{"title":"Iconcept Press","description":null,"products":[{"product_id":"neurological-disorders-black-and-white-book-iconcept-press-9781922227737","title":"Neurological Disorders (Black and White)","description":null,"brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51105748549905,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51105752056081,"sku":"NIN9781922227737","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1922227730.jpg?v=1751282087"},{"product_id":"breeding-and-genetic-engineering-book-iconcept-press-9781922227355","title":"Breeding and Genetic Engineering","description":null,"brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51118250787089,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51118252654865,"sku":"NIN9781922227355","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1922227358.jpg?v=1751062196"},{"product_id":"research-on-diabetes-i-book-iconcept-press-9781477555019","title":"Research on Diabetes I","description":null,"brand":"WoB","offers":[{"title":"US \/ NEW \/ INGRAM","offer_id":51151844704529,"sku":"NIN9781477555019","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1477555013.jpg?v=1750716049"},{"product_id":"epidemiology-ii-book-iconcept-press-9781922227768","title":"Epidemiology II","description":null,"brand":"WoB","offers":[{"title":"- \/ - 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Cervical cancer is when cancer arises from the cervix. Early on there are typically no symptoms. Later symptoms may include abnormal vaginal bleeding, pelvic pain or pain during sex. Breast cancer is when cancer develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, or a red scaly patch of skin. Prostate cancer is when cancer develops in the prostate, a gland in the male reproductive system. It may initially cause no symptoms. In later stages it can cause difficulty urinating, blood in the urine, or pain in the pelvis, back or when urinating. This book provides some latest research and findings on breast cancer, cervical cancer and prostate cancer. The aim of this book is to serve as an important reference book for individuals working in biomedical laboratories, and for clinical professionals. \u003cp\u003e\u003c\/p\u003e There are totally 13 chapters in this book. Chapter 1 proposes an outlook on different endoscopic surgical procedures to treat cervical cancer, using traditional laparoscopy and robotics. Chapter 2 reviews the clinical results of carbon ion radiotherapy (C-ion RT) for uterine cervical cancer. Carbon-ion RT has been established as a safe short-term treatment for locally advanced uterine cervical cancer. Chapter 3 summarises chrysin inhibits proliferation, induces apoptosis and reduce angiogenesis in most tested cancer cells, including cervical cancer cells. Chapter 4 shows that involving physicians in the promotion of public health programs and initiatives is a viable option. \u003cp\u003e\u003c\/p\u003e Chapter 5 summarizes the published findings about the controversial role of METCAM, a cell adhesion molecule, in the progression of human breast cancer. Chapter 6 focuses on the biology of \u003ci\u003eneu\u003c\/i\u003e in breast cancer - the potential mechanisms that may contribute to tumor resistance and the numerous uncertainties that persist despite the bona-fide progress made in treating this particular subtype of breast cancer. Chapter 7 describes the mechanisms by which estrogen can exert its role in estrogenresponsive cells, focusing on specific aspects of estrogen receptor signaling. Moreover, this chapter shows how some of the proteins involved in estrogen receptor signaling can be used as predictive markers in breast cancer and describes a proposed clinical study related to the combined use of two drugs (bortezomib and tamoxifen) as therapeutic agents for estrogen receptor negative breast cancers. Chapter 8 summarizes the recent studies indicating that AngII facilitates breast cancer metastasis by contributing to the cross-talk between cancer cells and the host stroma. \u003cp\u003e\u003c\/p\u003e Chapter 9 focuses on a rationale pharmaceutical development along with a detailed understanding of biological effects so as to accelerate the incorporation of nanocarriers in breast cancer therapy. Chapter 10 summarizes the mTOR pathway and the clinical results in breast cancer treatment, relating them to results obtained using cultured MCF-7 breast cancer tamoxifen resistant sublines. Chapter 11 discusses how to develop a standard extraction method, yielding tomato products which are suitable for cell cultures, and enable product comparison of different tomato varieties. \u003cp\u003e\u003c\/p\u003eChapter 12 describes principles and processes that are involved in investigating biological or clinical problems with nuclear magnetic resonance (NMR) based metabolomics - an approach that involves the global analysis of metabolites. The authors use prostate cancer as a case study to outline the processes, applications and potential of metabolomics for inform scientists and clinicians. Chapter 13 discusses the epidemiology, screening, diagnosis and treatment options of prostate cancer and its association with osteoporosis.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51644597698833,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51644597960977,"sku":"NIN9781922227713","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1922227714.jpg?v=1751093001"},{"product_id":"cervical-breast-and-prostate-cancer-black-and-white-book-iconcept-press-9781922227720","title":"Cervical, Breast and Prostate Cancer (Black and White)","description":"Cervical cancer and breast cancer are two of the most common cancers found in women. Cervical cancer is when cancer arises from the cervix. Early on there are typically no symptoms. Later symptoms may include abnormal vaginal bleeding, pelvic pain or pain during sex. Breast cancer is when cancer develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, or a red scaly patch of skin. Prostate cancer is when cancer develops in the prostate, a gland in the male reproductive system. It may initially cause no symptoms. In later stages it can cause difficulty urinating, blood in the urine, or pain in the pelvis, back or when urinating. This book provides some latest research and findings on breast cancer, cervical cancer and prostate cancer. The aim of this book is to serve as an important reference book for individuals working in biomedical laboratories, and for clinical professionals. \u003cp\u003e\u003c\/p\u003e There are totally 13 chapters in this book. Chapter 1 proposes an outlook on different endoscopic surgical procedures to treat cervical cancer, using traditional laparoscopy and robotics. Chapter 2 reviews the clinical results of carbon ion radiotherapy (C-ion RT) for uterine cervical cancer. Carbon-ion RT has been established as a safe short-term treatment for locally advanced uterine cervical cancer. Chapter 3 summarises chrysin inhibits proliferation, induces apoptosis and reduce angiogenesis in most tested cancer cells, including cervical cancer cells. Chapter 4 shows that involving physicians in the promotion of public health programs and initiatives is a viable option. \u003cp\u003e\u003c\/p\u003e Chapter 5 summarizes the published findings about the controversial role of METCAM, a cell adhesion molecule, in the progression of human breast cancer. Chapter 6 focuses on the biology of \u003ci\u003eneu\u003c\/i\u003e in breast cancer - the potential mechanisms that may contribute to tumor resistance and the numerous uncertainties that persist despite the bona-fide progress made in treating this particular subtype of breast cancer. Chapter 7 describes the mechanisms by which estrogen can exert its role in estrogenresponsive cells, focusing on specific aspects of estrogen receptor signaling. Moreover, this chapter shows how some of the proteins involved in estrogen receptor signaling can be used as predictive markers in breast cancer and describes a proposed clinical study related to the combined use of two drugs (bortezomib and tamoxifen) as therapeutic agents for estrogen receptor negative breast cancers. Chapter 8 summarizes the recent studies indicating that AngII facilitates breast cancer metastasis by contributing to the cross-talk between cancer cells and the host stroma. \u003cp\u003e\u003c\/p\u003e Chapter 9 focuses on a rationale pharmaceutical development along with a detailed understanding of biological effects so as to accelerate the incorporation of nanocarriers in breast cancer therapy. Chapter 10 summarizes the mTOR pathway and the clinical results in breast cancer treatment, relating them to results obtained using cultured MCF-7 breast cancer tamoxifen resistant sublines. Chapter 11 discusses how to develop a standard extraction method, yielding tomato products which are suitable for cell cultures, and enable product comparison of different tomato varieties. \u003cp\u003e\u003c\/p\u003eChapter 12 describes principles and processes that are involved in investigating biological or clinical problems with nuclear magnetic resonance (NMR) based metabolomics - an approach that involves the global analysis of metabolites. The authors use prostate cancer as a case study to outline the processes, applications and potential of metabolomics for inform scientists and clinicians. Chapter 13 discusses the epidemiology, screening, diagnosis and treatment options of prostate cancer and its association with osteoporosis.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51679900303633,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51679900500241,"sku":"NIN9781922227720","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1922227722.jpg?v=1751028743"},{"product_id":"neurological-disorders-book-iconcept-press-9781922227744","title":"Neurological Disorders","description":"\u003cp\u003eA neurological disorder is any disorder of the body's nervous system. Symptoms include, but do not limited to, paralysis, muscle weakness, poor coordination, loss of sensation, seizures, confusion, and altered levels of consciousness. \u003ci\u003eNeurological Disorders - Clinical Methods\u003c\/i\u003e brings scholars and experts who are working in the areas directly related to neurological disorder in front of you, and presents the latest research findings to you.\u003c\/p\u003e \u003cp\u003eChapter 1 reviews Temporal Lobe Epilepsy (TLE). TLE is a well-described type of epilepsy but little is known about the epidemiology. The approach to patients with temporal lobe epilepsy is complex and requires a multidisciplinary team of trained specialists. Large-scale epidemiological studies are needed for improve the understanding of TLE is a therefore necessary.\u003c\/p\u003e \u003cp\u003eChapter 2 presents the latest knowledge on the understand of the current sources in epileptic activity in mesial areas. Current sources is a very promising tool to refine radiosurgical and improve classical surgical methods for temporal lobe epilepsy.\u003c\/p\u003e \u003cp\u003eChapter 3 highlights the atypical co-occurrence of two genetic disorders, Cornelia de Lange syndrome and Turner syndrome, in the same individual. It focuses on the clinical methods used to explain each clinical feature, with special emphasis on neurological findings. \u003c\/p\u003e \u003cp\u003eChapter 4 concerns the use of of probiotics to prevent fungal infection against the decrease of morbidity and mortality in ELBW, especially about long lasting neurological sequelae.\u003c\/p\u003e \u003cp\u003eChapter 5 describes an algorithm called Dynamic Autoregressive Neuromagnetic Causal Imaging (DANCI) which uses Granger causality to calculate effective connectivity from magnetoencephalography recordings. It also describes how this technique can be used to understand the fundamental reorganization of neural networks in neurodevelopmental disorders.\u003c\/p\u003e \u003cp\u003eChapter 6 provides important and necessary information regarding brain herniation. Brain herniation represents a shift of brain parenchyma across the various anatomical boundaries formed by intracranial bony ridges and dural folds. This chapter emphasises on the need of emergency resuscitation and step-wise management of the patients.\u003c\/p\u003e \u003cp\u003eChapter 7 describes spinal shortening as a new option for anterior reconstruction of the thoracic and lumbar spine after posterolateral debridment for spinal infections. Although technically demanding, this technique has a lot of advantages including short operative time, avoid morbidity of bone graft donor site, gives high biomechanical stability and high fusion rate.\u003c\/p\u003e \u003cp\u003eChapter 8 highlights the following two aspects: (1) The increase of high alpha relative to low alpha power is a reliable EEG marker of hippocampal atrophy and it is predictive of conversion of patients with Mild Cognitive Impairment (MCI) in Alzherimer's disease (AD); (2) The MCI subjects with higher a3\/a2 ratios showed minor atrophy in the impulsive disorders network bilaterally when compared to subjects with lower and middle a3\/a2 ratios. It could suggest a functional hyperactivity of the cortico-accumbens-ventral striatum loop in prodromal AD explaining some early cognitive-behavioral symptoms.\u003c\/p\u003e \u003cp\u003eChapter 9 provides an overview of the main schools of psychotherapy, the prevalence of psychological disorders, and main cultural issues in psychotherapy. It also describes an Omani study that explored the utilization of psychotherapy within an Arabic\/Islamic society, with unique value\/and belief systems.\u003c\/p\u003e","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51679900664081,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51679900827921,"sku":"NIN9781922227744","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1922227749.jpg?v=1751380218"},{"product_id":"cardiovascular-disease-i-book-iconcept-press-9781922227546","title":"Cardiovascular Disease I","description":"Cardiovascular disease is a class of diseases that involve the heart or blood vessels, such as arteries, capillaries and veins. Cardiovascular diseases remain the biggest cause of deaths worldwide, though over the last two decades, cardiovascular mortality rates have declined in many high-income countries. At the same time, cardiovascular deaths and disease have increased at a fast rate in low- and middle-income countries. The causes of cardiovascular disease are diverse but atherosclerosis and\/or hypertension are the most common ones. \u003cp\u003e\u003c\/p\u003e This book is targeted for researchers, scholars or other health care providers who need a ready reference for cardiovascular disease ranging from causes, signs and symptoms, and diagnosis through treatment and special considerations. There are two volumes. This book is the first volume. There are totally 12 chapters in this book. Chapter 1 proposes that the renal artery diameter could represents a marker of non-traditional cardiovascular risk factors in selected populations. A pathophysiological explanation, including main biophysical background, and clinical implication of this new finding has been critically discussed. Bicuspid aortic valve (BAV) is the commonest congenital cardiac disease and is characterized by the aortic valve only having two leaflets rather than the usual three. Chapter 2 provides a comprehensive review of the condition, from epidemiology and etiology to diagnosis and management. In the case of coronary artery disease, cardiomyocytes' oxygen supply and thus the heart's contractility diminishes with the consequence that the oxygen demands of the whole organism are no longer fulfilled. Chapter 3 focuses on retroperfusion and it is shown that it is possible to perform a regional venous retrobypass in a long term pig model. Chapter 4 discusses the FGF23\/Klotho system, which is a new biological system with a pivotal role in normal regulation of phosphorus homeostasis.. \u003cp\u003e\u003c\/p\u003e Chapter 5 assesses the effect of high-intensity and moderate intensity exercise on the exercise efficiency of ischaemic heart disease patients. Although ischemic heart disease patients were more inefficient during high-intensity exercise, this type of exercise may provide greater benefits for this population group due to eliciting a higher physiological response and energy expenditure. Chapter 6 presents the characteristics of cardiovascular manifestations, including cardiac manifestations, cerebrovascular disease, pulmonary vascular involvement, renal vascular involvement, intestinal vasculitis, and cutaneous vasculitis. All of them are analyzed and described using a retrospective review of the medical records of 1125 SLE patients examined in Juntendo University Hospital between 1955 and 2002. Chapter 7 shows that serotonin, angiotensin II, urotensin II, cardiotrophin-1 and salusin-B exert proatherogenic effects, whereas adiponectin, GLP-1, GIP, heregulin-B1 and salusin-a have antiatherogenic effects. Chapter 8 highlights the role mutations of mitochondrial genome in atherosclerosis. \u003cp\u003e\u003c\/p\u003e Chapter 9 reviews the relationship between thiamine and MI. Genetic studies provide opportunities to determine which proteins link thiamine to MI pathology. Chapter 10 illustrates a variety types of peripheral vascular disease including from etiology to endovascular treatment. Especially, venous vascular disease are shown as not only endovascular treatment but pharmaceutical therapy. Chapter 11 proposes conventional and new techniques\/methods for diagnosis and treatment of the cardiovascular disease. In addition, the chapter explain the comparison of conventional formulation and new nanomedicine therapy of cardiovascular disease. Chapter 12 describes all aspects of cardiogenic shock, especially as the complication of acute myocardial infarction.