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The application of these state-of-the-art techniques to further ourunderstanding of multi-species biofilms will be discussed and the reader will learn how the clinical microenvironment and the development of biofilm communities are considered when developing such tools.\u003c\/p\u003e\u003cp\u003eWith cutting-edge contributions from experts in the respective domains, this book will benefit translational and basic research scientists, as well as clinicians, and is an informative resource for educators and their students.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52131941515537,"sku":"NLS9783031153518","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9783031153518.jpg?v=1757513855"},{"product_id":"culture-negative-orthopedic-biofilm-infections-book-garth-d-ehrlich-9783642446832","title":"Culture Negative Orthopedic Biofilm Infections","description":"\u003cp\u003eDuring the recent transition between acute diseases caused by swarms of single planktonic bacteria, and chronic infections caused by bacteria growing in slime-enclosed biofilms, a general clinical consensus has emerged that pathologies with bacterial etiologies are frequently culture negative. 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The editors selected orthopedic biofilm infections as the subject of this book because these infections occur against a background of microbiological sterility in which modern molecular methods would be expected to find bacterial DNA, RNA-based microscopic methods would be expected to locate bacterial cells, and cultures would be negative. Moreover, in Orthopedics we find an already biofilm-adapted surgical group in which current strategies are based on the meticulous removal of compromised tissues, antibiotic options as based on high biofilm-killing local doses, and there are practical bedside strategies for dealing with biofilm infections. 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In addition to confirming that bacteria in root canals do not exist in free-floating planktonic states as previously assumed, this new information on root canal biofilm infections has provided an opportunity to re-evaluate conventional clinical protocols and improve endodontic therapeutic measures.  \u003c\/p\u003e","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52590653735185,"sku":"NLS9783662508763","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9783662508763.jpg?v=1761062487"},{"product_id":"biofilm-matrix-book-courtney-reichhardt-9783031704758","title":"Biofilm Matrix","description":"\u003cp\u003eThis book provides a comprehensive review of biofilm matrices. The main topics include an introduction to biofilm matrices and the range of biofilm matrix components (i.e., biofilm matrixome) as well as an overview of what is known about matrix structure, functionality, and regulation. Additional topics include recent progress in investigating the biofilm matrixome as well as challenges and outstanding questions and descriptions of the influence of matrix interactions on biofilm architecture and pathogen-host interactions.  \u003c\/p\u003e\n\n\u003cp\u003eThis book covers an important aspect of biofilm biology-microbial biofilm matrices.\u003c\/p\u003e\n\n\u003cp\u003eMicrobes form multicellular aggregates called biofilms, in which microbial cells are encased in an extracellular matrix. This enables microbes to withstand harsh environmental conditions including antibiotic treatment. Biofilms are ubiquitous in the environment and can be both beneficial and harmful. For example, they can be used to clean up wastewater, but they also cause serious and chronic infections. It is estimated that over 80% of infections in the United States are biofilm-associated. Some examples of biofilm-involved infections include infections of implanted medical devices or artificial joints and also chronic infections of burns and wounds, including diabetic ulcers. When biofilms show up during infections or human health problems, they act very differently than planktonic bacteria. For example, biofilms can be ~1000-fold more tolerant of antibiotics than their planktonic counterparts. The biofilm matrix is thought to be a key part of why these bacterial infections are so difficult to treat. Biofilm matrix composition varies between bacterial strains and under different growth conditions. In general, the biofilm matrix is rich in biopolymers and can contain exopolysaccharides, proteins, extracellular DNA (or eDNA), and lipids. The biofilm matrix promotes attachment and structurally reinforces bacterial aggregates, preventing clearance by mechanical forces. 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As one convocation follows another, and as our funding agencies pump billions of dollars into incremental research that ?lls every possible pigeon-hole in which a gene makes a protein, a small number of intellectual athletes seize a pivotal concept and plunge into the real world. It is this small band of nimble and impossibly brave intellectual halfbackswho win gamesin the real world, and this book is the result of the drive and intellectual athleticism of its editor and several of her contributors. Bacteria affect humans more than any other life forms with which we share the blue planet, but our understandingof these invisible companionshas developed in a staggering pattern, crippled by our panic and consequent shifts of emphasis. When our race was threatened by epidemic diseases, we visualized bacteria as swarms of potentially lethal planktoniccells from which we must remain isolated by sanitation and which we had to kill by immunization and chemical antibacterial compounds. 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Bacterial biofilms are one of the fundamental reasons for incipient wound healing failure in that they may impair natural cutaneous wound healing and reduce topical antimicrobial efficiency in infected skin wounds.  Their existence explains many of the enigmas of microbial infection and a better grasp of the process may well serve to establish a different approach to infection control and management.   