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Physical Principles in Sensing and Signaling By Robert G. Endres (Reader in Systems Biology, Imperial College London)

Physical Principles in Sensing and Signaling by Robert G. Endres (Reader in Systems Biology, Imperial College London)

Condition - Very Good
$37.99
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Summary

The book addresses how biological cells work, and specifically achieve their remarkable sensing and signaling properties using insights from physics and engineering. The book aims to teach concepts, omitting many of the technical details, and hence should attract a broad readership.

Physical Principles in Sensing and Signaling Summary

Physical Principles in Sensing and Signaling: With an Introduction to Modeling in Biology by Robert G. Endres (Reader in Systems Biology, Imperial College London)

Although invisible to the bare eye, bacterial cells are large enough to make complex decisions. Cells are composed of thousands of different molecular species including DNA, proteins, and smaller molecules, allowing them to sense their environment, to process this information, and to respond accordingly. Such responses include expression of genes or the control of their movement. Despite these properties, a living cell exists in the physical world and follows its laws. Keeping this in mind can help answer questions such as how cells work and why they implement solutions to problems the way they do. Applying physical principles in biology allows researchers to solve challenging problems at the interface between biology and the physical sciences, including how accurately biological cells can sense chemicals in their environment, how cells encode physical stimuli in biochemical pathways, or how cells amplify signals and adapt to persistent stimulation. In this book, the reader is introduced to this fascinating topic without the need for extensive mathematical details or huge prior knowledge in biological physics.

Physical Principles in Sensing and Signaling Reviews

This book organizes and communicates an amazing amount of biophysics using bacterial chemotaxis as an organizing theme. Endres, a leading researcher in cell signaling, writes in an accessible way and coherently covers a vast range of topics - e.g. diffusion, noise, allostery, membrane energetics, information theory, optimization - with crossover appeal to biologists, physicists, and engineers. This work is ideal for senior undergraduates or graduate students with an interest in the exploding field of quantitative biology. * Ned Wingreen, Molecular Biology Department, Princeton University *

About Robert G. Endres (Reader in Systems Biology, Imperial College London)

At Imperial College Robert Endres heads the Biological Physics Group. Recently he won the prestigious ERC Strating Grant award. Before moving to the United Kingdom, Robert was a postdoc with Prof. Ned Wingreen in the Molecular Biology Department at Princeton University, where his main research accomplishments were the understanding of the remarkable signalling properties of bacterial chemotaxis and the atomistic prediction of protein-DNA binding sites.

Table of Contents

1. Preface ; 2. Introduction ; 3. Physical concepts ; 4. Mathematical tools ; 5. Chemotaxis in bacterium Escherichia coli ; 6. Signal amplification and integration ; 7. Robust precise adaptation ; 8. Polar receptor localization and clustering ; 9. Accuracy of sensing ; 10. Motor impulse response ; 11. Optimization of pathway ; 12. 'Seeing' like a bacterium ; 13. Beyond E. coli chemotaxis

Additional information

GOR011247336
9780199600649
0199600643
Physical Principles in Sensing and Signaling: With an Introduction to Modeling in Biology by Robert G. Endres (Reader in Systems Biology, Imperial College London)
Used - Very Good
Paperback
Oxford University Press
2013-01-10
158
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
This is a used book - there is no escaping the fact it has been read by someone else and it will show signs of wear and previous use. Overall we expect it to be in very good condition, but if you are not entirely satisfied please get in touch with us

Customer Reviews - Physical Principles in Sensing and Signaling