Livestock Genome Editing Tools

Livestock Genome Editing Tools by Kui Li

Livestock Genome Editing Tools introduces applications and improvements to a series of new genome editing techniques in livestock, such as pigs, cattle, and sheep. These tools include zinc finger nucleases (ZFN), transcription activator–like effector nucleases (TALEN), and the clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) system, as well as the traditional gene targeting tools. The book also summarizes a series of genome editing–related techniques, including microinjection and somatic cell nuclear transfer. Written by international experts who have been working on livestock genetic editing field for more than 30 years, this book provides extensively theoretical and practical experience for readers to master the latest developments. This book explores the importance of research and application, as well as operation procedures, of livestock genetic editing tools. The writing of operation details makes this book an accessible read. This book is an important resource for researchers interested in genome-edited animals and scientists and technicians in breeding institutions and is also of interest to students major in animal reproduction and biological engineering.

Dr. Kui Li is a Professor at Chinese Academy of Agricultural Sciences. He graduated from Wuhan University of China and appointed as a full Professor at Huazhong (Central China) Agricultural University and Chinese Academy of Agricultural Sciences in China since 1996, respectively. He used to be a visiting scholar at the University of Sydney, Australia and a full-time visiting Professor at the Cornell University, USA. Prof. Li’s research interests include pig genome and breeding, pig genetic engineering, experimental mini-pigs and medical models. He has been working on these fields for more than 3 decades. Since 1996, Prof. Li systematically compared the multi-omics of different developmental stages of Chinese and Western pig breeds and found lots of multi-level molecular markers. He also identified several hundreds of molecular markers related to porcine economic traits which are used to develop pig breeds. He established steady platforms for porcine somatic cell nuclear transfer, pronuclear injection, and genome editing techniques. He also established the techniques to develop genetic modified pigs with multi-gene compound traits, controllable expression and friendly gene locus site directed integration. Excitingly, Prof. Li’s research group generated more than 20 new breeding materials for agriculture including MSTN-edited pigs, anti-porcine reproductive and respiratory syndrome pigs. His research group also generated genome edited pigs for biomedicine including cardiovascular disease and diabetes models, which showed great application perspective. Prof Li is a founder of Agsino Gensources Co., Ltd., an animal biotechnology breeding company. Dr. Bingyuan Wang is an Associate Professor at the Institute of Animal Sciences, Chinese Academy of Agricultural Sciences. In 2014, she graduated from Max Planck Institute for Molecular Biomedicine in Germany. From 2015 to 2023, she worked in the Porcine Gene Engineering and Plasma Innovation group, which is led by Prof. Kui Li. Her research interests include the molecular mechanisms underlying porcine spermatogonial cells proliferation and apoptosis, the influence of exogenous factors in the porcine reproduction using porcine oocytes and spermatogonial cells, induction of gametes from porcine spermatogonial cells, and the generation of genome-edited pigs using porcine spermatogonial cells.

SKU	Nicht verfügbar
ISBN 13	9780128190999
ISBN 10	012819099X
Titel	Livestock Genome Editing Tools
Autor	Kui Li
Buchzustand	Nicht verfügbar
Bindungsart	Hardback
Verlag	Elsevier Science Publishing Co Inc
Erscheinungsjahr	2024-04-18
Seitenanzahl	442
Hinweis auf dem Einband	Die Abbildung des Buches dient nur Illustrationszwecken, die tatsächliche Bindung, das Cover und die Auflage können sich davon unterscheiden.