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52755985006865,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52755985596689,"sku":"NIN9781922227546","price":0.0,"currency_code":"GBP","in_stock":false}]},{"product_id":"obesity-research-book-iconcept-press-9781922227676","title":"Obesity Research","description":"\u003cp\u003eObesity is a major contributor to serious health conditions including type-2 diabetes, cardiovascular disease and arthritis. It is a major threat to the health across all ages, races, and socioeconomic groups, and in particular within disadvantaged and underserved communities. Promoting healthy weight requires concerted efforts, including quality improvement, from health care, public health and communities. This book offers prompt publication of original research and presents new information. Specifically, the intent is to address the following areas with respect to obesity prevention: potential interventions, bariatric surgery, arthritis, type 1 and 2 diabetes mellitus, hypercholesterolemia and atherosclerosis.\u003c\/p\u003e \u003cp\u003eIn Chapter 1, the authors review comparative prevalence of obesity and its trend in Canada, various determinants and risk factors, and potential strategies for its prevention.\u003c\/p\u003e \u003cp\u003eChapter 2 synthesizes school-based obesity prevention interventions which incorporate environmental change. Recommendations for the development of future multi-component interventions which incorporate environmental change are provided. \u003c\/p\u003e \u003cp\u003eChapter 3 reviews the latest literature on the cost effectiveness of bariatric surgery. Analysis shows that bariatric surgery is cost effective compared to conventional treatment or no treatment, particularly in severely obese and diabetic patients with convincing incremental cost-utility ratios (ICUR) ranging from \\$1,000--\\$40,000 per quality adjusted life years.\u003c\/p\u003e \u003cp\u003eChapter 4 discusses the use of biologics for management of Rheumatoid Arthritis (RA). RA is a chronic, frequently progressive, and destructive autoimmune disease. As the disease progresses, irreversible joint damage may lead to loss of function and physical disability. Since this disease cannot be cured, management of this disease becomes an important endeavor with the aim of inducing and maintaining remission, and altering the course of disease.\u003c\/p\u003e \u003cp\u003eChapter 5 with the prevention of spinal glial activation by fluorocitrate in an attempt to maintain prolonged pain relief and the prevention of opioid dependence. It discusses the possibility that the analgesic effect of fluorocitrate intratecal (i.t.) administration in a rat model of experimental arthritis can be possibly modulated by the i.t. administration of D-serine.\u003c\/p\u003e \u003cp\u003eChapter 6 proposes that Lean type 2 diabetes is a distinct and fairly common clinical entity reported across the globe. It discusses the difference in pathophysiology and complication of lean type 2 diabetes from the obese.\u003c\/p\u003e \u003cp\u003eChapter 7 proposes that Dermcidin isoform-2, a stress protein induced acute coronary syntrome through the mediation of diabetes, hypertension and hyperchlosterolemia which are the leading cause of atherosclerosis in the disease.\u003c\/p\u003e","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52755985137937,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52755985727761,"sku":"NIN9781922227676","price":0.0,"currency_code":"GBP","in_stock":false}]},{"product_id":"endocrine-diseases-book-iconcept-press-9781922227782","title":"Endocrine Diseases","description":"Endocrine diseases are disorders of the endocrine system. The branch of medicine associated with endocrine disorders is known as endocrinology. Endocrine disorders can usually be divided into three categories: endocrine gland hyposecretion (leading to hormone deficiency), endocrine gland hypersecretion (leading to hormone excess) and tumours of endocrine glands. Endocrine disorders involve a mixed picture of hyposecretion and hypersecretion. \u003ci\u003eEndocrine Diseases\u003c\/i\u003e serves as an essential start to master the science and art of clinical practice and is going to discuss endocrine diseases. \u003cp\u003e\u003c\/p\u003e There are totally 7 chapters in this book. Chapter 1 gives an outline of pancreatic cancer and reviews the biological character and clinical utility of prostate stem cell antigen (PSCA) in the context of pancreatic cancer. It is worth noting that pancreatic cancer is a highly fatal neoplasm and recent studies revealed involvement of PSCA in its carcinogenesis. \u003cp\u003e\u003c\/p\u003e Chapter 2 proposes a role for zinc transporters in cell signalling and glycaemic control in disease processes, especially insulin resistance and type 2 diabetes. It reveals an exciting role for these transporters as novel targets with utility for therapeutic intervention in the treatment of these diseases. \u003cp\u003e\u003c\/p\u003eChapter 3 reviews the role of psychosocial factors including personality traits as well as stresses on the onset and clinical course of Graves' disease. In addition, this chapter also introduces the relationships between stress and other thyroid diseases including Hashimoto's thyroiditis, Plummer' disease and benign thyroid nodule. \u003cp\u003e\u003c\/p\u003eChapter 4 summarizes the current and future clinical applications of ghrelin, the endogenous ligand of the growth hormone secretagogue-receptor type-1a (GHS-R1a), in various disorders. Major clinical applications of the available pharmacological tools modulating ghrelin action, in relation to their pharmacological targets, are also discussed. \u003cp\u003e\u003c\/p\u003e Chapter 5 describes the regulatory mechanisms underlying the expression of the testis-specific gene PDHA2. Moreover, its somatic activation to correct pyruvate dehydrogenase complex deficiency caused by mutations in the paralog PDHA1 is discussed. \u003cp\u003e\u003c\/p\u003eChapter 6 has linked prolactin and PAK1 as the JAK2 substrate to the stimulation of cyclin D1 promoter activity. The authors propose two PAK1-dependent mechanisms to activate cyclin D1 promoter activity: via nuclear translocation of tyrosyl-phosphorylated PAK1 and via formation of a Nck-PAK1 complex that sequesters PAK1 in the cytoplasm. \u003cp\u003e\u003c\/p\u003eChapter 7 discusses the method of choice for adrenalectomy, depending on the size of the adrenal tumor.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52755985432849,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52755985858833,"sku":"NIN9781922227782","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227782.jpg?v=1763574961"},{"product_id":"research-on-virology-and-cytopathology-book-iconcept-press-9781922227706","title":"Research on Virology and Cytopathology","description":"\u003cp\u003eResearch on Cytopathology is a book presenting the information and practical applications of clinical cytology in determining the etiology, diagnosis, prognosis and therapeutic options of benign and malignant disease. Committed to bridging the gap between cytopathology and surgical pathology, this book stresses the value of clinical-pathological correlations, as well as the correlation between cytological and histological findings.\u003c\/p\u003e \u003cp\u003eChapter 1 discusses the emergence of a highly divergent Encephalomyocarditis Virus (EMCV) in Singapore.\u003c\/p\u003e \u003cp\u003eChapter 2 examines the roles of known cell adhesion molecules (CAMs) in synapse formation, and reviews the participation of these CAMs in brain disorders.\u003c\/p\u003e \u003cp\u003eChapter 3 reviews different types of tumor vessels in gastric cancer, their morphology and clinical importance.\u003c\/p\u003e \u003cp\u003eChapter 4 shows the impact of tumor regression in rectal cancer therapy decision tree.\u003c\/p\u003e \u003cp\u003eChapter 5 proposes the use of MR imaging and new catheters\/devices in cardiovascular interventions.\u003c\/p\u003e \u003cp\u003eChapter 6 brings the results of a five-year investigation about the influence of phytotherapy on the size and secretion activity of macroprolactinomas.\u003c\/p\u003e \u003cp\u003eChapter 7 discusses the differential diagnosis of brain calcifications in relation to the possible psychiatric presentations reported in the recent literature.\u003c\/p\u003e \u003cp\u003eChapter 8 aims to clarify the main positioning errors during a radiograph's performance to increase the knowledge of professionals\u003c\/p\u003e \u003cp\u003eChapter 9 presents the past and current situation regarding the HIV epidemic in Pakistan. It examines the phylogenetic evidence indicating the routes of HIV transmission, and the bridging of infection across various high risk groups.\u003c\/p\u003e \u003cp\u003eChapter 10 shows how the changing population immune-genetic pressures might affect HIV subtype A epidemic dynamics, genomic variability and epitope diversity, and steer immuno-evolution of this subtype in new directions.\u003c\/p\u003e","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52755985826065,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52755986186513,"sku":"NIN9781922227706","price":0.0,"currency_code":"GBP","in_stock":false}]},{"product_id":"cervical-breast-and-prostate-cancer-classical-cover-book-iconcept-press-9781922227867","title":"Cervical, Breast and Prostate Cancer (Classical Cover)","description":"Cervical cancer and breast cancer are two of the most common cancers found in women. Cervical cancer is when cancer arises from the cervix. Early on there are typically no symptoms. Later symptoms may include abnormal vaginal bleeding, pelvic pain or pain during sex. Breast cancer is when cancer develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, or a red scaly patch of skin. Prostate cancer is when cancer develops in the prostate, a gland in the male reproductive system. It may initially cause no symptoms. In later stages it can cause difficulty urinating, blood in the urine, or pain in the pelvis, back or when urinating. This book provides some latest research and findings on breast cancer, cervical cancer and prostate cancer. The aim of this book is to serve as an important reference book for individuals working in biomedical laboratories, and for clinical professionals. \u003cp\u003e\u003c\/p\u003e There are totally 13 chapters in this book. Chapter 1 proposes an outlook on different endoscopic surgical procedures to treat cervical cancer, using traditional laparoscopy and robotics. Chapter 2 reviews the clinical results of carbon ion radiotherapy (C-ion RT) for uterine cervical cancer. Carbon-ion RT has been established as a safe short-term treatment for locally advanced uterine cervical cancer. Chapter 3 summarises chrysin inhibits proliferation, induces apoptosis and reduce angiogenesis in most tested cancer cells, including cervical cancer cells. Chapter 4 shows that involving physicians in the promotion of public health programs and initiatives is a viable option. \u003cp\u003e\u003c\/p\u003e Chapter 5 summarizes the published findings about the controversial role of METCAM, a cell adhesion molecule, in the progression of human breast cancer. Chapter 6 focuses on the biology of \u003ci\u003eneu\u003c\/i\u003e in breast cancer - the potential mechanisms that may contribute to tumor resistance and the numerous uncertainties that persist despite the bona-fide progress made in treating this particular subtype of breast cancer. Chapter 7 describes the mechanisms by which estrogen can exert its role in estrogenresponsive cells, focusing on specific aspects of estrogen receptor signaling. Moreover, this chapter shows how some of the proteins involved in estrogen receptor signaling can be used as predictive markers in breast cancer and describes a proposed clinical study related to the combined use of two drugs (bortezomib and tamoxifen) as therapeutic agents for estrogen receptor negative breast cancers. Chapter 8 summarizes the recent studies indicating that AngII facilitates breast cancer metastasis by contributing to the cross-talk between cancer cells and the host stroma. \u003cp\u003e\u003c\/p\u003e Chapter 9 focuses on a rationale pharmaceutical development along with a detailed understanding of biological effects so as to accelerate the incorporation of nanocarriers in breast cancer therapy. Chapter 10 summarizes the mTOR pathway and the clinical results in breast cancer treatment, relating them to results obtained using cultured MCF-7 breast cancer tamoxifen resistant sublines. Chapter 11 discusses how to develop a standard extraction method, yielding tomato products which are suitable for cell cultures, and enable product comparison of different tomato varieties. \u003cp\u003e\u003c\/p\u003eChapter 12 describes principles and processes that are involved in investigating biological or clinical problems with nuclear magnetic resonance (NMR) based metabolomics - an approach that involves the global analysis of metabolites. The authors use prostate cancer as a case study to outline the processes, applications and potential of metabolomics for inform scientists and clinicians. Chapter 13 discusses the epidemiology, screening, diagnosis and treatment options of prostate cancer and its association with osteoporosis.