{"title":"Pharmaceutical Biotechnology","description":null,"products":[{"product_id":"rational-design-of-stable-protein-formulations-book-john-f-carpenter-9780306467417","title":"Rational Design of Stable Protein Formulations","description":"Recombinant proteins and polypeptides continue to be the most important class of biotechnology-derived agents in today's pharmaceutical industry. Over the past few years, our fundamental understanding of how proteins degrade and how stabilizing agents work has made it possible to approach formulation of protein pharmaceuticals from a much more rational point of view.   This book describes the current level of understanding of protein instability and the strategies for stabilizing proteins under a variety of stressful conditions.","brand":"WoB","offers":[{"title":"GB \/ VERY_GOOD \/ INTERNAL","offer_id":49559539122449,"sku":"GOR013450026","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"US \/ GOOD \/ SBYB","offer_id":49770049798417,"sku":"CIN0306467410G","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52336254091537,"sku":"NLS9780306467417","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53495017505041,"sku":"NIN9780306467417","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/0306467410.jpg?v=1751038362"},{"product_id":"vaccine-design-book-michael-f-powell-9780306448676","title":"Vaccine Design","description":null,"brand":"WoB","offers":[{"title":"US \/ WELL_READ \/ SBYB","offer_id":49887594938641,"sku":"CIN030644867XA","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/030644867X.jpg?v=1750908875"},{"product_id":"models-for-assessing-drug-absorption-and-metabolism-book-ronald-t-borchardt-9780306452437","title":"Models for Assessing Drug Absorption and Metabolism","description":"Pharmaceutical scientists in industry and academia will  appreciate this single reference for its detailed experimental  procedures for  conducting biopharmaceutical studies. This  well-illustrated guide  allows them to establish, validate, and  implement commonly used in  situ and in vitro model  systems. Chapters provide ready  access to these methodologies for  studies of the intestinal, buccal,  nasal and respiratory, vaginal,  ocular, and dermal epithelium as well  as the endothelial and  elimination barriers.","brand":"WoB","offers":[{"title":"US \/ GOOD \/ SBYB","offer_id":50300010234129,"sku":"CIN030645243XG","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52148332953873,"sku":"NLS9780306452437","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53511088668945,"sku":"NIN9780306452437","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/030645243X.jpg?v=1751259901"},{"product_id":"rational-design-of-stable-protein-formulations-book-john-f-carpenter-9781461351313","title":"Rational Design of Stable Protein Formulations","description":"Recombinant proteins and polypeptides continue to be the most important class of biotechnology-derived agents in today's pharmaceutical industry. Over the past few years, our fundamental understanding of how proteins degrade and how stabilizing agents work has made it possible to approach formulation of protein pharmaceuticals from a much more rational point of view.   This book describes the current level of understanding of protein instability and the strategies for stabilizing proteins under a variety of stressful conditions.","brand":"WoB","offers":[{"title":"US \/ NEW \/ INGRAM","offer_id":51027593265425,"sku":"NIN9781461351313","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52428855869713,"sku":"NLS9781461351313","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1461351316.jpg?v=1753687960"},{"product_id":"stability-of-protein-pharmaceuticals-book-tim-j-ahern-9780306441530","title":"Stability of Protein Pharmaceuticals","description":"Part B explores protein degradation occuring in vivo  during protein synthesis in cells, examines the isolation and  purification of proteins, details protein use in organisms, and  reviews techniques to enhance protein stability.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52124111667473,"sku":"NLS9780306441530","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780306441530.jpg?v=1757455541"},{"product_id":"protein-pharmacokinetics-and-metabolism-book-bobbe-l-ferraiolo-9780306441516","title":"Protein Pharmacokinetics and Metabolism","description":"Investigation of the pharmacokinetics and metabolism of human proteins has escalated over the last two decades because of the use of recombinant human proteins as therapeutic agents.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52126222090513,"sku":"NLS9780306441516","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780306441516.jpg?v=1757474445"},{"product_id":"formulation-characterization-and-stability-of-protein-drugs-book-rodney-pearlman-9780306453328","title":"Formulation, Characterization, and Stability of Protein Drugs","description":"Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are described from the perspective of their formulation, characterization, and stability. This ready reference also features recent data and an abundance of previously unpublished information. The in-depth coverage includes a highly useful compendium of degradation sites occurring in over 70 proteins. An invaluable aid in the rapid identification of potential hot spots' in proteins, this accessible compilation allows for inspection of the protein's primary structure and preparation of a hydroflex plot.