{"title":"Developments In Cardiovascular Medicine","description":"\u003cp\u003eDelve into the essential 'Developments in Cardiovascular Medicine' series. A key resource for medical professionals and researchers, this collection offers in-depth insights into the latest advancements in cardiac care.\u003c\/p\u003e","products":[{"product_id":"stress-echocardiography-book-thomas-h-marwick-9781402073694","title":"Stress Echocardiography","description":"Stress Echocardiography - Its Role in the Diagnosis and Evaluation of Coronary Artery Disease - Second Edition by Thomas Marwick is a concise, practical guide for anyone new to the field of stress echocardiography or an excellent summary of the existing evidence base for the experienced user.   Dr. W.F. Armstrong described the first edition of this book in his Foreword to the first edition as \"a thorough, comprehensive review of the basic and advanced concepts of stress echocardiography. This text represents an excellent starting point for individuals wishing to gain initial familiarity with stress echocardiography and a superb reference source for more experienced investigators and clinicians finding a need to further develop their understanding of the technique and advance its clinical relevance in their laboratories.\"","brand":"WoB","offers":[{"title":"GB \/ VERY_GOOD \/ INTERNAL","offer_id":49614650114321,"sku":"GOR013192148","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52433793089809,"sku":"NLS9781402073694","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1402073690.jpg?v=1753688485"},{"product_id":"growth-factors-and-the-cardiovascular-system-book-p-cummins-9780792324010","title":"Growth Factors and the Cardiovascular System","description":"Nature is totally amoral! There are at least 3-4 million people in France alone who suffer from arterial hypertension, and whose cardiovascular system is submitted day and night to both a haemodynamic and hormonal stress. In all cases, the vasculature hypertrophies as does the myocardium. This growth process is obviously mainly detrimental at the outset since it lowers compliance of the arteries and makes them stiffer. In contrast, myocardial hypertrophy is initially beneficial since the growth process multiplies the number of contractile units and by so doing improves external work. In addition, according to Starling's law, wall stress is lowered. Growth factors playa major role in this amoral process as a trigger for hypertrophy at the vascular level, and very likely at the level of the myocardium. Another major point of interest is the role of growth factors as determinants of restenosis after angioplasty and also of atherogenesis. Several chapters in this book are directly or indirectly concerned with this problem which is far from being purely academic since several groups are currently trying to control these processes by gene transfer. Certainly, one of the major clinical questions arising from such studies is why restenosis is not more frequent in clinical practice. After de-endotheliazation, the biologist would predict on the basis of recent studies on growth factors, and in contrast with current clinical opinion, that hypertrophy would occur in all cases with more or less complete restenosis.","brand":"WoB","offers":[{"title":"GB \/ GOOD \/ INTERNAL","offer_id":49625905824017,"sku":"GOR012340801","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52402756485393,"sku":"NLS9780792324010","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/0792324013.jpg?v=1751044081"},{"product_id":"mitochondria-and-the-heart-book-jos-marngarca-9781441938077","title":"Mitochondria and the Heart","description":"Mitochondria have been pivotal in the development of some of the most important ideas in modern biology. Since the discovery that the organelle has its own DNA and specific mutations were found in association with neuromuscular and cardiovascular diseases and with aging, an extraordi-nary number of publications have followed, and the term mitochondrial medicine was coined. Furthermore, our understanding of the multiple roles that mitochondria play in cardiac cell homeostasis opened the door for intensive experimentation to understand the pathogenesis and to find new treatments for cardiovascular diseases. Besides its role in adenosine triphosphate generation, mitochondria regu-late a complex network of cellular interactions, involving (1) generation and detoxification of reactive oxygen species, including superoxide anion, hy-drogen peroxide, and hydroxyl radical; (2) maintenance of the antioxidant glutathione in a reduced state and adequate level of mitochondrial matrix superoxide dismutase; (3) cytoplasmic calcium homeostasis, particularly under conditions of cellular calcium loading; (4) transport of metabolites between cytoplasm and matrix; (5) both programmed (apoptosis) and necrotic cell death; and (6) cell growth and development. It is therefore not surprising that this organelle has come to be the center stage in many current investigations of cardiovascular diseases, aging, and agi- related disease. Concomitant with these advances, an impressive effort is under- way for the development of new tools and methodologies to study mitochondrial structure and function, including powerful ways to visualize, monitor, and alter the organelle function to assess the genetic consequences of these perturbations.