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52756344570129,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52756345422097,"sku":"NIN9781922227867","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227867.jpg?v=1763575946"},{"product_id":"dermatology-and-allergology-book-iconcept-press-9781922227959","title":"Dermatology and Allergology","description":"Dermatology is the branch of medicine dealing with the skin and its diseases, a unique specialty with both medical and surgical aspects. Allergology is the study of allergy and hypersensitivity, in which allergy is a hypersensitivity disorder of the immune system and hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions produced by the normal immune system. Dermatology and allergology are two highly interrelated disciplines. \u003ci\u003e Dermatology and Allergology -- Principles and Practice\u003c\/i\u003e provides some latest research and concerns in these two areas. \u003cp\u003e\u003c\/p\u003e There are totally 8 chapters in this book. Chapter 1 discusses dermatologic disease with psychiatric manifestations, dermatologic disease influenced by psychosocial stress and psychiatric disorders with cutanous manifestations. Medical Illness with neuropsychiatric and dermatological manifestations and psychiatric side effects of dermatological treatment is also discussed. Chapter 2 describes the ocular surface defence and allergological mechanism when the ocular surface is introduced to foreign bodies, and reviews foreign body reaction caused by synthetic and organic fibers. Chapter 3 discusses podoconiosis, which is a debilitating disease common in several countries across the world. Unfortunately, despite its huge socio-economic and public health burden, podoconiosis has remained neglected in clinical, public health, and policy agendas until quite recently. Chapter 4 evaluates with a second generation antihistamine, like rupatadine, the overall efficacy in the control of morning (AM) and evening (PM) nasal symptoms in patients with allergic rhinitis. This analysis includes the pooled data from five randomized, double blind, placebo-controlled studies. The findings were that overall efficacy (T4SS) relief of symptoms was quite similar for AM or PM period with rupatadine 10 mg once daily, indicating a sustained 24-hour effect of rupatadine irrespective of time of dosing. \u003cp\u003e\u003c\/p\u003e Chapter 5 proposes to evaluate occupational and environmental risk factors for allergic and hypersensitivity reactions with a public health view. Based on the epidemiological data in developed and developing countries, the authors aim to draw attention to the current status and new ways of understanding allergies and propose solutions for the future. Chapter 6 recites the importance of clinical history for the diagnosis of anaphylaxis, validity of recent investigations\/tests in lieu of anaphylaxis and interpretation of various test in the background of clinical history of anaphylaxis. Chapter 7 discusses a common nonscarring, autoimmune disease that can affect any hair-bearing area called Alopecia areata (AA). AA occurs in all ethnic groups, ages, and both sexes and may affect a small area of scalp (patchy type), or involve the entire scalp (alopecia totalis) or whole body (alopecia universalis). Chapter 8 proposes ways of targeting the mycobacterial toxin mycolactone in treatment of Buruli ulcers. Mycolactone plays a central role in ulcer formation by acting on the host at cellular and subcellular levels via several mechanisms.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52756405747985,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52756406403345,"sku":"NIN9781922227959","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227959.jpg?v=1763576134"},{"product_id":"cardiovascular-disease-i-contemporary-cover-book-iconcept-press-9781922227898","title":"Cardiovascular Disease I (Contemporary Cover)","description":"Cardiovascular disease is a class of diseases that involve the heart or blood vessels, such as arteries, capillaries and veins. Cardiovascular diseases remain the biggest cause of deaths worldwide, though over the last two decades, cardiovascular mortality rates have declined in many high-income countries. At the same time, cardiovascular deaths and disease have increased at a fast rate in low- and middle-income countries. The causes of cardiovascular disease are diverse but atherosclerosis and\/or hypertension are the most common ones. \u003cp\u003e\u003c\/p\u003e This book is targeted for researchers, scholars or other health care providers who need a ready reference for cardiovascular disease ranging from causes, signs and symptoms, and diagnosis through treatment and special considerations. There are two volumes. This book is the first volume. There are totally 12 chapters in this book. Chapter 1 proposes that the renal artery diameter could represents a marker of non-traditional cardiovascular risk factors in selected populations. A pathophysiological explanation, including main biophysical background, and clinical implication of this new finding has been critically discussed. Bicuspid aortic valve (BAV) is the commonest congenital cardiac disease and is characterized by the aortic valve only having two leaflets rather than the usual three. Chapter 2 provides a comprehensive review of the condition, from epidemiology and etiology to diagnosis and management. In the case of coronary artery disease, cardiomyocytes' oxygen supply and thus the heart's contractility diminishes with the consequence that the oxygen demands of the whole organism are no longer fulfilled. Chapter 3 focuses on retroperfusion and it is shown that it is possible to perform a regional venous retrobypass in a long term pig model. Chapter 4 discusses the FGF23\/Klotho system, which is a new biological system with a pivotal role in normal regulation of phosphorus homeostasis.. \u003cp\u003e\u003c\/p\u003e Chapter 5 assesses the effect of high-intensity and moderate intensity exercise on the exercise efficiency of ischaemic heart disease patients. Although ischemic heart disease patients were more inefficient during high-intensity exercise, this type of exercise may provide greater benefits for this population group due to eliciting a higher physiological response and energy expenditure. Chapter 6 presents the characteristics of cardiovascular manifestations, including cardiac manifestations, cerebrovascular disease, pulmonary vascular involvement, renal vascular involvement, intestinal vasculitis, and cutaneous vasculitis. All of them are analyzed and described using a retrospective review of the medical records of 1125 SLE patients examined in Juntendo University Hospital between 1955 and 2002. Chapter 7 shows that serotonin, angiotensin II, urotensin II, cardiotrophin-1 and salusin-B exert proatherogenic effects, whereas adiponectin, GLP-1, GIP, heregulin-B1 and salusin-a have antiatherogenic effects. Chapter 8 highlights the role mutations of mitochondrial genome in atherosclerosis. \u003cp\u003e\u003c\/p\u003e Chapter 9 reviews the relationship between thiamine and MI. Genetic studies provide opportunities to determine which proteins link thiamine to MI pathology. Chapter 10 illustrates a variety types of peripheral vascular disease including from etiology to endovascular treatment. Especially, venous vascular disease are shown as not only endovascular treatment but pharmaceutical therapy. Chapter 11 proposes conventional and new techniques\/methods for diagnosis and treatment of the cardiovascular disease. In addition, the chapter explain the comparison of conventional formulation and new nanomedicine therapy of cardiovascular disease. Chapter 12 describes all aspects of cardiogenic shock, especially as the complication of acute myocardial infarction.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52756508082449,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52756508377361,"sku":"NIN9781922227898","price":0.0,"currency_code":"GBP","in_stock":false}]},{"product_id":"understand-cancer-book-iconcept-press-9781922227386","title":"Understand Cancer","description":"\u003cp\u003eCancer is a broad group of diseases involving unregulated cell growth, in which cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. Cancer may also spread to different parts of the body through the lymphatic system or the bloodstream. \u003ci\u003eUnderstand Cancer - Research and Treatment\u003c\/i\u003e discusses some recent advances in cancer research and treatment methods. \u003c\/p\u003e \u003col\u003e \u003cli\u003ePossible Roles of a Duplicated GA Motif as a Driver \u003ci\u003eCis\u003c\/i\u003e-element for Cancer-associated Genes\u003c\/li\u003e \u003cli\u003eThe Genetic Landscape of Acute Lymphoblastic Leukemia as drawn by Next Generation Sequencing Technology\u003c\/li\u003e \u003cli\u003eDynamics of VEGF-A and its Receptors in Cancer Vascularization - An Overview\u003c\/li\u003e \u003cli\u003eLaser Capture Microdissection in Tumor Angiogenesis Research related to Bcl-2 Expression on Endothelial Cells: A Review\u003c\/li\u003e \u003cli\u003eEffects of Co-Transplantation of Thymus and Stem Cells on Treatment of Malignant Tumors\u003c\/li\u003e \u003cli\u003eThe Preventive and Therapeutic Effect of Coptidis Rhizoma and Berberine in Cancer\u003c\/li\u003e \u003cli\u003eRole and Metabolism of Heme-derived Iron in Cancer\u003c\/li\u003e \u003cli\u003eNER Pathway and Wild-Type p53 in Platinum-Drug Resistance and Inhibition of Chemoresistance with PCK3145, a PSP94 Peptide Derivative\u003c\/li\u003e \u003cli\u003eX-ray Digital Tomosynthesis Imaging for Pulmonary Nodule Detection\u003c\/li\u003e \u003cli\u003eCarcinoma of the Gallbladder: Current State and Future Directions in Diagnosis and Treatment\u003c\/li\u003e \u003cli\u003eDiagnostic Values and Molecular-targeted of Oncofetal Glypican-3 for Hepatocellular Carcinoma\u003c\/li\u003e \u003cli\u003eOral Cavity Cancer: Literature Review and Current Management\u003c\/li\u003e \u003cli\u003eMorbidity of Inguinofemoral Lymphadenectomy in Vulvar Cancer and Evolution of Operative Treatment\u003c\/li\u003e \u003cli\u003eGrowths of the Cervix\u003c\/li\u003e \u003c\/ol\u003e","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52756509589777,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52756510245137,"sku":"NIN9781922227386","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227386.jpg?v=1763576372"},{"product_id":"virology-ii-book-iconcept-press-9781922227454","title":"Virology II","description":"A virus is a small infectious agent that replicates within living cells of organisms. Viruses infect all types of organisms, from animals and plants to bacteria and archaea. Today, around 5,000 viruses have been reported in detail, although there are potentially millions. Viruses are found in almost every ecosystem on Earth and are the most abundant type of biological entity. The study of viruses is known as virology, a sub-speciality of microbiology. \u003ci\u003eVirology\u003c\/i\u003e has two volumes. Volume 1 mainly discusses the latest research related to Human Immunodeficiency Virus (HIV). Volume 2 (this volume) discusses other important issues and trends within the research community. \u003cp\u003e\u003c\/p\u003e Chapter 1 highlights seminal findings from the basic sciences and describes the benefits and risks of current medications based on the recent advances in genetics, immunology, diagnostic imaging, medicinal chemistry, clinical therapeutics and health-care systems. \u003cp\u003e\u003c\/p\u003e Chapter 2 presents a brief description of foot-and-mouth disease virus (FMDV) and the different functions of various viral proteins. \u003cp\u003e\u003c\/p\u003e Chapter 3 proposes a model, in which humoral immunity against monomer capsid protein (CP) is immunopathogenic; whereas antibodies generated in response to the intact virion results in protective immunity. \u003cp\u003e\u003c\/p\u003e Chapter 4 discusses current understandings of human innate immune responses to respiratory viral infections in the airways, viral evasion strategies, and abnormalities in the immune responses in people with chronic airways diseases, leading to increased susceptibility and worsened outcome. \u003cp\u003e\u003c\/p\u003e Chapter 5 presents three replication modes: normal, rolling circle, and double rolling circle replication (DRCR). \u003cp\u003e\u003c\/p\u003e Chapter 6 considers the evidence for transmission of the flavivirus West Nile Virus (WNV) by ticks in addition to the major transmission vector, mosquitoes. \u003cp\u003e\u003c\/p\u003e Chapter 7 describes two tick-borne viruses that may be circulating in the Iberian Peninsula: the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) and the European Tick-Borne Encephalitis Virus (TBEV). \u003cp\u003e\u003c\/p\u003e Chapter 8 reviews the evidences supporting the contribution of miRNA regulation to Retinoic Acid (RA)-induced differentiation of neuroblastoma cells. \u003cp\u003e\u003c\/p\u003e Chapter 9 summarizes recent findings shedding light on how multiple geminiviral proteins interact with post-translational modification pathways, and how these interactions impact pathogenicity. \u003cp\u003e\u003c\/p\u003e Chapter 10 summarizes the structure and function of immunoregulatory molecule CD150 (SLAM), known also as a receptor of an important human pathogen, measles virus. \u003cp\u003e\u003c\/p\u003e Chapter 11 attempts to develop an \u003ci\u003eE.coli\u003c\/i\u003e expression and purification system that utilises the insoluble nature of inclusion bodies to produce soluble and endotoxin-free Bovine Viral Diarrhoea Virus (BVDV) E2 protein suitable for \u003ci\u003ein vivo\u003c\/i\u003e applications. \u003cp\u003e\u003c\/p\u003e Chapter 12 reviews how adenovirus alternative splicing is regulated during a lytic virus infection. Special emphasis is devoted to the significance of cellular protein kinases, phosphatases and SR proteins on the function of the adenovirus L4-33K alternative splicing factor. \u003cp\u003e\u003c\/p\u003e Chapter 13 provides an overview of the potential of resistance development to influenza antivirals in the enivironment due to the discharge of pharmaceutical residues. \u003cp\u003e\u003c\/p\u003e Chapter 14 describes the chronic phase of a disease called Chikungunya in a cohort of affected patients. \u003cp\u003e\u003c\/p\u003e Chapter 15 reviews the incidence of Mokola virus, an unusual member of the Lyssavirus genus in southern Africa and the subsequent antigenic and genetic studies thereof. \u003cp\u003e\u003c\/p\u003e Chapter 16 presents a review on the advances made so far in search of novel drug targets against the HCV (Hepatitis C virus)-encoded non-structural protein, NS3. \u003cp\u003e\u003c\/p\u003e Chapter 17 reviews, the potential role of eltrombopag in the context of hepatitis C virus (HCV)-related thrombocytopenia.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52756509982993,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52756510998801,"sku":"NIN9781922227454","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227454.jpg?v=1763576364"},{"product_id":"complication-book-iconcept-press-9781922227461","title":"Complication","description":null,"brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52756510114065,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52756510834961,"sku":"NIN9781922227461","price":0.0,"currency_code":"GBP","in_stock":false}]},{"product_id":"research-on-diabetes-ii-book-iconcept-press-9781922227478","title":"Research on Diabetes II","description":"Diabetes is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger). \u003ci\u003eResearch on Diabetes II\u003c\/i\u003e provides the latest research and development in the area of diabetes by presenting a succinct review of the works that researchers struggling to find answers for 200 million diabetics world-wide, where the number of those afflicted is expected to double, if not triple, in coming decades. \u003cp\u003e\u003c\/p\u003e Chapter 1 describes the strong relationship between diabetes (DM) and infection. Infections can elicit diabetes or make glycaemic control difficult. Chapter 2 presents the idea of using traditional indian medicinal plants used in the traditional Ayurvedic system to treat diabetes. Chapter 3 discusses the nutritional content of organic prickly pads. Findings show that different fiber quantity and mineral content along life cycle of prickly pads, suggesting that prickly pads are excellent option for people with diabetes due to the beneficial nutritional properties. \u003cp\u003e\u003c\/p\u003e Chapter 4 highlights the serious complications of diabetes mellitus, particularly oral complications. \u003cbr\u003e Chapter 5 discusses retropharyngeal abscess (RPA), a potentially serious deep space neck infection.