Failure! by Nicole Antebi
The trafficking of membrane proteins between cellular compartments is regulated by their cytoplasmic signal sequences that are recognised by adaptor proteins. Adaptor proteins recruit membrane proteins into vesicles that traffic to a specific target organelle. The cation-dependent mannose 6-phosphate receptor (CD-MPR) is a membrane receptor that transports newly synthesised lysosomal enzymes from the trans-Golgi network to the lysosome and is continuously recycled. This work focused on two sorting signals that regulate the intracellular trafficking of the CD-MPR at different cellular locations. Palmitoylation is a post-translational modification that prevents missorting of the CD-MPR to lysosomes. GA1 and AP-1 adaptor proteins bind to the cytoplasmic tail of the CD-MPR at a signal that overlaps with a phosphorylation site. This dissertation reveals novel aspects of these sorting signals and CD-MPR trafficking.| SKU | Nicht verfügbar |
| ISBN 13 | 9780979137709 |
| ISBN 10 | 0979137705 |
| Titel | Failure! |
| Autor | Nicole Antebi |
| Buchzustand | Nicht verfügbar |
| Bindungsart | Paperback |
| Verlag | Aesthetics and Protest Press |
| Erscheinungsjahr | 2008-03-01 |
| Seitenanzahl | 218 |
| Hinweis auf dem Einband | Die Abbildung des Buches dient nur Illustrationszwecken, die tatsächliche Bindung, das Cover und die Auflage können sich davon unterscheiden. |
| Hinweis | Nicht verfügbar |