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52147190268177,"sku":"NLS9780306453328","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780306453328.jpg?v=1757599717"},{"product_id":"development-and-manufacture-of-protein-pharmaceuticals-book-steve-l-nail-9780306467455","title":"Development and Manufacture of Protein Pharmaceuticals","description":"In this era of biotechnology there have been many books covering the fundamentals of recombinant DNA technology and protein chemistry. However, not many sources are available for the pharmaceutical develop- ment scientist and other personnel responsible for the commercialization of the finished dosage forms of these new biopharmaceuticals and other products from biotechnology. This text will help to fill this gap. Once active biopharmaceutical molecules are candidates for clinical trial investigation and subsequent commercialization, a number of other activities must take place while research and development on these molecules continues. The active ingredient itself must be formulated into a finished dosage form that can be conveniently used by health care professionals and patients. Properties of the biopharmaceutical molecule must be clearly understood so that the appropriate finished product formulation can be developed. Finished product formulation development includes not only the chemical formulation, but also the packaging system, the manufacturing process, and appropriate control strategies to assure such good manufacturing practice attributes as safety, identity, strength, purity, and quality.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52149995667729,"sku":"NLS9780306467455","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780306467455.jpg?v=1757608614"},{"product_id":"stability-and-characterization-of-protein-and-peptide-drugs-book-rodney-pearlman-9780306443657","title":"Stability and Characterization of Protein and Peptide Drugs","description":"This volume attemptsto provide the formulation scientist with casehistories involving the use of therapeutic proteins and peptides that have been mar- keted or are under clinical testing. In previous volumes of this series,funda- mental theories and principles ofprotein characterization and stability were presented in depth by researchers in their fieldsofexpertise. The way from theory to practice isnot alwaysobvious and straightforward. There isa need for practical examples of how the principles and theories are put into use, specificallyin the development of a pharmaceutical product. It is our hope that this volume will fulfillsuch a need. Itisnot asimple task to choose a panel ofproteinsand peptides from the over 200 agents in human clinical trials. We have tried to collect a wide representation of molecules of different sizes-from 10 amino acids (Leu- prolide) to 1020 amino acids (Muromonab CD3). The examples include agents derived from various sources including monoclonal antibodies (Mur- omonab CD3), recombinant DNA (human and bovine growth hormones), natural source (fibrolase), and chemical synthesis (Leuprolide). Clearly this list is not intended to be encyclopedic. It isthe first time a collection of this sort has been made accessibleto the formulation scientists involved in devel- oping protein and peptide products. Although each chapter in this volume focuses primarily on the charac- terization and stability of a specific molecule, each has unique aspects.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52332455756049,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52332456378641,"sku":"NLS9780306443657","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780306443657.jpg?v=1758151699"},{"product_id":"physical-methods-to-characterize-pharmaceutical-proteins-book-james-n-herron-9780306450266","title":"Physical Methods to Characterize Pharmaceutical Proteins","description":"This issue has also been examined in two prior volumes of this series: Volume 2: Stability of Protein Pharmaceuticals (Part A) and Volume 5: Stability and Characterization of Protein and Peptide Drugs.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52333467730193,"sku":"NLS9780306450266","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780306450266.jpg?v=1758154866"},{"product_id":"protein-delivery-book-lynda-m-sanders-9780306453595","title":"Protein Delivery","description":"Presents case histories and reviews of protein-drug delivery technologies. This book includes an overview of insulin delivery and a discussion of the use of biodegradable microspheres.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52333630750993,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52333631406353,"sku":"NLS9780306453595","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780306453595.jpg?v=1758155374"},{"product_id":"membrane-transporters-as-drug-targets-book-gordon-l-amidon-9780306460944","title":"Membrane Transporters as Drug Targets","description":"Because progress in the field of transporters has been  extraordinary, this volume will focus on recent advances in our  understanding of the structure, function, physiology, and molecular  biology of membrane transporters. There will be an emphasis on  transporters as molecular targets for drug delivery and disposition in  the body.