(NOTE: Each chapter contains a chapter summary, key concepts, and further readings.
)1. Philosophical Issues in Neuroscience.
Studying the Brain. The Mind/Body Problem. Box 1-1: Trephining. Box 1-2: Solipsism and Social Relativism
. Teleology Versus Deontology. The Whole and the Parts. "The Law of Equipotentiality". Box 1-3: Split Brains. 2. The Cellular Basis of Behavior.
Neuron Doctrine Versus Reticular Theory. Box 2-1: Santiago Ramon y Cajal
. The Plasma Membrane. Genetics in a Nutshell. Some Proteins Important to Cell Function. The Active Neuron.3. Communication Among Neurons: The Membrane Potential.
The Basics of Chemistry. A Semi-Permeable Membrane. Box 3-1: The Nernst Equation and the Goldman Equation
. Measuring the Membrane Potential. Three Forces and Three Gates. The "Equivalent Circuit". Box 3-2: Ohm's Law Simplified. Box 3-3: A Biologist's Definition of Life and Death
.4. Communicating Among Neurons: The Action Potential.
The Electrically Excitable Domain. Box 4-1: The Squid Giant Axon and the Voltage Clamp
. The Action Potential Explained. Functions of the Sodium Channel. Functions of the Potassium Channel. Heterogeneity and Homology. Box 4-2: Discovering Channel Structure
. The "Equivalent Circuit" Revisited. Box 4-3: Cable Properties of Neurons
. Special Channels for Calcium.5. Communicating Among Neurons: The Synaptic Potential.
The Chemically Excitable Domain. Summation and Integration. Special Channels for Calcium. The Quantal Nature of Synaptic Transmission. Receptor Theory. Box 5-1: The Importance of Poisons and Toxins
. Acetylcholine. Box 5-2: Otto Loewi and the Frog Heart
. Gamma-Amino Butyric Acid (GABA). Box 5-3: How GABA Blocks the Action Potential
. Glutamate, Aspartate, and Glycine. Catecholamines, Indolamines, and Histamine. Box 5-4: Parkinson's Disease and Homeostasis
. Peptide Synthesis. The Concept of Neuromodulation. Criteria for Transmitter Identification. Electrotonic Synapses.6. The Autonomic Nervous System.
Dual Innervation. Anatomy. Receptors. Nonsynaptic Release. The Adrenal Gland. How "Autonomic" is it? Box 6-1: Psychophysiology and the "Lie Detector" Test
. The Special Case of Sex. The Sensory Component. The Enteric Nervous System and Other Simple Systems. Transmitters Common to ANS and CNS. Box 6-2: Difficulties in Drug Design
.7. The Spinal Cord.
A Functional Segregation. Sensory Pathways. Box 7-1: Brown-Sequard Syndrome
. Motor Pathways. Box 7-2: Diseases of the Upper and Lower Motor Neuron
. Integrative Circuits in the Cord. Box 7-3: Animal Welfare and Animal Rights
.8. Functional Anatomy of the Brain.
Orientation. Gross Subdivisions of Brain. Box 8-1: Bell's Palsy and Carpal Tunnel Syndrome
. Brainstem Projections to the Forebrain. Basal Ganglia. Limbic System. Box 8-2: The "Hierarchy of Being"
. Hypothalamus and Pituitary. Thalamus. Neocortex. Box 8-3: Frontal Lobotomy. Box 8-4: Pseudoscience
. Other Neocortex. Ventricles. Meninges and the Blood Brain Barrier. Tract-Tracing Techniques and Stereotaxy.9. Sensory Systems.
Somatosensory Systems. Box 9-1: Homunculi
. Auditory System. Box 9-2: "The Cocktail Party Phenomenon"
. Olfaction and Gustation. Vision. Box 9-3: Serial or Parallel Processing?
. Six Principles of Sensory Physiology.10. Motor Systems.
The Frontal and Parietal Lobes. Box 10-1: Intention, Volition and "Free Will"
. The Basal Ganglia. The Cerebellum. Box 10-2: The Cerebellum as a Vector Analyzer
. The Importance of Inhibition. Box 10-3: An Experiment in Efference Copy
. Command Neurons and Motor Tapes.11. Pleasure and Pain.
The Problem of Definitions. Is There a "Pleasure Circuit" in the Brain? Box 11-1: Motivation and "Drive"
. Ascending Nociceptor Systems. Box 11-2: "Dale's Law"
. Descending Analgesia Systems. The Mechanism of Opioid Peptide Action. Box 11-3: Chronic Pain and Stimulation - Produced Analgesia. Box 11-4: Placebo and Opioid Peptides
.12. Hormones, Sex, and Reproduction.
Hormones and "the Master Gland". The Determination of Gender. Box 12-1: Mammals are Basically Female, with Male Characteristics Added. Box 12-2: Feminizing Effects of Pollution? Box 12-3: The Future of Chemical Castration
. Conception, Pregnancy, and Birth. Pheromones. Neural Circuits for Mating and Reproduction. Box 12-4: Neurobiology and the "Battle of the Sexes"
.13. Sleep and Dreaming.
Circadian Rhythms. Stages of Sleep. Neural Mechanisms for Sleep and Waking. Box 13-1: The "Reticular Activating System"
. Why Do We Sleep? Box 13-2: Sleep Deprivation Experiments
. Sleep Disorders. Box 13-3: "Sleeping Medication" and the Elderly
.14. Eating, Drinking, and Homeostasis.
Brain Metabolism. Blood Flow. Energy Use. Box 14-1: How Bright is the Bulb?
Techniques for Studying Brain Activity. Eating. Box 14-2: A Role for Insulin in the Brain? Box 14-3: CCK - A Satiety Signal?
Eating Disorders. Drinking.15. Development and Learning.
Development of the Nervous System. Neurogenesis. Neuronal Migration. Neuronal Differentiation. Axon Development and Growth Cone Guidance. Box 15-1: Levi-Montalcini and Nerve Growth Factor
. Synaptogenesis. Activity-Dependent Fine-Tuning of the Nervous System. Box 15-2: The Visual System as a Model for Development and Plasticity
. Learning Theory. Box 15-3: Learning of Bird Song: A Novel Neural Mechanism
. Simple System Models for Plasticity. Vertebrate Models for Plasticity. Vertebrate Model Systems.16. Language and Higher Cognitive Function.
Human Neurobiology. Box 16-1: The Importance of Introspection
. Results from Communication in and with Other Species. Results from Diagnostic Neurology. Box: 16-2 Prosopagnosia and "Blindsight". Box 16-3: Lateralization of Function
. Organic Brain Syndromes. Epilepsy. Results From Noninvasive Imaging Techniques. Results From Brain Stimulation. Consciousness and the Self. Box 16-4: Unilateral Neglect
Agonists and Antagonists. Pharmacokinetics. Addiction, Tolerance, and Withdrawal. Central Nervous System Depressants. Box 17-1: The GABA Receptor Complex
. Central Nervous System Stimulants. Box 17-2: The Problem of Specificity
. Hallucinogens. Opiates.18. The Biology of Mental Illness.
Taxonomy of Mental Illness: The DSM IV. Schizophrenia. Box 18-1: The Story of "Transmethylation"
. Affective Disorders. Box 18-2: John Cade and the Discovery of Lithium. Box 18-3: Ugo Cerletti and Electroconvulsive Shock
. Anxiety Disorders. The Hazards of Medication. Conclusion.Appendix: Further Topics in Biology and Chemistry. References. Further Readings. Name Index. Subject Index.