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ GARDNERS","offer_id":49732377379089,"sku":"NGR9781441938077","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52455733133585,"sku":"NLS9781441938077","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1441938079.jpg?v=1753686375"},{"product_id":"coronary-pressure-book-nh-pijls-9780792361701","title":"Coronary Pressure","description":"A little bit more than two years after the first edition, we are pleased to publish the second edition of this book. More than half of the chapters have been remodeled and completed as the result of technical improvements and recently acquired clinical data. During these two years, the number of coronary pressure measurements performed worldwide both during diagnostic and interventional procedures has increased almost exponentially. Most of the initial problems associated with this new approach have been overcome. Many colleagues have explored new research avenues and in many catheterization laboratories the method has matured from a research toy to a clinical tool. Classical indications such as the intermediate stenosis and guidance of PTCA or stent implantation, have been largely extended and coronary pressure measurement has proven to be useful in multi vessel disease, diffuse disease, long and serial stenosis, after myocardial infarction, and in many other diagnostic and interventional situations encountered in the catheterization laboratory. Quite unexpectedly, this approach has also enforced the ties with our surgical colleagues in the selection of patients suitable for minimal invasive surgery or hybride revascularization. Also in mild and intermediate left main disease, there is a role for coronary pressure measurement in the process of decision making. We would like to express our gratitude to all those many colleagues who trusted and applied this new approach for the benefit of their patients. Aalst, Eindhoven, Bernard De Bruyne. Nico H. J. Pijls. March, 2000. Table of Contents (overview) 1 1.","brand":"WoB","offers":[{"title":"US \/ GOOD \/ SBYB","offer_id":50074844463377,"sku":"CIN0792361709G","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52336340762897,"sku":"NLS9780792361701","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/0792361709.jpg?v=1751395196"},{"product_id":"progress-in-catheter-ablation-book-liong-bing-liem-9781402001475","title":"Progress in Catheter Ablation","description":"Catheter ablation is widely accepted as an effective and safe form of therapy for cardiac arrhythmia. In many instances this curative procedure is considered as the first line of therapy if not the ultimate treatment of choice. With the use of radiofrequency (RF) modality; which has revolutionized the technology from a barotraumatic, potentially injurious procedure using high­ voltage, direct-current (DC) shock to a safe and relatively painless one; catheter ablation procedure now carries a very low risk and is extremely effective for certain types of arrhythmia. Its efficacy rate in curing supraventricular tachycardia involving an accessory pathway or dual atrioventricular nodal pathways has been near perfect and its application for certain types of atrial and ventricular arrhythmia have also been very satisfactory. However, conventional RF ablation has several well known limitations, most notably is its ability to only produce relatively small, point lesions; rendering it effective only for an arrhythmia with a small and\/or a superficial target. It was soon recognized that the technology would not likely to have significant utility in arrhythmia with a more widespread target such as atrial fibrillation or those which involve scarred and deep myocardial tissue such as ventricular tachycardia. Indeed, the application of conventional RF technology in these complex but common arrhythmia has yielded unsatisfactory results.","brand":"WoB","offers":[{"title":"US \/ GOOD \/ SBYB","offer_id":50159561572625,"sku":"CIN1402001479G","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52428138971409,"sku":"NLS9781402001475","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1402001479.jpg?v=1751403384"},{"product_id":"cardiac-output-and-regional-flow-in-health-and-disease-book-a-m-salmasi-9780792319115","title":"Cardiac Output and Regional Flow in Health and Disease","description":"Cardiac output has always been a subject of interest to both  clinicians and researchers in different branches of medicine and  surgery. In the last decade more attention has also been paid to its  application in pediatrics, neonatology, fetal medicine and pregnancy.  Better understanding of the peripheral circulation has provided more  insight into the patholophysiology of different diseases. Many cardiac  and non-cardiac disorders affect cardiac outputs. Monitoring of the  changes in cardiac output is also important in the acutely ill  patient. There are several methods to measure cardiac output, each  with advantages and pitfalls.    