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Protein Kinase Functions By James Woodgett (Ontario Cancer Institute, University of Toronto)

Protein Kinase Functions by James Woodgett (Ontario Cancer Institute, University of Toronto)

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Protein Kinase Functions describes the cellular functions of protein kinases in the context of their signalling pathways. All the major processes involving protein kinase signal transduction are covered.

Protein Kinase Functions Summary

Protein Kinase Functions by James Woodgett (Ontario Cancer Institute, University of Toronto)

Since the publication of Protein Kinases in 1994 many novel protein kinases have been discovered, but perhaps more importantly there have been dramatic advances in our understanding of the cellular functions of this remarkably diverse class of proteins. Protein Kinase Functions is not just an update of the previous edition but provides a new focus on the context and function of protein kinases, thus reflecting the recent advances in kinase biology. Chapters on genetic approaches to protein kinase functions, the MAP kinase pathway, and cyclin-dependent kinases have been completely updated and new topics covered in depth are: phosphatidylinositol 3-kinase signalling, JAK-STAT signalling, suppression of tyrosine kinases by the SOCS family proteins, the TGFss superfamily, and the involvement of protein kinases in response to DNA damage. Throughout, emphasis is placed not on individual kinases, but on the functional aspects of the whole system and the relationship between processes and molecules. It is the aim of Protein Kinase Functions to enable the reader to assimilate, compare, and integrate the molecular machinery used by cells to co-ordinate and respond to their environments.

Protein Kinase Functions Reviews

" ... the book can be thoroughly recommended to anyone interested in the field." Trends in Cell Biology

Table of Contents

Phosphatidylinositol 3-kinase signalling: a tale of two kinase activities ; Mammalian MAP kinase pathways ; Genetic approaches to protein kinase function in lower eukaryotes ; Specificity in JAK-STAT signalling ; On the road to destruction: suppression of protein tyrosine kinase ; Cyclin-dependent protein kinases ; Mechanisms and biology of signalling by serine/threonine kinase receptors form the TGFss superfamily ; The ATM and DNA-PK proteins: The sensing, signaling and repair of DNA Damage

Additional information

Protein Kinase Functions by James Woodgett (Ontario Cancer Institute, University of Toronto)
Oxford University Press
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