{"title":"Developments In Nuclear Medicine","description":null,"products":[{"product_id":"clinical-pet-book-r-bares-9789401066242","title":"Clinical PET","description":"During the past decade Positron Emission Tomography (PET) has  turned from a highly sophisticated tool developed for basic research  in neurology and cardiology into an advanced nuclear medicine imaging  technique ready for routine use. Along with remarkable technical  improvements, an overwhelming number of PET studies has been published  covering not only scientific but also relevant clinical problems. Due  to this rapid development, comprehensive information about the current  status of 'clinical' PET is lacking. \u003cbr\u003e  In this book the applications of PET in neurology, cardiology and  oncology are discussed in separate sections. In each section,  following an introduction reviewing the present clinical demands,  special diagnostic problems and their possible solution by PET are  addressed. Results of conventional scintigraphic techniques are also  mentioned, and compared with PET. In the last section, technical  aspects (e.g. instrumentation, software) are presented, including  statements of representatives of leading manufacturers in the field.  \u003cbr\u003e  \u003cem\u003eClinical PET\u003c\/em\u003e provides a critical overview of relevant  applications of PET for all those who are starting to run a PET  facility or are planning to do so. The book is also dedicated to  interested clinicians who are willing to utilize the diagnostic  potential of PET.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52089505349905,"sku":"NLS9789401066242","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789401066242.jpg?v=1756907498"},{"product_id":"imaging-of-hypoxia-book-hj-machulla-9780792355298","title":"Imaging of Hypoxia","description":"Although the clinical importance of hypoxia  imaging is obviously great, to date neither the clinical nor the  scientific community at an international level has focused many  research activities on the hypoxia problem.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52123621916945,"sku":"NLS9780792355298","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780792355298.jpg?v=1757451533"},{"product_id":"age-related-factors-in-radionuclide-metabolism-and-dosimetry-book-gb-gerber-9780898389531","title":"Age-Related Factors in Radionuclide Metabolism and Dosimetry","description":"Proceedings of a Workshop Held in Angers, France, November  26-28, 1986, Sponsored by the Commission of the European Communities  Directorate General for Science, Research and Development","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52126543806737,"sku":"NLS9780898389531","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780898389531.jpg?v=1757476805"},{"product_id":"amplitude-phase-patterns-in-dynamic-scintigraphic-imaging-book-axel-bossuyt-9789400960114","title":"Amplitude\/phase patterns in dynamic scintigraphic imaging","description":"Conventional nuelear medieine proeedures study the dis- tribution of radiolabelled eompounds (radiopharmaeeutieals) in the body under physiologieal as well as under pathologieal eonditions. Beeause of their ability to visua- lise and to quantify the distribution of radiopharmaeeuti- eals within the body by means of external deteetors, nuelear medieine teehniques are basieally non invasive and funetion oriented. The spatial variation of the traeer distribution in the field of view, or the ehange in distribution during a time interval are interpreted as representing speeifie phy- siologie or pathophysiologie processes. As eompared to other diagnostie imaging teehniques, the spatial resolution of seintigraphie images is rather poor, their temporal resolu- tion is good. Faetors that will therefore determine the ultimate diag- nostie value of a seintigraphie study inelude 1. The speeifieity of the labelled eompounds for the process under study, 2. The resolution in time and space of the instrumentation, and its ability of measuring quantitatively tissue aetivity eoneentrations, 3. The formulation of physiologieal or pathophysiologieal models from whieh the distribution of the traeer ean be predieted. 2 While interpreting nuclear medicine data, the interrelations between these factors should permanently remain under consi- deration. The generalised use of minicomputers has resulted in major advances in information processing in nuclear medicine imaging procedures. Central to this is image digitisation.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52126640570641,"sku":"NLS9789400960114","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789400960114.jpg?v=1757477526"},{"product_id":"radioisotope-studies-in-cardiology-book-hj-biersack-9789401087247","title":"Radioisotope studies in cardiology","description":"During the last decade many significant advances have been made in the in vivo diagnosis of disease. An area of partic- ular success has been the application of nuclear medical procedures to the detection of cardiac disease. Not only is it possible to detect infarction or ischemia by scintigraphic techniques but by the use of labelled metabol- ites and analogues of potassium the viability of myocardial tissue can be evaluated. The efficiency of the heart pump can be calculated and wall motility observed in one simple proce- dure. The use of ultra short life radionuclides has made the evaluation of rapid changes in myocardial function feasible. Altogether a broad and impressive diagnostic package. In this volume up-to-date reviews of all of the available techniques have been collected including methods which are still in the development phase. There is an inherent emphasis on European experience in Nuclear Cardiology which is then placed in context with world wide experience in the field. This volume will be of interest to all concerned with cardiac diseases and we hope that it will serve to stimulate further developments in the future. H.J. Biersack, Bonn P.H. Cox, Rotterdam VI CONl'RIBUTORS Bauer, R. - Nukleanredizinisdl.e Klinik und Poliklinik redl.ts der Isar der Tedlnisdl.en Universitat Mlinchen, FRS. Biersack, H.J. - Institut fur klinisdl.e und experimentelle Nukleanredizin der Universitat Bonn, FRG. Breuel, H.P. - Degussa Phanna Horrburg, Frankfurt 1, FRG. Cox, P .H. - Department of Nuclear Hedicine, Rotterdamsdl. Radio-Therapeutisdl.