This book deals with all relevant aspects of cardiac output in eight  parts: part one describes the methods of measuring cardiac output and  a comparison between the catheterisation based and the noninvasive  techniques, while part two describes the changes in cardiac output due  to physiological causes. Part three describes cardiac output in  cardiac diseases and systemic hypertension. Cardiac output in acutely  ill patients is discussed in part four. Effect of cardiac medications,  temporary atrial pacing, permanent pacing, pharmacologic stress  testing and anesthesia are covered in detail in part six, while  changes in cardiac output in noncardiac diseases are described in part  seven. Finally great attention has been paid in part eight to the  regional circulation including cerebral, coronary, skeletal and  splanchnic circulations. A separate chapter discusses in detail the  dynamics of blood flow.    This book will be useful both to the cardiologists as well as to  physicians in other fields of surgery and medicine and to their  trainees. Readers will find this book an interesting and a useful  reference on the topic of cardiac output.","brand":"WoB","offers":[{"title":"US \/ GOOD \/ SBYB","offer_id":50189003620625,"sku":"CIN0792319117G","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"US \/ NEW \/ INGRAM","offer_id":51007130796305,"sku":"NIN9780792319115","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52432451010833,"sku":"NLS9780792319115","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/0792319117.jpg?v=1750913816"},{"product_id":"excitation-contraction-coupling-and-cardiac-contractile-force-book-donald-bers-9780792371588","title":"Excitation-Contraction Coupling and Cardiac Contractile Force","description":"The main aim of this monograph is to provide an overview of calcium regulation in cardiac muscle cells, particularly with respect to excitation-contraction coupling and the control of cardiac contractile force. It is my hope that this book will be useful to students of the cardiovascular system and muscle at all different levels and in different disciplines (such as physiology, biochemistry, pharmacology and pathophysiology). I also hope that it will find use for those studying developmental, comparative and disease processes as well as more integrative phenomenon. I kept several goals in mind in writing this monograph. First, it should be easily readable. Second, I chose to include numerous illustrations and tables to help integrate results from numerous investigators in practical formats and also present key figures from important papers. Thus, this monograph may serve as a resource of information for people working in the areas described herein. Third, the presentation is a very personal one, and I have necessarily drawn extensively on my personal experience in this field over the past 15 years. This, I think, helps maintain a certain continuity of thought from chapter to chapter. Fourth, I have made serious attempts to make each chapter up to date, despite the breadth of topics covered. I have also tried to be equitable in choosing references while not intending to be comprehensive or exhaustive. Neither of these aims can be perfectly matched, and I apologize to the many investigators whose papers I have not cited, but should have.","brand":"WoB","offers":[{"title":"US \/ GOOD \/ SBYB","offer_id":50359971774737,"sku":"CIN0792371585G","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ VERY_GOOD \/ INTERNAL","offer_id":51912543895825,"sku":"GOR004125530","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52128564216081,"sku":"NLS9780792371588","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/0792371585.jpg?v=1753785195"},{"product_id":"textbook-of-coronary-thrombosis-and-thrombolysis-book-r-c-becker-9780792399230","title":"Textbook of Coronary Thrombosis and Thrombolysis","description":"Teleologically, the hemostatic mechanism is among The of Coronary Thrombosis and the most fundamental yet complex physiologic pro- in essence, represents a heartfelt gift of cesses in humans. Early scientists and physicians were knowledge from a dedicated group of scientists and fascinated by the blood's ability to remain in a liquid clinicians, who collectively have set out on a mission state only to clot in response to vascular injury. The to minimize the societal impact of\"hemostasis in the cellular and noncellular components of normal wrong place. \" The book is divided into four distinct hemostasis took centuries to discover, and the intrica- sections: Part 1, Scientific Principles, lays down the cies of their delicate interactions are still being unrav- supporting foundation; Part 2, Clinical Application eled today. As is so often the case, an in-depth of Scientific Principles, places the knowledge base in appreciation of physiologic hemostasis, representing a a working perspective, directly applying science to basic life-sustaining sequence of events, paved the patient care; Part 3, New Dimensions, provides a way for understanding abnormal hemostasis or glimpse of tomorrow. Steering the field clear of se- pathologic thrombosis. Aristotle, Malpighi, and proclaimed victory and the dangers of complacency as Osier, representing but a few of the founding fathers we move into the 21st century, Part 4, Evolution of in the field, would undoubtedly be honored to see Thrombocardiology, focuses on laboratory standards, their observations form the