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Bacterial Signal Transduction: Networks and Drug Targets By Ryutaro Utsumi

Bacterial Signal Transduction: Networks and Drug Targets by Ryutaro Utsumi

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This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been unearthed.

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Bacterial Signal Transduction: Networks and Drug Targets Summary

Bacterial Signal Transduction: Networks and Drug Targets by Ryutaro Utsumi

A decade has passed since Drs. Hoch and Silhavy edited their comprehensive work entitled Two-Component Signal Transduction. This fascinating book encour- aged many microbiologists and students to enter the new worldofsignal transduction in microbiology. In 2003, Dr. Inouye edited Histidine Kinase in Signal Transduc- tion, which focused on histidine kinases and presented the wealth ofinformation accumulated on this protein family. Bacteria usually possess a numberofTwo-Component Systems (TCSs), rang- ing from a few to over 100. InE. coli, 29 histidine kinases, 32 response regulators, and 1histidine-containing phosphor transmitter (HPt) domain have been found by analyses ofthe K-12 genome. Several examples ofin vitro and in vivo cross-talks and signal transductioncascadesbetweenTCSs inE. coli have beenreported,which suggests the existence ofa TCS network (Chapter 1). Interactions among different TCSs enable one system to respond to multiple signals, which is important for bacteria to minutely adjust themselves to complex environmental changes. Such interactions are found or predicted in various bacteria in this book. Many ofthese interactions might be connected by small proteins such as B1500(Chapter 1)and PmrD (Chapter2). More examplesofsuch proteins should be identified in the near future in order to fill-in the missing parts ofthe bacterial signal transduction network, a new paradigm that is increasingly recognized as the signal transduction pathway in bacterial cells. For drug discovery, this pathway is consideredas important as the signal transductionpathway in animal cells (Chapters 15 and 16).

Bacterial Signal Transduction: Networks and Drug Targets Reviews

Aus den Rezensionen:

"... Dieses Buch ... gibt einen vertiefenden Einblick in die Komplexitat ausgewahlter Histidinkinase/ Antwortregulator-Systeme ... Das Buch ist eine Zusammenstellung aktueller UEbersichtsartikel zu einzelnen Systemen und liefert somit Wissenschaftlern, die an diesen Themen forschen, eine Fulle von Daten ..." (Kirsten Jung, in: BIOspektrum, 2009, Vol. 15, Issue 5, S. 581)

Table of Contents

Introduction to bacterial signal transduction networks.- The PhoQ/PhoP Regulatory Network of Salmonella enterica.- Structural Basis of the Signal Transduction in the Two-Component System.- The two-component network and the general stres sigma factor RpoS (sS) in Escherichia coli.- Small RNAs Controled by Two-Component Systems.- Two-Component Signaling and Gram Negative Envelope Stres Response Systems.- Dual Regulation with Ser/Thr Kinase Cascade and a His/Asp TCS in Myxococcus xanthus.- Two-Component Signaling Systems and Cel Cycle Control in Caulobacter crescentus.- Reg B/Reg A, A Global Redox -Responding Two-Component System.- The BvgS/BvgA Phosphorelay System of Pat hogenic Bordetellae: Structure, Function and Evolution.- Capturing the VirA/VirG TCS of Agrobacterium tumefaciens.- Quorum Sensing and Biofilm Formation by Streptococcus mutans.- The Roles of Two-Component Systems in Virulence of Pat hogenic Escherichia coli and Shigella spp.- Vancomycin Resistance VanS/VanR Two-Component Systems.- Tearing Down the Wall : Peptidoglycan Metabolism and the WalK /Wal R (YycG/YycF) Essential Two-Component System.-Inhibitors Targeting Two-Component Signal Transduction.-

Additional information

Bacterial Signal Transduction: Networks and Drug Targets by Ryutaro Utsumi
Springer-Verlag New York Inc.
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