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When Pierre died tragically in 1906 from an automobile accident, Marie was appointed by the Sorbonne to fill his professorship, and thus she became the first female member of the faculty in the 650-year history of the university. Despite the great loss of her husband and the burden of having to raise two daughters alone, Marie carried on the work that she and Pierre had begun. In 1910, her fundamental treatise on radioactivity was published, and in 1911 she was awarded the Nobel Prize for Chemistry for the isolation of pure radium.  Unfortunately, her many years of close work with radioactive substances eventually had deleterious health consequences and finally in 1934 she died of leukemia. 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