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52126817386769,"sku":"NLS9789401087247","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789401087247.jpg?v=1757480328"},{"product_id":"blood-cells-in-nuclear-medicine-part-ii-book-gerhard-f-fueger-9789400960329","title":"Blood cells in nuclear medicine, part II","description":"G. F. FUEGER Among the many processes in Physiology few appear mo e inviting to be studied by tracers and external imaging than the variety of the routes of migratory (blood) cells in health and disease. Much emphasis has been placed lately on the methods of labelling of the white blood cells. It is obviously quite important and necessary to refine the methods of leucocytic labelling, particularly to search for ways to label selectively a specific group of white blood cells, but there is also the need to review and keep abreast with the developing knowledge of the white blood cells themselves, especially their behaviour under pathological conditions, as seen by histology and scintigraphy, their biological properties, their immunological characteristics and the mechanisms of the control of leucocytic functions. Similarly, it appears desirable to analyze animal models of inflammation as well as to review the dosimetry and the biodistribution of labelled white blood cells in humans. This book is the result of a cooperative effort to review certain highlights of the physiology of leucocytes, labelled and unlabelled, as a corollary to the effort concerning the labelling of white blood cells. In preparing this book we aim for a better understanding and definition of the goals to be achieved by the successful labelling of the migratory cells of the body. XI CONTRIBUTORS Becker, H. Medizinische Universitaetsklinik der Uni- versitaet Graz, Graz, Landeskrankenhaus, haus, Austria Bjurman, B. Department of Radiation Physics, General Hospital, Malmoe, Sweden Chiles, C.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52126915625233,"sku":"NLS9789400960329","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789400960329.jpg?v=1757481197"},{"product_id":"progress-in-radiopharmacology-1985-book-ph-cox-9789401087278","title":"Progress in Radiopharmacology 1985","description":"This volume is based upon presentations made to the 4th European Symposium on Radiopharmacology which was held under the auspices of the European Joint Committee on Radiopharma- ceuticals (ENMS \/ SNME) in Athens from March 28 - 31, 1984. The Medical Insurance Foundation of the National Bank of Greece (TYPET) sponsored this meeting and the Joint Committee would like to express their gratitude to the local organising committee: G. Limouris, M. Pierroutsakou, A. Sarris, A. Tzoulis and C. Binas. A word of thanks also to Mrs. Tineke Busker who prepared the camera ready copy. The meeting reflects the continuing and growing interest in biodistribution and factors which can influence bio- distribution in the clinical situation. The choice of sub- jects, respiration, cerebral function, biodistribution and metabolism complement earlier volumes in this series and reflect European interests in these areas. P. H. Cox Rotterdam, April 1985 VII CONTENTS Foreword P. H. Cox v Contributors XI I. THE RESPIRATORY SYSTEM Physiology and pathophysiology of the respiratory system J. Roth, E. Henze, W. E. Adam 3 Generator-produced Krypton-81m in gas and liquid phases for medical applications M.\nGuillaume, N. Garzaniti, H. Zicot, T. Khuc, P. Bartsch 23 Noble radionuclides for lung ventila- tion studies I. Bofilias 49 Radioaerosols in nuclear medicine M. Pillay, B. Shapiro, P. H. Cox 57 99m A dry aerosol of Tc -albuminmilli- micro spheres for lung ventilation scintigraphy: preparation, inhalation apparatus and examples of clinical results P. Angelberger, I. Zolle, A. Strigl, H. Kahn, A. Mostbeck, W.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52127204966673,"sku":"NLS9789401087278","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789401087278.jpg?v=1757484471"},{"product_id":"radioiodination-theory-practice-and-biomedical-applications-book-mrinal-k-dewanjee-9780792314912","title":"Radioiodination: Theory, Practice, and Biomedical Applications","description":"Among the readily available -emitting radionuclides, the nuclides of iodine have the greatest versatility in labeling both the hydrophilic and the lipophilic compounds that are used in biology and medicine. Biologically important micrmolecules, semimacromolecules, and macromolecules have been identified which, after iodination, almost maintain the same molecular configuration and similar biologic specificity as those of the parent molecules. The multiple techniques for iodination and the clinical use of iodinated products have made possible the present status of the development of diagnostic nuclear medicine. 125r, with a half-life of 60 days, has a crucial role in competitive protein-binding studies. 131r is useful for measuring thyroid uptake, for the diagnosis of thyroid carcinoma and metastasis, and for therapy. 