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In recent years it has been recognized that strake pathophysiology is a dynamic pracess, and that delayed pracesses, which occur dur- ing the days and weeks following arterial occIusion, may lead to further deterioration or to impairment of recovery and rehabilitation in subacute and chranic stages. Evidence is accumulating that neu- rainflammation is a major player in these delayed pathophysiologi- cal pracesses. While some components of neurainflammation such as removal of cell debris and release of traphic factors may support recovery pracesses, others such as the generation of free radicals and other cytotoxic mediators are deleterious for brain tissue after isch- emia. Thus, neurainflammation after strake can be considered a dou- ble-edged sword, having potentially both detrimental and beneficial effects. 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In addition, thrombolysis and neuroprotection by hypothermia, first described in animal models, are key examples of treatment modalities that have made it successfully into clinical practice. In Rodent Models of Stroke, an international consortium of authors aims at critically addressing the issues on a very practical level, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. The structure and content of the book reflect both the authors' longstanding expertise in experimental and clinical stroke research and their roles in training the scientific community in the tools of the trade. As a volume in the successful Neuromethods series, the chapters provide authoritative reviews of the most commonly used, well-honed approaches in the field today. Stimulating and easy-to-use, Rodent Models of Stroke will help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52121423380753,"sku":"NLS9781493981670","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781493981670.jpg?v=1757430714"},{"product_id":"optical-imaging-of-brain-function-and-metabolism-book-ulrich-dirnagl-9780306445286","title":"Optical Imaging of Brain Function and Metabolism","description":"- . . . . At last the doctor will be freed from the tedious interpretation of screens and photographs. Instead, he will examine and scan through his patient directly. Wearing optical-shutter spectacles and aiming a pulsed laser torch, he will be able to peer at the beating heart, study the movement of a joint or the flexing of a muscle, press on suspect areas to see how the organs beneath respond, check that pills have been correctly swallowed or that an implant is savely in place, and so on. A patient wearing white cotton or nylon clothes that scatter but hardly absorb light, may not even have to undress . . . . -. David Jones, Nature (1990) 348:290 Optical imaging of the brain is a rapidly growing field of heterogenous techniques that has attracted considerable interest recently due to a number of theoretical advantages in comparison with other brain imaging modalities: it uses non- ionizing radiation, offers high spatial and temporal resolution, and supplies new types of metabolic and functional information. From a practical standpoint it is important that bedside examinations seem feasible and that the implementations will be considerably less expensive compared with competing techniques. In October 1991, a symposium was held at the Eibsee near Garmisch, Germany to bring together the leading scientists in this new field.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52129251262737,"sku":"NLS9780306445286","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780306445286.jpg?v=1757495711"},{"product_id":"rodent-models-of-stroke-book-ulrich-dirnagl-9781607617495","title":"Rodent Models of Stroke","description":"1. From Bedside to Bench: How Clinical Reality Should Instruct Stroke Modeling Pauline Patak and Dirk M. Hermann 2. How to Avoid Bumping into the Translational Roadblock Malcolm Macleod 3. Modeling Focal Cerebral Ischemia in Rodents: Introduction and Overview Vincent Prinz and Matthias Endres 4. Focal Cerebral Ischemia in the Mouse and Rat Using the Intraluminal Suture-Filament Model Ludmila Belayev, Matthias Endres, and Vincent Prinz 5. Focal Ischemia Models: Middle Cerebral Artery Occlusion Induced by Electrocoagulation, Occluding Devices, and Endothelin-1 I. Mhairi Macrae 6. Rodent Models of Thromboembolic Stroke Cyrille Orset, Benoit Haelewyn, Kilian Vivien, Denis Vivien, and Alan R. Young 7. Photochemical and Endothelin Models of Focal Brain Ischemia Otto W. Witte 8. Housing in an Enriched Environment: A Tool to Study Functional Recovery after Experimental Stroke Karsten Ruscher and Tadeusz Wieloch 9. Modeling Risk Factors and Confounding Effects in Stroke Barry McColl, David Howells, Nancy Rothwell, and Adam Denes 10. Effect of Anesthesia in Stroke Models Richard J. Traystman 11. Non-Invasive Brain Imaging in Small Animal Stroke Models: MRI and PET Anna M. Planas 12. Noninvasive Optical Imaging in Small Animal Models of Stroke Andreas Wunder and Jan Klohs 13. Behavioral Testing in Mouse Models of Stroke Mustafa Balkaya and Matthias Endres 14. Behavioral Testing in Rodent Models of Stroke Gerlinde A. Metz 15. Histology and Infarct Volume Determination Clemens Sommer 16. Ethics of Modeling of Cerebral Ischemia in Small Animals Ute Lindauer 17. Quality Control and Standard Operating Procedures Ulrich Dirnagl 18. Statistics in Experimental Stroke Research: From Sample Size Calculation to Data Description and Significance Testing Ulrich Dirnagl 19. 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