\u003cbr\u003e Chapter 6 addresses the issue of erectile dysfunction. It is a common health related and quality of life issue in the diabetic patients population. \u003cp\u003e\u003c\/p\u003e Chapter 7 presents that fact that the presence of infection in a patient on dialysis has a substantial effect on cardiovascular mortality and morbidity, and should influence decisions regarding the use of therapies intended to minimize that risk.Chapter 8 discusses various cardiovascular effects of diabetes in the pediatric population as diabetes is a chronic disease which affects in a way or another all the stages of childhood. Chapter 9 uses carotid intima media thickness measurement to determine significant risk factors for atherogenic vascular disease in a cohort of Nigerians with Diabetes Mellitus. \u003cp\u003e\u003c\/p\u003e Chapter 10 discusses diabetes mellitus, a metabolic disease which is said to cause gastrointestinal complications amongst long standing patients. Chapter 11 provides several important and handy tools which can be used by obstetricians, embryologists, perinatologists, forensic pathologists and clinical anthropologists for their diagnostic armamentarium so that they can arrive at highly scientific management of their patients even in areas far removed from sophisticated clinical gadgetry. Chapter 12 attempts to advance our understanding of genetic basis of autoimmunity in disease pathogenesis, facilitates determining an individual's disease status and promotes better treatment modalities against systemic lupus erythematosus. \u003cp\u003e\u003c\/p\u003e Chapter 13 illustrates the complicated relationship from the pathogenetic mechanisms to the potential source of infections for humans. Convincing evidence to date indicates that viral and bacterial agents could be associated with Diabetes Mellitus development and progression. Chapter 14 provides a brief overview of molecular level studies on neuroimmune state of patients with long-term diabetes mellitus, including those with acute ischemic stroke, and demonstrates implication of neuroimmune alterations in pathomechanisms responsible for development and progression of diabetic complications.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52756510310673,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52756511064337,"sku":"NIN9781922227478","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227478.jpg?v=1763576364"},{"product_id":"protein-purification-book-iconcept-press-9781922227409","title":"Protein Purification","description":"\u003cp\u003eChapter 1 uses SILAC and TMT quantitative MS methods to identify novel target proteins modulated in the erlotinib (EGFR TKI) resistant lung cancer cells. The use of multiplex quantitative proteomic strategies, such as SILAC and TMT protein labeling are powerful methods for identifying a large number of novel biomarkers.\u003c\/p\u003e \u003cp\u003eChapter 2 describes a MALDI-TOF\/TOF based proteomic approach to profile HAPE-related proteomic changes in plasma. 25 differential plasma proteins responsible for the discrimination between the two groups from HAPE subjects and healthy controls have been identified and studied based on their biological functions. Furthermore, two of the 25 proteins (Haptoglobin and Apoliprotein A- I) have been considered as putative biomarkers for HAPE.\u003c\/p\u003e \u003cp\u003eChapter 3 discusses an important oxidative stress-mediated tyrosine nitration in a protein in tumorigenesis, and addresses the principles of nitroproteomics, isolation and purification of nitroproteins, mass spectrometry characteristics of nitropeptides, methodology used for nitroproteomics in pituitary adenomas, current status of human pituitary nitroproteomics studies, and future trends.\u003c\/p\u003e \u003cp\u003eChapter 4 introduces the fabrication process of boron nitride nanopores and demonstrates the conductance change in ionic current due to the translocation of both dsDNA and ssDNA through the nanopore. It open a window for DNA sensing with boron nitride nanopores and a potential platform for future DNA sequencing application.\u003c\/p\u003e \u003cp\u003eChapter 5 shows the purification of fission yeast Dmc1 and its accessory proteins, and describes a conventional method to monitor DNA strand exchange reaction, which is a powerful tool to understand the biological significance of Dmc1 as well as its accessory proteins.\u003c\/p\u003e \u003cp\u003eChapter 6 aims to detail with necessary basic methods in protein purification and analysis that leads us to grasp new roles assigned to the $\\alpha$1--$\\beta$2 (and $\\alpha$2--$\\beta$1) interface of the human hemoglobin molecule: one is for stabilizing the HbO2 tetramer against acidic autoxidation, and the other is for controlling the fate (removal) of its own erythrocyte from the blood circulation.\u003c\/p\u003e \u003cp\u003eChapter 7 summarizes mouse and human studies that provide mechanisms by which cholesterol could affect inflammation. Apart from the direct effects, its intracellular localization as well as the contribution of different types of cholesterol to the inflammatory response is highlighted -- when oxidized, cholesterol is more likely to instigate inflammation.\u003c\/p\u003e \u003cp\u003eChapter 8 summarizes major cell sources, important proteins, transcription factors and signaling cascades, which governs mesenchymal stromal cell (MSC) fate towards the osteogenic lineage as well as new trends in the development of scaffold materials with osteoconductive and osteoinductive properties.\u003c\/p\u003e \u003cp\u003eChapter 9 describes features, purification methods and applications of proteins such as membrane bound proteins, enzymes or recombinant proteins produced by halophilic bacteria.\u003c\/p\u003e \u003cp\u003eChapter 10 discusses various tau modifications associated with tau aggregation. Tau aggregation is a pathological hallmark of many neurodegenerative diseases including AD.\u003c\/p\u003e \u003cp\u003eChapter 11 discusses the properties of the Clostridium difficile toxins, the mechanism of action, and the immunopathogenesis of the toxins. Clostridium difficile toxins will trigger Clostridium difficile infection (CDI) which is the leading cause of hospital-acquired and antibiotic-associated bacterial diarrhea in the United States.\u003c\/p\u003e \u003cp\u003eChapter 12 discusses the design of bioseparation strategy for engineering purification of conjugated proteins. The strategy is built on physicochemical properties which include molecular size, surface charge distribution and relative hydrophobicity for size exclusion, ion exchange and hydrophobic interaction chromatography respectively. \u003c\/p\u003e","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52756510408977,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52756511162641,"sku":"NIN9781922227409","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227409.jpg?v=1763576364"},{"product_id":"cardiovascular-disease-ii-book-iconcept-press-9781922227577","title":"Cardiovascular Disease II","description":"Cardiovascular disease is a class of diseases that involve the heart or blood vessels, such as arteries, capillaries and veins. Cardiovascular diseases remain the biggest cause of deaths worldwide, though over the last two decades, cardiovascular mortality rates have declined in many high-income countries. At the same time, cardiovascular deaths and disease have increased at a fast rate in low- and middle-income countries. The causes of cardiovascular disease are diverse but atherosclerosis and\/or hypertension are the most common ones. \u003cp\u003e\u003c\/p\u003e There are totally 13 chapters in this book. Chapter 1 reviews the signs and symptoms of heat stress illnesses, and discusses a formula for heat stress evaluation, discusses guidelines for screening, reviews accommodations for those persons working or playing with physical incapacity and specific illness in hot environments. \u003cp\u003e\u003c\/p\u003e Chapter 2 shows the effects of different exercises on the cardiovascular system in elderly people. Aerobic exercise is the most known and recommended for prevention, control and treatment of cardiovascular diseases, especially, the hypertension. Yet, the resistance training with low intensity has also present satisfactory results for the hypotensive effect after exercise. Thus, the aerobic and resistance exercises may have a potential protective non-pharmacological effect and also in the associated treatment for diseases such as hypertension. Chapter 3 describes recent evidence of exercise therapy in the prevention of sarcopenia, glucocorticoid caused myopathy and in case of skeletal muscle unloading. \u003cp\u003e\u003c\/p\u003e Chapter 4 discusses the spatio-temporal evolution of simultaneously recorded voltage and calcium alternans in the heart. It also discusses whether voltage and calcium alternans can be predicted using slopes of restitution curves. \u003cp\u003e\u003c\/p\u003e Chapter 5 deals with the evaluation of the effect of storage under various conditions on the concentrations of diagnostically most important bovine acute phase proteins. \u003cp\u003e\u003c\/p\u003e Chapter 6 reviews the current status of HCM molecular genetics. It addresses the importance of transcriptomics for revealing new diagnostic and therapeutic biomarkers and bioinformatic approaches to improve the translation between the bench and the clinic. \u003cp\u003e\u003c\/p\u003e Chapter 7 focuses on the role of the immune-system in glaucoma, with special attention on the activation of glial cells from the retina and the increased antigen-presenting activity in macro- and macroglia cells both, in the contralateral (normotensive) and hypertensive eyes of unilateral experimental ocular hypertension. \u003cp\u003e\u003c\/p\u003e Chapter 8 describes the relationships between severity of hypocholesterolemia, abnormalities of plasma amino acids, severity of hypercatabolism and organ dysfunction, and extreme metabolic disruption in trauma patients with sepsis. \u003cp\u003e\u003c\/p\u003e Chapter 9 summarizes recent advances in cyclic nucleotide signaling and its capacity to control abnormal vascular smooth muscle growth in the context of cardiovascular disease. \u003cp\u003e\u003c\/p\u003e Chapter 10 describes classifications of endoscopic injuries to the esophagus, the incidence of such burns as well as methods to try to reduce this injury. \u003cp\u003e\u003c\/p\u003e Chapter 11 proposes the role of autonomic nervous system (ANS), both ANS itself and after the remodeling of it, in atrial fibrillation. \u003cp\u003e\u003c\/p\u003e In Chapter 12, an application of VCG for detection of cardiac ischemia is explained, a synthesized VCG from standard 12-lead ECG signal is constructed, and a new method to convert a VCG to ECG signals by using partial linear transformation is introduced. \u003cp\u003e\u003c\/p\u003e Chapter 13 discusses cardiovascular disease in liver cirrhosis. The incidence of cardiovascular diseases in patients with liver cirrhosis is high, and vary according to the underlying cause of liver cirrhosis.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52756511031569,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52756511785233,"sku":"NIN9781922227577","price":0.0,"currency_code":"GBP","in_stock":false}]},{"product_id":"protein-purification-and-analysis-ii-book-iconcept-press-9781922227638","title":"Protein Purification and Analysis II","description":"Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues. The sequence of amino acids in a protein is defined by the sequence of a gene, which is encoded in the genetic code. The complexity and sheer number of proteins in a cell are impediments to identifying proteins of interest or purifying proteins for function and structure analysis. Thus, reducing the complexity of a protein sample or in some cases purifying a protein to homogeneity is necessary. \u003ci\u003eProtein Purification and Analysis\u003c\/i\u003e discusses varies aspect related to protein analysis. There are totally three volumes. This book is the second volume. \u003cp\u003e\u003c\/p\u003e Chapter 1 describes protein-based methods for the analysis of plant alcohol dehydrogenases. \u003cp\u003e\u003c\/p\u003e Chapter 2 demonstrates production of recombinant fungal cell wall-degrading enzymes and their tag-affinity purification and biochemical analyses. Cell wall-degrading enzymes act on cleaving glycosidic bonds of polysaccharides and oligosaccharides, affecting morphological changes, plant-microbe interactions and nutrient acquisition. \u003cp\u003e\u003c\/p\u003e Chapter 3 contains a number of methodologies including recombinant protein purification and analysis, enzymatic reporter assays and fluorescent tag detection. \u003cp\u003e\u003c\/p\u003e Chapter 4 allows the reader to become acquainted with methods of recombinant expression, purification and determination of the level of activity of staphylococcal epidermolytic toxins. \u003cp\u003e\u003c\/p\u003e Chapter 5 discussed the recombinant expression, purification and biochemical analysis of a variety of extremophilic enzymes with potential industrial application. \u003cp\u003e\u003c\/p\u003e Chapter 6 discusses tellurite, which is highly toxic for most living organisms. The chapter describes how the mechanism by which this oxyanion exerts its toxicity can be assessed by studying the effect of some metabolic enzymes which seem to help in detoxifying the toxicant. \u003cp\u003e\u003c\/p\u003e Chapter 7 describes the principle of, devices used for, protocol for, and mechanism underlying gene introduction. \u003cp\u003e\u003c\/p\u003e Chapter 8 outlines a SELEX method for the discovery of a target-specific aptamer. The aptamer is then used to purify the target (SEB) from a mixture of closely related enterotoxins using non-fat dry milk as a representative food matrix. \u003cp\u003e\u003c\/p\u003e Chapter 9 proposes an overview of the methodologies employed for the manipulation of membrane protein transporters, from their purification to their reconstitution into proteoliposomes. The authors presented an original approach they developed for the functional study of a multidrug efflux pump responsible for the active transport of antibiotics in bacteria. \u003cp\u003e\u003c\/p\u003e Chapter 10 is about the versatility of substrate analogues containing unnatural amino acids in the challenging study of peptidyl-aminoacyl-L\/D-isomerases. Enzymes of this class catalyze an exciting post-translational reaction, namely the change of chirality of amino acids within peptide linkage whereby an L-amino acid is converted to the D-isomer. \u003cp\u003e\u003c\/p\u003e Chapter 11 investigates the the effects of combined heat and pressure on whole beef muscle proteins and isolated myofibril solubility and protein electrophoretic pattern. It attempts to understand the relative effects of heat and pressure treatments on the proteins of beef muscle. \u003cp\u003e\u003c\/p\u003e Chapter 12 reviews the normal synovium including it's microscopic structure, cell origins and recruitment, function and its clinical relevance as a target of immunologic disease.