Developmental Programming of Cardiovascular Disease by Barbara T Alexander

Developmental Programming of Cardiovascular Disease by Barbara T Alexander

Numerous epidemiological studies report that birth weight is inversely associated with blood pressure, suggesting that slow growth during fetal life programs hypertension and increased risk for cardiovascular disease in later life. Different experimental models are used to provide proof of concept for the theory of developmental programming of cardiovascular disease, and studies in these different animal models are providing insight into the etiology of chronic disease programmed by an imbalance in nutrition during early life or exposure to maternal complications during pregnancy. Alterations in the regulatory systems key to the long-term control of blood pressure are implicated in the etiology of hypertension that results from adverse exposures during early development. Epigenetic processes are also implicated in the increased risk for programmed cardiovascular disease and the passage of programmed cardiovascular risk to the next generation. Sex, age, and early postnatal growth impact later programmed risk; programmed risk is also amplified in response to a secondary challenge that includes normal physiological processes such as pregnancy. Thus, this book will highlight how events during early life impact later cardiovascular health in a manner that is sex- and age-dependent and can be transmitted to the next generation. Table of Contents: Introduction / Historical Perspective / Epidemiological Studies / Experimental Models of Developmental Programming / Mechanisms of Developmental Programming / Birth Weight and Clinical Considerations / Birth Weight and Cardiovascular Disease: Translational Considerations / Summary and Conclusions / References / Author Biography

Alexander, Barbara T.: - Dr. Barbara T. Alexander, Ph.D., FAHA, FAPS, Professor of Physiology and Biophysics at the University of Mississippi Medical Center (UMMC) in Jackson MS, has made major contributions to our understanding of the link between birth weight and blood pressure with a special emphasis on the mechanisms by which insults during fetal life lead to sex differences in the developmental programming of hypertension. The author of over 90 publications, Dr. Alexander's research has been funded by the National Institutes' of Health (NIH) and/or American Heart Association (AHA) for over 20 years. Dr. Alexander's research has been recognized by numerous awards throughout her career including the Arthur Guyton New Investigator Award from the Consortium for Southeastern Hypertension Control, the Merck Young Investigator Award of the AHA, the American Society of Hypertension Young Scholar Award, the New Investigator Award of the American Physiology Society (APS) Water and Electrolyte Section, the Excellence in Research Award Platinum Level at UMMC and most recently, the Harriet Dustan Award for Excellence in Hypertension Research from the AHA. She is an elected faculty member of her institution's Alpha Omega Alpha Chapter and is a Fellow of the AHA and the APS. She has served on the organizing committee for numerous scientific research conferences and provides extensive service to her professional societies and her institution. She was a member of the Leadership Committee of the Council on Hypertension during her service as Editor for the AHA's Connections Newsletter and role as Chair of the AHA Membership Committee. A former Councilor to the APS, she has held numerous other leadership roles in the APS and is active in APS committee involvement. Dr. Alexander is an Associate Editor for Biology of Sex Differences, a BMC journal for Springer Nature. A member of the editorial board for several journals, she is a standing member of the Hypertension and Microcirculatory Study Section for the NIH. Dr. Alexander serves as Director of Basic Research for the NIH / Centers of Biomedical Research Excellence (COBRE), Mississippi Center for Excellence in Perinatal Research. She also provides service as a Core leader for another NIH COBRE, the Cardiorenal and Metabolic Diseases Research Center. She is a founding member of the Women's Health Research Center and the Developmental Disorders Research Center at UMMC. Dr. Alexander has an extensive list of current and former mentees from the undergraduate to the post-doctoral level, many who are now established investigators that continue research in areas related to perinatal health.

SKU	Nicht verfügbar
ISBN 13	9781615046027
ISBN 10	161504602X
Titel	Developmental Programming of Cardiovascular Disease
Autor	Barbara T Alexander
Buchzustand	Nicht verfügbar
Bindungsart	Paperback
Verlag	Morgan & Claypool Publishers
Erscheinungsjahr	2013-06-30
Seitenanzahl	77
Hinweis auf dem Einband	Die Abbildung des Buches dient nur Illustrationszwecken, die tatsächliche Bindung, das Cover und die Auflage können sich davon unterscheiden.
Hinweis	Nicht verfügbar