1nr, with a reasonably shorter half-life, is almost ideal for thyroid workup and for a few useful labeled radiopharmaceutical. Although c is used more widely in diagnostic procedures, the radionuclides of iodine will always have a major role in biology and medicine. A considerable amount of information is scattered in the literature regarding the chemistry of radioiodination and the mechanism of tracer localization in cells and tissues. Labeled peptides, proteins, and antibodies are extensively used for protein turnover studies, receptor binding and tumor imaging studies, and radioimmunoassay. The general trend in the use of tracers in clinical nuclear medicine has been an evolution from 3H, 14C, 11C, and 13 to 125, 131 and 123r to c and 111rn.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52127348130065,"sku":"NLS9780792314912","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780792314912.jpg?v=1757485757"},{"product_id":"positron-emission-tomography-in-clinical-research-tracer-modelling-and-radiorece-book-c-beckers-9780792302544","title":"Positron Emission Tomography in Clinical Research: Tracer Modelling and Radioreceptors","description":"Proceedings of a workshop held in Brussels, Belgium within  the framework of the European Community Medical and Public Health  Research","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52127729123601,"sku":"NLS9780792302544","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53588758298897,"sku":"NIN9780792302544","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780792302544.jpg?v=1757487806"},{"product_id":"imaging-of-infection-and-inflammation-book-ph-cox-9780792350873","title":"The Imaging of Infection and Inflammation","description":"Discusses the role of nuclear medicine in three parts: a review of the pathophysiology of infection; a technical description of those nuclear medicine techniques which can be used in imaging infection; and, a review including thoracic, abdominal and orthopaedic infection.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52133888065809,"sku":"NLS9780792350873","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53558367355153,"sku":"NIN9780792350873","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780792350873.jpg?v=1757536758"},{"product_id":"principles-of-radiopharmacology-book-h-deckart-9780898387742","title":"Principles of Radiopharmacology","description":"This publication contains a collection of 22 manuscripts by authors invited to write review articles. They are based on lectures presented on the First and Second Training Course in Radiopharmacy and Radiopharmacology. These courses were organized under the auspices of the Joint Committee on Radiopharmaceuticals of both European Societies of Nuclear Medicine (ENMS and SNME) and were sponsored by the European Society of Nuclear Medicine (ENMS). Recent developments in radiopharmacy and radiopharmacology have been very complex; they cannot be overlooked by the medical staff in nuclear medical departments. This book has been written to provide access to recent research and to practical daily routine in patients' investigations. It provides a wide-ranging and topical overview of radiopharmacology in- cluding chapters on basic chemistry and physics, incorporation dosimetry, interference of drugs in radiopharmacokinetics, legal aspects and stable isotope-labelled pharmaceuticals. Style of presentation is not uniform. Par- tial overlapping concerning the content of papers has not been avoided in order to ensure different views and aspects of the same subject. We hope that the interdisciplinary approach will be stimulating and thought-provok- ing for the reader. Consequently, this book is designed for specialists work- ing in nuclear medical centres which involve different disciplines such as pharmacists, radiochemists, physicists, biochemists, biologists, mathemati- cians, electronic engineers, physicians with different specialities, and tech- nicians.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52134340296977,"sku":"NLS9780898387742","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780898387742.jpg?v=1757541282"},{"product_id":"scintigraphy-of-inflammation-with-nanometer-sized-colloidal-tracers-book-marc-de-schrijver-9780792302728","title":"Scintigraphy of Inflammation with Nanometer-sized Colloidal Tracers","description":"The work presented here is based upon contact with excellent scientists who did not measure their time sparingly to be of assistance. It has also benefited from the infrastructure some col- leagues made available to me, and without which considerable delays and expenditure would have been unavoidable. In this respect, I am particularly indebted to a number of people. Dr. J. Abramovici, Professor S. Orloff and Professor R. Fridrich reviewed my data critically and gave me access to their Insti- tutes, enabling me to collect the clinical evi- dence required to complete this work. The latter benefited also from the efforts of Dr. K. Streule who supervised the cross-over study upon which the final conclusions have been based. Dr. R. Senekowitsch and her staff were of inva- luable help with the animal experimental data and was, together with Professor H. Kriegel, kind enough to enable me to complete this particular part. Dr. H.L. Chia's laboratory data provided me with the possibility to widen the radiopharmaceu- tical aspects of the theme under discussion. I am also indebted to Dr. K.J. Panek for personal com- ments regarding the radiation dosimetry of lll- v vi SCINTIGRAPHY OF INFLAMMATION labelled leukocytes.