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Mast Cells By Michael R. Hughes

Mast Cells by Michael R. Hughes

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Mast Cells Summary

Mast Cells: Methods and Protocols by Michael R. Hughes

Mast Cells: Methods and Protocols, Second Edition expands upon the previous edition with current, detailed reviews that cover topics of interest to mast cell neophytes and cognoscenti alike. With new chapters on methods for the enumeration of tissue mast cells and isolation of mature mast cells and mast cell progenitors from mammalian tissues, Danio rerio (zebrafish) model in the study of mast cell development and function, the functions of mast cells in human health and disease and methods for the isolation, methods for the investigation of the molecular mechanisms of mast cell activation and their effector functions, assays for the detection and analysis of mast cell secretory and cell surface phenotype and, mast cell activation state, and experimental mouse models of disease that have been deemed useful for the assessment of mast cell functions in the regulation of innate and adaptive immune response in cancer, tissue fibrosis, auto-inflammation and allergic disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Mast Cells: Methods and Protocols, Second Edition provides a sampler of useful methods and techniques in the further study of mast cell biology.

Mast Cells Reviews

Cutting-edge, easily reproducible protocols and methods for the isolation of mast cells and investigation of the molecular mechanisms of their activation and functions can help investigators plan and carry out their experiments. ... aimed primarily at laboratory researchers but also may be useful for all specialists who are interested in mast cell biology. The book is well written, illustrated, summarizes extensive recommendations of world-renowned experts in the field and offers an up-to-date and in-depth look into mast cell biology. (Pavel Kolkhir, World Allergy Organization, WAO Medical Book Reviews,, July, 2016)

Table of Contents

Part I: Ontology, Phylogeny, and Tissue Distribution of Mast Cells

1. Paul Ehrich's Mastzellen: A Historical Perspective of Relevant Developments in Mast Cell Biology

Hana Saleh, Harsha Vyas, Emma Peiris, Niva Misra, and Guha Krishnaswamy

2. The Phylogenetic Profile of Mast Cells

Enrico Crivellato , Luciana Travan, and Domenico Ribatti

3. Mast Cell Development and Function in the Zebrafish

Sahar I Da'as, Tugce B. Balci, and Jason N. Berman

4. Human Mast Cell and Basophil/Eosinophil Progenitors

Gail M Gauvreau and Judah A Denburg

5. Methods for the Study of Mast Cell Recruitment and Accumulation in Different Tissues

Tatiana G. Jones and Michael F. Gurish

6. Notch2 Signaling in Mast-cell Development & Distribution in the Intestine

Mamiko Sakata-Yanagimoto and Shigeru Chiba

Part II: Mast Cells in Human Health and Disease7. Mast Cells in Human Health and DiseaseErin J. DeBruin, Matthew Gold, Bernard C. Lo, Kimberly Snyder, Alissa Cait, Nikola Lasic, Martin Lopez, Kelly M. McNagny, and Michael R. Hughes

8. The Emerging Prominence of the Cardiac Mast Cell as a Potent Mediator of Adverse Myocardial Remodeling

Joseph S. Janicki, Gregory L. Brower, and Scott P. Levick

9. The Parasympathetic Nervous System as a Regulator of Mast Cell Function

Paul Forsythe

10. Growth of Human Mast Cells from Bone Marrow and Peripheral Blood-Derived CD34+ Pluripotent Hematopoietic CellsGeethani Bandara, Dean D. Metcalfe, and Arnold S. Kirshenbaum

11. Isolation and Characterization of Human Intestinal Mast Cells

Axel Lorentz, Gernot Sellge, and Stephan C. Bischoff

12. Human Mast Cell Activation with Viruses and Pathogen Products

Ian Haidl and Jean S. Marshall

Part III: Molecular Mechanisms of Mast Cell Function

13. Basic Techniques to Study FceRI Signaling in Mast Cells

Yuko Kawakami and Toshiaki Kawakami

14. Membrane-cytoskeleton Dynamics in the Course of Mast Cell Activation

Pavel Draber and Petr Draber

15. Fc RI Expression and Dynamics on Mast Cells

Eon J. Rios and Janet Kalesnikoff

16. Regulation of Mast Cell Survival and Apoptosis

Christine Moeller Westerberg, Maria Ekoff and Gunnar Nilsson

17. Protein Tyrosine Phosphatases in Mast Cell Signaling

Alexander Geldman and Catherine J. Pallen

18. MicroRNA Function in Mast Cell Biology:Protocols to Characterize and Modulate microRNA Expression

Steven Maltby, Maximilian Plank, Catherine Ptaschinski, Joerg Mattes, and Paul S. Foster

Part IV: Mast Cell Products and Mediators

19. Assay of Mast Cell Mediators

Madeleine Radinger, Bettina M. Jensen, Emily Swindle, and Alasdair M. Gilfillan

20. Induction Of Mast Cell Apoptosis By A Novel Secretory Granule-Mediated Pathway

Fabio R. Melo, Sara Wernersson, and Gunnar Pejler

21. Measurement of Nitric Oxide in Mast Cells with the Fluorescent Indicator DAF-FM Diacetate

Chris D. St. Laurent, Tae Chul Moon, and A. Dean Befus

22. Real-time Imaging of Ca2+ Mobilization and Degranulation in Mast Cells

Roy Cohen, David A. Holowka, and Barbara A. Baird#

23. Flow Cytometry-based Monitoring of Mast Cell Activation

Glenn Cruse, Alasdair M. Gilfillan, and Daniel Smrz

24. Measurement of Mast Cell Surface Molecules using High-throughput Immunophenotyping using Transcription (HIT)

D. James Haddon, Justin A. Jarrell, Michael R. Hughes, Kimberly Snyder, Kelly M. McNagny, Michael G. Kattah, and Paul J. Utz

Part V: Mouse Models of Disease to Study Mast Cell Function

25. Investigatiotion using Novel Mouse Models of Mast Cell Deficiency and Mast Cell-specific Gene Inactivation

Katrin Peschke, Anne Dudeck, Anja Rabenhorst, Karin Hartmann, and Axel Roers

26. Evaluation of Synovial Mast Cell Functions in Autoimmune Arthritis

Kichul Shin and Peter A. Nigrovic

27. Methods for the Study of Mast Cells in Cancer

Nichole R. Blatner, FuNien Tsai, and Khashayarsha Khazaie

28. Studying Mast Cells in Peripheral Tolerance by using a Skin Transplantation Model

Victor C. de Vries, Isabelle Le Mercier, Elizabeth C. Nowak, and Randolph J. Noelle

29. The Function of Mast Cells in Autoimmune Glomerulonephritis

Renato C. Monteiro, Walid Beghdadi, Lydia Celia Madjene, Maguelonne Pons, Michel Peuchmaur, and Ulrich Blank

30. A Mouse Model of Atopic Dermatitis

Yuko Kawakami and Toshiaki Kawakami

31. Mouse Models of Allergic Asthma

Matthew Gold, David Marsolais, and Marie-Renee Blanchet

32. Methods in Assessment of Airway Reactivity in Mice

Matthew Gold and Marie-Renee Blanchet

Additional information

Mast Cells: Methods and Protocols by Michael R. Hughes
Humana Press Inc.
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