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Calcium Signaling By Masayoshi Yamaguchi

Calcium Signaling by Masayoshi Yamaguchi

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Summary

Signal transduction plays a pivotal role in cellular regulation. The second messenger is generated in cells once the first messenger binds to the receptors of plasma membranes. The second messenger, which was found firstly, is cyclic adenosine monophosphate. This book provides an examination of calcium signalling.

Calcium Signaling Summary

Calcium Signaling by Masayoshi Yamaguchi

Signal transduction plays a pivotal role in cellular regulation. The second messenger is generated in cells once the first messenger binds to the receptors of plasma membranes. The second messenger, which was found firstly, is cyclic adenosine monophosphate. After that, intracellular calcium ion (Ca2+) has been demonstrated to play a role as a second messenger for hormonal stimulation in cells. The pivotal role of Ca2+ in cellular regulation was established with the finding of calmodulin and protein kinase C that modulate the effect of Ca2+ in the regulation of cellular functions. Calcium signalling is probably the most ubiquitous cellular signal that mediates the action of many hormones, cytokines, and neurotransmitters. This book provides an in depth examination of calcium signalling.

About Masayoshi Yamaguchi

Masayoshi Yamaguchi, Ph.D., IOM, FAOE, DDG, DG, is Adjunct Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA (2013 - ). Dr. Yamaguchi is engaged in the fields of endocrinology and cell signaling since 1971, and these researches are developed in the aspect of biochemistry, molecular biology, endocrinology, metabolism, nutrition, pharmacology, and toxicology. Dr Yamaguchi has an interesting for cell signaling mechanism, bone biology, nutritional factor and osteoporosis prevention, diabetes and diabetic osteoporosis, cancer biology, and cancer cell bone metastasis. Dr. Yamaguchi discovered two novel proteins and genes; cell signaling suppressor protein (named regucalcin; 1978) and transcriptional factor RGPR-p117 (regucalcin gene promoter region-related protein; 2001). Dr Yamaguchi generated regucalcin transgenic rats, which were registered as international patents including USA, EU and Japan, and this animal was found to induce osteoporosis and hyperlipidemia. Moreover, Dr. Yamaguchi proposed the potential role of regucalcin as a key suppressor protein in carcinogenesis. Thus far, Dr Yamaguchi published over 550 English articles to professional journals with peer-review, and registered over 20 national and international patents.

Table of Contents

Preface; Ca2+ Signaling in Lower Eukaryote (I.V. Shemarova); Role of calcium in stress mediated signaling in plants; Calmodulin signaling inside-out: Intracellular & extracellular calmodulin & its interaction with a matricellular cysteine-rich calmodulin-binding protein; A tale of three proteins: The nucleolar calmodulin-binding protein nucleomorphin & its binding partners calcium-binding protein 4a & puromycin-sensitive aminopeptidase; Insights into the role of intracellular Ca2+ concentration changes during in vitro chondrogenesis; Cav2.1 channelopathies & mouse genetic approaches for investigating Cav2.1 channel function & dysfunction; Regucalcin: Role as a suppressor protein in calcium signaling; Calcium ([Ca2+]i ) signaling as a key-target for cancer treatment; Index.

Additional information

NGR9781613243138
9781613243138
1613243138
Calcium Signaling by Masayoshi Yamaguchi
New
Hardback
Nova Science Publishers Inc
2012-03-26
244
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
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