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52136912421137,"sku":"NLS9780792302728","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780792302728.jpg?v=1757555676"},{"product_id":"x-ray-fluorescent-scanning-of-the-thyroid-book-mh-jonckheer-9789400967076","title":"X-ray fluorescent scanning of the thyroid","description":"Just prior to the 1982 Annual Meeting of the European Thyroid Association in Brussels, a number of outstanding experts in the field of X-ray fluorescence gathered at the Academisch Ziekenhuis of the Free University of Brussels in a joint effort to more clearly define the actual place and value of the latest newcomer among the techniques available for the in vivo assessment of thyroid function. It is the merit of Prof. M. Jonckheer to have organised this meeting and to have made available the work presented there to a larger public in the form of this monograph. Both, the meeting and the written accounts thereof are greatly appreciated by all thyroidologists who care for properly defining the genuine value of X-Ray fluorescence in scientific research and in clinical management of thyroid disorder. Three main conclusions can be drawn from the work presented 1. X-ray fluorescence has become a safe, convenient and reliable tool for measuring intrathyroidal iodine stores in vivo with an inter-assay reproducibility estimated at roughly 10% 2. X-ray fluorescence, used by expert hands, is a highly interesting tool to follow changes of intra thyroidal iodine stores in time, subsequent e. g. to the exposure of the thyroid gland to excess iodine 3. In contrast, no definite place of X-ray fluorescence as a technique in routine assessment of thyroid disease is yet at the horizon This latter conclusion may appear somewhat disappointing.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52141229048081,"sku":"NLS9789400967076","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789400967076.jpg?v=1757576786"},{"product_id":"safety-and-efficacy-of-radiopharmaceuticals-1987-book-knud-kristensen-9789401080163","title":"Safety and efficacy of radiopharmaceuticals 1987","description":"Safety and Efficacy of Radiopharmaceuticals was established as a very important and comprehensive subject at the First Europe  an Symposium on Radiopharmacy and Radiopharmaceuticals in Denmark in 1983.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52141382041873,"sku":"NLS9789401080163","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789401080163.jpg?v=1757577057"},{"product_id":"clinical-application-of-radiolabelled-platelets-book-c-kessler-9789401067492","title":"Clinical Application of Radiolabelled Platelets","description":"AIMS OF THE COLOGNE-SYMPOSIUM ON RADIOLABELLED PLATELETS In 1976, M. Thakur et al (1) were the first to publish a paper concerning the in vivo thrombus detection with 111- In-labelled platelets. Previous attempts at scintigraphic thrombus localisation had been disappointing because of the unspecific binding of a number of the isotopes used, as well as the poor labelling efficiency or an insufficient low gamma-emitting property. Because of its physical characteristics (2.8 days half-life, 94% gamma emission) 111 Indium turned out to be the best isotope for platelet kinetic studies as well as for the measurement of platelet incorporation by Thrombi to be used up until now. The lipophile complexes of Ill-In (8-hydroxyquinoline, acetylacetone, tropolone) diffuse passively into the platelets without altering the function or the life span of the platelets. This advantage has let to an increase in the clinical applications of 1211-In labelled platelets. Today, radiolabelled platelets are used for thrombus detection in several different medical areas such as cardiology, nephrology. angiology or neurology. Even though many scientists and hospital doctors now routinely use radiolabelled platelet as a diagnostic tool, there is as yet not a standardized labelling method. In addition to this, there are neither standardized image procedures for the different clinical applications nor an agreement about specificity and sensitivity of the method. In 1983, a symposium on Radiolabelled Cellular Blood Elements was organized by M.Thakur, M.R.Hardeman and M.D.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52141655261457,"sku":"NLS9789401067492","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789401067492.jpg?v=1757577834"},{"product_id":"blood-cells-in-nuclear-medicine-part-i-book-mr-hardeman-9789400960299","title":"Blood cells in nuclear medicine, part I","description":"xi List of first authors xiii Acknowledgements xv INTRODUCTICN Approaches to radiolabelling blood d-c cells: past, present and future M. L. Thakur 3 CELL LABELLllJG TEDlNIQUES 2 Labelling techniques of granulocytes and platelets 17 with 111 In-oxinate M. R. Hardeman, E. G. J. Eitjes-van Overbeek, A. J. M. van Velzen, M. H. Rovekarnp 111rndium-labelling of human washed platelets; kinetics 3 29 and in vivo sequestration sites M. Eber, J. P. Cazenave, J. C. Grob, J. Abecassis, G. !o1ethlin 111Indium loss from platelets by in vitro and ex 4 44 vivo manipulation R. J. Hawker, C. E. Hall, H. C-oldman, C. N. McCollum PIATELEl'S: KrnETIC STUDIES 5 The maturation of megakaryocytes and their precursors 65 J. H. Paulus 6 !o1egakaryocytic precursors 74 J. Breton-Gorius, W. Vainchenker 7 !-1ethods of quantification of platelet production 86 in man. A critical analysis Y. Najean vi 8 Platelet production rate deteDmination with (75se)_ seleno-m:thionine R. Cardinaud, E. Dassin 96 9 Platelet kinetics: the state of the art A. duP Heyns 110 10 Platelet kinetics A. M. Peters 130 Evaluation of models to deteDmine platelet life 11 span and survival curve shape M. G. LOtter, C. P. Herbst, P. N.\nBadenhorst, A. duP Heyns, P. Wessels, P. C. Minnaar 139 12 Canparison of three m:thods evaluating platelet survival tim: in patients with prosthetic heart valve J. Schbath, D. Ville, B. Hathy, B. Sanchini, E. Benveniste, J. Belleville, M. Dechavanne, J. P. Boissel, J.