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52337415848209,"sku":"NLS9780306460944","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780306460944.jpg?v=1758166579"},{"product_id":"formulation-characterization-and-stability-of-protein-drugs-book-rodney-pearlman-9781475770476","title":"Formulation, Characterization, and Stability of Protein Drugs","description":"Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are described from the perspective of their formulation, characterization, and stability. This ready reference also features recent data and an abundance of previously unpublished information. The in-depth coverage includes a highly useful compendium of degradation sites occurring in over 70 proteins. An invaluable aid in the rapid identification of potential hot spots' in proteins, this accessible compilation allows for inspection of the protein's primary structure and preparation of a hydroflex plot.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52409577832721,"sku":"NLS9781475770476","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52750344192273,"sku":"NIN9781475770476","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781475770476.jpg?v=1758775213"},{"product_id":"models-for-assessing-drug-absorption-and-metabolism-book-ronald-t-borchardt-9781489918659","title":"Models for Assessing Drug Absorption and Metabolism","description":"Pharmaceutical scientists in industry and academia will  appreciate this single reference for its detailed experimental  procedures for  conducting biopharmaceutical studies. This  well-illustrated guide  allows them to establish, validate, and  implement commonly used in  situ and in vitro model  systems. Chapters provide ready  access to these methodologies for  studies of the intestinal, buccal,  nasal and respiratory, vaginal,  ocular, and dermal epithelium as well  as the endothelial and  elimination barriers.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52409631998225,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52409632620817,"sku":"NLS9781489918659","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781489918659.jpg?v=1758775384"},{"product_id":"physical-methods-to-characterize-pharmaceutical-proteins-book-james-n-herron-9781489910813","title":"Physical Methods to Characterize Pharmaceutical Proteins","description":"This issue has also been examined in two prior volumes of this series: Volume 2: Stability of Protein Pharmaceuticals (Part A) and Volume 5: Stability and Characterization of Protein and Peptide Drugs.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52409722274065,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52409723060497,"sku":"NLS9781489910813","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781489910813.jpg?v=1758775807"},{"product_id":"protein-pharmacokinetics-and-metabolism-book-bobbe-l-ferraiolo-9781489923318","title":"Protein Pharmacokinetics and Metabolism","description":"Investigation of the pharmacokinetics and metabolism of human proteins has escalated over the last two decades because of the use of recombinant human proteins as therapeutic agents.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52409989726481,"sku":"NLS9781489923318","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781489923318.jpg?v=1758776584"},{"product_id":"biological-barriers-to-protein-delivery-book-kenneth-l-andus-9781461362562","title":"Biological Barriers to Protein Delivery","description":"In response to the tremendous increase in the number of protein  and peptide drugs, this treatise critically reviews transport and  metabolism mechanisms relating to the delivery of endogenous and  recombinant proteins to mammalian organs, tissues, and cells. It will  promote fruitful collaboration among academic and industrial  scientists in the fields of pharmacology, cell biology, biochemistry,  physiology, and immunology.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52428263686417,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52428264407313,"sku":"NLS9781461362562","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461362562.jpg?v=1759163598"},{"product_id":"development-and-manufacture-of-protein-pharmaceuticals-book-steve-l-nail-9781461351276","title":"Development and Manufacture of Protein Pharmaceuticals","description":"In this era of biotechnology there have been many books covering the fundamentals of recombinant DNA technology and protein chemistry. However, not many sources are available for the pharmaceutical develop- ment scientist and other personnel responsible for the commercialization of the finished dosage forms of these new biopharmaceuticals and other products from biotechnology. This text will help to fill this gap. Once active biopharmaceutical molecules are candidates for clinical trial investigation and subsequent commercialization, a number of other activities must take place while research and development on these molecules continues. The active ingredient itself must be formulated into a finished dosage form that can be conveniently used by health care professionals and patients. Properties of the biopharmaceutical molecule must be clearly understood so that the appropriate finished product formulation can be developed. Finished product formulation development includes not only the chemical formulation, but also the packaging system, the manufacturing process, and appropriate control strategies to assure such good manufacturing practice attributes as safety, identity, strength, purity, and quality.