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Handbook of the Biology of Aging Summary

Handbook of the Biology of Aging by Nicolas Musi (Sam and Ann Barshop Insititute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA)

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others.

About Nicolas Musi (Sam and Ann Barshop Insititute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA)

Dr. Nicolas Musi is a tenured Professor of Medicine (Division of Geriatrics and Gerontology and Division of Diabetes) and Director of the Barshop Institute for Longevity and Aging Studies, the San Antonio Claude D. Pepper Older Americans Independence Center, and the San Antonio Geriatric Research, Education and Clinical Center. He is an active educator and research mentor, and supervises clinical and research fellows, residents and graduate students. In this role, he also functions as Director of a T32 Training Grant on the Biology of Aging. Dr. Peter Hornsby obtained a Ph.D. in Cell Biology at the Institute of Cancer Research of the University of London. He has held faculty positions at the University of California SanDiego, the Medical College of Georgia, and Baylor College of Medicine. Currently he is Professor in Department of Physiology and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio.

Table of Contents

Foreword Preface Section I: Basic Mechanisms of Aging: Models and Systems Chapter 1 - Longevity as a Complex Genetic Trait George L. Sutphin and Ron Korstanje Chapter 2 - The mTOR Pathway and Aging Katherine H. Schreiber, Monique N. O'Leary, and Brian K. Kennedy Chapter 3 - Sirtuins, Healthspan, and Longevity in Mammals William Giblin and David B. Lombard Chapter 4 - The Hypoxic Response and Aging Scott F. Leiser, Hillary A. Miller, and Matt Kaeberlein Chapter 5 - The Role of Neurosensory Systems in the Modulation of Aging Michael J. Waterson and Scott D. Pletcher Chapter 6 - The Naked Mole-Rat: A Resilient Rodent Model of Aging, Longevity, and Healthspan Kaitlyn N. Lewis and Rochelle Buffenstein Chapter 7 - Contributions of Telomere Biology to Human Age-Related Disease Ting-Lin B. Yang, Shufei Song, and F. Brad Johnson Chapter 8 - Systems Approaches to Understanding Aging Lei Hou, Dan Wang, Hao Cheng, Bo Xian, and Jing-Dong J. Han Chapter 9 - Integrative Genomics of Aging Joao Pedro de Magalhaes and Robi Tacutu Chapter 10 - NIA Interventions Testing Program: A Collaborative Approach for Investigating Interventions to Promote Healthy Aging Nancy L. Nadon, Richard A. Miller, Randy Strong, and David E. Harrison Chapter 11 - Comparative Biology of Aging: Insights from Long-Lived Rodent Species Michael Van Meter, Vera Gorbunova, and Andrei Seluanov Section II: The Pathobiology of Human Aging Chapter 12 - Genetics of Human Aging Miook Cho and Yousin Suh Chapter 13 - The Aging Arterial Wall Mingyi Wang, Robert E. Monticone, and Edward G. Lakatta Chapter 14 - Age-Related Alterations in Neural Plasticity Shannon J. Moore and Geoffrey G. Murphy Chapter 15 - The Aging Immune System: Dysregulation, Compensatory Mechanisms, and Prospects for Intervention Ludmila Muller and Graham Pawelec Chapter 16 - Vascular Disease in Hutchinson Gilford Progeria Syndrome and Aging: Common Phenotypes and Potential Mechanisms Ingrid A. Harten, Michelle Olive, and Thomas N. Wight Chapter 17 - Cardiac Aging Dao-Fu Dai, Ying-Ann Chiao, Robert J. Wessells, Rolf Bodmer, Hazel H. Szeto, and Peter S. Rabinovitch Chapter 18 - Current Status of Research on Trends in Morbidity, Healthy Life Expectancy, and the Compression of Morbidity Eileen M. Cr4immins and Morgan E. Levine Chapter 19 - On the Compression of Morbidity: From 1980 to 2015 and Beyond James F. Fries

Additional information

Handbook of the Biology of Aging by Nicolas Musi (Sam and Ann Barshop Insititute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA)
Used - Like New
Elsevier Science Publishing Co Inc
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The book has been read, but looks new. The book cover has no visible wear, and the dust jacket is included if applicable. No missing or damaged pages, no tears, possible very minimal creasing, no underlining or highlighting of text, and no writing in the margins

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