template for lifesaving clinical trials, and drugs in development.","brand":"WoB","offers":[{"title":"US \/ GOOD \/ SBYB","offer_id":50360026530065,"sku":"CIN0792399234G","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"US \/ NEW \/ INGRAM","offer_id":51007130108177,"sku":"NIN9780792399230","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52665729614097,"sku":"NLS9780792399230","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/0792399234.jpg?v=1751395205"},{"product_id":"coronary-pressure-book-nico-h-j-pijls-9780792346722","title":"Coronary Pressure","description":"Coronary pressure measurement has emerged over the last few years as a major step forward in the invasive assessment of coronary artery disease. This was due on the one hand to major technical progress in developing pressure-monitoring guide wires, and on the other to a theoretical innovation, the concept of coronary pressure-derived fractional flow reserve, which closely relates distal coronary pressure to myocardial blood flow during maximum arteriolar vasodilation. In the catheterization laboratory, this new approach enables an \"on-the-spot\" diagnosis as to what extent a given epicardial stenosis contributes to reversible myocardial ischemia and the decision as to whether revascularization of the stenosis is warranted or not. In addition, pressure-derived fractional flow reserve appears to be a useful index in monitoring and guiding coronary intervention, including stent deployment. In \"Coronary Pressure\", the theoretical and physiological background of this approach is systematically reviewed and advanced clinical applications are illustrated, for both diagnostic and interventional catheterization, including tips, tricks, and potential pitfalls of this approach. This book caters for two types of reader: first, as a guide to the interventionalist who wants to make a quick start; and second, for cardiologists, radiologists, physiologists, and fellows in training for those specialties, who would like to understand the most recent progress in the field of invasive functional assessment of coronary artery disease. This book is an aid to the understanding and treatment of coronary artery disease and could be a major influence on practice in the catheterization laboratory in the next decade.","brand":"WoB","offers":[{"title":"US \/ GOOD \/ SBYB","offer_id":50365217505553,"sku":"CIN0792346726G","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/0792346726.jpg?v=1750786155"},{"product_id":"cardiomyopathies-and-heart-failure-book-akira-matsumori-9781402074387","title":"Cardiomyopathies and Heart Failure","description":"Heart failure is a major, cause of death worldwide, most frequently secondary toacardiomyopathicdisorder. The rolesofviruses, immunity, cytokines and genetics as sources of heart failure have been relatively understated in the rapidly developing world of clinical cardiology. Yet, great progress in molecular biology and the recent application of new techniquesto studiesoftheetiologyandpathogenesisofcardiomyopathies and heart failure has shed new light in an area ready to undergo major developmentsandadvances. This book is an effort to present an up-to-date account of eXIstmg knowledge,includingrecentdevelopmentsinthisfield. Chapterscovering severaldisciplinesincludingbiochemistry,immunology,molecularbiology, virology,epidemiologyandclinicalmedicinehavebeenincluded,offeringa \"bench-to-bedside\"and\"bedside-to-bench\"criticalreviewofeveryaspects of heart failure and cardiomyopathies, by world renowned, expert researchers and clinicians. These opinion leaders review all significant advances in our understandingofheart failure and cardiomyopathies, and describe theimprovements indiagnosis and treatment that areexpectedto optimize the overall management of patients. The identification of establishedornewlyrecognizedmolecules,cytokines,viruses,andgenes,as well as an understandingofthe mechanisms by which these factors may cause cardiomyopathic disorders and induce heart failure depends on a multidisciplinaryapproachwhichthisbookattemptstouniquelyencompass. Therefore,wehopethatitwillbeanimportantresource,notonlyforclinical cardiologists,butalso forgeneralpractitioners,pediatriciansandspecialists in infectious diseases, as well as trainees and graduates in biochemistry, immunology, genetics, molecular biology, virology, pharmacology, and epidemiology. AkiraMatsumori,MD,PhD Ie INTRODUCTORYCHAPTER CARDIOMYOPATHIESANDHEARTFAILURE Biomolecular,InfectiousandImmuneMechanisms AkiraMatsumori,MD,PhD DepartmentofCardiovascularMedicine KyotoUniversityGraduateSchoolofMedicine Kyoto,Japan 1 SUMMARY Theclinicalpresentationofviralmyocarditisisvariable. Whenmyocardial necrosis is diffuse, congestive heart failure develops, and later, dilated cardiomyopathy. If the myocardial lesions are localized, a ventricular aneurysmforms. Whencomplicatedbyarrhythmias,myocarditispresentsas arrhythmogenic right ventricular cardiomyopathy. When myocardial necrosisislocalizedtothesubendocardialregion,restrictivecardiomyopathy may develop. While it has not been established that hypertrophic cardiomyopathy maybeacomplicationofviral myocarditis, asymmetrical septal hypertrophy has, in fact, sometimesbeen observed in patients with