{"title":"Colloquium Series On Developmental Biology","description":"\u003cp\u003eDelve into the frontiers of developmental biology with this essential series. Explore the latest research, cutting-edge insights, and emerging trends shaping our understanding of life's intricate processes. Ideal for students and researchers alike.\u003c\/p\u003e","products":[{"product_id":"developmental-genetics-of-the-pharyngeal-arch-system-book-jeffry-m-cesario-9781615046805","title":"Developmental Genetics of the Pharyngeal Arch System","description":"The pharyngeal arches are embryonic structures that develop into the face, neck, a part of the heart, and several endocrine glands in animals. They are thought to have played a key role in vertebrate evolution as their derivatives impact the mode of feeding and breathing. Moreover, perturbation in pharyngeal arch development is associated with several major groups of birth defects in humans. During early embryonic development, cells from all three germ layers come together to assemble the pharyngeal arches. Subsequently, the pharyngeal arches undergo growth, morphogenesis, and cell type differentiation to give rise to musculoskeletal, cardiovascular, neural, and glandular components. These processes are guided by interactions amongst different tissues, via signaling molecules. A large number of genes, with a complex network of regulatory relationships, govern each aspect of pharyngeal arch development. With the advance of molecular genetics tools in model organisms such as mice, we are beginning to understand the molecular and cellular mechanisms underlying development of the pharyngeal arches and related birth defects. This eBook will provide an introduction into development of the pharyngeal arch system, with a detailed discussion on the genetic regulation of this process.","brand":"WoB","offers":[{"title":"US \/ NEW \/ INGRAM","offer_id":51101520134417,"sku":"NIN9781615046805","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52137770615057,"sku":"NLS9781615046805","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1615046801.jpg?v=1750830883"},{"product_id":"transcriptional-control-of-neural-crest-development-book-brian-nelms-9781615040483","title":"Transcriptional Control of Neural Crest Development","description":"The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecifi ed, nonmigratory population to a wide array of dynamic, differentiated cell types-some of which retain stem cell characteristics presumably to replenish these derivatives-requires a complex network of molecular switches to control the gene programs giving these cells their defi ning structural, enzymatic, migratory, and signaling capacities. This review will bring together current knowledge of neural crest-specifi c transcription factors governing these progressions throughout the course of development. A more thorough understanding of the mechanisms of transcriptional control in differentiation will aid in strategies designed to push undifferentiated cells toward a particular lineage, and unraveling these processes will help toward reprogramming cells from a differentiated to a more naive state. Table of Contents: Introduction \/ AP Genes \/ bHLH Genes \/ ETS Genes \/ Fox Genes \/ Homeobox Genes \/ Hox Genes \/ Lim Genes \/ Pax Genes \/ POU Domain Genes \/ RAR\/RXR Genes \/ Smad Genes \/ Sox Genes \/ Zinc Finger Genes \/ Other Miscellaneous Genes \/ References \/ Author Biographies","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51103908856081,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51103912263953,"sku":"NIN9781615040483","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52148749467921,"sku":"NLS9781615040483","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/161504048X.jpg?v=1751277566"},{"product_id":"wnt-catenin-signaling-in-vertebrate-posterior-neural-development-book-yaniv-m-elkouby-9781615040544","title":"Wnt\/?-Catenin Signaling in Vertebrate Posterior Neural Development","description":"The Wnt\/β-catenin signaling pathway is a key regulator of cell fate specification, differentiation, and growth in multiple systems throughout the animal kingdom. In vertebrate posterior neural development, Wnt\/β-catenin signaling controls this complex multistep process. It initially induces the posterior regions of the nervous system, including the mid-hindbrain border, hindbrain, spinal cord and neural crest, and then subsequently fine-tunes the pattern of each region and determines the different cell fates within them. In this review, we explore the function of the Wnt\/β-catenin pathway during the formation of these specific posterior neural regions. We have examined the important transcriptional targets of the Wnt\/β-catenin pathway acting downstream to mediate its morphogenetic activity. Different regulatory networks are activated in different posterior neural regions, and these networks induce specific neural cell types in each region. Eludidating how each of these networks specify different cell fates is crucial for understanding the basic tenets of how Wnt morphogenetic activity induces the posterior nervous system during the earliest stages of vertebrate development.","brand":"WoB","offers":[{"title":"US \/ NEW \/ INGRAM","offer_id":51103920619793,"sku":"NIN9781615040544","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52148732395793,"sku":"NLS9781615040544","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1615040544.jpg?v=1751342810"},{"product_id":"maternal-control-of-development-in-vertebrates-book-florence-l-marlow-9781615040513","title":"Maternal