan-9781032920832","title":"Hormesis in Health and Disease","description":"Some mild stresses have positive effects on survival and aging as shown in animal models. There is also a large body of research that demonstrates these hormetic effects on aging, health, and resistance to severe stresses and diseases in human beings. However, the data are dispersed in the literature and are not always interpreted as hormetic effects. Hormesis in Health and Disease reviews the evidence for hormesis in humans as achieved through a variety of stresses or stimuli, and discusses mechanisms of hormesis and its ethical and legal issues.  Divided into four sections, this book presents the current state of research, including questions, debates, doubts, and controversies in hormesis. Section I covers the history and terminology of hormesis, describing its main features and providing necessary background information. Section II shows that hormetic effects can be caused by various stresses—including physical exercise, nutritional components, fasting, micronutrients, irradiation, heat, ischemia, and mental challenge—and can be observed both in organs and at the organism level. Section III reviews possible mechanisms of hormesis that have been elucidated at this point. Section IV discusses the wider consequences hormesis may have for everyone.  This book demonstrates that health beneficial hormetic effects do exist in human beings. It offers information to inspire key players to initiate new strategies to elucidate the strengths and limits of the dual nature of stress.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":53651859144977,"sku":"NLS9781032920832","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781032920832.jpg?v=1781350688"}],"url":"https:\/\/www.worldofbooks.com\/collections\/oxidative-stress-and-disease-book-series.oembed","provider":"World of Books ","version":"1.0","type":"link"}