{"title":"M.Briggs","description":null,"products":[{"product_id":"economic-history-of-england-rare-book-m-briggs-1669663516brc","title":"Economic History Of England","description":"1929. 2nd Edition, 4th Impression. 548 pages. No dust jacket. Green cloth. Binding remains firm. Pages have light tanning and foxing throughout. Pen mark to contents page. Boards have moderate shelf-w","brand":"WoB","offers":[{"title":"GB \/ WELL_READ \/ INTERNAL","offer_id":50074064093457,"sku":"1669663516BRC","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1669663516BRC_1.jpg?v=1722882457"},{"product_id":"a-textbook-of-economics-rare-book-m-briggs-1655128207lee","title":"A Textbook of Economics","description":"1929. Second Edition. 527 pages. No dust jacket. Green cloth boards with gilt lettering. Minor cracking to gutters, with exposed netting. Clean pages with light tanning and mild foxing throughout. Bin","brand":"WoB","offers":[{"title":"GB \/ WELL_READ \/ INTERNAL","offer_id":50075430125841,"sku":"1655128207LEE","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1655128207LEE_1.jpg?v=1722887258"},{"product_id":"a-text-book-of-economics-rare-book-m-briggs-1690200807tmb","title":"A Text Book Of Economics","description":"1923. Second Edition. 527 pages. No dust jacket. Green cloth boards with gilt lettering. Clean pages with noticeable tanning and foxing throughout. More pronounced to free endpapers and pastedowns. Pe","brand":"WoB","offers":[{"title":"GB \/ WELL_READ \/ INTERNAL","offer_id":50080582664465,"sku":"1690200807TMB","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1690200807TMB_1.jpg?v=1722905397"},{"product_id":"progress-in-hormone-biochemistry-and-pharmacology-book-m-briggs-9789401177146","title":"Progress in Hormone Biochemistry and Pharmacology","description":"Somatostatin was discovered in 1971, by Guillemin and his colleagues during their search for the hypothalamic growth hormone-releasing factor. A peptide was found in ovine hypothalamus which inhibited the release of growth hormone from cultured anterior pituitary cells. 1,2 Determination 3 of its amino acid sequence indicated that it was a tetradecapeptide with a molecular weight of 1639 (Figure lJ. An identical peptide was later isolated from porcine hypothalamus by Schally and his coworkers. 4 The peptide was named somatostatin in the belief that it was a hypothalamic releasing factor whose sole function was to inhibit the secretion of growth hormone. It soon became evident, however, that a peptide with identical immunologic characteristics and biologic activity was present in the D cells of pancreatic islets, in D-like cells of the gastrointestinal tract, in parafollicular cells of the thyroid gland, and in extrahypo- thalamic neurons of both the central and peripheral nervous system in various species, including man. Moreover, studies employing synthetic somatostatin5 demonstrated that the peptide possessed a wide spectrum of biologic activities in addition to its inhibition of growth hormone. 56 S 0 MAT 0 S TAT I N 6 1 2 3 4 5 7 Ala-Gly-Cys-Lys-Asn-Phe-Phe I I S Trp 8 L S 9 I I Cys-Ser-Thr-Phe-Thr 14 13 12 11 10 FIG. 1: Structure of somatostatin 57 I. GENERAL DISTRIBUTION AND ACTIONS Somatostatin is widely distributed within both the central and peripheral nervous systems and in various other tissues (Table 1).","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52660634943761,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52660635762961,"sku":"NLS9789401177146","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789401177146.jpg?v=1762265654"}],"url":"https:\/\/www.worldofbooks.com\/en-gb\/collections\/author-books-by-m-briggs.oembed","provider":"World of Books ","version":"1.0","type":"link"}