Biofilms and their associated complications have been found to be involved in up to 80% of all infections.  A large number of studies targeted at the bacterial biofilms have been conducted, and many of them are referred to in this book, which is the first of its kind.   These clinical observations emphasize the importance of biofilm formation to both superficial and systemic infections, and the inability of current antimicrobial therapies to ‘cure’ the resulting diseases even when the in vitro tests suggest that they should be fully effective.\u003c\/p\u003e\u003cp\u003eIn veterinary medicine the concept of biofilms and their role in the pathogenesis of disease has lagged seriously behind that in human medicine.  This is all the more extraordinary when one considers that much of the research has been carried out using veterinary species in experimental situations.   The clinical features of biofilms in human medicine is certainly mimicked in the veterinary species but there is an inherent and highly regrettable indifference to the failure of antimicrobial therapy in many veterinary disease situations, and this is probably at its most retrograde in veterinary wound management. \u003c\/p\u003e\u003cp\u003eBiofilms and Veterinary Medicine is specifically focused on discussing the concerns of biofilms to health and disease in animals and provides a definitive text for veterinary practitioners, medical and veterinary students, and researchers.\u003c\/p\u003e","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52676992532753,"sku":"NLS9783642269974","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9783642269974.jpg?v=1762305202"},{"product_id":"multispecies-biofilms-book-karishma-s-kaushik-9783031153488","title":"Multispecies Biofilms","description":"\u003cp\u003eIn an age of antibiotic resistant infections, the study of biofilms is increasingly important. Microbes more than often exist in complex multi-species or polymicrobial communities, making infections difficult to detect, diagnose and treat. Given the increased focus on studying biofilms in research and laboratory settings, particularly under conditions that closely mimic the clinical state, it is important to get an overview of the recent methods, model systems and tools being developed and employed in this context.\u003c\/p\u003e\u003cp\u003eThis book offers readers the opportunity to learn more about current methods being used in the investigation of multi-species biofilms, both in vivo and in vitro. For this, the book highlights new technologies built and designed for the study of multiple species within biofilm communities, including those that can be leveraged for the evaluation of antimicrobial treatment approaches. The application of these state-of-the-art techniques to further ourunderstanding of multi-species biofilms will be discussed and the reader will learn how the clinical microenvironment and the development of biofilm communities are considered when developing such tools.\u003c\/p\u003e\u003cp\u003eWith cutting-edge contributions from experts in the respective domains, this book will benefit translational and basic research scientists, as well as clinicians, and is an informative resource for educators and their students.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52683528962321,"sku":"NLS9783031153488","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9783031153488.jpg?v=1762320879"},{"product_id":"fungal-biofilms-book-gordon-ramage-9783031933141","title":"Fungal Biofilms","description":"\u003cp\u003eThis book provides a comprehensive and up-to-date compendium of critical information for those working in the field of fungal biofilms, and those entering the field. The WHO has published a list of critical high-priority fungal pathogens, many of which are capable of forming biofilms. The editors have brought together a team of world experts to impart their knowledge of specific elements of fungal biofilm biology and their clinical underpinning. The book covers critical areas of state-of-the-art research that are shaping the direction of travel within the biofilm research community. It focuses on the basic biology of how biofilms are formed and controlled, through applied areas of research where we can effectively manage these complex infections.\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52686351827217,"sku":"NLS9783031933141","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9783031933141.jpg?v=1762327827"},{"product_id":"biofilm-infections-and-treatment-strategies-book-thomas-bjarnsholt-9783032282583","title":"Biofilm Infections and Treatment Strategies","description":"\u003cp\u003eThis volume distinguishes itself by focusing specifically on biofilm-associated infections within the context of the infectious microenvironment. Rather than providing a general overview, it integrates host–pathogen interactions, polymicrobial complexity, and microenvironmental heterogeneity to frame biofilms as dynamic drivers of chronic and treatment-refractory disease.\u003c\/p\u003e\n\u003cp\u003eInterest in the biofilm mode of microbial growth has evolved into a central paradigm in infection biology. Since the concept was introduced by J. William Costerton and later recognized by the American Society for Microbiology as a distinct mode of growth, the field has expanded substantially, with numerous books addressing biofilm structure, physiology, and antimicrobial tolerance.\u003c\/p\u003e\n\u003cp\u003eAuthored by leading experts, the book provides a critical and up-to-date synthesis of biofilm involvement across diverse clinical settings, while highlighting emerging diagnostic and therapeutic strategies. It is intended for researchers and clinicians seeking a mechanistic and translational perspective on biofilm infections within modern biomedical science.\u003c\/p\u003e","brand":"WoB","offers":[{"title":"GB \/ NEW \/ GARDNERS","offer_id":53605925945617,"sku":"NGR9783032282583","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9783032282583.jpg?v=1782880242"}],"url":"https:\/\/www.worldofbooks.com\/collections\/springer-series-on-biofilms-book-series.oembed","provider":"World of Books ","version":"1.0","type":"link"}