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Genetic Epidemiology By M. Dawn Teare

Genetic Epidemiology by M. Dawn Teare

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Genetic Epidemiology Summary

Genetic Epidemiology by M. Dawn Teare

Arising from firm foundations laid by mathematical population genetics, clinical genetics, and statistical epidemiology, genetic epidemiology attempts to identify the many components of risk

attributable to genes, environments, and interactions, and the course of its research can follow many diverse paths. In Genetic Epidemiology, the success of genome-wide association studies in their identification of hundreds of disease susceptibility loci has inspired renowned experts to contribute thorough methodologies, which aim to bring together bioinformaticians, geneticists, clinicians, statisticians, and epidemiologists in the study of this vital field. The volume opens with chapters covering the basics; however, it quickly moves on to coverage of more specialist topics such as twin studies, Mendelian randomization, genetic association studies, more advanced areas, as well as case studies. As a part of the highly successful Methods in Molecular Biology (TM) series, this work provides the detailed description of the application and analysis of the most commonly employed methods that are necessary for a firm grounding in the field.

Authoritative and cutting-edge, Genetic Epidemiology aims to provide a basic framework for crucial interdisciplinary communication and understanding suited to newcomers to the field as well as experienced researchers and graduate level students.

Table of Contents

Part I: Introduction

1. Molecular Genetics and Genetic Variation

Mohammed Elfatih Twfieg and M. Dawn Teare

2. Terminology, Concepts, and Models in Genetic Epidemiology

M. Dawn Teare and Mauro F Santibanez Koref

3. An Introduction to Epidemiology

Cother Hajat

Part II: Genetic Linkage Mapping

4. Genetic Distance and Markers Used in Linkage Mapping

Kristina Allen-Brady and Nicola J. Camp

5. Approaches to Genetic Linkage Analysis

M. Dawn Teare

Part III: Genetic Mapping by Association

6. Fine-Scale Structure of the Genome and Markers Used in Association Mapping

Karen Curtin and Nicola J. Camp

7. Genome-Wide Association Studies

Mark M. Iles

8. Candidate Gene Association Studies

M. Dawn Teare

9. Family-Based Association Studies

Frank Dudbridge

10. Genome Variation: A Review of Web Resources

Andrew Collins and William Tapper

Part IV: Emerging Themes

11. Advanced Methods in Twin Studies

Jaakko Kaprio and Karri Silventoinen

12. Mendelian Randomization: A Tool for Assessing Causality in Observational Epidemiology

Nuala A. Sheehan, Sha Meng, and Vanessa Didelez

13. Copy Number Variation

Louise V. Wain and Martin D. Tobin

14. Epigenetic Variation

Kevin Walters

Part V: Case Studies

15. Modeling the Effect of Susceptibility Factors (HLA and PTPN22) in Rheumatoid Arthritis

Herve Perdry and Francoise Clerget-Darpoux

16. Coronary Artery Disease: An Example Case Study

Jennifer H. Barrett

17. The Genetic Epidemiology of Obesity: A Case Study

Laura Johnson

Additional information

Genetic Epidemiology by M. Dawn Teare
Humana Press Inc.
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