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52142097170705,"sku":"NLS9789400960299","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789400960299.jpg?v=1757579178"},{"product_id":"progress-in-radiopharmacology-3-book-ph-cox-9789400976719","title":"Progress in Radiopharmacology 3","description":"The publication of this volume, which is based upon presentations made to the Third European Symposium on Radiopharmacology at Noordwijkerhout, April 22 - 24, 1982, is indicative of the continued interest in this sub-branch of Nuclear Medicine.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52142113095953,"sku":"NLS9789400976719","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789400976719.jpg?v=1757579267"},{"product_id":"progress-in-radiopharmacy-book-ph-cox-9789401084109","title":"Progress in Radiopharmacy","description":"The contents of this volume are based upon presentations made to the Second European Symposium on Radiopharmacy and Radiopharmaceuticals which was held in St. Catharine's College Cambridge in March 1985. This meeting was organized by the Radiopharmacy Group of the British Nuclear Medicine Society under the auspices of the European Joint Committee on Radio­ pharmaceuticals of the ENMS \/ SNME. The Joint Committee acknowledges the special effort which was made by the local organizers to prepare this meeting the quality of which is undoubtedly reflected in the proceedings. The wide ranging aspects of Radiopharmacy are reflected in this volume which not only deals with specialized topics, such as aerosols and biodistribution studies, but which also deals with the professional aspects of Radiopharmacy Practice. We are of the opinion that this book complements earlier publications to give an ongoing picture of the practice of Radiopharmacy and the state of the art in Europe. As well as acknowledging the contribution of the British Radiopharmacists I would also mention the support of my co­ chairman Prof. Dr M.G. Woldring, the members of the Joint Committee and last but not least Mrs. M. Busker, who prepared the camera ready copy. P.H. Cox Co-ordinating Chairman European Joint Committee on Radiopharmaceuticals Rotterdam XI CCNrRIBUTORS Anderson, M.L. - Pharnacy department, London Hospital London, UK. Angelberger, P. - Osterreichische Forschungszentrum Seibersdorf GmbH, Wien, Austria. Claessens, R.A.M.J. - Department of Nuclear Medicine, St. Radboud Ziekenhuis, Nijrnegen, The Netherlands.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52142710030609,"sku":"NLS9789401084109","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789401084109.jpg?v=1757581308"},{"product_id":"theory-and-practice-of-3d-pet-book-b-bendriem-9780792351085","title":"The Theory and Practice of 3D PET","description":"The application of 3D methodology has recently been receiving  increasing attention at many PET centres, and this monograph is an  attempt to provide a state-of-the-art review of this methodology,  covering 3D reconstruction methods, quantitative procedures, current  tomography performance, and clinical and research applications. No  such review has been available until now to assist PET researchers in  understanding and implementing 3D methodology, and in evaluating the  performance of the available imaging technology. In all the chapters,  the subject matter is treated in sufficient depth to appeal equally to  the physicist or engineer who wishes to establish the methodology, and  to PET investigators with experience in 2D PET who wish to familiarize  themselves with the concepts and advantages of 3D, and to be made  aware of the pitfalls.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52147161530641,"sku":"NLS9780792351085","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53518215053585,"sku":"NIN9780792351085","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780792351085.jpg?v=1757599621"},{"product_id":"clinical-use-of-antibodies-book-richard-p-baum-md-9789401055550","title":"Clinical Use of Antibodies","description":"It was at Frankfurt\/Mainin 1899 that Paul Ehrlich first expounded his famous \"site-chain theory\" -which described the basic immunological principal of antibody-antigen interactio- on the occasion of the opening of the Institute for Experimental Therapeutics (which was later named after him). Nearly 100 years have passed since, and in retrospect it can be said that the \"Ehrlich Era\" (first steps in immunology \"Magic Bullet\" concept) and the \"Behring Era\" (detection of antibodies and serum therapy) formed the essential basis in the development of immunology. Niels K. Jerne, the former director of the Paul Ehrlich Institute in Frankfurt\/Main received, together with Georges Kohler and Cesar Milstein, the Nobel Prize in Medicine 1984. These late successors of Ehrlich and Behring first described the hybridoma technology (in 1975) which enabled one of the most important and revolutionary technological innovations in the field of immunology -the production of monoclonal antibodies. It happens that, the time of the publication of this book, just a decade has passed since the first use of radiolabelled monoclonal antibodies in man (by the Lausanne Group). Over these 10 years a tremendous progress has taken place in the field of immunoscintigraphy:A large panel of highly specific monoclonal antibodies against tumour-associated antigens as well as normal cell compounds have been developed. Enormous progress has been made in the field of radiolabelling -from iodine-131 to technetium-99mor even positron-emittingradionuclides, e. g. iodine-124.