{"title":"Abdel-Majid Khatib","description":null,"products":[{"product_id":"proprotein-convertases-book-abdel-majid-khatib-9781615045365","title":"The Proprotein Convertases","description":"Proprotein convertases (PCs) are a family of proteases including PC1, PC2, Furin, PC4, PACE4, PC5, and PC7. These enzymes are involved in the maturation of many precursor proteins involved in the process of tumorigenesis and metastasis. Since their discovery, PCs were suggested as potential targets for anti-cancer therapy, and their activity was found to directly affect tumor cell proliferation, migration invasion, and the malignant phenotypes of tumor cells. Here, we discuss a number of previous and recent findings on the PCs features, their implication in the regulation of multiple cellular functions that impact on the invasive\/metastatic potential of cancer cells, and their clinical relevance in cancer patients. Among the substrates of the proprotein convertases, various growth factors, their receptors, adhesion molecules, and proteases were identified. The PCs are inhibited by endogenous and exogenous inhibitors. To date, only pro7B2, a specific chaperone of PC2, and the granine-like precursor of neuroendocrine protein proSAS, a selective ligand of PC1, have been identified as endogenous inhibitors of the PCs found in the regulated pathway. However, only PCs prosegments, several bioengineered inhibitors, peptides, and non-peptide compounds were found to inhibit the activity of the PCs found in the secretory pathway.","brand":"WoB","offers":[{"title":"GB \/ VERY_GOOD \/ INTERNAL","offer_id":49637460541713,"sku":"GOR012700850","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"US \/ NEW \/ INGRAM","offer_id":51219706970385,"sku":"NIN9781615045365","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52589280493841,"sku":"NLS9781615045365","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1615045368.jpg?v=1751088670"},{"product_id":"regulation-of-carcinogenesis-angiogenesis-and-metastasis-by-the-proprotein-conve-book-abdel-majid-khatib-9789401780902","title":"Regulation of Carcinogenesis, Angiogenesis and Metastasis by the Proprotein Convertases (PC's)","description":"Convertases are widely expressed activating enzymes involved in various physiological and pathological processes. The purpose of this book is to provide detailed and updated information on the role of these molecules in cancer. This book is the first to summarize current knowledge about the importance of protein precursors maturation by the convertases in tumor progression, angiogenesis and metastasis. In each chapter, the importance of the convertases in the activation of various cancer-related molecules including growth factors, adhesion molecules and proteases is discussed. Also this book covers the role of some convertases in the clinical setting.       The book will be of interest to basic researchers as well as clinicians. It will also interest those working in the cancer research area and the pharmaceutical industry, who are looking for new strategies in cancer therapy. Finally, this book is also a useful reference for researchers and clinicians pursuing research on growth factors, adhesion molecules, proteases and their implications in the processes of tumor progression, angiogenesis and metastasis.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52341777334545,"sku":"NLS9789401780902","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789401780902.jpg?v=1758172084"},{"product_id":"regulation-of-carcinogenesis-angiogenesis-and-metastasis-by-the-proprotein-conve-book-abdel-majid-khatib-9781402047930","title":"Regulation of Carcinogenesis, Angiogenesis and Metastasis by the Proprotein Convertases (PC's)","description":"Convertases are widely expressed activating enzymes involved in various physiological and pathological processes. The purpose of this book is to provide detailed and updated information on the role of these molecules in cancer. This book is the first to summarize current knowledge about the importance of protein precursors maturation by the convertases in tumor progression, angiogenesis and metastasis. In each chapter, the importance of the convertases in the activation of various cancer-related molecules including growth factors, adhesion molecules and proteases is discussed. Also this book covers the role of some convertases in the clinical setting.       The book will be of interest to basic researchers as well as clinicians. It will also interest those working in the cancer research area and the pharmaceutical industry, who are looking for new strategies in cancer therapy. Finally, this book is also a useful reference for researchers and clinicians pursuing research on growth factors, adhesion molecules, proteases and their implications in the processes of tumor progression, angiogenesis and metastasis.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52455723630865,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52455723860241,"sku":"NLS9781402047930","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781402047930.jpg?v=1759375165"}],"url":"https:\/\/www.worldofbooks.com\/en-gb\/collections\/author-books-by-abdel-majid-khatib.oembed","provider":"World of Books ","version":"1.0","type":"link"}