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Jean-Pierre Changeux, an internationally renowned neurobiologist, and Alain Connes, one of the most eminent living mathematicians, find themselves deeply divided by these questions. The problematic status of mathematical objects leads Changeux and Connes to the organization and function of the brain, the ways in which its embryonic and post-natal development influences the unfolding of mathematical reasoning and other kinds of thinking, and whether human intelligence can be simulated, modeled,--or actually reproduced-- by mechanical means. The two men go on to pose ethical questions, inquiring into the natural foundations of morality and the possibility that it may have a neural basis underlying its social manifestations. This vivid record of profound disagreement and, at the same time, sincere search for mutual understanding, follows in the tradition of Poincare, Hadamard, and von Neumann in probing the limits of human experience and intellectual possibility. 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Or  is there an unbridgeable distance between the work of neuroscience and the workings of human consciousness? In an exchange between neuroscientist Jean-Pierre Changeux and philosopher Paul Ricoeur, this study explores the vexed territory between these divergent approaches - and comes to a deeper, more complex perspective on human nature. Ranging across diverse traditions, from phrenology to PET scans and from Spinoza  to Charles Taylor, \"What Makes Us Think?\" revolves around a  central issue: the relation between the facts (or \"what is\") of science and the prescriptions (or \"what ought to be\") of ethics. Changeux and Ricoeur ask: will neuroscientific knowledge influence our moral conduct? Is a naturally based ethics possible? Pursuing these questions, they attack key topics at the intersection of philosophy and neuroscience: What are the relations between brain states and psychological experience? Between language and truth? Memory and culture? Behaviour and action? 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