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52756511195409,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52756511850769,"sku":"NIN9781922227638","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227638.jpg?v=1763576366"},{"product_id":"protein-purification-and-analysis-iii-book-iconcept-press-9781922227669","title":"Protein Purification and Analysis III","description":"Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues. The sequence of amino acids in a protein is defined by the sequence of a gene, which is encoded in the genetic code. The complexity and sheer number of proteins in a cell are impediments to identifying proteins of interest or purifying proteins for function and structure analysis. Thus, reducing the complexity of a protein sample or in some cases purifying a protein to homogeneity is necessary. \u003ci\u003eProtein Purification and Analysis\u003c\/i\u003e discusses varies aspect related to protein analysis. There are totally three volumes. This book is the second volume. \u003cp\u003e\u003c\/p\u003e Chapter 1 describes protein-based methods for the analysis of plant alcohol dehydrogenases. \u003cp\u003e\u003c\/p\u003e Chapter 2 demonstrates production of recombinant fungal cell wall-degrading enzymes and their tag-affinity purification and biochemical analyses. Cell wall-degrading enzymes act on cleaving glycosidic bonds of polysaccharides and oligosaccharides, affecting morphological changes, plant-microbe interactions and nutrient acquisition. \u003cp\u003e\u003c\/p\u003e Chapter 3 contains a number of methodologies including recombinant protein purification and analysis, enzymatic reporter assays and fluorescent tag detection. \u003cp\u003e\u003c\/p\u003e Chapter 4 allows the reader to become acquainted with methods of recombinant expression, purification and determination of the level of activity of staphylococcal epidermolytic toxins. \u003cp\u003e\u003c\/p\u003e Chapter 5 discussed the recombinant expression, purification and biochemical analysis of a variety of extremophilic enzymes with potential industrial application. \u003cp\u003e\u003c\/p\u003e Chapter 6 discusses tellurite, which is highly toxic for most living organisms. The chapter describes how the mechanism by which this oxyanion exerts its toxicity can be assessed by studying the effect of some metabolic enzymes which seem to help in detoxifying the toxicant. \u003cp\u003e\u003c\/p\u003e Chapter 7 describes the principle of, devices used for, protocol for, and mechanism underlying gene introduction. \u003cp\u003e\u003c\/p\u003e Chapter 8 outlines a SELEX method for the discovery of a target-specific aptamer. The aptamer is then used to purify the target (SEB) from a mixture of closely related enterotoxins using non-fat dry milk as a representative food matrix. \u003cp\u003e\u003c\/p\u003e Chapter 9 proposes an overview of the methodologies employed for the manipulation of membrane protein transporters, from their purification to their reconstitution into proteoliposomes. The authors presented an original approach they developed for the functional study of a multidrug efflux pump responsible for the active transport of antibiotics in bacteria. \u003cp\u003e\u003c\/p\u003e Chapter 10 is about the versatility of substrate analogues containing unnatural amino acids in the challenging study of peptidyl-aminoacyl-L\/D-isomerases. Enzymes of this class catalyze an exciting post-translational reaction, namely the change of chirality of amino acids within peptide linkage whereby an L-amino acid is converted to the D-isomer. \u003cp\u003e\u003c\/p\u003e Chapter 11 investigates the the effects of combined heat and pressure on whole beef muscle proteins and isolated myofibril solubility and protein electrophoretic pattern. It attempts to understand the relative effects of heat and pressure treatments on the proteins of beef muscle. \u003cp\u003e\u003c\/p\u003e Chapter 12 reviews the normal synovium including it's microscopic structure, cell origins and recruitment, function and its clinical relevance as a target of immunologic disease.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52756511293713,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52756511883537,"sku":"NIN9781922227669","price":0.0,"currency_code":"GBP","in_stock":false}]},{"product_id":"cancer-book-iconcept-press-9781922227492","title":"Cancer","description":"Cancer is a broad group of diseases involving unregulated cell growth, in which cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. Cancer may also spread to different parts of the body through the lymphatic system or the bloodstream. \u003ci\u003e Cancer -- Cares, Treatments and Preventions\u003c\/i\u003e discusses some recent advances in cancer research. \u003cp\u003e\u003c\/p\u003e Chapter 1 discusses the epidemiology of smoking and tobacco prevention efforts globally with emphasis on anti-tobacco education at the Elementary School level. Chapter 2 considers both the protection and inclusion of pregnant women in clinical trials. Guidance and an algorithm for determining which is appropriate for studies is included. Chapter 3 describes a method called Multiple reaction monitoring (MRM), which is a a targeted MS-based technology that provides the specificity, throughput, and multiplexing capabilities required for candidate biomarker quantitation in patient samples. Chapter 4 discusses monoclonal antibodies (mAbs). mAbs and their derivatives, continue to be the focus of the biopharmaceutical industry for many diagnostic and therapeutic applications. In spite of vast improvements in our capability to deal with mAbs, they still pose many challenges. \u003cp\u003e\u003c\/p\u003e Chapter 5 reviews four currently distinguished strategies to achieve tumor-specific infection and presents a transductional targeting strategies to specifically redirect viruses towards surface receptors on tumor cells. Chapter 6 reviews past and present treatment philosophies and regimens for treating Ewing's sarcoma. The authors also highlights how the identification of new therapeutic targets can be exploited through the use of tumor-specific agents. Chapter 7 examines what can be expected from using animal models to learn about cancers that affect humans. As humans and animals are examples of evolved, complex systems extrapolating outcomes from perturbations that occur at or effect higher levels of organization will be unlikely. This in part explains the profound lack of progress in finding treatments to human cancers. Chapter 8 provides a comprehensive overview of mitochondrial energy metabolism and cancer, analyzes mitochondrial protection and energy metabolic improvement of Astragalus Polysaccharides (APS), proposes a novel cancer-preventive mechanism from the perspective of effects of APS on mitochondrial oxidative phosphorylation and intracellular adenylates levels, and provides a new way of perspective, thinking and hope for the prevention and treatment of cancer. \u003cp\u003e\u003c\/p\u003e Chapter 9 discusses clinically applied radiopharmaceuticals studied and used in Oncology. Constructive summary tables and up-to-date references provide the student and clinician with a working knowledge and understanding of different Nuclear Medicine techniques. Chapter 10 identifies indications for DT technique for chest imaging. Moreover, the authors performed experiments to measure the artificial pulmonary nodules detection capabilities of the DT imaging system for use as an effective screening method and compared the results with those of radiography and CT imaging. Chapter 11 presents a study to understand the behaviours of normal and diseased breast images from the Digital Database for Screening Mammography (DDSM), considering measures of lacunarity and fractal dimension with the corresponding texture signatures. The malignant nodules with the respective adjacent structures (partial pixels) also were quantified applying a multilevel segmentation method based on maximum entropy. All obtained results provide important information about the studied structures and may contribute with the developments of CAD systems. Chapter 12 presents recent advances in the field of Raman-based optical-biopy for cancer detection. A revision concerned applications to breast, oral, cervical cancers, technological challenges and perspectives is discussed.","brand":"WoB","offers":[{"title":"US \/ NEW \/ INGRAM","offer_id":52756516962577,"sku":"NIN9781922227492","price":0.0,"currency_code":"GBP","in_stock":false}]},{"product_id":"epidemiology-i-book-iconcept-press-9781922227829","title":"Epidemiology I","description":"Epidemiology is the study (or the science of the study) of the patterns, causes, and effects of health and disease conditions in defined populations. Epidemiology has developed into a vibrant scientific discipline that brings together the social and biological sciences, incorporating everything from statistics to the philosophy of science in its aim to study and track the distribution and determinants of health events. \u003cp\u003e\u003c\/p\u003e There are totally 14 chapters in this book. Chapter 1 proposes to assess whether caries restorative treatment can result in the selection and\/or emergence of cariogenic mutans streptococci (MS) genetic strains in children with severe early childhood caries, and also characterizes the xylitol-resistance properties of select dominant and minor MS strains. Chapter 2 describes and explores a new research model of dental practce-based research network by reviewing the current dietary evidence collected from clinical epidemiology research, describing the Dental PBRN, and presenting the results from research conducted using the Dental PBRN model. Chapter 3 discusses the biological effects of solar radiation, describes the risk factors, incidence and mortality rates for skin cancer and melanoma. In addition, it also describes the necessity of sun protection knowledge especially in children and teens and gives information for the most famous sun education programs all over the world. Chapter 4 discusses basal cell carcinoma which comprises the vast majority of skin cancers. It predominantly affects fair-skinned individuals, and its incidence is rising rapidly. \u003cp\u003e\u003c\/p\u003e Chapter 5 highlights possible detrimental effects associated with persistent exposure to antimicrobial agent-containing consumer products, particularly medicated soaps. Chapter 6 discusses the course of melanoma in patients post-organ transplant and in the settings of iatrogenic and lymphoproliferative disease-associated immunosuppression. It concludes with a discussion of potential new targets and therapeutic modalities for the treatment of malignant melanoma. Chapter 7 summarizes a comprehensive methodology to evaluate new technology in Radiation Oncology. With rapidly expanding technology in Medicine, decision makers are forced to make choices as to how to provide care for their population. Chapter 8 discusses the neuroprotective effects of endogenous carbon monoxide (CO) and use of exogenous CO as a neuroprotective and neurotherapeutic agent. It is worth noting that exogenous administration of inhaled carbon monoxide or carbon monoxide releasing molecules impart similar neurophysiological responses as the endogenous gas. \u003cp\u003e\u003c\/p\u003e Chapter 9 reviews an extremely rare pathology where miliary brain metastases are associated with poor prognosis. This chapter aims at providing detailed information on this condition and review the recent literature. Chapter 10 gives an up-to-date review and provides a synthesis of our collective knowledge regarding the application of computational epidemiologic modeling and risk analysis in addressing HIV\/AIDS in both macro- and micro-settings. Chapter 11 discusses the relationship between HIV and maternal mortality in Africa and suggests some methods for addressing the problem. Chapter 12 analyses cellular gene expression profiles by comparing HBV producing cells to its parental HBV non-producing cells. It shows that considerable numbers of gene expression level was altered by HBV amplification. \u003cp\u003e\u003c\/p\u003e Chapter 13 proposes current computer models for the prediction of particle deposition in the respiratory tracts of children and adults. Chapter 14 discusses epidemiology in tilapia fish. Most of the chapters in this book focuses on human beings, whereas this chapter focuses on some other species, hoping to let our readers to get borden their vision on epidemiology.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52756649181457,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52756649836817,"sku":"NIN9781922227829","price":0.0,"currency_code":"GBP","in_stock":false}]},{"product_id":"coronary-artery-disease-book-iconcept-press-9781922227928","title":"Coronary Artery Disease","description":"\u003cp\u003eCoronary artery disease, or more commonly known as heart disease, is usually a result of plaque buildup in coronary arteries, a condition called atherosclerosis. This book covers original research with a clinical emphasis as well as advances in laboratory research that contribute to the understanding of coronary artery disease about its causes, symptoms and treatments. There are 6 chapters in this book.\u003c\/p\u003e \u003cp\u003eChapter 1 proposes a basis for the establishment of effective rehabilitation planning. It discusses the clinical effect of 8-week rehabilitation program on physical, cognitive, and depressive symptoms and the variables influencing changes in depressive symptoms for the reduction of the psychological stress of chronic stroke. \u003c\/p\u003e \u003cp\u003eChapter 2 provides an overview of our current understanding of cyclic nucleotide-driven protein kinase signals as essential components in arterial smooth muscle physiology and pathology underlying coronary artery disease.\u003c\/p\u003e \u003cp\u003eChapter 3 discusses the presence of rhabdomyolysis as an adverse event after concomitant use of statins and antimicrobial agents and mechanisms involved to these interactions.\u003c\/p\u003e \u003cp\u003eChapter 4 aims to provide the extended version of presently published content on chitosan activities towards platelet and blood coagulation mechanisms. Since we are exploring on platelet activities which involve in the coagulation process, as a new contribution to the society, chitosan-based hemostatic agents could be a new strategy biomaterial to achieve hemostasis.\u003c\/p\u003e \u003cp\u003eChapter 5 highlights the major findings and recent advances in the study of micro-biota-dependent mechanism involved in the development of Coronary Artery Disease (CAD) and discuss important roles of probiotic bacteria and plant compounds in prevention and treatment of CAD.\u003c\/p\u003e \u003cp\u003eChapter 6 discusses the value of heart rate in the physiopathology and management of coronary artery disease. Physiology of heart rate value is discussed, along with topics that relate heart rate to endothelial dysfunction, atherosclerosis, hypertension, and other co-morbidities that predispose to coronary artery disease. The role of inflammation and autonomic nervous system are also presented.\u003c\/p\u003e","brand":"WoB","offers":[{"title":"US \/ NEW \/ INGRAM","offer_id":52756744667409,"sku":"NIN9781922227928","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227928.jpg?v=1763576926"},{"product_id":"obesity-epidemic-book-iconcept-press-9781477554968","title":"Obesity Epidemic","description":null,"brand":"WoB","offers":[{"title":"US \/ NEW \/ INGRAM","offer_id":53083258192145,"sku":"NIN9781477554968","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781477554968.jpg?v=1769969050"},{"product_id":"endocrine-diseases-classical-cover-black-and-white-book-iconcept-press-9781922227904","title":"Endocrine Diseases (Classical Cover, Black and White)","description":"Endocrine diseases are disorders of the endocrine system. The branch of medicine associated with endocrine disorders is known as endocrinology. Endocrine disorders can usually be divided into three categories: endocrine gland hyposecretion (leading to hormone deficiency), endocrine gland hypersecretion (leading to hormone excess) and tumours of endocrine glands. Endocrine disorders involve a mixed picture of hyposecretion and hypersecretion. \u003ci\u003eEndocrine Diseases\u003c\/i\u003e serves as an essential start to master the science and art of clinical practice and is going to discuss endocrine diseases. \u003cp\u003e\u003c\/p\u003e There are totally 7 chapters in this book. Chapter 1 gives an outline of pancreatic cancer and reviews the biological character and clinical utility of prostate stem cell antigen (PSCA) in the context of pancreatic cancer. It is worth noting that pancreatic cancer is a highly fatal neoplasm and recent studies revealed involvement of PSCA in its carcinogenesis. \u003cp\u003e\u003c\/p\u003e Chapter 2 proposes a role for zinc transporters in cell signalling and glycaemic control in disease processes, especially insulin resistance and type 2 diabetes. It reveals an exciting role for these transporters as novel targets with utility for therapeutic intervention in the treatment of these diseases. \u003cp\u003e\u003c\/p\u003eChapter 3 reviews the role of psychosocial factors including personality traits as well as stresses on the onset and clinical course of Graves' disease. In addition, this chapter also introduces the relationships between stress and other thyroid diseases including Hashimoto's thyroiditis, Plummer' disease and benign thyroid nodule. \u003cp\u003e\u003c\/p\u003eChapter 4 summarizes the current and future clinical applications of ghrelin, the endogenous ligand of the growth hormone secretagogue-receptor type-1a (GHS-R1a), in various disorders. Major clinical applications of the available pharmacological tools modulating ghrelin action, in relation to their pharmacological targets, are also discussed. \u003cp\u003e\u003c\/p\u003e Chapter 5 describes the regulatory mechanisms underlying the expression of the testis-specific gene PDHA2. Moreover, its somatic activation to correct pyruvate dehydrogenase complex deficiency caused by mutations in the paralog PDHA1 is discussed. \u003cp\u003e\u003c\/p\u003eChapter 6 has linked prolactin and PAK1 as the JAK2 substrate to the stimulation of cyclin D1 promoter activity. The authors propose two PAK1-dependent mechanisms to activate cyclin D1 promoter activity: via nuclear translocation of tyrosyl-phosphorylated PAK1 and via formation of a Nck-PAK1 complex that sequesters PAK1 in the cytoplasm. \u003cp\u003e\u003c\/p\u003eChapter 7 discusses the method of choice for adrenalectomy, depending on the size of the adrenal tumor.