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Acute Neuronal Injury By Denson G. Fujikawa

Acute Neuronal Injury by Denson G. Fujikawa

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Summary

This book sets out to explain the clinically relevant basic mechanisms of excitotoxic neuronal death, which in the adult mammalian brain is morphologically necrotic, not apoptotic, and which involve caspase-independent mechanisms of programmed cell death.

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Acute Neuronal Injury Summary

Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms by Denson G. Fujikawa

Denson G. Fujikawa 2+ In the early 1980s it was recognized that excessive Ca influx, presumably through 2+ 2+ voltage-gated Ca channels, with a resultant increase in intracellular Ca , was associated with neuronal death from cerebral ischemia, hypoglycemia, and status epilepticus (Siejo 1981). Calcium activation of phospholipases, with arachidonic acid accumulation and its oxidation, generating free radicals, was thought to be a potential mechanism by which neuronal damage occurs. In cerebral ischemia and 2+ hypoglycemia, energy failure was thought to be the reason for excessive Ca influx, whereas in status epilepticus it was thought that repetitive depolarizations were responsible (Siejo 1981). Meanwhile, John Olney found that monosodium glutamate, the food additive, when given to immature rats, was associated with neuronal degeneration in the arcuate nucleus of the hypothalamus, which lacks a blood-brain barrier (Olney 1969). He followed up this observation with a series of observations in the 1970s that administration of kainic acid, which we now know activates the GluR5-7 subtypes of glutamate receptor, and other glutamate analogues, caused not only post-synaptic cytoplasmic swelling, but also dark-cell degeneration of neurons, when viewed by electron microscopy (Olney 1971; Olney et al. 1974).

Acute Neuronal Injury Reviews

"This is an outstanding book concerning the molecular and cellular mechanisms of trauma and ischemia in the mammalian brain. ... I recommend his book to neurophysiologists, neurologists, and neurosurgeons." (Joseph J. Grenier, Amazon.com, September, 2015)

About Denson G. Fujikawa

Dr. Denson Fujikawa is an Adjunct Professor of Neurology at the David Geffen School of Medicine at UCLA, a member of the Brain Research Institute at UCLA and a Staff Neurologist at the Department of Veterans Affairs Greater Los Angeles Healthcare System. His interest in mechanisms of nerve cell death in the brain began during a two-year epilepsy research fellowship with Dr. Claude Wasterlain, from 1981 to 1983. He is a Fellow of the American Academy of Neurology and is a member of the American Epilepsy Society, American Neurological Association, International Society for Cerebral Blood Flow and Metabolism and the Society for Neuroscience.

Table of Contents

INTRODUCTION: Programmed mechanisms and the clinical spectrum of excitotoxic neuronal death (Denson G. Fujikawa).- PART 1: Caspase-independent programmed cell death: general considerations.- Chapter 1: Caspase-independent cell death mechanisms in simple animal models (Matthias Rieckher and Nektarios Tavernarakis).- Chapter 2: Programmed necrosis: a 'new' cell death outcome for injured adult neurons? (Slavica Krantic and Santos A. Susin).- Chapter 3: Age-dependence of neuronal apoptosis and of caspase activation (Denson G. Fujikawa).- Chapter 4: Excitotoxic programmed cell death involves caspase-independent mechanisms (Ho Chul Kang, Ted M. Dawson and Valina L. Dawson).- PART 2: Focal Cerebral ischemia.- Chapter 5: Apoptosis-inducing factor translocation to nuclei in focal cerebral ischemia (Carsten Culmsee and Nicholas Plesnila).- Chapter 6: The role of poly(ADP-ribose) polymerase-1 (PARP-1) activation in focal cerebral ischemia (Giuseppe Faraco and Alberto Chiarugi).- PART 3: Transient Global Ischemia.- Chapter 7: Transient global cerebral ischemia produces necrotic, not apoptotic neurons (Frederick Colbourne and Roland Auer).- Chapter 8: Apoptosis-inducing factor translocation to nuclei after transient global ischemia (Can Liu, Armando P. Signore, Guodong Cao and Jun Chen).- Chapter 9: Role of -calpain I and lysosomal cathepsins in hippocampal neuronal necrosis after transient global ischemia in primates (Anton B. Tonchev and Tetsumori Yamashima).- PART 4: Traumatic central nervous system (CNS) injury.- Chapter 10: Mitochondrial damage in traumatic CNS injury (Laurie M. Davis and Patrick G. Sullivan).- Chapter 11: Programmed mechanisms in traumatic CNS injury (Bogdan A. Stoica and Alan I. Faden).- PART 5: Hypoglycemic neuronal death.- Chapter 12: Hypoglycemic neuronal death: morphological considerations (tentative title pending receipt of manuscript; Roland Auer).- Chapter 13:The role of poly(ADP-ribose) polymerase-1 (PARP-1) in hypoglycemic neuronal death (tentative title pending receipt of manuscript; Sang Won Suh and Raymond A. Swanson).- PART 6: Seizure-induced neuronal death.- Chapter 14: p53 activation is necessary in seizure-induced neuronal death (Zhiquin Tan and Steven S. Schreiber).- Chapter 15: DNA damage and repair in the brain: implications for seizure-induced neuronal injury, endangerment, and neuroprotection (Samantha L. Crowe and Alexei D. Kondratyev).- Chapter 16: Activation of caspase-independent programmed pathways in seizure-induced neuronal necrosis (Denson G. Fujikawa).- CONCLUDING REMARKS (Denson G. Fujikawa)

Additional information

NLS9781489982858
9781489982858
148998285X
Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms by Denson G. Fujikawa
New
Paperback
Springer-Verlag New York Inc.
2014-09-05
306
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
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