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52330905043217,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52330905665809,"sku":"NLS9789401055550","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789401055550.jpg?v=1758146798"},{"product_id":"nuclear-medicine-in-gastroenterology-book-hj-biersack-9789401054645","title":"Nuclear Medicine in Gastroenterology","description":"During the last two decades significant advances have been made in the in vivo-diagnosis of gastrointestinal diseases. Although Ultrasound and CT as well as Endoscopy have had a major impact on the evaluation of liver, pancreas and bile diseases, there are a lot of indications for Nuclear Medicine procedures. These include new investigational procedures like esophageal scintigraphy, proof of bleeding sites, scintigraphy of inflammatory diseases, and intestinal resorption tests. Further, immunoscintigraphy with radiol- elled antibodies has gained wide-spread application especially in colon cancer. The differential diagnosis of liver tumors like haemangioma and focal nodular hyperplasia by means of blood pool and HID A-scintigraphy is nowadays a routine procedure. Other established methods like hepatobiliary scintigraphy and liver perfusion scintigraphy have proved to be reliable tools in the pre-and postoperative evaluation of patients with bile duct obstruction and portal hypertension. The aim of this book is to present the entire spectrum of Nuclear Medicine in Gastroenterology to our colleagues from internal medicine and surgery. Ultrasound and Sonography as well as CT will rule the field of gastroenterology, but there remain a certain number of unanswered questions. Nuclear Medicine provides a lot of reliable answers. H. J. Biersack and P. H. Cox July 1990 VB List of contributors Duncan M. Ackery, Department of Nuclear Medicine, Southampton General Hospital, Tremona Road, Southampton, Hampshire S09 4XY, U. K. Roland Bares (co-author: U. Buell), Department of Nuclear Medicine, Te- nical University of Aachen, Pauwelsstr. 1, DW-5100 Aachen, Germany.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52331622400273,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52331623448849,"sku":"NLS9789401054645","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789401054645.jpg?v=1758149039"},{"product_id":"radioiodination-theory-practice-and-biomedical-applications-book-mrinal-k-dewanjee-9781461365563","title":"Radioiodination: Theory, Practice, and Biomedical Applications","description":"Among the readily available -emitting radionuclides, the nuclides of iodine have the greatest versatility in labeling both the hydrophilic and the lipophilic compounds that are used in biology and medicine. 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A considerable amount of information is scattered in the literature regarding the chemistry of radioiodination and the mechanism of tracer localization in cells and tissues. Labeled peptides, proteins, and antibodies are extensively used for protein turnover studies, receptor binding and tumor imaging studies, and radioimmunoassay. 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PET allows one to follow the effect of a drug on a  variety of patients' metabolic parameters. In addition, PET may be  used to follow the fate in vivo of a compound, allowing visualisation  of its binding to specific receptors and a direct study of the  mechanism of drug action in normal and pathological situations. \u003cbr\u003e  The book shows the fields in which PET offers new and unique  information for the development of drugs (conception, toxicity,  pharmacokinetics and metabolism, clinical research, and relations  between clinical and biological effects) and evaluates fields in which  PET may shorten the development time of drugs. \u003cbr\u003e  \u003cem\u003eAudience:\u003c\/em\u003e Professionals in the pharmaceutical industry in all  areas of drug discovery and pharmacology, pre-clinical testing,  pharmacokinetics and metabolism, clinical evaluation, registration and  regulatory affairs. Government health authority representatives who  assess data and documentation on new drug development and  radiopharmaceuticals. Academic experts concerned with any of these  areas.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52341492580625,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52341493104913,"sku":"NLS9789401041911","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789401041911.jpg?v=1758171761"},{"product_id":"current-directions-in-radiopharmaceutical-research-and-development-book-steven-j-mather-9780792342540","title":"Current Directions in Radiopharmaceutical Research and Development","description":"Radiophannaceutical research has recently undergone a major change in direction. In past years it has been concerned mainly with the development of perfusion tracers, the biodistribution of which reflect the regional blood flow to areas of major organs such as the heart and brain. However, a major new direction of interest now lies in the development of receptor-binding radio-tracers which can be used to perform in-vivo characterisation of diseased tissues and it is likely that much of the future research in this field will follow this direction. The difficulties in developing such tracers are considerable. The researcher must first identify a promising target for radiopharmaceutical development. High specific activity radioactive molecules must be designed and synthesised which will both bind to the target receptor with high affinity, and also have the physicochemical characteristics which will allow them to reach the target site in sufficient quantity while at the same time showing minimal uptake in non-target tissues. Thus the knowledge base required for radiophannaceutical development has now expanded beyond the limits of radiopharmaceutical chemistry to include aspects of biochemistry, molecular biology and conventional drug design. The portfolio of basic knowledge required to support current radiopharmaceutical development is changing and scientists working in this arena need to be trained in this regard. 