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":53084117369105,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53084117860625,"sku":"NIN9781922227904","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227904.jpg?v=1769976867"},{"product_id":"cervical-breast-and-prostate-cancer-classical-cover-black-and-white-book-iconcept-press-9781922227874","title":"Cervical, Breast and Prostate Cancer (Classical Cover, Black and White)","description":"Cervical cancer and breast cancer are two of the most common cancers found in women. Cervical cancer is when cancer arises from the cervix. Early on there are typically no symptoms. Later symptoms may include abnormal vaginal bleeding, pelvic pain or pain during sex. Breast cancer is when cancer develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, or a red scaly patch of skin. Prostate cancer is when cancer develops in the prostate, a gland in the male reproductive system. It may initially cause no symptoms. In later stages it can cause difficulty urinating, blood in the urine, or pain in the pelvis, back or when urinating. This book provides some latest research and findings on breast cancer, cervical cancer and prostate cancer. The aim of this book is to serve as an important reference book for individuals working in biomedical laboratories, and for clinical professionals. \u003cp\u003e\u003c\/p\u003e There are totally 13 chapters in this book. Chapter 1 proposes an outlook on different endoscopic surgical procedures to treat cervical cancer, using traditional laparoscopy and robotics. Chapter 2 reviews the clinical results of carbon ion radiotherapy (C-ion RT) for uterine cervical cancer. Carbon-ion RT has been established as a safe short-term treatment for locally advanced uterine cervical cancer. Chapter 3 summarises chrysin inhibits proliferation, induces apoptosis and reduce angiogenesis in most tested cancer cells, including cervical cancer cells. Chapter 4 shows that involving physicians in the promotion of public health programs and initiatives is a viable option. \u003cp\u003e\u003c\/p\u003e Chapter 5 summarizes the published findings about the controversial role of METCAM, a cell adhesion molecule, in the progression of human breast cancer. Chapter 6 focuses on the biology of \u003ci\u003eneu\u003c\/i\u003e in breast cancer - the potential mechanisms that may contribute to tumor resistance and the numerous uncertainties that persist despite the bona-fide progress made in treating this particular subtype of breast cancer. Chapter 7 describes the mechanisms by which estrogen can exert its role in estrogenresponsive cells, focusing on specific aspects of estrogen receptor signaling. Moreover, this chapter shows how some of the proteins involved in estrogen receptor signaling can be used as predictive markers in breast cancer and describes a proposed clinical study related to the combined use of two drugs (bortezomib and tamoxifen) as therapeutic agents for estrogen receptor negative breast cancers. Chapter 8 summarizes the recent studies indicating that AngII facilitates breast cancer metastasis by contributing to the cross-talk between cancer cells and the host stroma. \u003cp\u003e\u003c\/p\u003e Chapter 9 focuses on a rationale pharmaceutical development along with a detailed understanding of biological effects so as to accelerate the incorporation of nanocarriers in breast cancer therapy. Chapter 10 summarizes the mTOR pathway and the clinical results in breast cancer treatment, relating them to results obtained using cultured MCF-7 breast cancer tamoxifen resistant sublines. Chapter 11 discusses how to develop a standard extraction method, yielding tomato products which are suitable for cell cultures, and enable product comparison of different tomato varieties. \u003cp\u003e\u003c\/p\u003eChapter 12 describes principles and processes that are involved in investigating biological or clinical problems with nuclear magnetic resonance (NMR) based metabolomics - an approach that involves the global analysis of metabolites. The authors use prostate cancer as a case study to outline the processes, applications and potential of metabolomics for inform scientists and clinicians. Chapter 13 discusses the epidemiology, screening, diagnosis and treatment options of prostate cancer and its association with osteoporosis.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":53084117598481,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53084117991697,"sku":"NIN9781922227874","price":0.0,"currency_code":"GBP","in_stock":false}]},{"product_id":"genomics-iii-book-iconcept-press-9781922227416","title":"Genomics III","description":"Genomics is the study of the genomes of organisms. The field includes intensive efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping efforts. It is a discipline in genetics that applies recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyse the function and structure of genomes. Genomics III - Methods, Techniques and Applications is the last volume of our Genomics series. \u003cp\u003e\u003c\/p\u003e Chapter 1 presents an overview of exome sequencing technology and details its use in identification of molecular bases of rare diseases in human. \u003cp\u003e\u003c\/p\u003e Chapter 2 describes and compares different methods of whole genome amplification (WGA) for replenishing DNA samples for genetic studies. \u003cp\u003e\u003c\/p\u003e Chapter 3 ilustrates the method of whole genome microarray gene expression profiling and its application to study the treatment effect of a widely used cardiovascular drug. \u003cp\u003e\u003c\/p\u003e Chapter 4 describes a brief history of large-insert libraries and their utility in exploring organisms with poor genetic and genome information. \u003cp\u003e\u003c\/p\u003e Chapter 5 proposes a bio-molecular approach for the evaluation of the anaerobic digestion performance. \u003cp\u003e\u003c\/p\u003e In Chapter 6, quantitative issues of the transposon-based gene delivery methods are addressed. Using the \u003ci\u003eSleeping Beauty\u003c\/i\u003e transposon system as a prominent example, special detailed focus is given to copy number determination and to transposon excision efficiency quantification by real-time PCR based methodologies. \u003cp\u003e\u003c\/p\u003e Chapter 7 provides an overview of extraction of a compendium of sequence and structural features, as well as the methodology for function prediction based on the techniques from Artificial Intelligence and Machine learning. \u003cp\u003e\u003c\/p\u003e Chapter 8 presents a statistical method and a data mining solution for the problem of insertion site analysis and characterization of Alu elements \u003cp\u003e\u003c\/p\u003e Chapter 9 investigates how Mutual Information (MI) can be used to improve methods of predicting functional residues and enhance structural data to describe the topological properties of amino acid coevolution networks within a protein and their interactions. \u003cp\u003e\u003c\/p\u003e Chapter 10 attempts to validate MLVA to see if it could predict MRSA clones that were previously characterized by PFGE, MLST, and staphylococcal cassette chromosome mec (SCCmec) typing and to establish possible criteria of clustering MLVA patterns, looking for high concordance levels. \u003cp\u003e\u003c\/p\u003e Chapter 11 introduces a web server which allows the user to perform genome rearrangement analysis using reversals, block-interchanges (also called generalized transpositions) and translocations (including fusions and fissions). \u003cp\u003e\u003c\/p\u003e Chapter 12 discussed an algorithm which is used to optimally align simple sequence repeat (microsatellite) regions as they evolve uniquely through a process called polymerase slippage. \u003cp\u003e\u003c\/p\u003e Chapter 13 possesses a background of the RUN domain research with an emphasis on the interaction between RUN domain protein including RUFY proteins and small GTPases with respect to the cell polarity and membrane trafficking. \u003cp\u003e\u003c\/p\u003e In Chapter 14, the authors detail recent advances in understanding mechanisms of gene regulation in Drosophila.\u003cbr\u003e Chapter 15 provides guidelines for human molecular geneticists to perform genetic screenings using next generation sequencing. \u003cp\u003e\u003c\/p\u003e Chapter 16 describes the process that was used to locate and characterize small group I introns in the rRNA gene locus of fungi. \u003cp\u003e\u003c\/p\u003e Chapter 17 summarizes recent insights in the biology of variant gene transcription in human and murine malaria species and addresses the molecular mechanisms at work which regulate the expression of important virulence factors.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":53084117893393,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53084118221073,"sku":"NIN9781922227416","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227416.jpg?v=1769976869"},{"product_id":"research-on-diabetes-ii-black-and-white-book-iconcept-press-9781922227485","title":"Research on Diabetes II (black and white)","description":"Diabetes is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger). \u003ci\u003eResearch on Diabetes II\u003c\/i\u003e provides the latest research and development in the area of diabetes by presenting a succinct review of the works that researchers struggling to find answers for 200 million diabetics world-wide, where the number of those afflicted is expected to double, if not triple, in coming decades. \u003cp\u003e\u003c\/p\u003e Chapter 1 describes the strong relationship between diabetes (DM) and infection. Infections can elicit diabetes or make glycaemic control difficult. Chapter 2 presents the idea of using traditional indian medicinal plants used in the traditional Ayurvedic system to treat diabetes. Chapter 3 discusses the nutritional content of organic prickly pads. Findings show that different fiber quantity and mineral content along life cycle of prickly pads, suggesting that prickly pads are excellent option for people with diabetes due to the beneficial nutritional properties. \u003cp\u003e\u003c\/p\u003e Chapter 4 highlights the serious complications of diabetes mellitus, particularly oral complications. \u003cbr\u003e Chapter 5 discusses retropharyngeal abscess (RPA), a potentially serious deep space neck infection.\u003cbr\u003e Chapter 6 addresses the issue of erectile dysfunction. It is a common health related and quality of life issue in the diabetic patients population. \u003cp\u003e\u003c\/p\u003e Chapter 7 presents that fact that the presence of infection in a patient on dialysis has a substantial effect on cardiovascular mortality and morbidity, and should influence decisions regarding the use of therapies intended to minimize that risk.Chapter 8 discusses various cardiovascular effects of diabetes in the pediatric population as diabetes is a chronic disease which affects in a way or another all the stages of childhood. Chapter 9 uses carotid intima media thickness measurement to determine significant risk factors for atherogenic vascular disease in a cohort of Nigerians with Diabetes Mellitus. \u003cp\u003e\u003c\/p\u003e Chapter 10 discusses diabetes mellitus, a metabolic disease which is said to cause gastrointestinal complications amongst long standing patients. Chapter 11 provides several important and handy tools which can be used by obstetricians, embryologists, perinatologists, forensic pathologists and clinical anthropologists for their diagnostic armamentarium so that they can arrive at highly scientific management of their patients even in areas far removed from sophisticated clinical gadgetry. Chapter 12 attempts to advance our understanding of genetic basis of autoimmunity in disease pathogenesis, facilitates determining an individual's disease status and promotes better treatment modalities against systemic lupus erythematosus. \u003cp\u003e\u003c\/p\u003e Chapter 13 illustrates the complicated relationship from the pathogenetic mechanisms to the potential source of infections for humans. Convincing evidence to date indicates that viral and bacterial agents could be associated with Diabetes Mellitus development and progression. Chapter 14 provides a brief overview of molecular level studies on neuroimmune state of patients with long-term diabetes mellitus, including those with acute ischemic stroke, and demonstrates implication of neuroimmune alterations in pathomechanisms responsible for development and progression of diabetic complications.","brand":"WoB","offers":[{"title":"US \/ NEW \/ INGRAM","offer_id":53084118384913,"sku":"NIN9781922227485","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227485.jpg?v=1769976870"},{"product_id":"research-on-immunology-book-iconcept-press-9781922227911","title":"Research on Immunology","description":"\u003cp\u003eChapter 1 presents a real-world analysis using cancer registry linked to medical claims data evaluated treatment patterns and outcomes among elderly, medically unfit, chronic lymphocytic leukemia (CLL) patients. The results suggest that chemoimmunotherapy is more effective than chemotherapy alone in elderly CLL patients with a high prevalence of comorbidity, and this supports conclusions from clinical trials in younger, medically fit patients.\u003c\/p\u003e \u003cp\u003eChapter 2 discusses the role of the leukocyte adhesion cascade for the pathophysiology of nasal polyps in chronic rhinosinusitis patients, with a special view to the predominant immune imbalance within nasal polyps.\u003c\/p\u003e \u003cp\u003eChapter 3 discusses the efficiency and safety of the combination of DC\/CIK cytotherapy with TRT in advanced NSCLC. The authors found that this novel strategy is a potentially viable option for patients with advanced NSCLC.\u003c\/p\u003e \u003cp\u003eChapter 4 reviews the innate and adaptive components of the human immune system that mediate allergic reactions as well as immune tolerance toward cow's milk proteins. Possible therapeutic strategies to induce immune tolerance in subjects with a risk to develop cow's milk allergy are discussed. Mechanistic interactions between cow's milk allergy and other inflammatory diseases are analysed as well.\u003c\/p\u003e \u003cp\u003eChapter 5 discusses the importance of immune reactions in the current understanding of the molecular pathogenesis of non-alcoholic fatty liver disease and potential immune-related treatments to be considered in future therapeutic paradigms. Given that this disease entity is still not completely understood, therefore efforts should be made to fully investigate the pathogenesis and treatment strategies.