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Coauthored by three leading epidemiologists, with sixteen additional contributors, this Third Edition is the most comprehensive and cohesive text on the principles and methods of epidemiologic research. The book covers a broad range of concepts and methods, such as basic measures of disease frequency and associations, study design,field methods, threats to validity, and assessing precision.  It also covers advanced topics in data analysis such as Bayesian analysis, bias analysis, and hierarchical regression. 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Coauthored by three leading epidemiologists, with contributions from sixteen experts in a variety of epidemiologic sub-disciplines, this new edition is by far the most comprehensive and cohesive text on the principles and methods of epidemiologic research. The book covers a broad range of concepts and methods, including epidemiologic measures of occurrence and effect, study designs, validity, precision, statistical interference, and causal diagrams. Topics in data analysis range from Bayesian analysis, sensitivity analysis, and bias analysis, with an extensive overview of modern regression methods including logistic and survival regression, splines, hierarchical (multilevel) regression, propsensity scores and other scoring methods, and g-estimation. Special-topics chapters cover disease surveillance, ecologic studies, social epidemiology, infectious disease epidemiology, genetic and molecular epidemiology, nutritional epidemiology, environmental epidemiology, reproductive epidemiology, clinical epidemiology, and meta-analysis. 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