The Proprotein Convertases by Abdel-Majid Khatib

The Proprotein Convertases by Abdel-Majid Khatib

Proprotein convertases (PCs) are a family of proteases including PC1, PC2, Furin, PC4, PACE4, PC5, and PC7. These enzymes are involved in the maturation of many precursor proteins involved in the process of tumorigenesis and metastasis. Since their discovery, PCs were suggested as potential targets for anti-cancer therapy, and their activity was found to directly affect tumor cell proliferation, migration invasion, and the malignant phenotypes of tumor cells. Here, we discuss a number of previous and recent findings on the PCs features, their implication in the regulation of multiple cellular functions that impact on the invasive/metastatic potential of cancer cells, and their clinical relevance in cancer patients. Among the substrates of the proprotein convertases, various growth factors, their receptors, adhesion molecules, and proteases were identified. The PCs are inhibited by endogenous and exogenous inhibitors. To date, only pro7B2, a specific chaperone of PC2, and the granine-like precursor of neuroendocrine protein proSAS, a selective ligand of PC1, have been identified as endogenous inhibitors of the PCs found in the regulated pathway. However, only PCs prosegments, several bioengineered inhibitors, peptides, and non-peptide compounds were found to inhibit the activity of the PCs found in the secretory pathway.

Khatib, Abdel-Majid: - University of Bordeaux, France

SKU	Nicht verfügbar
ISBN 13	9781615045365
ISBN 10	1615045368
Titel	The Proprotein Convertases
Autor	Abdel-Majid Khatib
Serie	Colloquium Series On Protein Activation And Cancer
Buchzustand	Nicht verfügbar
Bindungsart	Paperback
Verlag	Morgan & Claypool Publishers
Erscheinungsjahr	2013-02-28
Seitenanzahl	86
Hinweis auf dem Einband	Die Abbildung des Buches dient nur Illustrationszwecken, die tatsächliche Bindung, das Cover und die Auflage können sich davon unterscheiden.
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