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Tandem Repeat Polymorphisms By Anthony J. Hannan

Tandem Repeat Polymorphisms by Anthony J. Hannan

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Summary

This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease.

This book will be specially printed for your order, which means it may take a little longer to arrive (5 days). We do this to cut down on waste & to help protect our planet.

Tandem Repeat Polymorphisms Summary

Tandem Repeat Polymorphisms: Genetic Plasticity, Neural Diversity and Disease by Anthony J. Hannan

This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease. There are hundreds of thousands of unique tandem repeats in the human genome and their polymorphic distributions have the potential to greatly influence functional diversity and disease susceptibility. Recent discoveries in this expanding field are critically reviewed and discussed in a range of subsequent chapters, with a focus on the role of TRPs and their various gene products in evolution, development, diverse molecular and cellular processes, brain function and disease.

About Anthony J. Hannan

ANTHO NY J. HANNAN is Head of the Neural Plasticity Laboratory, Florey Neuroscience Institutes and Associate Professor at the University of Melbourne, Parkville, Australia. Following undergraduate and PhD degrees at the University of Sydney, Anthony received postdoctoral neuroscience training at the University of Oxford, supported by a Nuffield Medical Fellowship. He currently holds an Australian Research Council (ARC) Future Fellowship (FT3) and an Honorary Senior Research Fellowship from the National Health and Medical Research Council (NHMRC). Main research interests include pathogenic mechanisms mediating Huntington's disease and related tandem repeat expansion disorders, as well as other cognitive and psychiatric illnesses. In his laboratory, experimental models of gene-environment interactions are used to explore experience-dependent plasticity in the healthy and diseased brain.

Table of Contents

Tandem Repeat Polymorphisms: Mediators of Genetic Plasticity, Modulators of Biological Diversity and Dynamic Sources of Disease Susceptibility.- Evolution of Simple Sequence Repeats as Mutable Sites.- Single Amino Acid and Trinucleotide Repeats: Function and Evolution.- Promoter Microsatellites as Modulators of Human Gene Expression.- Dynamic Mutations: Where Are They Now.- Unstable Mutations in the FMR1 Gene and the Phenotypes.- Molecular Pathways to Polyglutamine Aggregation.- Polyglutamine Aggregation in Huntington and Related Diseases.- Selective Neurodegeneration, Neuropathology and Symptom Profiles in Huntington's Disease.- Kennedy's Disease: Clinical Significance of Tandem Repeat s in the Androgen Receptor.- Characterising the Neuropathology and Neurobehavioural Phenotype in Friedreich Ataxia: A Systematic Review.- Polyalanine Tract Disorders and Neurocognitive Phenotypes.

Additional information

NLS9781493954483
9781493954483
1493954482
Tandem Repeat Polymorphisms: Genetic Plasticity, Neural Diversity and Disease by Anthony J. Hannan
New
Paperback
Springer-Verlag New York Inc.
20160823
208
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