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52429744996625,"sku":"NLS9781461351276","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52953457754385,"sku":"NIN9781461351276","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461351276.jpg?v=1759167767"},{"product_id":"protein-delivery-book-lynda-m-sanders-9781441932594","title":"Protein Delivery","description":"Protein and peptide therapeutics currently represent eight of the top 100 prescription pharmaceuticals in the U.S., and biotechnology products are projected to account for 15% of the total US. prescription drug market by 2003. Of the protein and peptide products now on the market, many are administered as daily injections,though several are deliveredby noninvasive routes. For example, desmopressin is delivered as a nasal spray, and deoxyribonuclease I is administered by inhalation. Although cyclosporin A is orally active, as yet there are no general means to confer oral bioava- ability to peptides and proteins. A major advance in delivery ofpeptides was achieved with the introduction of a monthly injectable, biodegradable microsphere formulation of LHRH. Despite the enormous success of biotechnology products to date, much effort continues to be focused on the development of more convenient and noninvasive routes of administration for those products that require f- quent and prolonged dosing. Here we present an overview of the te- nologies, both developed and emerging, which are applicable to protein delivery. In addition, chapters 11 through 13 detail case studies on physical methods for delivery ofinsulin and growth hormone.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52481727987985,"sku":"NLS9781441932594","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781441932594.jpg?v=1759852152"},{"product_id":"stability-and-characterization-of-protein-and-peptide-drugs-book-rodney-pearlman-9781489912381","title":"Stability and Characterization of Protein and Peptide Drugs","description":"This volume attemptsto provide the formulation scientist with casehistories involving the use of therapeutic proteins and peptides that have been mar- keted or are under clinical testing. In previous volumes of this series,funda- mental theories and principles ofprotein characterization and stability were presented in depth by researchers in their fieldsofexpertise. The way from theory to practice isnot alwaysobvious and straightforward. There isa need for practical examples of how the principles and theories are put into use, specificallyin the development of a pharmaceutical product. It is our hope that this volume will fulfillsuch a need. Itisnot asimple task to choose a panel ofproteinsand peptides from the over 200 agents in human clinical trials. We have tried to collect a wide representation of molecules of different sizes-from 10 amino acids (Leu- prolide) to 1020 amino acids (Muromonab CD3). The examples include agents derived from various sources including monoclonal antibodies (Mur- omonab CD3), recombinant DNA (human and bovine growth hormones), natural source (fibrolase), and chemical synthesis (Leuprolide). Clearly this list is not intended to be encyclopedic. It isthe first time a collection of this sort has been made accessibleto the formulation scientists involved in devel- oping protein and peptide products. Although each chapter in this volume focuses primarily on the charac- terization and stability of a specific molecule, each has unique aspects.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52665249464593,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52665250382097,"sku":"NLS9781489912381","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781489912381.jpg?v=1762276797"},{"product_id":"membrane-transporters-as-drug-targets-book-gordon-l-amidon-9781475786316","title":"Membrane Transporters as Drug Targets","description":"Because progress in the field of transporters has been  extraordinary, this volume will focus on recent advances in our  understanding of the structure, function, physiology, and molecular  biology of membrane transporters. There will be an emphasis on  transporters as molecular targets for drug delivery and disposition in  the body.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52668086944017,"sku":"NLS9781475786316","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781475786316.jpg?v=1762284145"},{"product_id":"integration-of-pharmaceutical-discovery-and-development-book-ronald-t-borchardt-9780306457432","title":"Integration of Pharmaceutical Discovery and Development","description":"In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52672819888401,"sku":"NLS9780306457432","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780306457432.jpg?v=1762295540"},{"product_id":"biological-barriers-to-protein-delivery-book-kenneth-l-andus-9780306443688","title":"Biological Barriers to Protein Delivery","description":"In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52689553359121,"sku":"NLS9780306443688","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780306443688.jpg?v=1762335648"}],"url":"https:\/\/www.worldofbooks.com\/collections\/pharmaceutical-biotechnology-book-series.oembed","provider":"World of Books ","version":"1.0","type":"link"}