Control of Development in Vertebrates","description":"Eggs of all animals contain mRNAs and proteins that are supplied to or deposited in the egg as it develops during oogenesis. These maternal gene products regulate all aspects of oocyte development, and an embryo fully relies on these maternal gene products for all aspects of its early development, including fertilization, transitions between meiotic and mitotic cell cycles, and activation of its own genome. Given the diverse processes required to produce a developmentally competent egg and embryo, it is not surprising that maternal gene products are not only essential for normal embryonic development but also for fertility. This review provides an overview of fundamental aspects of oocyte and early embryonic development and the interference and genetic approaches that have provided access to maternally regulated aspects of vertebrate development. Some of the pathways and molecules highlighted in this review, in particular, Bmps, Wnts, small GTPases, cytoskeletal components, and cell cycle regulators, are well known and are essential regulators of multiple aspects of animal development, including oogenesis, early embryogenesis, organogenesis, and reproductive fitness of the adult animal. Specific examples of developmental processes under maternal control and the essential proteins will be explored in each chapter, and where known conserved aspects or divergent roles for these maternal regulators of early vertebrate development will be discussed throughout this review.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51103924781329,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51103926780177,"sku":"NIN9781615040513","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52129410122001,"sku":"NLS9781615040513","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/161504051X.jpg?v=1750959514"},{"product_id":"induction-and-segregation-of-the-vertebrate-cranial-placodes-book-byung-yong-park-9781615041022","title":"Induction and Segregation of the Vertebrate Cranial Placodes","description":"During evolution the vertebrate head has acquired a number of unique features including specialized paired sense organs and cranial sensory ganglia. These evolutionary novelties arise from discrete thickenings of the head ectoderm known as cranial placodes. They include the adenohypophyseal, olfactory, lens, trigeminal, profundal, otic, epibranchial and lateral line placodes. While distinct in the derivatives and cell types they will form, all cranial placodes originate from a common preplacodal domain surrounding the anterior neural plate. Recent evidence suggests that the induction of this pre-placodal domain and its subsequent subdivision into individual placodes with specific identities is a multi-step process. Here we describe the development of these placodes and their derivatives and summarize recent advances in the characterization of the repertoire of transcription factors underlying their development. We also review recent studies that have started to address the role of several classes of signaling molecules in placode induction and segregation, including Bone Morphogenetic Proteins, Fibroblast Growth Factors and Wnt molecules. Table of Contents: Introduction \/ Cranial Placodes and Their Derivatives \/ Molecular Identity of Cranial Placodes \/ Induction and Segregation of the Cranial Placodes \/ Conclusion \/ Acknowledgments \/ References \/ Author Biographies","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51127080026385,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51127080354065,"sku":"NIN9781615041022","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52146459672849,"sku":"NLS9781615041022","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1615041028.jpg?v=1751213590"},{"product_id":"fgf-signalling-in-vertebrate-development-book-mary-elizabeth-pownall-9781615040636","title":"FGF Signalling in Vertebrate Development","description":"The fibroblast growth factors (FGFs) represent one of the relatively few families of extracellular signalling peptides that have been shown in recent decades to be key regulators of metazoan development. FGFs are required for multiple processes in both protostome and deuterostome groups. Given the wide range of regulatory roles attributed to the FGFs, it is perhaps not surprising that misregulation of this signalling pathway has been implicated in a number of human disease conditions. The focus of the present review is to look at the fundamental components of the FGF pathway and illustrate how this highly conserved regulatory cassette has been deployed to regulate multiple, diverse processes during vertebrate development. This review will explore examples from several vertebrate model organisms and include discussions of the role of FGF signalling in regulating the establishment of the mesoderm, neural patterning, morphogenesis, myogenesis, limb development, and the establishment of right-left asymmetry.","brand":"WoB","offers":[{"title":"- \/ - \/ -","offer_id":51226951876881,"sku":"","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":51226952761617,"sku":"NIN9781615040636","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52149181710609,"sku":"NLS9781615040636","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1615040633.jpg?v=1751375258"}],"url":"https:\/\/www.worldofbooks.com\/en-gb\/collections\/colloquium-series-on-developmental-biology-book-series.oembed","provider":"World of Books ","version":"1.0","type":"link"}