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J. H. F. Remme, World Health Organisation, 1993. If it is true that science is not limited by frontiers and all research Institutions then belong to mankind, so it is natural for each Institution to be responsible for the problems of those who live in the geographic area under its influence. There are no specific aspects concerning physical, chemical or philosophical concepts and facts, but specificity does exist concerning geology, sociology and pathology. It is the duty of each Institution to study the particular aspects concerning its geographic region, as missing links of the chain of universal knowledge may be found there. H. L. de Oliveira, fonner Rector of the University ofSiio Paulo, 1967. Nuclear Medicine is cost effective, especially in the developing countries. 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The portfolio of basic knowledge required to support current radiopharmaceutical development is changing and scientists working in this arena need to be trained in this regard. 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Is it  possible to use positron tomography to measure some of them, and what  is their meaning in normal and pathological situations? These  questions have been addressed for a long time and no satisfactory  answer has yet been given.\u003cbr\u003e  This book, which derives from an EEC workshop organized in the frame  of the Concerted Action on `PET Investigation of Cellular Regeneration  and Degeneration', held in Lyon in February 1992, gives the present  state of knowledge in this field based on the most recent studies.  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This book, written by a series of experts not just in the fields of  nuclear medicine but also infectious disease and radiology, discusses  the role of nuclear medicine in three parts:    a  review of the pathophysiology of infection;   a technical  description of those nuclear medicine techniques which can be used in  imaging infection;   an extensive systematic review including  thoracic, abdominal and orthopaedic infection as well as a special  section on the acutely ill patient, the immunosuppressed patient and  the patient with pyrexia of unknown origin.        This book will be of interest to all clinicians looking after patients  with infection and who need to use imaging techniques. 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The development of high resolution PET and SPET for clinical applications facilitates the development of new radiopharmaceuticals by the use of models to quantitatively evaluate drug effects, and progression of disease, and hence to arrive at better diagnosis and treatments for animals and humans. 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This was followed by Radiochemistry, Methodology and Standardization in PET at the Service Hospitalier Frederic Joliot in Orsay, France, in March 1985. Both these meetings were, in the opinion of all participants, great successes, and it was agreed that such work- shops should continue and be organized on the same basis. After these two workshops on the fundamentals of PET, time now is ripe to evaluate the clinical efficacy of PET investigations, and to discuss to what extend the information provided by this high technology and theoretical area has contributed to the understanding of disease mechanisms, leading to immediate clinical applications. As pointed out in the previous meetings, PET using short-lived radioisotopes produced in an on-line cyclotron is restricted to a few centers. Therefore, the topics studied so far were mainly of scientific interest and clinical problems were dealt with only marginally. 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These courses were organized under the auspices of the Joint Committee on Radiopharmaceuticals of both European Societies of Nuclear Medicine (ENMS and SNME) and were sponsored by the European Society of Nuclear Medicine (ENMS). Recent developments in radiopharmacy and radiopharmacology have been very complex; they cannot be overlooked by the medical staff in nuclear medical departments. This book has been written to provide access to recent research and to practical daily routine in patients' investigations. It provides a wide-ranging and topical overview of radiopharmacology in- cluding chapters on basic chemistry and physics, incorporation dosimetry, interference of drugs in radiopharmacokinetics, legal aspects and stable isotope-labelled pharmaceuticals. Style of presentation is not uniform. Par- tial overlapping concerning the content of papers has not been avoided in order to ensure different views and aspects of the same subject. We hope that the interdisciplinary approach will be stimulating and thought-provok- ing for the reader. Consequently, this book is designed for specialists work- ing in nuclear medical centres which involve different disciplines such as pharmacists, radiochemists, physicists, biochemists, biologists, mathemati- cians, electronic engineers, physicians with different specialities, and tech- nicians.