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Clinical depression, however, unhinges us from everything we know about the world and makes us strangers to those we love. It is the predominant mental-health problem worldwide, affecting more than 250 million people. Yet how much do we really know about the condition and how to treat it? Drawing on his own experience of a disorder that has afflicted humanity throughout history, Oliver Kamm charts the progress of science in understanding depression and explores insights from writers and artists through the ages. 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