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However, progress has been noticeably slower than for prokaryotes, essentially because of the difficulty in genetic analysis of eukaryo- tic DNA replication. In June 1980, a workshop was organized in Cargese, Corsica (France) to facilitate exchanges of information between workers spe- cializing in prokaryotes and those specializing in eukaryotes, and to allow discussion of new experimental approaches. 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From war and insurrection, to prosperity and development, the changes wrought by history have meant that a whole swathe of our built past no longer survives, save through the magic of the camera lens. 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High inflation and fluctuating exchange rates in the de- veloped Western world have served to strengthen the forces of disequilibrium in the fmancial markets, leading to an investment situation with several unusual but significant factors. Capital spending by business, leading to the creation of new jobs, has not been reduced substantially during this period of uncertainty, as happened in similar periods in the past. This is shown in part by the continuing low unemployment rates in evidence during the period, which are in contradic- tion to the trend exhibited in similar past periods. The expanding financing re- quirements resulting from high price inflation have led to an increase in the capital intensity of firms, and thus to enhanced sensitivity of their income streams to economic fluctuations. 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