myocarditis. TheimportanceofhepatitisCvirusinfectionhasrecentlybeen notedinpatientswithmyocarditis,dilatedandhypertrophiccardiomyopathy.","brand":"WoB","offers":[{"title":"US \/ VERY_GOOD \/ SBYB","offer_id":50372264722705,"sku":"CIN1402074387VG","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52663918428433,"sku":"NLS9781402074387","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1402074387.jpg?v=1750954970"},{"product_id":"myocardial-viability-book-as-iskandrian-9789401045100","title":"Myocardial viability","description":"In the past few years it has become clear that left ventricular  dysfunction, even of severe degree, may be reversible after coronary  revascularization in some patients. As a result, myocardial viability  has captured the imagination of researchers and clinicians seeking to  unravel the cellular and subcellular mechanisms and define appropriate  diagnostic modalities. These diagnostic modalities include: cardiac  catheterization, positron-emission tomography, magnetic resonance  imaging, two-dimensional echocardiography and single-photon imaging.  This book, for the first time, brings together a diverse array of  information in a comprehensive and concise fashion using a template of  ten chapters written by experts in the field. It will be required  reading for cardiologists, radiologists, nuclear medicine specialists,  cardiac surgeons, anesthesiologists, internists and basic researchers  and their trainees who are involved in the management of patients with  coronary artery disease in whom myocardial viability is a clinically  relevant issue.","brand":"WoB","offers":[{"title":"US \/ VERY_GOOD \/ SBYB","offer_id":50399623938321,"sku":"CIN9401045100VG","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52356069720337,"sku":"NLS9789401045100","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9401045100.jpg?v=1750904482"},{"product_id":"textbook-of-coronary-thrombosis-and-thrombolysis-book-r-c-becker-9781475770780","title":"Textbook of Coronary Thrombosis and Thrombolysis","description":"Teleologically, the hemostatic mechanism is among The of Coronary Thrombosis and the most fundamental yet complex physiologic pro- in essence, represents a heartfelt gift of cesses in humans. Early scientists and physicians were knowledge from a dedicated group of scientists and fascinated by the blood's ability to remain in a liquid clinicians, who collectively have set out on a mission state only to clot in response to vascular injury. The to minimize the societal impact of\"hemostasis in the cellular and noncellular components of normal wrong place. \" The book is divided into four distinct hemostasis took centuries to discover, and the intrica- sections: Part 1, Scientific Principles, lays down the cies of their delicate interactions are still being unrav- supporting foundation; Part 2, Clinical Application eled today. As is so often the case, an in-depth of Scientific Principles, places the knowledge base in appreciation of physiologic hemostasis, representing a a working perspective, directly applying science to basic life-sustaining sequence of events, paved the patient care; Part 3, New Dimensions, provides a way for understanding abnormal hemostasis or glimpse of tomorrow. Steering the field clear of se- pathologic thrombosis. Aristotle, Malpighi, and proclaimed victory and the dangers of complacency as Osier, representing but a few of the founding fathers we move into the 21st century, Part 4, Evolution of in the field, would undoubtedly be honored to see Thrombocardiology, focuses on laboratory standards, their observations form the template for lifesaving clinical trials, and drugs in development.","brand":"WoB","offers":[{"title":"US \/ GOOD \/ SBYB","offer_id":50481005789457,"sku":"CIN1475770782G","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"US \/ NEW \/ INGRAM","offer_id":51028401422609,"sku":"NIN9781475770780","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52676585292049,"sku":"NLS9781475770780","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1475770782.jpg?v=1754485377"},{"product_id":"pathophysiology-of-heart-failure-book-naranjan-s-dhalla-9780792335719","title":"Pathophysiology of Heart Failure","description":"Pathophysiology of Heart Failure brings together leading  basic scientists and clinicians, presenting new approaches to this  complex problem, involving cardiomyopathic processes and ischemia  perfusion injury. The result is a synthesis of state-of-the-art  information on molecular biology, cellular physiology and  structure-function relationships in the cardiovascular system.  The role which excess intracellular calcium plays in the genesis of  cardiac dysfunction is described as a fundamental mechanism underlying  heart failure; one which may lead to improved prevention and  treatment.    Audience: Clinical and experimental cardiologists will find the  book a helpful source of ideas and inspiration.