\u003c\/p\u003e \u003cp\u003eChapter 6 discusses the discovery about the cytokine immunopathogenesis of enterovirus 71 infection and insights into agents, IVIG and milrinone, modulate the cytokine storm.\u003c\/p\u003e \u003cp\u003eChapter 7 presents studies that: (i) characterize the L1 genetic variability of HPV 16 and HPV 18 genotypes, working with both single infection and multiple HPV infection samples, (ii) assess the prevalence of HPV variants in our region and (iii) analyze the relationship between variants and type of cervical lesion.\u003c\/p\u003e \u003cp\u003eChapter 8 discusses various nanosystems which have shown the ability to simplify drug regimens, enhancing antiretroviral activity, while reducing their toxicity and increasing patient's compliance, preventing development of drug resistance.\u003c\/p\u003e \u003cp\u003eChapter 9 presents an update on the West Nile virus Infection (epidemiology, etiology, parthenogenesis, clinical aspects and treatment) and also the association with Opsoclonus Myoclonus Syndrome (a pluri-ethiological neurological disorder) through the personal experience of the authors.\u003c\/p\u003e \u003cp\u003eChapter 10 proposes a histological image mosaicing approach to create the panoramic image automatically by mosaicing all the images acquired from a specimen. It effectively compensates for the congenital narrowness in field of views.\u003c\/p\u003e \u003cp\u003eChapter 11 reviews the problems related to phylogenetic tree searches, sequence alignment, and phylogenetic uncertainty estimation. In addition, parallel approaches to these issues are outlined, and examples are provided of their use with microbial datasets.\u003c\/p\u003e","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":53084118090001,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53084118286609,"sku":"NIN9781922227911","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227911.jpg?v=1769976870"},{"product_id":"coronary-artery-disease-book-iconcept-press-9781922227980","title":"Coronary Artery Disease","description":"\u003cp\u003eCoronary artery disease, or more commonly known as heart disease, is usually a result of plaque buildup in coronary arteries, a condition called atherosclerosis. This book covers original research with a clinical emphasis as well as advances in laboratory research that contribute to the understanding of coronary artery disease about its causes, symptoms and treatments. There are 6 chapters in this book.\u003c\/p\u003e \u003cp\u003eChapter 1 proposes a basis for the establishment of effective rehabilitation planning. It discusses the clinical effect of 8-week rehabilitation program on physical, cognitive, and depressive symptoms and the variables influencing changes in depressive symptoms for the reduction of the psychological stress of chronic stroke. \u003c\/p\u003e \u003cp\u003eChapter 2 provides an overview of our current understanding of cyclic nucleotide-driven protein kinase signals as essential components in arterial smooth muscle physiology and pathology underlying coronary artery disease.\u003c\/p\u003e \u003cp\u003eChapter 3 discusses the presence of rhabdomyolysis as an adverse event after concomitant use of statins and antimicrobial agents and mechanisms involved to these interactions.\u003c\/p\u003e \u003cp\u003eChapter 4 aims to provide the extended version of presently published content on chitosan activities towards platelet and blood coagulation mechanisms. Since we are exploring on platelet activities which involve in the coagulation process, as a new contribution to the society, chitosan-based hemostatic agents could be a new strategy biomaterial to achieve hemostasis.\u003c\/p\u003e \u003cp\u003eChapter 5 highlights the major findings and recent advances in the study of micro-biota-dependent mechanism involved in the development of Coronary Artery Disease (CAD) and discuss important roles of probiotic bacteria and plant compounds in prevention and treatment of CAD.\u003c\/p\u003e \u003cp\u003eChapter 6 discusses the value of heart rate in the physiopathology and management of coronary artery disease. Physiology of heart rate value is discussed, along with topics that relate heart rate to endothelial dysfunction, atherosclerosis, hypertension, and other co-morbidities that predispose to coronary artery disease. The role of inflammation and autonomic nervous system are also presented.\u003c\/p\u003e","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":53084118679825,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53084119105809,"sku":"NIN9781922227980","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227980.jpg?v=1769976873"},{"product_id":"oncology-book-iconcept-press-9781922227805","title":"Oncology","description":"Oncology is a branch of medicine that deals with cancer. Onco means bulk, mass, or tumor while -logy means study. Each of the cells of the body have a tightly regulated system that controls their growth, maturity, reproduction and eventual death. Cancer begins when cells in a part of the body start to grow out of control. There are many kinds of cancer, but they all start because of out-of-control growth of abnormal cells. This book focus on the recent progress and research on oncology and serves as an essential guide for oncologists. Oncologists are medical professionals who practice oncology. These oncologists have several specific roles. They help in diagnosis of the cancer, help in staging the cancer and grading the aggressive nature of the cancer. \u003cp\u003e\u003c\/p\u003e There are totally 10 chapters in this book. Chapter 1 shows that chronic IGF-1 stimulation can bypass chemoresistance and support Ewing sarcoma cell apoptosis in combination with the death ligand Apo2L\/TRAIL. The findings may have important implications for the biology as well as the clinical management of the Ewing sarcoma family of tumor. Chapter 2 tests total cfDNA concentration, cfDNA integrity, BRAFV600E mutation and RASSF1A promoter methylation associated to cfDNA in melanoma patients and healthy controls in order to identify a sequential multi-marker panel in cfDNA able to increase the predictive capability in the diagnosis of cutaneous melanoma. Chapter 3 overviews transforming growth factor-B (TGF-B)-mediated tumour suppressive pathways and outlines the molecular mechanisms of these effects. Chapter 4 reviews the contribution of urokinase-type plasminogen activator system in breast cancer; the most common cancer in women worldwide. Better understanding of the molecular biology of this malignancy leads to efficient prognosis and therapies for the disease. \u003cp\u003e\u003c\/p\u003e Chapter 5 describes how non coding RNA families can influence the development of neuroblastoma and also possibly give further insights to new diagnostic procedures and therapies for this devastating paediatric cancer. Chapter 6 reviews the current knowledge of Thymidine Kinase 1 a clinically relevant cancer biomarker which is significantly elevated in serum and tissue of cancer patients. Measurement of Thymidine Kinase 1 is useful as an aid in diagnosis and prognosis of many different cancer types and has recently been shown to have vast clinical potential especially as a screening and monitoring tool for cancer patients. Chapter 7 discusses the characteristic pathological, immunophenotypic, and genetic features of different GI lymphomas categorized according to World Health Organization (WHO) classification. Chapter 8 provides an overview of the chemokine system in homeostasis and cancer, with a focus on the CX3CL1\/CX3CR1 axis to illustrate the complex interplay between the chemokines and other molecules that shape tumor's microenvironment and its progression. \u003cp\u003e\u003c\/p\u003e Chapter 9 reviews the recent advances in cohesin and its associate proteins and discusses the relation between their deregulation and tumorigenesis. Cohesin plays a critical role in regulating sister chromatid cohesion and separation, DNA damage signaling and repair, gene expression, as well as centrosome biogenesis, etc. Chapter 10 reviews the current diagnostic issues that are focused on the identification of the thyroid biomarkers. It shows that thyroid biomarkers has a potential to improve the diagnostic accuracy.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":53084118712593,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53084119171345,"sku":"NIN9781922227805","price":0.0,"currency_code":"GBP","in_stock":false}]},{"product_id":"dermatology-and-allergology-book-iconcept-press-9781922227935","title":"Dermatology and Allergology","description":"Dermatology is the branch of medicine dealing with the skin and its diseases, a unique specialty with both medical and surgical aspects. Allergology is the study of allergy and hypersensitivity, in which allergy is a hypersensitivity disorder of the immune system and hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions produced by the normal immune system. Dermatology and allergology are two highly interrelated disciplines. \u003ci\u003e Dermatology and Allergology -- Principles and Practice\u003c\/i\u003e provides some latest research and concerns in these two areas. \u003cp\u003e\u003c\/p\u003e There are totally 8 chapters in this book. Chapter 1 discusses dermatologic disease with psychiatric manifestations, dermatologic disease influenced by psychosocial stress and psychiatric disorders with cutanous manifestations. Medical Illness with neuropsychiatric and dermatological manifestations and psychiatric side effects of dermatological treatment is also discussed. Chapter 2 describes the ocular surface defence and allergological mechanism when the ocular surface is introduced to foreign bodies, and reviews foreign body reaction caused by synthetic and organic fibers. Chapter 3 discusses podoconiosis, which is a debilitating disease common in several countries across the world. Unfortunately, despite its huge socio-economic and public health burden, podoconiosis has remained neglected in clinical, public health, and policy agendas until quite recently. Chapter 4 evaluates with a second generation antihistamine, like rupatadine, the overall efficacy in the control of morning (AM) and evening (PM) nasal symptoms in patients with allergic rhinitis. This analysis includes the pooled data from five randomized, double blind, placebo-controlled studies. The findings were that overall efficacy (T4SS) relief of symptoms was quite similar for AM or PM period with rupatadine 10 mg once daily, indicating a sustained 24-hour effect of rupatadine irrespective of time of dosing. \u003cp\u003e\u003c\/p\u003e Chapter 5 proposes to evaluate occupational and environmental risk factors for allergic and hypersensitivity reactions with a public health view. Based on the epidemiological data in developed and developing countries, the authors aim to draw attention to the current status and new ways of understanding allergies and propose solutions for the future. Chapter 6 recites the importance of clinical history for the diagnosis of anaphylaxis, validity of recent investigations\/tests in lieu of anaphylaxis and interpretation of various test in the background of clinical history of anaphylaxis. Chapter 7 discusses a common nonscarring, autoimmune disease that can affect any hair-bearing area called Alopecia areata (AA). AA occurs in all ethnic groups, ages, and both sexes and may affect a small area of scalp (patchy type), or involve the entire scalp (alopecia totalis) or whole body (alopecia universalis). Chapter 8 proposes ways of targeting the mycobacterial toxin mycolactone in treatment of Buruli ulcers. Mycolactone plays a central role in ulcer formation by acting on the host at cellular and subcellular levels via several mechanisms.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":53084118843665,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53084119269649,"sku":"NIN9781922227935","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227935.jpg?v=1769976874"},{"product_id":"tuberculosis-book-iconcept-press-9781922227942","title":"Tuberculosis","description":"Tuberculosis is a common, and in many cases lethal, infectious disease caused by various strains of \u003ci\u003emycobacteria\u003c\/i\u003e, such as \u003ci\u003eMycobacterium tuberculosis\u003c\/i\u003e.Tuberculosis typically attacks the lungs, but can also affect other parts of the body. The classic symptoms are a chronic cough with blood-tinged sputum, fever, night sweats, and weight loss. \u003ci\u003eTuberculosis -- A Comprehensive Clinical Reference\u003c\/i\u003e serves as a useful reference for individuals working in biomedical laboratories, and for clinical professionals. It provides the latest research you need to know about tuberculosis. There are totally 10 chapters in this book. Chapter 1 highlights health systems weaknesses that are hampering diseases control efforts and proposes possible health system strengthening interventions that can easily be implemented. Strengthened health systems are essential for the control of tuberculosis. Chapter 2 proposes an original model for preparing and dispensing the drugs and monitoring of patients with tuberculosis under a direct observed treatment (DOT) program. It also includes the results and analysis of the model after the implantation. Chapter 3 shows the associated cost to an original program of Direct observed treatment (DOT) using the perspective of the Spanish Health Care System and comparing for each case of DOT, the cost of a Self-administered Treatment (SAT) based on a theoretical model. Chapter 4 reviews the present scenario of Multi-Drug Resistance Tuberculosis (MDR-TB) and the advantages of newer molecular approaches for the laboratory diagnosis of MDR-RB, with special reference to Rifampicin resistance as a surrogate marker for it. Chapter 5 mainly focuses on the algorithmic approach in diagnosis of tuberculosis-related uveitis. It also gives key points in the pathogenesis, clinical manifestations and treatment of tuberculosis-related uveitis. Pulmonary tuberculosis can lead to various forms of complications. It can be categorized as parenchymal, airway, vascular, pleural lesions and general complications. Chapter 6 describes the pathogenesis, clinical manifestations, diagnostic criteria and management of complications of pulmonary tuberculosis. Chapter 7 discusses \u003ci\u003eMycobacterium tuberculosis\u003c\/i\u003e complex in human beings. Tuberculosis in humans is caused mainly by two of the seven closely related bacteria within \u003ci\u003eMycobacterium tuberculosis\u003c\/i\u003e complex (MTBC), namely \u003ci\u003eMycobacterium tuberculosis\u003c\/i\u003e (MTB) and \u003ci\u003eMycobacterium africanum\u003c\/i\u003e (MAF). Chapter 8 aims on difficulties of anti-TB chemotherapy, especially for Urogenital Tuberculosis, and discusses the way to minimise the side effects. Chapter 9 aims on improving in-time diagnosis of extrapulmonary tuberculosis and particularly urogenital tuberculosis by making clear its features. Chapter 10 deals with the comparative genomics, bioinformatic analyses and genome-wide screening approaches for the better understanding of these immunologically important proteins, and summarizes that PEPPE domain from mycobacteria belongs to the family of serine hydrolase proteins and the phylogenetic analysis has shown that Mycobacterium tuberculosis is of recent decent","brand":"WoB","offers":[{"title":"US \/ NEW \/ INGRAM","offer_id":53084119433489,"sku":"NIN9781922227942","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227942.jpg?v=1769976875"},{"product_id":"mental-disorder-book-iconcept-press-9781922227966","title":"Mental Disorder","description":"Mental disorder is a psychological pattern or anomaly, potentially reflected in behaviour, that is generally associated with distress or disability, and which is not considered part of normal development in a person's culture. The recognition and understanding of mental health conditions have changed over time and across cultures and there are still variations in definition, assessment and classification. The causes of mental disorders are varied and in some