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52410546782481,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52410547110161,"sku":"NLS9789401083843","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789401083843.jpg?v=1758778665"},{"product_id":"progress-in-radiopharmacy-book-august-p-schubiger-9780792315254","title":"Progress in Radiopharmacy","description":"This book is a compilation of the invited papers, which were presented at the Fourth European Symposium on Radiopharmacy and Radiopharmaceuticals, which was held in Baden, Switz- land, 1-4 May, 1991. The First and Third Symposia on Radiopharmacy and Radiopharmaceuticals (Elsinore, Denmark, 1983, 1987) concentrated on the safety and efficacy of radiopharmaceuticals, whereas this Fourth Symposium to some extent followed up the subject of the Second Symposium (Cambridge, UK, 1985): recent developments in radiopharmacy and current research on radiopharmaceuticals. The symposium was organized by the Radiopharmacy Group of the Swiss Society of Medical Radiology (Section Nuclear Medicine) under the auspices of the task group on radiopharmaceu- cals of the European Association of Nuclear Medicine (EANM). The organizing committee consisted of the cochairmen Drs. P.A. Schubiger (Paul Scherrer Institute (PSI), Villigen) and G. Westera (University Hospital, ZiJrich) and the members H.-F. Beer, P. Bl iuenstein, P. Hasler (all PSI) and H. M icke (Cantonal Hospital, Basel). The subjects of this Symposium ranged from isotope production to clinical testing of radioph- maceuticals, including the organisational prerequisites. In addition, the development of new radiopharmaceuticals and of PET radiopharmacy, and the concomittant ongoing evolution of regulatory guidelines by national (various European countries, USA) and international (EC) authorities, induced us to honor the vivid interest in this subject and to make it an important part of this symposium.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52429391495441,"sku":"NLS9780792315254","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52740053434641,"sku":"NIN9780792315254","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780792315254.jpg?v=1759166793"},{"product_id":"progress-in-radiopharmacy-book-ph-cox-9780898388237","title":"Progress in Radiopharmacy","description":"The contents of this volume are based upon presentations made to the Second European Symposium on Radiopharmacy and Radiopharmaceuticals which was held in St. Catharine's College Cambridge in March 1985. This meeting was organized by the Radiopharmacy Group of the British Nuclear Medicine Society under the auspices of the European Joint Committee on Radio­ pharmaceuticals of the ENMS \/ SNME. The Joint Committee acknowledges the special effort which was made by the local organizers to prepare this meeting the quality of which is undoubtedly reflected in the proceedings. The wide ranging aspects of Radiopharmacy are reflected in this volume which not only deals with specialized topics, such as aerosols and biodistribution studies, but which also deals with the professional aspects of Radiopharmacy Practice. We are of the opinion that this book complements earlier publications to give an ongoing picture of the practice of Radiopharmacy and the state of the art in Europe. As well as acknowledging the contribution of the British Radiopharmacists I would also mention the support of my co­ chairman Prof. Dr M.G. Woldring, the members of the Joint Committee and last but not least Mrs. M. Busker, who prepared the camera ready copy. P.H. Cox Co-ordinating Chairman European Joint Committee on Radiopharmaceuticals Rotterdam XI CCNrRIBUTORS Anderson, M.L. - Pharnacy department, London Hospital London, UK. Angelberger, P. - Osterreichische Forschungszentrum Seibersdorf GmbH, Wien, Austria. Claessens, R.A.M.J. - Department of Nuclear Medicine, St. Radboud Ziekenhuis, Nijrnegen, The Netherlands.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52429947961617,"sku":"NLS9780898388237","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":53149910401297,"sku":"NIN9780898388237","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780898388237.jpg?v=1759168341"},{"product_id":"theory-and-practice-of-3d-pet-book-b-bendriem-9789048150403","title":"The Theory and Practice of 3D PET","description":"The application of 3D methodology has recently been receiving  increasing attention at many PET centres, and this monograph is an  attempt to provide a state-of-the-art review of this methodology,  covering 3D reconstruction methods, quantitative procedures, current  tomography performance, and clinical and research applications. 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In addition, the development of new radiopharmaceuticals and of PET radiopharmacy, and the concomittant ongoing evolution of regulatory guidelines by national (various European countries, USA) and international (EC) authorities, induced us to honor the vivid interest in this subject and to make it an important part of this symposium.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52660123566353,"sku":"NLS9789401051408","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9789401051408.jpg?v=1762264552"},{"product_id":"pet-for-drug-development-and-evaluation-book-d-comar-9780792337164","title":"PET for Drug Development and Evaluation","description":"The book shows the fields in which PET offers new and unique  information for the development of drugs (conception, toxicity,  pharmacokinetics and metabolism, clinical research, and relations  between clinical and biological effects) and evaluates fields in which  PET may shorten the development time of drugs.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52662983688465,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52662984311057,"sku":"NLS9780792337164","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780792337164.jpg?v=1762270846"},{"product_id":"spect-imaging-of-the-brain-book-r-duncan-9780792341864","title":"SPECT Imaging of the Brain","description":"This text gives an account of the SPECT technique, including basic aspects of radiation, radiation dosimetry and radiation protection, and the use of SPECT in major domains such as epilepsy, psychiatric disorders, head injury, cerebrovascular disorders, and cerebral neoplasm. 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