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Gene Environment Interactions By Moyra Smith (Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California Irvine, Irvine, CA, United States)

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Gene Environment Interactions Summary

Gene Environment Interactions: Nature and Nurture in the Twenty-first Century by Moyra Smith (Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California Irvine, Irvine, CA, United States)

Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome's intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders. Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population.

About Moyra Smith (Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California Irvine, Irvine, CA, United States)

Moyra Smith is Professor Emeritus of Pediatrics and Human Genetics at the School of Medicine at University of California, Irvine. Following graduation from medical school and internships in South Africa and Scotland, she was accepted to the PhD Program in Biochemical Genetics at University College London. Since then, she has had many years working in Clinical Genetics, in research studying biochemical variation, chromosome analyses in cloning and mapping genes, and studying gene expression. In recent years, she has also been involved in research in autism and attention deficit hyperactivity. She was awarded the 2017 UCI Outstanding Emerita Award due to her continuing research on genetics and genomics, her strong record of publications including numerous books, her active engagement in the programs within the Department of Pediatrics, her mentoring of graduate students, and her involvement with the CART Autism Center.

Table of Contents

1. Interacting with the environment receiving and interpreting signals 2. Environment as Provider 3. Human Evolution and adaptations to environments and to pathogen encounters 4. Genetic mechanisms in environmental adaptations 5. Epigenetics and the regulatory genome 6. The microbiome: The external life forms within 7. Human development, behaviors, impacts of environment and genetic variations 8. Joint Roles of Genes and Environment in etiology of specific diseases 9. Personalized Precision Medicine 10. Identifying and mitigating effects of Harmful factors in the Intrinsic or Extrinsic Environment 11. Questions relating to climate change

Additional information

NLS9780128196137
9780128196137
0128196130
Gene Environment Interactions: Nature and Nurture in the Twenty-first Century by Moyra Smith (Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California Irvine, Irvine, CA, United States)
New
Paperback
Elsevier Science Publishing Co Inc
2020-01-14
438
N/A
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