cases unclear, and theories may incorporate findings from a range of fields. Services are based in psychiatric hospitals or in the community, and assessments are carried out by psychiatrists, clinical psychologists and clinical social workers, using various methods but often relying on observation and questioning. \u003ci\u003eMental Disorder\u003c\/i\u003e explains the latest research on mental disorders. It serves as an essential start to mastering the science and art of clinical practice. \u003cp\u003e\u003c\/p\u003e Chapter 1 examines youth suicide ideation from a cross-cultural perspective and to focus specifically on gender differences by examining data from 19 countries and cities. Chapter 2 examines the relationship between the locus of control scale as an indicator of internality-externality and the Kessler 10 scale as an indicator of psychological distress, and analyses the effects of socio-demographic and employment-related factors on this relationship.Chapter 3 examines the prevalence of mental health issues and future aspirations among service-seeking youth living in the slums of Kampala. Chapter 4 reviews the literature regarding cognitive deficits in children with type 1 diabetes mellitus as well as explores original research investigating prospective memory in this cohort. This study demonstrates the need for additional studies clarifying the relationship between prospective memory and glycemic control. \u003cp\u003e\u003c\/p\u003e Chapter 5 discusses HCV (Hepatitis C Virus) among patients with mental disorders. Guidelines and universal strategies are suggested to minimize, prevent and treat HCV among patients with mental patients. Future prospects and new concepts in modeling HCV among these patients have also been highlighted and evaluated in this chapter. Chapter 6 describes concept of social anxiety disorder, and presents recent evidence-based treatment algorithm and available further treatment options for them including pharmacotherapy and psychotherapy. Chapter 7 focuses on delayed matching-to-sample procedures that could be useful for identifying problems of short-term memory in people with dementia. The results with use of a titrated delayed matching-to-sample, showed that small titrating steps were more useful than larger titrating steps. Chapter 8 presents the process of adult hippocampal neurogenesis and its relationship with neurological disorders, as well as reviews its role in relation to disease etiology, pathogenesis and areas of future therapeutic targeting. \u003cp\u003e\u003c\/p\u003e Chapter 9 compares a single (pharmacological treatment) versus a multi-element interventions (pharmacological treatment, social skills training, psychoeducation for relatives and family therapy for first episode-psychosis patients and their relatives) know as integrated treatment to determine clinical and functional outcome improvements. It shows that a greater proportion of patients receiving integrated treatment fulfilled the remission criteria and a higher psychosocial functioning improvement when compared to those receiving standard treatment. In addition, a higher number of patients of integrated treatment fulfilled both criteria: symptomatic remission and a better level of psychosocial functioning achieving better functional outcome compared to patients of standard treatment. Chapter 10 provides knowledge, information and clinical skills that are related to examine Psychosis.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":53084119073041,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53084119400721,"sku":"NIN9781922227966","price":0.0,"currency_code":"GBP","in_stock":false}]},{"product_id":"protein-purification-and-analysis-ii-book-iconcept-press-9781922227621","title":"Protein Purification and Analysis II","description":"Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues. The sequence of amino acids in a protein is defined by the sequence of a gene, which is encoded in the genetic code. The complexity and sheer number of proteins in a cell are impediments to identifying proteins of interest or purifying proteins for function and structure analysis. Thus, reducing the complexity of a protein sample or in some cases purifying a protein to homogeneity is necessary. \u003ci\u003eProtein Purification and Analysis\u003c\/i\u003e discusses varies aspect related to protein analysis. There are totally three volumes. This book is the second volume. \u003cp\u003e\u003c\/p\u003e Chapter 1 describes protein-based methods for the analysis of plant alcohol dehydrogenases. \u003cp\u003e\u003c\/p\u003e Chapter 2 demonstrates production of recombinant fungal cell wall-degrading enzymes and their tag-affinity purification and biochemical analyses. Cell wall-degrading enzymes act on cleaving glycosidic bonds of polysaccharides and oligosaccharides, affecting morphological changes, plant-microbe interactions and nutrient acquisition. \u003cp\u003e\u003c\/p\u003e Chapter 3 contains a number of methodologies including recombinant protein purification and analysis, enzymatic reporter assays and fluorescent tag detection. \u003cp\u003e\u003c\/p\u003e Chapter 4 allows the reader to become acquainted with methods of recombinant expression, purification and determination of the level of activity of staphylococcal epidermolytic toxins. \u003cp\u003e\u003c\/p\u003e Chapter 5 discussed the recombinant expression, purification and biochemical analysis of a variety of extremophilic enzymes with potential industrial application. \u003cp\u003e\u003c\/p\u003e Chapter 6 discusses tellurite, which is highly toxic for most living organisms. The chapter describes how the mechanism by which this oxyanion exerts its toxicity can be assessed by studying the effect of some metabolic enzymes which seem to help in detoxifying the toxicant. \u003cp\u003e\u003c\/p\u003e Chapter 7 describes the principle of, devices used for, protocol for, and mechanism underlying gene introduction. \u003cp\u003e\u003c\/p\u003e Chapter 8 outlines a SELEX method for the discovery of a target-specific aptamer. The aptamer is then used to purify the target (SEB) from a mixture of closely related enterotoxins using non-fat dry milk as a representative food matrix. \u003cp\u003e\u003c\/p\u003e Chapter 9 proposes an overview of the methodologies employed for the manipulation of membrane protein transporters, from their purification to their reconstitution into proteoliposomes. The authors presented an original approach they developed for the functional study of a multidrug efflux pump responsible for the active transport of antibiotics in bacteria. \u003cp\u003e\u003c\/p\u003e Chapter 10 is about the versatility of substrate analogues containing unnatural amino acids in the challenging study of peptidyl-aminoacyl-L\/D-isomerases. Enzymes of this class catalyze an exciting post-translational reaction, namely the change of chirality of amino acids within peptide linkage whereby an L-amino acid is converted to the D-isomer. \u003cp\u003e\u003c\/p\u003e Chapter 11 investigates the the effects of combined heat and pressure on whole beef muscle proteins and isolated myofibril solubility and protein electrophoretic pattern. It attempts to understand the relative effects of heat and pressure treatments on the proteins of beef muscle. \u003cp\u003e\u003c\/p\u003e Chapter 12 reviews the normal synovium including it's microscopic structure, cell origins and recruitment, function and its clinical relevance as a target of immunologic disease.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":53084120088849,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53084120285457,"sku":"NIN9781922227621","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227621.jpg?v=1769976884"},{"product_id":"research-and-biology-of-cancer-ii-book-iconcept-press-9781922227423","title":"The Research and Biology of Cancer II","description":"Cancer is a broad group of diseases involving unregulated cell growth, in which cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. Cancer may also spread to different parts of the body through the lymphatic system or the bloodstream. \u003ci\u003eThe Research and Biology of Cancer\u003c\/i\u003e discusses some recent advances in cancer research. There are totally two volumes: Volume I mainly discusses the role of some important enzymes and proteins in cancer, whereas Volume II discusses different types of cancers, including head and neck cancer, oral cancer, kidney cancer, colon cancer, and thyroid cancer. \u003cp\u003e\u003c\/p\u003e Chapter 1 discusses personalised combination therapy targeting PI3K\/Akt, STAT3, ERK, and EGFR signalling pathways which may provide clinical benefits for patients with HNSCC. Such therapy is useful because molecular cross-talk between the EGFR and other RTK signalling pathways through PI3K\/Akt, STAT3, and ERK in HNSCCs, EGFR inhibitors alone may be unable to suppress EGFR downstream. \u003cp\u003e\u003c\/p\u003e Chapter 2 describes tissue based LCM, which is a powerful technique that combines morphology, histopathology, and molecular biological analysis. The ability of LCM to retrieve specific populations of interested cells, combined with the analysis of gene sequencing and gene expression in these sub-population of cells, has made LCM an critical device in clinical and investigative oral oncology. \u003cp\u003e\u003c\/p\u003e Chapter 3 discussed several aspects about the use of the Micronucleus Test to identify genetic damage in individuals at higher risk of developing oral squamous cell carcinoma and evaluated the malignant transformation potential of precancerous lesions. \u003cp\u003e\u003c\/p\u003eChapter 4 aims to picture the landscape of metastatic renal cancer starting from its pathogenesis, molecular markers, prognostic factors, metastatic potential, with emphasis on the recent evolution in the treatment of metastatic renal cancer cases. \u003cp\u003e\u003c\/p\u003e Chapter 5 discusses skin-level jejunostomy (SLJ) tube placement technique using the G-tube, which is a safe procedure in patients with esophageal cancer. It allows the creation of a long-term feeding jejunostomy. \u003cp\u003e\u003c\/p\u003e Chapter 7 offers a comprehensive review of the small bowel neoplasms, as well as its varied clinical manifestations, diagnostic challenges and management principles. \u003cp\u003e\u003c\/p\u003e Chapter 8 reviews the current research efforts to identify biomarkers suitable for non-invasive colon cancer screening. \u003cp\u003e\u003c\/p\u003e Chapter 9 conducted a pilot study to determine the safety and feasibility of an early start of chemotherapy after the resection of colorectal cancer with distant metastases. Chemotherapy usually starts after 4 weeks of surgical resection of colorectal cancer. Unfortunately, there is no study on the optimal length of this delay. A patient may die because postoperative chemotherapy was not started soon enough and so a metastatic tumor was able to develop rapidly. This chapter gives a good review of this problem. \u003cp\u003e\u003c\/p\u003e Chapter 10 focuses on the putative role of intestinal microbiota in the development of colorectal cancer, describing his metabolic functions and relation with diet, and his interaction with host's immunity and with molecular and morpho-functional activity of gastrointestinal tract. \u003cp\u003e\u003c\/p\u003e Chapter 11 describes an approach used for identification of a novel PPI. It shows that an uncharacterized protein, two-transmembrane protein 88 (TMEM88), is a binding partner of Dishevelled (Dvl\/Dsh) by using a combination of techniques, including bioinformatic, biophysical, and biochemical methods.","brand":"WoB","offers":[{"title":"US \/ NEW \/ INGRAM","offer_id":53084122087697,"sku":"NIN9781922227423","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227423.jpg?v=1769976898"},{"product_id":"protein-purification-and-analysis-iii-book-iconcept-press-9781922227652","title":"Protein Purification and Analysis III","description":"Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues. The sequence of amino acids in a protein is defined by the sequence of a gene, which is encoded in the genetic code. The complexity and sheer number of proteins in a cell are impediments to identifying proteins of interest or purifying proteins for function and structure analysis. Thus, reducing the complexity of a protein sample or in some cases purifying a protein to homogeneity is necessary. \u003ci\u003eProtein Purification and Analysis\u003c\/i\u003e discusses varies aspect related to protein analysis. There are totally three volumes. This book is the second volume. \u003cp\u003e\u003c\/p\u003e Chapter 1 describes protein-based methods for the analysis of plant alcohol dehydrogenases. \u003cp\u003e\u003c\/p\u003e Chapter 2 demonstrates production of recombinant fungal cell wall-degrading enzymes and their tag-affinity purification and biochemical analyses. Cell wall-degrading enzymes act on cleaving glycosidic bonds of polysaccharides and oligosaccharides, affecting morphological changes, plant-microbe interactions and nutrient acquisition. \u003cp\u003e\u003c\/p\u003e Chapter 3 contains a number of methodologies including recombinant protein purification and analysis, enzymatic reporter assays and fluorescent tag detection. \u003cp\u003e\u003c\/p\u003e Chapter 4 allows the reader to become acquainted with methods of recombinant expression, purification and determination of the level of activity of staphylococcal epidermolytic toxins. \u003cp\u003e\u003c\/p\u003e Chapter 5 discussed the recombinant expression, purification and biochemical analysis of a variety of extremophilic enzymes with potential industrial application. \u003cp\u003e\u003c\/p\u003e Chapter 6 discusses tellurite, which is highly toxic for most living organisms. The chapter describes how the mechanism by which this oxyanion exerts its toxicity can be assessed by studying the effect of some metabolic enzymes which seem to help in detoxifying the toxicant. \u003cp\u003e\u003c\/p\u003e Chapter 7 describes the principle of, devices used for, protocol for, and mechanism underlying gene introduction. \u003cp\u003e\u003c\/p\u003e Chapter 8 outlines a SELEX method for the discovery of a target-specific aptamer. The aptamer is then used to purify the target (SEB) from a mixture of closely related enterotoxins using non-fat dry milk as a representative food matrix. \u003cp\u003e\u003c\/p\u003e Chapter 9 proposes an overview of the methodologies employed for the manipulation of membrane protein transporters, from their purification to their reconstitution into proteoliposomes. The authors presented an original approach they developed for the functional study of a multidrug efflux pump responsible for the active transport of antibiotics in bacteria. \u003cp\u003e\u003c\/p\u003e Chapter 10 is about the versatility of substrate analogues containing unnatural amino acids in the challenging study of peptidyl-aminoacyl-L\/D-isomerases. Enzymes of this class catalyze an exciting post-translational reaction, namely the change of chirality of amino acids within peptide linkage whereby an L-amino acid is converted to the D-isomer. \u003cp\u003e\u003c\/p\u003e Chapter 11 investigates the the effects of combined heat and pressure on whole beef muscle proteins and isolated myofibril solubility and protein electrophoretic pattern. It attempts to understand the relative effects of heat and pressure treatments on the proteins of beef muscle. \u003cp\u003e\u003c\/p\u003e Chapter 12 reviews the normal synovium including it's microscopic structure, cell origins and recruitment, function and its clinical relevance as a target of immunologic disease.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":53084122349841,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53084122644753,"sku":"NIN9781922227652","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781922227652.jpg?v=1769976902"}],"url":"https:\/\/www.worldofbooks.com\/en-gb\/collections\/author-books-by-iconcept-press.oembed?page=2","provider":"World of Books ","version":"1.0","type":"link"}