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Finally, in common with other areas of cell biology, the wealth of information that can be obtained at the nucleic acid level has provided the stimulus for identification and characterisation of metabolic processes in far greater detail than previously envisaged. The result of these advances it that researchers now have the confidence to address problems in plant metabolism at levels not previously attempted. 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Of key importance in this  process is the availability and reliability of specific bioassay  methods, but chapters also discuss chemical and biological diversity  and how to dereplicate natural product extracts to increase efficiency  in lead discovery. \u003cbr\u003e  Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and  immunomodulatory natural products are discussed. 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