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Cyclic ADP-Ribose and NAADP By Hon Cheung Lee

Cyclic ADP-Ribose and NAADP
by Hon Cheung Lee

In Stock
£79.99
In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers.
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Cyclic ADP-Ribose and NAADP Summary


Cyclic ADP-Ribose and NAADP: Structures, Metabolism and Functions by Hon Cheung Lee

In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers. A wide range of physiological functions are now known to be mediated by them in cells spanning three biological kingdoms from protist, plant to animal. This is the first book devoted entirely to the field. The story behind the emergence of the field is told and followed by comprehensive reviews of the enzymology, regulations and gene structures of ADP-ribosyl cyclases responsible for metabolizing cADPR and NAADP. Also covered is some of the current methodology developed for and widely used in the field. The rest of the book focuses on and details the Ca2+ signaling mechanisms and specific physiological functions of these two messengers in various cellular systems.

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Table of Contents


Preface. Cyclic ADP-Ribose and NAADP: A Story of Two Calcium Messengers; H.C. Lee. ADP-Ribosyl Cyclases: A Family of cADPR and NAADP Metabolizing Enzymes; H.C. Lee, et al. Regulation of Synthesis of cADPR and NAADP; A. Galioni. A Natural History of the Human CD38 Gene; E. Ferrero, F. Malavasi. A Yeast Expression System of High Efficiency for Producing Recombinant Enzymes; C.B. Munshi, H.C. Lee. Novel Cycling Assays for cADPR and NAADP; R. Graeff, H.C. Lee. Pharmacology of Cyclic ADP-Ribose and NAADP Synthesis and Properties of Analogs; T.F. Walseth, H.C. Lee. Separate but Interacting Calcium Stores; H.C. Lee. Sensitizing Calcium-Induced Calcium Release Role of cADPR as an Endogenous Modulator; A.J. Morgan, A. Galione. Spatial and Temporal Control of Calcium Signaling by NAADP; G.C. Churchill, et al. Regulation of Immune Responses by CD38 and cADPR; F.E. Lund, et al. Subcellular and Extracellular Trafficking of NAD+ and Cyclic ADP-Ribose: A New Way for Regulating Intracellular Calcium Homeostasis; A.De Flora, et al. The CD38-Cyclic ADP-Ribose Signal System in Pancreatic beta-Cells. The Discovery and Biological Significance of a Novel Signal System in Mammalian Cells; S. Takasawa, H. Okamoto. The Role of cADPR and NAADP in T Cell Calcium Signaling and Activation; A.H. Guse. Calcium Signaling by cADPR in Cardiac Myocytes; S. Rakovic, D.A. Terrar. Cyclic ADP-Ribose and Vasomotor Response; P.L. Li, et al. Coordination of Calcium Signaling by cADPR and NAADP in Pancreatic Acinar Cells; J.M. Cancela. Calcium and Calcium-Linked Second Messengers are Main Actors in the Maturation and Fertilization of Starfish Oocytes; L. Santella, et al. ADP-Ribosylation and CD38 Signaling; U.H. Kim, et al. Retinoid-Mediated Signaling and CD38 Expression; K. Mehta. Calcium Regulation in Smooth Muscle Through the CD38/Cyclic ADP-Ribose Pathway; T.A. White, et al. Author Index. Subject Index.

Additional information

GOR009936605
Cyclic ADP-Ribose and NAADP: Structures, Metabolism and Functions by Hon Cheung Lee
Hon Cheung Lee
Used - Very Good
Hardback
Springer-Verlag New York Inc.
2002-11-30
460
1402072813
9781402072819
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
This is a used book - there is no escaping the fact it has been read by someone else and it will show signs of wear and previous use. Overall we expect it to be in very good condition, but if you are not entirely satisfied please get in touch with us.