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51007185256721,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51007187648785,"sku":"NIN9780792335719","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52584004714769,"sku":"NLS9780792335719","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/0792335716.jpg?v=1751395192"},{"product_id":"quantitative-coronary-angiography-in-clinical-practice-book-pw-serruys-9780792323686","title":"Quantitative Coronary Angiography in Clinical Practice","description":"Quantitative coronary angiography has become an invaluable tool  for the interventional cardiologist, providing objective and  reproducible measurements of coronary artery dimensions, which can be  used to study progression or regression of coronary atherosclerosis,  as well as the immediate and long term effects of percutaneous  interventions. Until recently, this powerful imaging technology was  confined to a small number of so-called high level institutions.  Fortunately, with the development of digital cardiac imaging equipment  and adaptation of cine-angiographically based computer software for  on-line use in the catheterization room, quantitative coronary  angiography is now available to all interventionalists.    This book is a timely guide for the impending QCA user, providing  practical as well as theoretical and scientific information. A  comprehensive evaluation of the clinical usefulness of QCA is covered,  from the fundamental principles through experimental validation  studies, application to clinical trials of a wide range of  pharmacological and interventional therapies in the full spectrum of  clinical presentation of coronary disease syndromes, evaluation of the  therapeutic efficacy of various new devices for coronary intervention,  together with extensive presentation of its physiological, functional  and anatomical correlations, by comparison with other intracoronary  measurement and imaging techniques. In addition, evolving theories and  concepts in the ever topical `restenosis phenomenon' after  percutaneous intervention, based on serial QCA studies, are presented  and discussed and a potentially unifying methodological approach to  further study of this ubiquitous problem is offered.    This book, thanks to the collaboration of many experts in the field of  intracoronary imaging and measurement, provides stimulating,  interesting and practical information, both for the academic scientist  and practising clinician.","brand":"WoB","offers":[{"title":"US \/ NEW \/ INGRAM","offer_id":51007201640721,"sku":"NIN9780792323686","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52150682550545,"sku":"NLS9780792323686","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/0792323688.jpg?v=1751200872"},{"product_id":"excitation-contraction-coupling-and-cardiac-contractile-force-book-donald-bers-9780792371571","title":"Excitation-Contraction Coupling and Cardiac Contractile Force","description":"How is the heartbeat generated? What controls the strength of  contraction of heart muscle? What are the links between cardiac  structure and function? How does our understanding of skeletal and  smooth muscle and non-muscle cells influence our thinking about force  development in the heart? Are there important species differences in  how contraction is regulated in the heart? How do the new molecular  data fit together in understanding the heart beat? What goes wrong in  ischemia, hypertrophy, and heart failure? This book paints a modern  `portrait' of how the heart works and in this picture the author shows  a close-up of the structural, biochemical, and physiological links  between excitation and contraction.    The author takes the reader through a series of important,  interrelated topics with great clarity and continuity and also  includes many useful illustrations and tables. The book starts by  considering the cellular structures involved in  excitation-contraction coupling and then described the  characteristics of the myofilaments as the end effector of  excitation-contraction coupling. A general scheme of calcium  regulation is described and the possible sources and sinks of calcium  are discussed in simple, but quantitative terms. The cardiac action  potential and its many underlying currents are reviewed. Then the  characteristics of some key calcium transport systems (calcium  channels, sodium\/calcium exchange and SR calcium uptake and release)  are discussed in detail. This is then built into a more integrated  picture of calcium regulation in succeeding chapters by detailed  discussions of excitation-calcium coupling mechanisms (in  skeletal, cardiac, and smooth muscle), the interplay between calcium  regulatory processes, and finally mechanisms of cardiac inotropy,  calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and  heart failure).    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Cardiologists attempting to follow  this new and exciting field may easily be confused by the growth and  expansion of new devices, the technical details relevant to each  device and enthusiastic claims of success. This monograph is a  comprehensive and objective assessment of restenosis from the  perspective of these new technologies including stenting, atherectomy,  rotational abrasion and lasers, written by innovators and pioneers.     The international breadth of experience is reflected in the summary of  experiences from both sides of the Atlantic, at times with conflicting  observations and results which in itself is valuable, given the  diverse experience to date. 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